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Dietary supplement

Krill Healthy Joint Formula Ingredients & Drug Interactions

by Life Extension

Krill Healthy Joint Formula label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Krill Healthy Joint Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Krill Healthy Joint Formula is a dietary supplement by Life Extension with 3 active ingredients. Its ingredients are commonly taken for skin hydration and aging, joint comfort and osteoarthritis, dry eyes.Based on those ingredients, 838 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are natural Astaxanthin, Antarctic Krill (Euphausia superba) Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Krill Healthy Joint Formula by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Krill Healthy Joint Formula by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Krill Healthy Joint Formula by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Healthy Joint Proprietary Blend” is a proprietary blend — the label gives one combined amount (353 mg) without saying how much of each component you get.

This formula has 3 active ingredients. Hyaluronic acid is a natural compound that helps retain moisture in tissues.

Natural astaxanthin is a carotenoid—a pigment with antioxidant properties. Antarctic krill oil is rich in omega-3 fatty acids and phospholipids from tiny crustaceans.

The product also contains inactive ingredients: gelatin, olive oil, sorbitol, glycerin, purified water, beeswax, and vanillin as a flavoring.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Joint comfort and healthy joint structure.
  • We looked for evidence on: Osteoarthritis, Rheumatoid arthritis (RA), Carpal tunnel syndrome, Joint inflammation, Cartilage support.
  • The closest evidence on file: Hyaluronic Acid is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Carpal tunnel syndrome, Osteoarthritis, Rheumatoid arthritis (RA).
  • Also on file: Krill Oil is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis, Rheumatoid arthritis (RA).

The evidence on this formula's ingredients is mixed. Hyaluronic acid is possibly effective for dry eye and venous leg ulcers, but evidence is insufficient to rate it for aging skin, hay fever, or sexual dysfunction.

Krill oil is possibly effective for dry eye as well, but evidence is insufficient for aging skin, Alzheimer's disease, cancer, cholesterol levels, or cognitive function. Astaxanthin's effectiveness hasn't been reliably established for any condition—evidence is insufficient to rate it for age-related cognitive decline, macular degeneration, aging skin, Alzheimer's disease, athletic performance, or carpal tunnel syndrome.

The evidence, ingredient by ingredient Hyaluronic Acid Astaxanthin Krill Oil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

All three ingredients are generally well tolerated orally. Hyaluronic acid and krill oil appear safe for most adults when taken by mouth, though long-term safety data are limited.

The most common side effects with krill oil are gastrointestinal: bloating, decreased appetite, diarrhea, fishy burps, flatulence, heartburn, nausea, and stomach discomfort—though these tend to be milder with krill oil than with fish oil. Astaxanthin may cause abdominal pain, diarrhea, or red-colored stool; at very high doses, stomach pain has been reported.

Avoid this product if you have a shellfish allergy, and use caution if you have a bleeding disorder. For pregnancy and breastfeeding, the data on astaxanthin and krill oil advises against use unless your doctor clears it; safety information for hyaluronic acid isn't on file.

Side effects, ingredient by ingredient Hyaluronic Acid Astaxanthin Krill Oil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Astaxanthin, Krill Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 839 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs (like warfarin or aspirin)—krill oil may increase bleeding risk. Also flag diabetes medications (since krill oil may theoretically lower blood sugar further) and any drugs metabolized through CYP3A4 or CYP2B6 liver pathways (since astaxanthin may theoretically slow their clearance, though this hasn't been seen in humans yet).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This is a three-ingredient joint formula best suited for people without blood clotting disorders or allergies to shellfish. If you take blood thinners, diabetes medications, or drugs metabolized by certain liver enzymes, you'll need to check with your doctor or pharmacist before starting.

Expect possible gastrointestinal side effects, especially from the krill oil. The evidence on whether it actually works for joint health isn't established in the data we hold.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Krill Healthy Joint Formula, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870160038
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 231904
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Krill Healthy Joint Formula by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
737870160038
IngredientAmount% DV
Hyaluronic Acid0 NP--
natural Astaxanthin0 NP--
Antarctic Krill (Euphausia superba) Oil0 NP--
Healthy Joint Proprietary Blend353 mg--

Other ingredients: Gelatin, Olive Oil, Sorbitol, Glycerin, purified Water, Beeswax, Vanillin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. Directions: Take one (1) softgel daily, or as recommended by a healthcare practitioner.

Precautions

Caution: If you are taking anticoagulant or antiplatelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Contains crustacean shellfish (krill).

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Storage

Store tightly closed in a cool, dry place.

Brand IP Statement(s)

Licensed from Valensa International. Zanthin is a registered trademark of Valensa International, Inc. U.S. Patent Nos. 8,481,072 and 8,524.980.

Formulation

Gluten free Non GMO LE Certified

Promotes healthy joint function and mobility

Seals/Symbols

Non GMO LE Certified

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Krill Healthy Joint Formula by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Krill Healthy Joint Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Krill Healthy Joint Formula by Life Extension

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Healthy Joint Proprietary Blend

353 mg per serving

Other (inactive) ingredients: Gelatin, Olive Oil, Sorbitol, Glycerin, Purified Water, Beeswax, Vanillin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Krill Healthy Joint Formula by Life Extension Drug Interactions

Want to check YOUR meds against Krill Healthy Joint Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
838Drugs
838 Moderate

Ingredients driving the most interactions

natural Astaxanthin 671
Antarctic Krill (Euphausia superba) Oil 208

Individual Drug Interactions

The ingredients in Krill Healthy Joint Formula interact with 838 drugs. Click any drug to see the details.

2 of the 3 ingredients in Krill Healthy Joint Formula interact with drugs. Each result below shows which ingredient is responsible. natural Astaxanthin Antarctic Krill (Euphausia superba) Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Krill Healthy Joint Formula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

natural Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
natural Astaxanthin full monograph & interactions

Antarctic Krill (Euphausia superba) Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Antarctic Krill (Euphausia superba) Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Krill Healthy Joint Formula, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Krill Healthy Joint Formula by Life Extension: Common Questions

Does Krill Healthy Joint Formula by Life Extension interact with any medications?
Yes. Based on its ingredients, Krill Healthy Joint Formula has a known interaction with 838 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Krill Healthy Joint Formula contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm on a blood thinner like warfarin?
Not without checking first. Krill oil in this formula may theoretically increase bleeding risk when combined with blood thinners or antiplatelet drugs—that's a Moderate-severity concern. Talk to your doctor or pharmacist before starting; they may need to monitor you more closely or adjust your dose.
Can I take this if I'm pregnant or breastfeeding?
The safety data for astaxanthin and krill oil advise against use during pregnancy and breastfeeding unless your doctor says it's okay. Safety information for hyaluronic acid isn't on file. Talk with your doctor or pharmacist for personalized advice based on your situation.
What's the krill oil in this formula for?
Krill oil contains omega-3 fatty acids and phospholipids that may support dry eye and has been studied for various other health conditions. Evidence is sufficient to call it possibly effective for dry eye, but for other uses like joint health or aging skin, the evidence is insufficient to rate.
Will I get stomach upset from this?
Krill oil commonly causes gastrointestinal side effects—bloating, decreased appetite, diarrhea, fishy burps, flatulence, heartburn, nausea, and stomach discomfort. The good news is these tend to be milder with krill oil than with fish oil. Astaxanthin may also cause abdominal pain or diarrhea at higher doses.
Is this safe if I have a shellfish allergy?
No—krill are tiny shellfish, so this product should be avoided if you have a shellfish allergy. The facts specifically caution against use if you're allergic.
Does this really help with joint health?
The evidence on these ingredients for joint health isn't established in the data we hold. Hyaluronic acid is possibly effective for dry eye and leg ulcers, and krill oil is possibly effective for dry eye, but evidence is insufficient for aging skin and other conditions the supplement is marketed for.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Krill Healthy Joint Formula label
Go deeper

The Full Monographs Behind Krill Healthy Joint Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph → Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph →
Sources

Sources & How We Checked

Krill Healthy Joint Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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