Krill Oil Ingredients & Drug Interactions
by Kala Health
What is this page for?
First and foremost: checking Krill Oil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Krill Oil is a dietary supplement by Kala Health with 8 active ingredients. Its ingredients are commonly taken for heart health, healthy cooking fat, skin moisturizing.Based on those ingredients, 838 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Total Astaxanthin, Krill Oil, Oleic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Krill Oil by Kala Health
Ask about any prescription or over-the-counter medication and we check it for interactions with Krill Oil by Kala Health — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Krill Oil by Kala Health
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This krill oil capsule contains 8 ingredients total. The active components are the omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid (the main reason people take krill oil), along with other fatty acids including oleic acid, palmitoleic acid, and linoleic acid, plus astaxanthin — a potent antioxidant that gives krill its reddish color.
The product also lists total omega-3, omega-6, omega-7, and omega-9 fatty acids as blend containers, with their individual components broken out separately. The capsule itself is made from bovine gelatin, glycerin, and water.
Does it work?
Moderate evidence
For dry eye, krill oil is rated Possibly Effective — meaning some evidence supports its use, though more research would help confirm it. For most other claimed uses — aging skin, Alzheimer's disease, cancer prevention, high cholesterol, and cognitive function — the evidence is not yet established in our data.
Oleic acid, one of the fatty acids in the product, is rated Possibly Effective for high cholesterol and coronary heart disease based on preliminary research, though that work focused on oleic acid from olive oil in the diet rather than concentrated supplement form.
How safe is it?
Well-documented data
Krill oil is generally well tolerated when used up to 4 grams daily. The most common side effects are mild gastrointestinal — bloating, decreased appetite, diarrhea, fishy burps, flatulence, heartburn, nausea, and stomach discomfort.
Headache, tiredness, and dizziness have been reported rarely. Notably, these effects tend to be less severe or happen less often with krill oil than with fish oil.
Avoid this product if you have a shellfish allergy, and use caution if you have a bleeding disorder. For pregnancy and breastfeeding, the safety data are not adequate — talk to your doctor or pharmacist before using in either situation.
Astaxanthin safety data during pregnancy and breastfeeding are too limited; the facts advise against it in both.
Meds to double-check
Moderate interaction found
Double-check this product with your pharmacist if you take blood thinners or diabetes drugs — both carry Moderate interaction risk. Also flag any medications metabolized by your liver's CYP3A4 or CYP2B6 enzymes, as astaxanthin may reduce their effectiveness.
No interactions are documented for several of the fatty acid components we could not fully check.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Krill oil is worth considering if you're looking for dry eye support or want omega-3 fatty acids from a marine source that may cause fewer GI side effects than fish oil. If you take blood thinners or diabetes medication, or if you're pregnant or breastfeeding, check with your pharmacist first.
Run your exact medications through the interaction checker on this page before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Krill Oil, straight from the product label.
| Brand | Kala Health |
|---|---|
| Barcode (UPC) | 8719322752062 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2024 |
| DSLD ID | 311300 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Krill Oil by Kala Health, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Eicosapentaenoic Acid | 120 mg | -- |
| Docosahexaenoic Acid | 60 mg | -- |
| Total Omega-3 Fatty Acids | 240 mg | -- |
| Total Omega-6 Fatty Acids | 10 mg | -- |
| Palmitoleic Acid | 40 mg | -- |
| Total Omega-9 Fatty Acids | 80 mg | -- |
| Oleic Acid | 60 mg | -- |
| Krill Oil | 1000 mg | -- |
| Total Astaxanthin | 190 mcg | -- |
| Linoleic Acid | 6 mg | -- |
| Total Phospholipids | 400 mg | -- |
| Total Omega-7 Fatty Acids | 60 mg | -- |
Other ingredients: Bovine Gelatin, Glycerin, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Kala Health oil is a dark red colored viscous oil extrac-ted from Antarctic krill, Euphausia superba. Krill oil is rich in omega-3 fatty acids, mainly bound as phospholipids which gives the fatty acids superior stability and bioavailability. Krill oil also contains the natural antioxidant astaxanthin.
Food supplement, containing fatty acids.
Suggested/Recommended/Usage/Directions
Recommended use: Adults: take one capsule twice daily with a meal, or as recommended. For children adapt dosage according to body weight.
Precautions
Do not exceed the recommended dosage.
Storage: store in a dark, dry place, out of reach of young children.
A food supplement should not be used as a substitute for a varied diet.
Allergy information: May contains traces of crustacean proteins
Storage
Storage: store in a dark, dry place, out of reach of young children.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Krill Oil by Kala Health label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Krill Oil by Kala Health
These are the 8 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Total Omega-3 Fatty Acids
- › Eicosapentaenoic Acid
- › Docosahexaenoic Acid
Total Omega-6 Fatty Acids
- › Linoleic Acid
Total Omega-9 Fatty Acids
Krill Oil
Interacts with208 drugs
Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...
Krill Oil monograph & interactionsTotal Astaxanthin
Interacts with671 drugs
Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...
Total Astaxanthin monograph & interactionsTotal Phospholipids
Total Omega-7 Fatty Acids
- › Palmitoleic Acid
Other (inactive) ingredients: Bovine Gelatin, Glycerin, Water. These complete the product’s ingredient list but are not active constituents.
Krill Oil by Kala Health Drug Interactions
HelloPharmacist Interaction Report
Krill Oil by Kala Health has documented interactions with several medication types.
The most serious concern involves blood thinners (anticoagulant and antiplatelet drugs), where krill oil may increase bleeding risk at higher doses — a Moderate severity interaction. Krill oil's omega-3 fatty acids can modestly reduce how platelets clump together, so combining it with blood thinners warrants caution.
Read the full breakdown — every affected drug type, severity by severity
The product also carries Moderate interactions with diabetes medications. Krill oil may theoretically lower blood sugar, which could increase the risk of low blood sugar (hypoglycemia) if you're already taking a diabetes drug — though a small study in type 2 diabetes patients saw no blood sugar reduction.
Additionally, astaxanthin (one of the actives here) may decrease how your liver processes certain medications metabolized by CYP3A4 and CYP2B6 enzymes; this affects a broad range of prescription drugs including some cholesterol, heart, and psychiatric medications.
Several of the fatty acid components — eicosapentaenoic acid, docosahexaenoic acid, palmitoleic acid, and linoleic acid — we could not check for interactions. Altogether, these interactions span 827 individual medications.
Use the medication checker on this page with your exact prescriptions before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Krill Oil?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Krill Oil interact with 838 drugs. Click any drug to see the details.
3 of the 8 ingredients in Krill Oil interact with drugs. Each result below shows which ingredient is responsible. Total Astaxanthin Krill Oil Oleic Acid
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Krill OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Krill Oil + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Krill OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Krill Oil + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Krill Oil — through 2 ingredients. Tap an ingredient for the detail:
Krill OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Krill Oil + Acarbose interactionOleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Krill OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Krill Oil + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Krill OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Krill Oil + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Krill Oil — through 2 ingredients. Tap an ingredient for the detail:
Krill OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Krill Oil + Acetaminophen, Aspirin, Caffeine interactionTotal AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Krill Oil — through 1 ingredient. Tap an ingredient for the detail:
Total AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Total Astaxanthin + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Krill Oil with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Total Astaxanthin
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.
Krill Oil
Anticoagulant/Antiplatelet Drugs
Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.
Antidiabetes Drugs
Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.
Oleic Acid
Antidiabetes Drugs
Theoretically, oleic acid might increase the effects of antidiabetes drugs. Preliminary clinical research in patients with type 2 diabetes taking oral hypoglycemic drugs shows that eating a diet rich in oleic acid from olive oil decreases fasting blood glucose levels when compared to eating a diet rich in linoleic acid from sunflower oil. It is unknown if taking oleic acid supplements would have this effect or if this change is clinically significant. Until more is known, use caution. Dose adjustment may be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.
Brand information
Manufacturer and brand details for Krill Oil, from the product label.
Kala Health
See all Kala Health products- Name
- Kala Health BV
- Street Address
- 2201 GN 40
- Web Address
- www.kalahealth.eu
Krill Oil by Kala Health: Common Questions
Does Krill Oil by Kala Health interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this with my blood thinner?
What side effects should I watch for?
Is this safe during pregnancy?
What is astaxanthin and why is it in here?
Will this help my cholesterol?
Can I take this if I have a shellfish allergy?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Krill Oil is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Krill Oil’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Oleic Acid
Interacts with 86 drugsOleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replace...
Read the full Oleic Acid monograph → Herb & supplement monographKrill Oil
Interacts with 208 drugsKrill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...
Read the full Krill Oil monograph → Herb & supplement monographAstaxanthin
Interacts with 671 drugsAstaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...
Read the full Astaxanthin monograph →Sources & How We Checked
Krill Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 35 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Oleic Acid 19 references
- Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
- Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427. PubMed
- Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiova
- Cater, N. B., Heller, H. J., and Denke, M. A. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am.J Clin.Nutr PubMed
- Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr. 2009;63(Suppl 2):S22-33. PubMed
- Cao Y, Hou L, Wang W. Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. Int J Cancer. 2016;138(8):1894-904. doi: 10.1002/ijc.29938. PubMed
- FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
- Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity. 2016;24(11):2261-2268. PubMed
- Bowen KJ, Kris-Etherton PM, West SG, et al. Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. J Nutr. 2019;149(3 PubMed
- Steffen BT, Duprez D, Szklo M, Guan W, Tsai MY. Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: The Multi-Ethnic Study of Atherosclerosis. J Clin Lipidol. 2018;12(6):1404-1412. PubMed
- Banim PJ, Luben R, Khaw KT, Hart AR. Dietary oleic acid is inversely associated with pancreatic cancer - Data from food diaries in a cohort study. Pancreatology. 2018;18(6):655-660. PubMed
- Morin SJ, Gaziano JM, Djoussé L. Relation between plasma phospholipid oleic acid and risk of heart failure. Eur J Nutr. 2018;57(8):2937-2942. PubMed
- Samieri C, Féart C, Proust-Lima C, et al. Olive oil consumption, plasma oleic acid, and stroke incidence: the Three-City Study. Neurology. 2011;77(5):418-25. PubMed
- Compher CW, Kinosian BP, Rubesin SE, Ratcliffe SJ, Metz DC. Energy absorption is reduced with oleic acid supplements in human short bowel syndrome. JPEN J Parenter Enteral Nutr. 2009;33(1):102-8. PubMed
- Ben Fradj MK, Ouanes Y, Hadj-Taieb S, et al. Decreased oleic acid and marine n?-?3 polyunsaturated fatty acids in Tunisian patients with urothelial bladder cancer. Nutr Cancer. 2018;70(7):1043-1050.
- de Silva PS, Luben R, Shrestha SS, Khaw KT, Hart AR. Dietary arachidonic and oleic acid intake in ulcerative colitis etiology: a prospective cohort study using 7-day food diaries. Eur J Gastroenterol Hepatol. 2014;26(1):11-8. PubMed
- Higashi K, Shige H, Ito T, et al. Effect of a low-fat diet enriched with oleic acid on postprandial lipemia in patients with type 2 diabetes mellitus. Lipids. 2001;36(1):1-6. PubMed
- Lin HC, van Citters GW, Heimer F, Bonorris G. Slowing of gastrointestinal transit by oleic acid: a preliminary report of a novel, nutrient-based treatment in humans. Dig Dis Sci. 2001;46(2):223-9. PubMed
- Li D, Tong Y, Li Y. Associations between dietary oleic acid and linoleic acid and depressive symptoms in perimenopausal women: The Study of Women's Health Across the Nation. Nutrition. 2020 Mar;71:110602. PubMed
Krill Oil 13 references
- Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
- Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
- Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
- Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
- Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
- Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
- Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
- Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
- Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
- Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
- Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
- van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
- van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed
Astaxanthin 3 references
- Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
- Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
- Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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