Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Krill Oil 300 mg Ingredients & Drug Interactions

by Nature Made

Krill Oil 300 mg label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Krill Oil 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Krill Oil 300 mg is a dietary supplement by Nature Made with 5 active ingredients. Its ingredients are commonly taken for heart and cholesterol support, high triglycerides, joint pain and inflammation.Based on those ingredients, 838 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Krill Oil 300 mg by Nature Made

Ask about any prescription or over-the-counter medication and we check it for interactions with Krill Oil 300 mg by Nature Made — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Krill Oil 300 mg by Nature Made

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (114 mg) without saying how much of each component you get.

Nature Made Krill Oil 300 mg contains five active ingredients: krill oil (the main component, a crustacean-derived source of omega-3 fatty acids), eicosapentaenoic acid and docosahexaenoic acid (two specific omega-3 types), phospholipids (fat compounds in krill), and astaxanthin (a carotenoid antioxidant from krill that gives it a reddish color). The product also contains inactive ingredients—gelatin, glycerin, water, ethyl vanillin, and tocopherols—as a softgel capsule base.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: helps support a healthy heart.
  • We looked for evidence on: Cardiovascular disease (CVD), Hypertension, Hyperlipidemia, Hypertriglyceridemia, Heart failure, Coronary artery disease — and 1 related terms.
  • The closest evidence on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Heart failure (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Hypertension.
  • Also on file: Krill Oil is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, Hypertriglyceridemia.

Krill oil is rated possibly effective for dry eye. For other uses listed in the facts—aging skin, Alzheimer disease, cancer, high cholesterol (hyperlipidemia), and cognitive function—the evidence isn't established well enough to rate.

Astaxanthin shows the same picture: insufficient evidence for age-related cognitive decline, age-related macular degeneration, aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome. The data we hold doesn't support claims about these conditions.

The evidence, ingredient by ingredient Krill Oil Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Krill oil is generally well tolerated at doses up to 4 grams daily, but the most common side effects are gastrointestinal: bloating, decreased appetite, diarrhea, fishy burps, flatulence, heartburn, nausea, and stomach discomfort. These tend to be milder or less frequent with krill oil than with fish oil.

Headache, tiredness, and dizziness have been reported rarely. Avoid krill oil if you have a shellfish allergy, and use caution if you have a bleeding disorder.

For pregnancy and breastfeeding, there isn't enough reliable safety data for krill oil—talk with your doctor before using it. Astaxanthin is best avoided during pregnancy and breastfeeding due to insufficient safety data.

Long-term safety data for astaxanthin are also limited. Astaxanthin's most common side effects are abdominal pain, diarrhea, and red-colored stools; higher doses (40 mg daily) have caused severe stomach pain in a small number of trial participants.

Side effects, ingredient by ingredient Krill Oil Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Astaxanthin, Krill Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 839 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you're on anticoagulant or antiplatelet drugs (blood thinners and anti-clotting medications)—krill oil may increase bleeding risk. Also flag antidiabetes drugs, as krill oil might lower blood sugar further.

Drugs metabolized through CYP3A4 and CYP2B6 liver pathways should be reviewed too, since astaxanthin may reduce their effectiveness, though this hasn't been confirmed in humans yet.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Krill oil may help with dry eye, but evidence for other uses is lacking. If you take blood thinners, diabetes medications, or drugs processed through your liver, check with your doctor or pharmacist before starting—the interactions could matter.

Gastrointestinal side effects are common but usually mild. Pregnancy and breastfeeding require a conversation with your own healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Krill Oil 300 mg, straight from the product label.

Brand Nature Made
Barcode (UPC) 031604027384
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Sep 21, 2018
DSLD ID 179775
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Krill Oil 300 mg by Nature Made, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
UPC/BARCODE
031604027384
IngredientAmount% DV
Calories5 Calorie(s)--
Krill Oil600 mg--
Eicosapentaenoic Acid60 mg--
Docosahexaenoic Acid32 mg--
Phospholipids240 mg--
Cholesterol15 mg5%
Astaxanthin120 mcg--
Total Omega-3 Fatty Acids114 mg--

Other ingredients: Gelatin, Glycerin, Water, Ethyl Vanillin, Tocopherols

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General

List No. 2738 ILL201 Cat. A625 5A044

General Statements

Actual size

Helps support a healthy heart Superior absorption No fishy odor or aftertaste

Krill Oil Country of Origin is Israel. Encapsulated and quality tested in the U.S.A. Superior Omega -3 fatty acids (EPA+DHA) absorption compared to an equal amount of regular triglyceride fish oil. USP has tested and verified ingredients, potency, and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

USP Dietary Supplement Verified

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

No color added No yeast or starch Gluten free

Suggested/Recommended/Usage/Directions

Suggested use: Take 2 softgels daily with a meal. For easier swallowing, take with water before and during ingestion.

Storage

Keep bottle tightly closed. Store in a cool, dry place, out of reach of children.

Precautions

Store in a cool, dry place, out of reach of children.

Do not use if imprinted seal under cap is broken or missing.

Caution: If you are pregnant or nursing, allergic to shellfish, taking medications, facing surgery, have bleeding problems, or undergoing any other treatment that may affect the ability of blood to clot, consult your physician before taking this product.

Contains: Shellfish (krill).

Formula

Contains: Shellfish (krill).

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Krill Oil 300 mg by Nature Made label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Krill Oil 300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Krill Oil 300 mg by Nature Made

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Krill Oil

Interacts with
208 drugs
600 mg per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Krill Oil monograph & interactions

Phospholipids

240 mg per serving

Astaxanthin

Interacts with
671 drugs
120 mcg per serving

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Total Omega-3 Fatty Acids

114 mg per serving
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid

Other (inactive) ingredients: Gelatin, Glycerin, Water, Ethyl Vanillin, Tocopherols. These complete the product’s ingredient list but are not active constituents.

Interaction report

Krill Oil 300 mg by Nature Made Drug Interactions

Want to check YOUR meds against Krill Oil 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
838Drugs
838 Moderate

Ingredients driving the most interactions

Astaxanthin 671
Krill Oil 208

Individual Drug Interactions

The ingredients in Krill Oil 300 mg interact with 838 drugs. Click any drug to see the details.

2 of the 5 ingredients in Krill Oil 300 mg interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin Krill Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Krill Oil 300 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions

Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Krill Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Krill Oil 300 mg, from the product label.

Nature Made

See all Nature Made products
Name
Nature Made Nutritional Products
City
Mission Hills
State
CA
ZipCode
91346-9606
Phone Number
1-800-276-2878
Web Address
www.NatureMade.com
Pharmacist Counseling Corner

Krill Oil 300 mg by Nature Made: Common Questions

Does Krill Oil 300 mg by Nature Made interact with any medications?
Yes. Based on its ingredients, Krill Oil 300 mg has a known interaction with 838 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Krill Oil 300 mg contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take krill oil if I'm on a blood thinner?
Not without checking first. Krill oil's omega-3 fatty acids can reduce how blood clots, and combining them with blood thinners or anti-clotting medications carries a moderate risk of bleeding. Talk with your doctor or pharmacist before adding it.
Will krill oil lower my blood sugar if I take diabetes medication?
Possibly. Some research shows krill oil might lower blood glucose, so taking it with antidiabetes drugs could theoretically raise your low blood sugar (hypoglycemia) risk. However, one small study found no blood sugar reduction in type 2 diabetes patients. Ask your doctor or pharmacist before starting.
What's astaxanthin, and why is it in this product?
Astaxanthin is a carotenoid antioxidant that comes from krill and gives it a reddish color. It's included for potential antioxidant benefits, though the evidence for specific health claims isn't established in the data we hold.
What side effects should I expect?
The most common are gastrointestinal—bloating, diarrhea, fishy burps, heartburn, nausea, and stomach discomfort. These are usually mild and happen less often with krill oil than fish oil. Rarely, people report headache, tiredness, or dizziness.
Can I take krill oil if I have a shellfish allergy?
No. Krill are crustaceans, so krill oil should be avoided if you have a shellfish allergy. The facts advise against it for that reason.
Is it safe to take during pregnancy or breastfeeding?
There isn't enough safety data to know. Talk with your doctor or pharmacist before using krill oil (or the astaxanthin in it) during pregnancy or breastfeeding—they can give you personalized advice based on your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Krill Oil 300 mg label
Go deeper

The Full Monographs Behind Krill Oil 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Krill Oil 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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