L-Lysine 500 mg Ingredients & Drug Interactions
by Equaline
What is this page for?
First and foremost: checking L-Lysine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Lysine 500 mg is a dietary supplement by Equaline with 1 active ingredient. Its ingredients are commonly taken for cold sores (herpes labialis), genital herpes outbreaks, supporting protein and collagen formation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are L-Lysine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Lysine 500 mg by Equaline
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Lysine 500 mg by Equaline — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Lysine 500 mg by Equaline
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-Lysine, an amino acid your body uses to build protein and support immune and tissue health. The tablet also includes inactive ingredients — cellulose, polyethylene glycol, magnesium stearate, croscarmellose sodium, and silicon dioxide — that help form and preserve the pill.
Does it work?
Moderate evidence
L-Lysine is possibly effective for cold sores (herpes labialis). For other uses listed in the research — child growth, pressure ulcers, and diabetic foot ulcers — the evidence isn't established well enough for us to rate it, meaning we don't have solid data supporting those purposes yet.
How safe is it?
Well-documented data
L-Lysine from food is fine, but the supplement form hasn't been studied long-term at high doses, and taking too much may cause stomach upset, diarrhea, or abdominal pain. For pregnancy, the safety data on the supplement isn't solid enough to say it's safe, so talk with your doctor first if you're pregnant or planning to be.
There isn't enough reliable information on supplement use while breastfeeding either, so check with your doctor or pharmacist before taking it if you're nursing. One rare case of kidney inflammation has been reported, though this is not a common side effect.
Meds to double-check
Minor interactions only
If you take a 5-HT4 agonist (a medication for certain digestive conditions), check with your doctor or pharmacist before adding L-Lysine, as it may reduce how well the drug works.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.
L-Lysine is a solid choice if you're looking at it for cold sores and want to see if it helps. If you're pregnant, breastfeeding, or take a 5-HT4 agonist for digestive symptoms, talk with your doctor or pharmacist before starting — they can tell you whether it's right for you and if any timing adjustments are needed.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 26, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Lysine 500 mg, straight from the product label.
| Brand | Equaline |
|---|---|
| Barcode (UPC) | 041163231740 |
| Net contents | 100 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Apr 26, 2012 |
| DSLD ID | 7492 |
| Product type | Amino Acid/protein |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Lysine 500 mg by Equaline, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Lysine | 500 mg | -- |
Other ingredients: L-Lysine Monohydrochloride, Cellulose, Polyethylene Glycol, Magnesium Stearate, Croscarmellose Sodium, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
NO PRESERVATIVES ADDED NO LACTOSE NO ARTIFICIAL COLOR OR FLAVOR NO GLUTEN
Precautions
Keep out of the reach of children.
If pregnant, nursing or taking any medications, consult your healthcare professional before taking this product.
Storage
Keep in a cool dry place, tightly closed.
General Statements
USP has tested and verified ingredients, potency, and manufacturing process. USP sets official standards for dietary supplements. See www.uspverified.org
Healthy lips and mouth tissue may be affected by sun exposure, trauma, emotional anxiety, and high body temperature. Lysine, an amino acid, may be helpful in maintaining healthy lips and mouth tissue.* Lysine also helps calcium absorption, helps collagen and tissue renewal, and aids in the production of antibodies, hormones, and enzymes.*
FRESHNESS AND POTENCY GUARANTEED THROUGH:
natural
healthy lips and collagen renewal*
Suggested/Recommended/Usage/Directions
Suggested use: Take one tablet one to three times daily with a full glass of water, preferably after a meal.
FDA Disclaimer Statement
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
* THIS STATEMENT HAS NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.
Seals/Symbols
QUALITY Promise We are committed to your satisfaction and guarantee the quality of this product.
DIETARY SUPPLEMENT USP VERIFIED(TM)
FDA Statement of Identity
dietary supplement
General
EAL4410A06
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Lysine 500 mg by Equaline label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Lysine 500 mg by Equaline
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
L-Lysine
Interacts with1 drug
Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...
L-Lysine monograph & interactionsOther (inactive) ingredients: L-Lysine Monohydrochloride, Cellulose, Polyethylene Glycol, Magnesium Stearate, Croscarmellose Sodium, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
L-Lysine 500 mg by Equaline Drug Interactions
HelloPharmacist Interaction Report
Equaline's L-Lysine 500 mg has one documented drug interaction.
L-Lysine may reduce the effects of 5-HT4 agonists — a small class of medications used mainly for digestive issues. The interaction is Minor in severity, based on animal research suggesting that lysine acts as a partial antagonist to the serotonin receptor these drugs target.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 1 individual medication.
If you take a 5-HT4 agonist, check with your doctor or pharmacist before starting L-Lysine to see whether the timing or dose of either medication needs adjusting. Use the search tool on this page to run your exact medications through our interaction checker.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Lysine 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Lysine 500 mg interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in L-Lysine 500 mg interact with drugs. Each result below shows which ingredient is responsible. L-Lysine
TegaserodZelnorm
How Tegaserod interacts with L-Lysine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-lysine5-ht4 Agonists Minor
Interaction Summary
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Read the full L-lysine + Tegaserod interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Lysine 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Lysine
5-Ht4 Agonists
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.
Brand information
Manufacturer and brand details for L-Lysine 500 mg, from the product label.
L-Lysine 500 mg by Equaline: Common Questions
Does L-Lysine 500 mg by Equaline interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does L-Lysine actually work for cold sores?
What side effects might I get from this?
Is it safe to take if I'm pregnant?
Can I take it while breastfeeding?
What is L-Lysine and what does it do in my body?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Lysine 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Lysine 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Lysine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 7 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lysine 7 references
- Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
- McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
- DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
- Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
- Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
- Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
- Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC