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Dietary supplement

Krill Oil 1,000 mg Ingredients & Drug Interactions

by Healthy Origins

Krill Oil 1,000 mg label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Krill Oil 1,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Krill Oil 1,000 mg is a dietary supplement by Healthy Origins with 1 active ingredient. Its ingredients are commonly taken for heart and cholesterol support, high triglycerides, joint pain and inflammation.Based on those ingredients, 840 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Krill Oil 1,000 mg by Healthy Origins

Ask about any prescription or over-the-counter medication and we check it for interactions with Krill Oil 1,000 mg by Healthy Origins — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Krill Oil 1,000 mg by Healthy Origins

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (190 mg) without saying how much of each component you get.
  • “Krill Oil” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

Krill Oil 1,000 mg delivers 4 active ingredients: eicosapentaenoic acid and docosahexaenoic acid (two omega-3 fatty acids), total omega-3 fatty acids as a group measure, and astaxanthin, a carotenoid antioxidant naturally present in krill. The product comes in a softgel capsule with inactive ingredients including gelatin, glycerin, purified water, vanilla, and several emulsifiers and thickeners.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Astaxanthin product and its label doesn't state a use — see Astaxanthin's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish reliable effectiveness for astaxanthin in age-related cognitive decline, age-related macular degeneration, aging skin, Alzheimer disease, athletic performance, or carpal tunnel syndrome—all are rated as having insufficient evidence to rate. We don't have effectiveness data on file for the omega-3 fatty acids in this product.

The evidence, ingredient by ingredient Krill Oil Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astaxanthin is generally well tolerated in studies, though long-term safety data are limited. The most common side effects reported orally are abdominal pain, diarrhea, and red fecal color (which is harmless).

A small number of trial participants experienced increased bowel movements or red stools at 6 mg daily; at a higher dose of 40 mg daily, two patients reported severe abdominal pain. The safety data advise against use during pregnancy and while breastfeeding.

Side effects, ingredient by ingredient Krill Oil Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 674 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Healthy Origins Krill Oil, have your doctor or pharmacist check whether you take any drugs broken down by the CYP3A4 or CYP2B6 liver enzymes (moderate severity for both). Common examples include certain statins, blood pressure medications, and some psychiatric drugs—but the best way to know is to ask your pharmacist to review your medication list against our interaction checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is mainly a source of krill-derived omega-3 fatty acids plus astaxanthin. The astaxanthin component theoretically interacts with a large group of medications metabolized by your liver—though in lab settings only.

If you take any prescription medications, especially those for heart disease, mental health, or any chronic condition, check your exact drugs with your pharmacist or doctor before starting this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Krill Oil 1,000 mg, straight from the product label.

Brand Healthy Origins
Barcode (UPC) 603573814533
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 305560
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Krill Oil 1,000 mg by Healthy Origins, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
603573814533
IngredientAmount% DV
Calories10 Calorie(s)--
Eicosapentaenoic Acid100 mg--
Docosahexaenoic Acid55 mg--
Total Omega-3 Fatty Acids190 mg--
Total Fat1 Gram(s)1%
Krill Oil1000 mg--
Astaxanthin200 mcg--
Phospholipids400 mg--

Other ingredients: Gelatin, Glycerin, Water, Purified, natural Vanilla, Ethylcellulose, Sodium Alginate, Ammonium Hydroxide, Medium Chain Triglyceride, Oleic Acid, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement for adults, take one (1) softgel daily with your first meal, or as directed by a physician.

Formula

Healthy Origins Krill Oil is extracted from the Euphausia superba species of krill found in the Antarctic waters of the southern ocean. Euphausia superba, with a biomass of over 500,000,000 tons, is one of the most abundant life forms on the planet. Since the 19th century, krill has been harvested as a food source for humans and animals, but only in more recent times has it been harvested to extract the oils contained within the krill. These oils contain substantial levels of Omega 3s, Phospholipids and Astaxanthin.

Kreal Premium krill oil

Formulation

Manufactured in a cGMP facility.

Not manufactured with wheat, gluten, soy, milk, egg, fish, peanut or tree nut derived ingredients.

Non GMO

Natural Supports joint, brain and cardiovascular health

Storage

Store in a cool, dry place.

Precautions

Keep out of reach of children.

Caution: Consult a physician before use if you are pregnant, nursing, taking anti-coagulant or other medication, have a seafood allergy, or any other medical condition.

Contains: Shellfish (krill)

Caution: Consult a physician before use if you are pregnant, nursing, taking anti-coagulant or other medication, have a seafood allergy, or any other medical condition.

Brand IP Statement(s)

K-Real is a registered trademark of the Aker Group.

Healthy Origins Since 1996

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

3rd party tested

General Statements

New look

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Krill Oil 1,000 mg by Healthy Origins label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Krill Oil 1,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Krill Oil 1,000 mg by Healthy Origins

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Krill Oil

Interacts with
208 drugs
1000 mg per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Krill Oil monograph & interactions
  • › Total Omega-3 Fatty Acids
  • › Astaxanthin
  • › Phospholipids

Other (inactive) ingredients: Gelatin, Glycerin, Water, Purified, Natural Vanilla, Ethylcellulose, Sodium Alginate, Ammonium Hydroxide, Medium Chain Triglyceride, Oleic Acid, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Krill Oil 1,000 mg by Healthy Origins Drug Interactions

Want to check YOUR meds against Krill Oil 1,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
840Drugs
840 Moderate

Ingredients driving the most interactions

Krill Oil 208

Individual Drug Interactions

The ingredients in Krill Oil 1,000 mg interact with 840 drugs. Click any drug to see the details.

1 of the 1 ingredient in Krill Oil 1,000 mg interact with drugs. Each result below shows which ingredient is responsible. Krill Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Krill Oil 1,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Krill Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Krill Oil 1,000 mg, from the product label.

Healthy Origins

See all Healthy Origins products
Name
Healthy Origins
City
Pittsburgh
State
PA
ZipCode
15241
Phone Number
1-888-228-6650
Pharmacist Counseling Corner

Krill Oil 1,000 mg by Healthy Origins: Common Questions

Does Krill Oil 1,000 mg by Healthy Origins interact with any medications?
Yes. Based on its ingredients, Krill Oil 1,000 mg has a known interaction with 840 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Krill Oil 1,000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or nursing?
The safety data advise against using astaxanthin—the active antioxidant in this product—during pregnancy and while breastfeeding because there isn't enough study data. Talk with your doctor or pharmacist about whether krill oil is right for you in these situations.
What's astaxanthin and why is it in here?
Astaxanthin is a natural red pigment (carotenoid antioxidant) found in krill. We don't have reliable evidence it works for any particular health condition in our data, but it's included as part of the krill's natural content.
Will this supplement help with brain health or aging?
Our data show insufficient evidence to rate astaxanthin for age-related cognitive decline, Alzheimer disease, or aging skin. We don't have effectiveness ratings on file for the omega-3 fatty acids in this product either.
What side effects might I notice?
The most common are abdominal pain, diarrhea, and red-colored stools. Red stools are just a color effect and harmless. Astaxanthin is generally well tolerated, but long-term safety data are limited.
Is this product safe with my medications?
That depends on which drugs you take. Astaxanthin may theoretically slow how your body clears certain medications, which could change their levels in your blood. Check your exact medications with our interaction search tool below, or ask your pharmacist or doctor before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Krill Oil 1,000 mg label
Go deeper

The Full Monographs Behind Krill Oil 1,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph → Herb & supplement monograph

Astaxanthin

Interacts with 673 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Krill Oil 1,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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