No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Juglans Regia Ingredients & Drug Interactions

by UNDA Gemmo

Juglans Regia label
See full label image
Liquid Category: Botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Juglans Regia against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Juglans Regia is a dietary supplement by UNDA Gemmo with 1 active ingredient. Its ingredients are commonly taken for heart and cholesterol health, brain health, general nutrition (omega-3 source).We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of Juglans Regia by UNDA Gemmo

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: English Walnut (Juglans regia) bud extract. The liquid also includes glycerin, ethanol, and purified water as inactive ingredients that help deliver the extract.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded English Walnut's overall clinical evidence instead.

Moderate

Some clinical evidence supports English Walnut for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Hypercholesterolemia — rated "Possibly Effective" (Natural Medicines).

The data shows English Walnut is possibly effective for high cholesterol (hypercholesterolemia). For coronary heart disease and diabetes, the evidence isn't established well enough to rate — we simply don't have reliable data yet on whether it helps with those conditions.

The evidence, ingredient by ingredient English Walnut

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

English Walnut, when consumed as whole food, is generally well tolerated. The most common side effects are mild — softening of stools and mild bloating.

If you have a tree nut allergy, this is important: walnuts can cause serious allergic reactions, including oral allergy syndrome (itching in your mouth right after you consume it) and, rarely, swelling of your lips and tongue (angioedema). The safety of concentrated supplements like this one hasn't been well studied, so caution is warranted if you're sensitive.

One study found that walnut leaf extract caused mild diarrhea in about 39% of adults who used it daily. Pregnancy and lactation data show conflicting ratings — one entry says likely safe, another says possibly unsafe — so talk with your doctor or pharmacist for personalized guidance if you're pregnant or nursing.

Side effects, ingredient by ingredient English Walnut

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredient we could check. Still, check your exact medications with the search tool on this page or ask your doctor or pharmacist before starting.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

If you have high cholesterol and no tree nut allergy, this product may be worth discussing with your doctor. If you do have a walnut or tree nut allergy, skip it — the risk of an allergic reaction outweighs any potential benefit.

Either way, run it past your own pharmacist or doctor before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Juglans Regia, straight from the product label.

Brand UNDA Gemmo
Barcode (UPC) 88319630990
Net contents 4.2 Fluid Ounce(s); 125 mL
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 244849
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Juglans Regia by UNDA Gemmo, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.25 mL
Maximum serving Sizes:
1.25 mL
Servings per container
100
UPC/BARCODE
88319630990
IngredientAmount% DV
English Walnut (Juglans regia) bud extract1.25 mL--

Other ingredients: Glycerin, Ethanol, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Dose: Adults and Children (over 12 years): Take 50 drops (1.25 ml) three times daily in a small amount of water or as recommended by your healthcare practitioner.

Precautions

Risk Information: If you are pregnant or breastfeeding, do not use, unless directed by your healthcare practitioner.

For risk information, see outer box. Do not use if seal is missing or broken.

Keep out of reach of children.

Formula

Gemmae Bud

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place.

General Statements

V1.0

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Juglans Regia by UNDA Gemmo label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Juglans Regia label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Juglans Regia by UNDA Gemmo

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1.25 mL Dosage formLiquid Servings per container100 Amounts shown are per serving.

English Walnut (Juglans regia) bud extract

No known
interactions
1.25 mL per serving

English walnut is a nutritious tree nut rich in plant-based omega-3 fats, fiber, and antioxidants, and eating it as part of a balanced diet may suppor...

English Walnut (Juglans regia) bud extract monograph & interactions

Other (inactive) ingredients: Glycerin, Ethanol, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Juglans Regia by UNDA Gemmo Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Juglans Regia. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Juglans Regia, from the product label.

UNDA Gemmo

See all UNDA Gemmo products
Name
Seroyal USA
City
Pittsburg
State
PA
ZipCode
15275
Phone Number
1-888-737-6925
Pharmacist Counseling Corner

Juglans Regia by UNDA Gemmo: Common Questions

Does Juglans Regia by UNDA Gemmo interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Juglans Regia. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Juglans Regia contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have a tree nut allergy?
No. Walnuts are tree nuts and can cause serious allergic reactions in people with this allergy, including mouth itching, and rarely, swelling of the lips and tongue. Skip this product if you're allergic to tree nuts.
What side effects should I expect?
Most people who take it feel fine. The most common mild effects are softening of stools and mild bloating. Walnut leaf extract has been reported to cause mild diarrhea in some people, especially with daily use.
Does this work for high cholesterol?
The data shows it's possibly effective for high cholesterol. That means there's some evidence it may help, but it's not a substitute for diet changes, exercise, or prescription medications your doctor prescribes.
Is it safe to take while pregnant or nursing?
The data we hold shows conflicting information — one rating says likely safe, another says possibly unsafe. Because of this conflict, talk with your doctor or pharmacist for personalized advice before taking it during pregnancy or while nursing.
What is bud extract, and why use it instead of whole walnut?
Bud extract is a concentrated form made from walnut buds. The safety of concentrated supplements like this hasn't been well studied, so this product should be used with more caution than whole walnuts as food.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Juglans Regia is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Juglans Regia label
Go deeper

The Full Monographs Behind Juglans Regia’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

English Walnut

English walnut is a nutritious tree nut rich in plant-based omega-3 fats, fiber, and antioxidants, and eating it as part of a balanced diet may support heart health. Most concentrated supple...

Read the full English Walnut monograph →
Sources

Sources & How We Checked

Juglans Regia's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

English Walnut 16 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  4. Zambon D, Sabate J, Munoz S, et al. Substituting walnuts for monounsaturated fat improves the serum lipid profile of hypercholesterolemic men and women. A randomized crossover trial. Ann Intern Med 2000;132:538-46. PubMed
  5. Chisholm A, Mann J, Skeaff M, et al. A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hyperlipidaemic subjects. Eur J Clin Nutr 1998;52:12-6. PubMed
  6. Sabate J, Fraser GE, Burke K, et al. Effects of walnuts on serum lipid levels and blood pressure in normal men. N Engl J Med 1993;328:603-7. PubMed
  7. Feldman EB. The scientific evidence for a beneficial health relationship between walnuts and coronary heart disease. J Nutr 2002;132:1062S-101S. PubMed
  8. Asero R. Detection and clinical characterization of patients with oral allergy syndrome caused by stable allergens in Rosaceae and nuts. Ann Allergy Asthma Immunol 1999;83:377-83. PubMed
  9. Bonamonte D, Foti C, Angelini G. Hyperpigmentation and contact dermatitis due to Juglans regia. Contact Dermatitis 2001;44:101-2. PubMed
  10. Hu FB, Stampfer MJ. Nut consumption and risk of coronary heart disease: a review of epidemiologic evidence. Curr Atheroscler Rep 1999;1:204-9. PubMed
  11. Tapsell LC, Gillen LJ, Patch CS, et al. Including walnuts in a low-fat/modified-fat diet improves HDL cholesterol-to-total cholesterol ratios in patients with type 2 diabetes. Diabetes Care 2004;27:2777-83. PubMed
  12. Rabiei K, Ebrahimzadeh MA, Saeedi M, et al. Effects of a hydroalcoholic extract of Juglans regia (walnut) leaves on blood glucose and major cardiovascular risk factors in type 2 diabetic patients: a double-blind, placebo-controlled clinical trial. BMC Com PubMed
  13. Hosseini S, Jamshidi L, Mehrzadi S, et al. Effects of Juglans regia L. leaf extract on hyperglycemia and lipid profiles in type two diabetic patients: a randomized double-blind, placebo-controlled clinical trial. J Ethnopharmacol. 2014;152(3):451-6. PubMed
  14. FDA. Qualified Health Claims: Letter of Enforcement Discretion - Walnuts and Coronary Heart Disease (Docket No 02P-0292). March 2004. Available at: http://wayback.archive-it.org/7993/20171114183649/https:/www.fda.gov/Food/IngredientsPackagingLabeling/Labe
  15. Food and Drug Administration. Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA); Public Law 108-282, Title II. Accessed on May 19, 2021. Available at: https://www.fda.gov/food/food-allergensgluten-free-guidance-documents-regulatory-infor
  16. Mirzababaei A, Daneshvar M, Abaj F, et al. The Effect of Walnut (Juglans regia) Leaf Extract on Glycemic Control and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Clin Nutr Re

See these in context on the English Walnut monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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