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Dietary supplement

Sunflower PS 100 mg Ingredients & Drug Interactions

by Healthy Origins

Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Sunflower PS 100 mg is a dietary supplement by Healthy Origins with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sharp PS Green. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Sunflower PS 100 mg by Healthy Origins

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: phosphatidylserine (marketed as Sharp PS Green), a compound derived from sunflower seeds. The capsule also contains several inactive ingredients — medium-chain triglyceride oil, gelatin, glycerin, purified water, silicon dioxide, natural mixed tocopherols, and ascorbyl palmitate — which serve as the delivery system and preservatives.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: cognitive support with age-related decline.
  • We looked for evidence on: Age-related cognitive decline, Cognitive function, Alzheimer disease, Dementia, Memory, Mental clarity — and 1 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Possibly Effective" for Alzheimer disease.
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Dementia.

Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease based on the evidence we hold. For athletic performance, ADHD, general cognitive function, and dementia, the evidence isn't established enough for us to rate it.

If you're considering it for one of those conditions, talk with your doctor or pharmacist about whether the research fits your situation.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, though long-term safety hasn't been fully established. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea — with gastrointestinal upset possible at doses around 200–300 mg/day and insomnia more likely at higher doses like 600 mg.

There isn't enough safety information to recommend this supplement during pregnancy, so avoidance is advised. Safety while breastfeeding is also unknown, so it's best to avoid it then too.

Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check whether you take any anticholinergic drugs (like antihistamines or certain antispasmodics) or cholinergic drugs (like those for myasthenia gravis). Both are Moderate-severity interactions with phosphatidylserine.

Use the medication checker on this page to verify your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Sunflower PS 100 mg may be worth considering if you have age-related cognitive decline or Alzheimer disease and want to explore a plant-based option. Anyone taking anticholinergic or cholinergic medications needs to check with their pharmacist first — this supplement could affect how those drugs work.

Pregnant or breastfeeding people should skip it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sunflower PS 100 mg, straight from the product label.

Brand Healthy Origins
Barcode (UPC) 603573430153
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 306243
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sunflower PS 100 mg by Healthy Origins, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
120
UPC/BARCODE
603573430153
IngredientAmount% DV
Calories5 Calorie(s)--
Total Fat0.5 Gram(s)1%
Sharp PS Green100 mg--

Other ingredients: Medium Chain Triglyceride, Gelatin, Glycerin, Water, Purified, Silicon Dioxide, Mixed Tocopherols, Natural, Ascorbyl Palmitate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement for adults, take one (1) softgel up to three (3) times daily, or as directed by a physician.

Formula

Healthy Origins Sunflower PS featuring Sharp PS Green is a unique, soy-free source of phosphatidylserine derived from European, Non-GMO sunflower lecithin.

Phosphatidylserine is a phospholipid compound found naturally in brain cell membranes, however, with advancing age, our natural phosphatidylserine levels can diminish, which may impact our cognitive abilities. Unfortunately, obtaining significant amounts of phosphatidylserine through our diet has proven to be quite difficult. Therefore, many individuals have chosen to take phosphatidylserine supplements. Supplementation with phosphatidylserine may help to replenish depressed levels of phosphatidylserine, enhance cognitive focus, nourish brain cell membranes and support healthy cognitive function.

Phosphatidylserine Sharp PS Green

Brand IP Statement(s)

Sharp PS is a registered trademark of Enzymotec, Ltd.

Healthy Origins Since 1996

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

New look

Formulation

Supports healthy cognitive function

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, peanut, or tree nut derived ingredients. Non GMO

Manufactured in a cGMP facility.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

3rd Party Tested

Precautions

Caution: Consult a physician before use if you are pregnant, nursing, taking medication or have a medical condition.

Keep out of reach of children

Storage

Store in a cool, dry place.

See for yourself

Sunflower PS 100 mg by Healthy Origins label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Sunflower PS 100 mg by Healthy Origins

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container120 Amounts shown are per serving.

Sharp PS Green

Interacts with
219 drugs
100 mg per serving Form: Phosphatidylserine

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Sharp PS Green monograph & interactions

Other (inactive) ingredients: Medium Chain Triglyceride, Gelatin, Glycerin, Water, Purified, Silicon Dioxide, Mixed Tocopherols, Natural, Ascorbyl Palmitate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sunflower PS 100 mg by Healthy Origins Drug Interactions

Want to check YOUR meds against Sunflower PS 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Sunflower PS 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sharp PS Green2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for Sunflower PS 100 mg, from the product label.

Healthy Origins

See all Healthy Origins products
Name
Healthy Origins
City
Pittsburgh
State
PA
ZipCode
15241
Phone Number
1-888-228-6650
Pharmacist Counseling Corner

Sunflower PS 100 mg by Healthy Origins: Common Questions

Does Sunflower PS 100 mg by Healthy Origins interact with any medications?
Yes. Based on its ingredients, Sunflower PS 100 mg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sunflower PS 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is phosphatidylserine, and what is it supposed to do?
Phosphatidylserine is a natural compound found in sunflower seeds that may support brain function. It's possibly effective for age-related cognitive decline and Alzheimer disease, but evidence for other uses like ADHD or general memory is not yet established.
Can I take this if I'm pregnant or breastfeeding?
No — there isn't enough safety data. Avoidance is recommended during pregnancy and while breastfeeding. Talk with your doctor or pharmacist about your specific situation.
What are the side effects I might experience?
Most common are flatulence, stomach upset, headache, insomnia, and nausea. Gastrointestinal upset can show up at doses around 200–300 mg/day, and insomnia is more likely at higher doses. These side effects are generally mild, but let your pharmacist know if they bother you.
Is long-term use safe?
Phosphatidylserine is generally well tolerated in studies, but long-term safety hasn't been fully established. If you plan to take it regularly, check in with your pharmacist.
Does this interact with blood pressure or heart medications?
The documented interactions we hold are with anticholinergic and cholinergic drugs. For your specific blood pressure or heart medications, use the checker on this page to see if they're affected.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sunflower PS 100 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sunflower PS 100 mg label
Sources

Sources & How We Checked

Sunflower PS 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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