Interactions on record — worth a quick check against your medications. Based on 3 of 7 ingredients. Check your meds →
Dietary supplement

Kang Gu Zeng Sheng Tablets Ingredients & Drug Interactions

by Plum Flower

Kang Gu Zeng Sheng Tablets label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Kang Gu Zeng Sheng Tablets against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Kang Gu Zeng Sheng Tablets is a dietary supplement by Plum Flower with 7 active ingredients. Its ingredients are commonly taken for kidney and adrenal support, anemia and blood building (traditional), inflammatory conditions.Based on those ingredients, 1,043 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Epimedium brevicornum Leaf Extract, Rehmannia glutinosa Root Extract, Raphanus sativus Seed Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Kang Gu Zeng Sheng Tablets by Plum Flower

Ask about any prescription or over-the-counter medication and we check it for interactions with Kang Gu Zeng Sheng Tablets by Plum Flower — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Kang Gu Zeng Sheng Tablets by Plum Flower

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (1,200 mg) without saying how much of each component you get.

Kang Gu Zeng Sheng Tablets contains seven active ingredients, most of them plant extracts delivered in a proprietary blend. The named actives are rehmannia root, drynaria rhizome, radish seed, cynomorium herb, spatholobus stem, pyrola herb, and horny goat weed leaf.

The inactive ingredients — dextrin, hypromellose, polyethylene glycol, and magnesium stearate — are fillers and binders that hold the tablet together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Chronic kidney disease (CKD) — rated "Possibly Effective" (Rehmannia) (Natural Medicines).

The evidence for this product's effectiveness is limited in our data. Rehmannia has possibly effective evidence for chronic kidney disease, but for other uses (aplastic anemia, bone health, diabetes, and diabetic kidney disease) the evidence is insufficient to rate.

Radish seed has insufficient evidence for biliary disorders and diabetes. Horny goat weed has insufficient evidence for bronchitis, sexual dysfunction, bone health, and heart disease.

Overall, what this product is designed to treat and how well it works are not established in the research we hold.

The evidence, ingredient by ingredient Rehmannia Radish Horny Goat Weed

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rehmannia is used in traditional medicine, but human safety data are limited and quality varies between products — use caution. Radish is widely eaten as food and safe in normal dietary amounts, though concentrated supplements are less well studied; large amounts may cause mild stomach irritation.

Horny goat weed appears well tolerated in short-term use, but human safety data are limited. The most common side effects reported with horny goat weed are dizziness, dry mouth, nosebleed, thirst, and vomiting.

Long-term use has been linked to vomiting, dry mouth, thirst, and nosebleed. A rare case of respiratory arrest has been reported.

One man developed an abnormal heart rhythm after two weeks of use, though it's unclear if horny goat weed alone was responsible. Do not use this product during pregnancy or while breastfeeding — there is not enough safety information for either, and horny goat weed is rated possibly unsafe in pregnancy.

Side effects, ingredient by ingredient Rehmannia Radish Horny Goat Weed

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Radish, Horny Goat Weed, Rehmannia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,044 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this if you use blood sugar medications (antidiabetes drugs), blood pressure medications (antihypertensive drugs), blood thinners (anticoagulants or antiplatelet drugs), estrogen-containing medications, or drugs processed through your liver's CYP3A4, CYP1A2, or CYP2B6 pathways — horny goat weed and rehmannia carry documented interactions with these drug types. No interactions are documented for the other ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This traditional formula may appeal to those seeking plant-based support, but the evidence for what it does is not well established in our data. Before you start, check your medications against the interactions listed here — especially blood pressure drugs, diabetes medications, blood thinners, estrogen products, and any drug your liver processes heavily.

If you are pregnant, breastfeeding, or taking any prescription medication, talk to your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Kang Gu Zeng Sheng Tablets, straight from the product label.

Brand Plum Flower
Barcode (UPC) 739934939321
Net contents 100 Tablet(s); 1.06 Ounce(s); 30 Gram(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 336478
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Kang Gu Zeng Sheng Tablets by Plum Flower, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Tablet(s)
Maximum serving Sizes:
4 Tablet(s)
Servings per container
25
UPC/BARCODE
739934939321
IngredientAmount% DV
Proprietary Extract Blend1200 mg--
Rehmannia glutinosa Root Extract0 NP--
Drynaria fortunei Rhizome Extract0 NP--
Raphanus sativus Seed Extract0 NP--
Cynomorium songaricum Herb Extract0 NP--
Spatholobus suberectus Stem Extract0 NP--
Pyrola calliantha Herb Extract0 NP--
Epimedium brevicornum Leaf Extract0 NP--

Other ingredients: Dextrin, Hypromellose, Polyethylene Glycol, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

GMP quality

US owned & family operated since 1969. Made in China

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Take 4 tablets 2 times daily or as directed by your health care practitioner

Precautions

Not for use during pregnancy

Keep out of reach of children

Seals/Symbols

Plum Flower Guarantee Sourced Sustainably FDA Registered cGMP Compliant Made at a cGMP Certified Facility Lab Tested Quality Verified Species Verified

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Kang Gu Zeng Sheng Tablets by Plum Flower label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Kang Gu Zeng Sheng Tablets label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Kang Gu Zeng Sheng Tablets by Plum Flower

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Tablet(s) Dosage formTablet Or Pill Servings per container25 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Extract Blend

1200 mg per serving

Other (inactive) ingredients: Dextrin, Hypromellose, Polyethylene Glycol, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Kang Gu Zeng Sheng Tablets by Plum Flower Drug Interactions

Want to check YOUR meds against Kang Gu Zeng Sheng Tablets?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,043Drugs
1,043 Moderate

Ingredients driving the most interactions

Epimedium brevicornum Leaf Extract 963
Rehmannia glutinosa Root Extract 258
Raphanus sativus Seed Extract 86

Individual Drug Interactions

The ingredients in Kang Gu Zeng Sheng Tablets interact with 1,043 drugs. Click any drug to see the details.

3 of the 7 ingredients in Kang Gu Zeng Sheng Tablets interact with drugs. Each result below shows which ingredient is responsible. Epimedium brevicornum Leaf Extract Rehmannia glutinosa Root Extract Raphanus sativus Seed Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Kang Gu Zeng Sheng Tablets with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Epimedium brevicornum Leaf Extract6 drug types · 963 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.

Likelihood Possible Evidence D
Epimedium brevicornum Leaf Extract full monograph & interactions

Rehmannia glutinosa Root Extract2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that rehmannia may have hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that rehmannia may have hypotensive effects. Laboratory research shows that formulations of dried and processed rehmannia root inhibit angiotensin-converting enzyme (ACE).

Likelihood Possible Evidence D
Rehmannia glutinosa Root Extract full monograph & interactions

Raphanus sativus Seed Extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, radish might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that radish extract, juice, and sprouts can reduce glucose levels. Animal research also shows that radish root juice 300 mg/kg reduces fasting and postprandial blood glucose in a rat model of diabetes, with effects similar to glibenclamide.

Likelihood Possible Evidence D
Raphanus sativus Seed Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Kang Gu Zeng Sheng Tablets, from the product label.

Plum Flower

Name
Mayway Herbs
City
Oakland
State
CA
Web Address
plumflowerherbs.com
Pharmacist Counseling Corner

Kang Gu Zeng Sheng Tablets by Plum Flower: Common Questions

Does Kang Gu Zeng Sheng Tablets by Plum Flower interact with any medications?
Yes. Based on its ingredients, Kang Gu Zeng Sheng Tablets has a known interaction with 1,043 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Kang Gu Zeng Sheng Tablets contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — there is not enough safety information to recommend this product during pregnancy or while breastfeeding. Horny goat weed is rated possibly unsafe in pregnancy. Talk to your doctor or pharmacist about whether this product is right for you.
What is horny goat weed supposed to do in this formula?
In traditional medicine, horny goat weed has been used for sexual dysfunction, coronary heart disease, bronchitis, and bone health. However, the evidence in our data is insufficient to rate whether it actually works for any of these uses.
Can this cause side effects?
Horny goat weed may cause dizziness, dry mouth, nosebleed, thirst, and vomiting, especially with longer use. Radish in large amounts may cause mild stomach irritation. Rehmannia safety data in humans are limited, so uncommon side effects might not be well documented.
Is radish safe to take?
Radish is generally safe in normal food amounts. A concentrated supplement form is less well studied for safety, and very large amounts may irritate your stomach. One rare allergy case has been reported with symptoms of throat tightness and hives.
What does this product actually treat?
We don't have established evidence in our data for what this formula is designed to treat. Rehmannia has possibly effective evidence for chronic kidney disease only; the other ingredients and uses lack sufficient reliable evidence to rate.
Why do I need to check my medications?
Horny goat weed affects the way your liver processes many common drugs, and both horny goat weed and rehmannia can lower blood sugar and blood pressure — effects that matter if you're already on those medications. The interaction checker will show you your exact risks.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Kang Gu Zeng Sheng Tablets is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Kang Gu Zeng Sheng Tablets label
Go deeper

The Full Monographs Behind Kang Gu Zeng Sheng Tablets’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rehmannia

Interacts with 258 drugs

Rehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health. Human evidence for most modern uses is limited, so i...

Read the full Rehmannia monograph → Herb & supplement monograph

Radish

Interacts with 86 drugs

Radish is a common edible root vegetable that is nutritious and generally safe to eat as food. Some people use radish (especially black radish) and its extracts for digestion and liver suppo...

Read the full Radish monograph → Herb & supplement monograph

Horny Goat Weed

Interacts with 963 drugs

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these uses is lacking. While short-term use s...

Read the full Horny Goat Weed monograph →
Sources

Sources & How We Checked

Kang Gu Zeng Sheng Tablets's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rehmannia 3 references
  1. Zhang R, Zhou J, Jia Z, et al. Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism. J Ethnopharmacol 2004;90:39-43. PubMed
  2. Zhang RX, Li MX, Jia ZP. Rehmannia glutinosa: review of botany, chemistry and pharmacology. J Ethnopharmacol 2008;117(2):199-214. PubMed
  3. Chao CH, Hsu JL, Chen MF, et al. Anti-hypertensive effects of Radix Rehmanniae and its active ingredients. Nat Prod Res. 2020;34(11):1547-1552.

See these in context on the Rehmannia monograph →

Radish 5 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Damiani E, Aloia AM, Priore MG, Nardulli S, Ferrannini A. Generalized urticaria after ingestion of Raphanus sativus. Ann Allergy Asthma Immunol. 2011 Feb;106(2):168. PubMed
  3. Evans M, Paterson E, Barnes DM. An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects. BMC Complement Altern Med. 2014 Dec 9;14:475. PubMed
  4. Banihani SA. Radish (Raphanus sativus) and diabetes. Nutrients. 2017;9(9). pii: E1014. PubMed
  5. Shukla S, Chatterji S, Mehta S, Rai PK, Singh RK, Yadav DK, Watal G. Antidiabetic effect of Raphanus sativus root juice. Pharm Biol. 2011 Jan;49(1):32-7.

See these in context on the Radish monograph →

Horny Goat Weed 11 references
  1. Cirigliano MD, Szapary PO. Horny goat weed for erectile dysfunction. Alt Med Alert 2001;4:19-22.
  2. Partin JF, Pushkin YR. Tachyarrhythmia and hypomania with horny goat weed. Psychosomatics 2004;45:536-7. PubMed
  3. De Naeyer A, Pocock V, Milligan S, De Keukeleire D. Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum. Fitoterapia 2005;76:35-40. PubMed
  4. Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
  5. Yap SP, Shen P, Li J, et al. Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. J Ethnopharmacol 2007;113:218-24. PubMed
  6. Yan, F. F., Liu, Y., Liu, Y. F., and Zhao, Y. X. Herba Epimedii water extract elevates estrogen level and improves lipid metabolism in postmenopausal women. Phytother.Res. 2008;22(9):1224-1228. PubMed
  7. Ramanathan VS, Mitropoulos E, Shlopov B, et al. An Enzyte'ing' case of acute hepatitis. J Clin Gastroenterol 2011;45(9):834-5. PubMed
  8. Zhong Q, Shi Z, Zhang L, et al. The potential of Epimedium koreanum Nakai for herb-drug interaction. J Pharm Pharmacol 2017;69(10):1398-408. doi: 10.1111/jphp.12773.
  9. Irfan M, Kwon TH, Lee DH, et al. Antiplatelet and Antithrombotic Effects of Epimedium koreanum Nakai. Evid Based Complement Alternat Med. Apr 2021;2021:7071987. PubMed
  10. Tan K, Yang W, Pang L, Hou F. Differences in clinical characteristics among 726 patients with Chinese herbal medicine- or Western medicine-induced liver injury. Medicine (Baltimore) 2022;101(32):e29909. PubMed
  11. Li K, Yu XH, Maskey AR, et al. Cytochrome P450 3A4 suppression by epimedium and active compound kaempferol leads to synergistic anti-inflammatory effect with corticosteroid. Front Pharmacol 2023;13:1042756. PubMed

See these in context on the Horny Goat Weed monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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