Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Joint Support Formula Ingredients & Drug Interactions

by Prime by Isotonix

Joint Support Formula label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Joint Support Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Joint Support Formula is a dietary supplement by Prime by Isotonix with 5 active ingredients. Its ingredients are commonly taken for eye and vision health, skin health and acne, immune support.Based on those ingredients, 731 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin A, Pine Bark Extract, Glucosamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Joint Support Formula by Prime by Isotonix

Ask about any prescription or over-the-counter medication and we check it for interactions with Joint Support Formula by Prime by Isotonix — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Joint Support Formula by Prime by Isotonix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Joint Support Formula contains five active ingredients. Vitamin A supports vision and skin health.

Pine bark extract (maritime pine) is used for circulation and joint comfort. Potassium is an electrolyte essential for heart and muscle function.

Sodium hyaluronate (hyaluronic acid) is a naturally occurring substance that may support skin hydration and joint lubrication. Glucosamine is commonly used for joint cartilage support.

The product also contains inactive ingredients including fructose, orange juice powder, citric acid, maltodextrin, malic acid, orange and mango flavors, silicon dioxide, stevia (rebaudioside A), luo han guo fruit extract, sodium bicarbonate, and stearic acid.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: supports joint health and flexibility.
  • We looked for evidence on: Joint pain, Kashin-Beck Disease, Osteoarthritis, Cartilage degeneration, Joint stiffness.
  • The strongest evidence on file: Glucosamine is rated "Likely Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Maritime Pine is rated "Possibly Effective" for Osteoarthritis.
  • Also on file: Glucosamine is rated "Insufficient Reliable Evidence To Rate" for Joint pain, Kashin-Beck Disease.

Glucosamine is likely effective for osteoarthritis. Vitamin A is effective for vitamin A deficiency and possibly effective for oral leukoplakia, aging skin, measles, ulcerative colitis, and bronchopulmonary dysplasia.

Pine bark extract is possibly effective for osteoarthritis, chronic venous insufficiency (poor circulation in the legs), and asthma, though it appears possibly ineffective for high cholesterol. Sodium hyaluronate is possibly effective for dry eye and venous leg ulcers, but the evidence for aging skin, hay fever, and sexual dysfunction is insufficient to rate.

We hold no effectiveness data for potassium in this context.

The evidence, ingredient by ingredient Vitamin A Maritime Pine Potassium Hyaluronic Acid Glucosamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin A is generally safe at recommended amounts, but high doses are toxic because the body stores it and it can build up over time. High-dose vitamin A (especially as retinol) can cause birth defects and should be avoided in pregnancy; recommended amounts are appropriate.

Potassium from food is fine, but supplements carry a serious risk in people with kidney disease and can cause dangerously high blood levels. Pine bark extract is generally well tolerated in studies, though long-term safety isn't fully established; it should be avoided in pregnancy and while breastfeeding due to insufficient safety data.

Sodium hyaluronate appears well tolerated for most adults, but oral supplement safety over the long term isn't fully studied; oral supplements should be avoided in pregnancy and breastfeeding unless your doctor advises otherwise. Glucosamine is generally well tolerated, though quality and benefit vary among products, and it should be avoided in pregnancy and breastfeeding unless your doctor advises otherwise.

A small number of people have reported allergic reactions to glucosamine, including rare cases of severe reactions.

Side effects, ingredient by ingredient Vitamin A Maritime Pine Potassium Hyaluronic Acid Glucosamine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Glucosamine, Potassium, Vitamin A, Maritime Pine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 732 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Joint Support Formula, double-check with your own doctor or pharmacist if you take retinoid skin medications, blood thinners like warfarin or other anticoagulants, antiplatelet drugs like aspirin, blood pressure medications (ACE inhibitors or angiotensin receptor blockers), potassium-sparing diuretics, diabetes medications, immunosuppressants, tetracycline antibiotics, or cancer drugs—especially topoisomerase II inhibitors. The potassium content also poses a serious risk if you have kidney disease.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This formula combines ingredients used for joint and skin support, with glucosamine likely effective for osteoarthritis and vitamin A effective for deficiency. However, the multiple ingredients interact with numerous medication classes—especially blood thinners, blood pressure drugs, diabetes medications, and cancer drugs.

If you take any prescription medication, especially for the heart, blood clotting, blood pressure, diabetes, or cancer, check your exact medications with the tool on this page before starting, and talk it over with your own doctor or pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Joint Support Formula, straight from the product label.

Brand Prime by Isotonix
Barcode (UPC) 848570006295
Net contents 10.6 Ounce(s); 300 Gram(s)
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 298791
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Joint Support Formula by Prime by Isotonix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6.6 Gram(s)
Maximum serving Sizes:
6.6 Gram(s)
Servings per container
45
UPC/BARCODE
848570006295
IngredientAmount% DV
Calories10 Calorie(s)--
Total Carbohydrates2 Gram(s)1%
Vitamin A150 mcg RAE1%
Added Sugars2 Gram(s)4%
Total Sugars2 Gram(s)--
Pine Bark Extract25 mg--
Potassium150 mg3%
Sodium Hyaluronate25 mg--
Glucosamine1000 mg--

Other ingredients: Fructose, Orange Juice, Powder, Citric Acid, Maltodextrin, Malic Acid, Orange Flavor, Mango flavor, Silicon Dioxide, Rebaudioside A, Luo Han Guo fruit extract, Sodium Bicarbonate, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Promotes normal cartilage synthesis and regeneration Helps maintain joint comfort Helps maintain healthy joint fluidity and flexibility

This product contains no added wheat, soy, yeast, gluten, artificial colors, starch, salt, preservatives or milk.

Gluten free

Brand IP Statement(s)

Prime Anti-Aging Nutraceuticals

As Pycogenol. Pycogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one of more U.S. Patents and other international patents.

FDA Statement of Identity

An Isotonic-Capable Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions for use: Pour 2 level, white bottle capfuls of powder into a cup. Add 4 fl oz/120 ml (line on the overcap indicates 2 fl oz/60 ml) of water and stir. As a dietary supplement, take once daily or as directed by your healthcare provider. Maximum absorption occurs when taken on an empty stomach. This product is only isotonic only if the specific amounts of powder and water are used.

Precautions

Warning: If you are currently using warfarin (Coumadin), other antiplatelet/anticoagulant drugs, or antihypertensive drugs, consult your healthcare provider before using this product. If you are currently using any other prescription drugs or have an ongoing medical condition, consult your healthcare provider before using this product. If you have a known allergy to shellfish, or if you are pregnant or breastfeeding, do not use this product.

If you have a known allergy to shellfish, or if you are pregnant or breastfeeding, do not use this product.

Keep out of the reach of children.

Do not use if safety seal is broken or missing.

Resale on third-party websites is strictly prohibited unless specifically authorized by Market America or its corporate affiliates. If barcodes are altered or you purchase this product from an unauthorized third-party website, the product is not guaranteed by Market America or its corporate affiliates.

Contains: Shellfish (crab, shrimp, lobster and prawns).

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

As Pycogenol.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Joint Support Formula by Prime by Isotonix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Joint Support Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Joint Support Formula by Prime by Isotonix

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size6.6 Gram(s) Dosage formPowder Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin A

Interacts with
387 drugs
150 mcg RAE per serving Form: Beta-Carotene

Vitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplemen...

Vitamin A monograph & interactions

Pine Bark Extract

Interacts with
327 drugs
25 mg per serving

Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research...

Pine Bark Extract monograph & interactions

Potassium

Interacts with
62 drugs
150 mg per serving Form: Potassium Bicarbonate

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Sodium Hyaluronate

No known
interactions
25 mg per serving

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...

Sodium Hyaluronate monograph & interactions

Glucosamine

Interacts with
170 drugs
1000 mg per serving Form: Glucosamine Hydrochloride

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of...

Glucosamine monograph & interactions

Other (inactive) ingredients: Fructose, Orange Juice, Powder, Citric Acid, Maltodextrin, Malic Acid, Orange Flavor, Mango flavor, Silicon Dioxide, Rebaudioside A, Luo Han Guo fruit extract, Sodium Bicarbonate, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Joint Support Formula by Prime by Isotonix Drug Interactions

Want to check YOUR meds against Joint Support Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
731Drugs
11 Major 719 Moderate 1 Minor

Ingredients driving the most interactions

Vitamin A 387
Pine Bark Extract 327
Glucosamine 170
Potassium 62

Individual Drug Interactions

The ingredients in Joint Support Formula interact with 731 drugs. Click any drug to see the details.

4 of the 5 ingredients in Joint Support Formula interact with drugs. Each result below shows which ingredient is responsible. Vitamin A Pine Bark Extract Glucosamine Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Joint Support Formula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin A4 drug types · 387 drugs

Retinoids

Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Retinoids, which are vitamin A derivatives, could have additive toxic effects when taken with vitamin A supplements.

Likelihood Probable Evidence D
Hepatotoxic Drugs

Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
The tolerable upper intake level (UL) is the highest level of intake that is likely to pose no risk of adverse effects. Doses of vitamin A above the UL can cause hepatotoxicity, ranging from elevated liver enzymes to liver failure.

Likelihood Possible Evidence C
Tetracycline Antibiotics

Theoretically, taking tetracycline antibiotics with high doses of vitamin A can increase the risk of pseudotumor cerebri.
Benign intracranial hypertension (pseudotumor cerebri) can occur with tetracyclines and with acute or chronic vitamin A toxicity. Case reports suggest that taking tetracyclines and vitamin A concurrently can increase the risk of this condition. Avoid high doses of vitamin A in people taking tetracyclines chronically.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, high doses of vitamin A could increase the risk of bleeding with warfarin.
Vitamin A toxicity is associated with hemorrhage and hypoprothrombinemia, possibly due to vitamin K antagonism. Advise patients taking warfarin to avoid doses of vitamin A above the tolerable upper intake level of 10,000 IU/day for adults.

Likelihood Possible Evidence D
Vitamin A full monograph & interactions

Pine Bark Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Clinical research suggests that maritime pine bark extract inhibits platelet aggregation. However, the clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
One clinical study shows that maritime pine bark extract decreases blood sugar in patients with diabetes being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
In vitro and animal research suggests that maritime pine bark extract has immunostimulant activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Pine Bark Extract full monograph & interactions

Glucosamine4 drug types · 170 drugs

Warfarin (Coumadin)

Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in international normalized ratio (INR) in patients previously stabilized on warfarin. In one case, the increase in INR occurred only after tripling the dose of a glucosamine/chondroitin supplement from 500 mg/400 mg daily to 1500/1200 mg daily. Additionally, 20 voluntary case reports to the U.S. Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone to increased INR in patients taking warfarin. The mechanism of this interaction is unclear. Glucosamine is a small component of heparin, but is not thought to have anticoagulant activity; however, animal research suggests that it might have antiplatelet activity.

Likelihood Probable Evidence D
Topoisomerase Ii Inhibitors

Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
In vitro research suggests that glucosamine might induce resistance to etoposide (VP16, VePesid) and doxorubicin (Adriamycin) by reducing inhibition of topoisomerase II, an enzyme required for DNA replication in tumor cells. This effect has not been reported in humans.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Anecdotal reports suggest that adding glucosamine to an acetaminophen regimen might decrease pain control in patients with osteoarthritis. Some research suggests that the sulfate portion of glucosamine sulfate might contribute to its effect in osteoarthritis. Since acetaminophen metabolism requires sulfur and reduces serum sulfate concentrations, acetaminophen could theoretically interfere with the action of glucosamine sulfate. Conversely, the administration of sulfate could theoretically decrease the effectiveness of acetaminophen in sulfate-deficient people by increasing its clearance.

Likelihood Possible Evidence B
Antidiabetes Drugs

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
In vitro and animal research has suggested that glucosamine might increase insulin resistance or decrease insulin production. This has raised concerns that taking glucosamine might worsen diabetes and decrease the effectiveness of diabetes drugs. However, clinical research suggests that glucosamine does not have adverse effects on blood glucose or glycated hemoglobin (HbA1C) in healthy, obese, or type 2 diabetes patients.

Likelihood Unlikely Evidence B
Glucosamine full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Joint Support Formula, from the product label.

Prime by Isotonix

Name
Market America, Inc.
Street Address
1302 Pleasant Ridge Road
City
Greensboro
State
NC
ZipCode
27409
Pharmacist Counseling Corner

Joint Support Formula by Prime by Isotonix: Common Questions

Does Joint Support Formula by Prime by Isotonix interact with any medications?
Yes. Based on its ingredients, Joint Support Formula has a known interaction with 731 medications, including 11 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Joint Support Formula contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this during pregnancy?
The safety data is mixed. Vitamin A at recommended amounts is likely safe, but high-dose vitamin A can cause birth defects and should be avoided. Pine bark extract and glucosamine should be avoided in pregnancy because there isn't enough safety data. Potassium from normal diet is fine, but supplements need medical guidance. There's no data on file for sodium hyaluronate in pregnancy. Talk with your doctor or pharmacist for personalized advice about whether this product is right for you.
Can I take this while breastfeeding?
Pine bark extract should be avoided while breastfeeding due to insufficient safety data. Glucosamine also should be avoided unless your doctor advises otherwise. Potassium from diet is appropriate, but check with your doctor before using supplements. We don't have safety data on file for sodium hyaluronate during breastfeeding. Discuss this product with your doctor or pharmacist before starting.
What are the most common side effects?
Potassium may cause abdominal pain, belching, diarrhea, flatulence, nausea, and vomiting. Glucosamine commonly causes bloating, constipation, cramps, diarrhea, heartburn, and nausea. Pine bark extract may cause gastrointestinal complaints, dizziness, and vertigo. Vitamin A at recommended doses is generally well tolerated. At high doses, vitamin A can cause dry skin, rashes, and hair loss.
Does glucosamine really work for joint pain?
Glucosamine is likely effective for osteoarthritis based on our data. However, the evidence for back pain and other joint conditions is insufficient to rate. Results vary between people and products, so talk with your doctor about whether it's right for you.
Why does this formula have potassium in it?
Potassium is an electrolyte essential for heart rhythm, muscle function, and nerve signaling. It's included in joint support formulas because electrolyte balance supports overall body function. However, if you have kidney disease or take certain blood pressure or diuretic medications, the potassium in supplements can be risky—check with your doctor before taking it.
Can I take acetaminophen (Tylenol) with this?
Glucosamine may interact with acetaminophen and potentially decrease pain relief, though the evidence is limited to anecdotal reports. If you need pain relief while taking this formula, talk with your pharmacist about the best option for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Joint Support Formula label
Go deeper

The Full Monographs Behind Joint Support Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin A

Interacts with 387 drugs

Vitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplements are mainly useful for correcting a tr...

Read the full Vitamin A monograph → Herb & supplement monograph

Maritime Pine

Interacts with 327 drugs

Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research is promising, but many studies are small...

Read the full Maritime Pine monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph → Herb & supplement monograph

Glucosamine

Interacts with 170 drugs

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of the knee. The evidence is mixed, with so...

Read the full Glucosamine monograph →
Sources

Sources & How We Checked

Joint Support Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 119 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin A 31 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Griffiths JK. The vitamin A paradox. J Pediatr 2000;137:604-7.. PubMed
  3. Hardman JG, Limbird LL, Molinoff PB, eds. Goodman and Gillman's The Pharmacological Basis of Therapeutics, 9th ed. New York, NY: McGraw-Hill, 1996.
  4. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  5. FDA Talk Paper. Vitamin A and birth defects (T95-56). Food and Drug Administration, U.S. Department of Health and Human Services, Rockville, MD. October 6, 1995.
  6. Russell RM. The vitamin A spectrum: from deficiency to toxicity. Am J Clin Nutr 2000;71:878-84. PubMed
  7. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  8. Feskanich D, Singh V, Willett WC, Colditz GA. Vitamin A intake and hip fractures among postmenopausal women. JAMA 2002;287:47-54. PubMed
  9. Melhus H, Michaelsson K, Kindmark A, et al. Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture. Ann Intern Med 1998;129:770-8. PubMed
  10. Michaelsson K, Lithell H, Vessby B, Melhus H. Serum retinol levels and the risk of fracture. N Engl J Med 2003;348:287-94.. PubMed
  11. Botterweck AA, van den Brandt PA, Goldbohm RA. Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up. Cancer 2000;88:737-48.. DOI
  12. Meyskens FL Jr, Graham V, Chvapil M, et al. A phase I trial of beta-all-trans-retinoic acid delivered via a collagen sponge and a cervical cap for mild or moderate intraepithelial cervical neoplasia. J Natl Cancer Inst 1983;71:921-5..
  13. Hathcock JN, Hattan DG, Jenkins MY, et al. Evaluation of vitamin A toxicity. Am J Clin Nutr 1990;52:183-202.. PubMed
  14. Walters BN, Gubbay SS. Tetracycline and benign intracranial hypertension: report of five cases. Br Med J 1981;282:19-20.. PubMed
  15. Pearson MG, Littlewood SM, Bowden AN. Tetracycline and benign intracranial hypertension (letter). Br Med J 1981;282:568-9.. PubMed
  16. Azais-Braesco V, Pascal G. Vitamin A in pregnancy: requirements and safety limits. Am J Clin Nutr 2000;71:1325S-33S. PubMed
  17. Smedts HP, de Vries JH, Rakhshandehroo M, et al. High maternal vitamin E intake by diet or supplements is associated with congenital heart defects in the offspring. BJOG 2009;116:416-23. PubMed
  18. Grotto, I., Mimouni, M., Gdalevich, M., and Mimouni, D. Vitamin A supplementation and childhood morbidity from diarrhea and respiratory infections: a meta-analysis. J Pediatr 2003;142(3):297-304. PubMed
  19. Mahalanabis, D., Lahiri, M., Paul, D., Gupta, S., Gupta, A., Wahed, M. A., and Khaled, M. A. Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute l
  20. Long, K. Z., Montoya, Y., Hertzmark, E., Santos, J. I., and Rosado, J. L. A double-blind, randomized, clinical trial of the effect of vitamin A and zinc supplementation on diarrheal disease and respiratory tract infections in children in Mexico City, Mex
  21. Fritz, H., Kennedy, D., Fergusson, D., Fernandes, R., Doucette, S., Cooley, K., Seely, A., Sagar, S., Wong, R., and Seely, D. Vitamin A and retinoid derivatives for lung cancer: a systematic review and meta analysis. PLoS.One. 2011;6(6):e21107. PubMed
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Maritime Pine 14 references
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Potassium 12 references
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Hyaluronic Acid 4 references
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Glucosamine 58 references
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