No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Lactoferrin-250 Ingredients & Drug Interactions

by AOR Advanced Orthomolecular Research Advanced

Capsule Category: Amino Acid/protein
No known interaction
The interaction bottom line No known interaction

Lactoferrin-250 is a dietary supplement by AOR Advanced Orthomolecular Research Advanced with 1 active ingredient. Its ingredients are commonly taken for iron deficiency and anemia support, immune support, gut health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Lactoferrin-250 by AOR Advanced Orthomolecular Research Advanced

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: lactoferrin, a protein found naturally in milk and body fluids that plays a role in immune function and iron transport. Each capsule delivers 250 mg of this protein.

The inactive ingredients are the capsule itself and sodium stearyl fumarate, a flow agent used in manufacturing.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: immune support and iron transport.
  • We looked for evidence on: Iron deficiency anemia, Pregnancy-related iron deficiency, Helicobacter pylori, Respiratory tract infections, Immune function, Gut barrier integrity.
  • The strongest evidence on file: Lactoferrin is rated "Possibly Effective" for Pregnancy-related iron deficiency (Natural Medicines).
  • Also on file: Lactoferrin is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections, Helicobacter pylori, Iron deficiency anemia.

The evidence on lactoferrin is mixed. It's rated possibly effective for sepsis and for treating iron deficiency in pregnancy — meaning some studies suggest benefit, but the data isn't rock-solid yet.

For preventing fetal and premature infant mortality and necrotizing enterocolitis (a serious intestinal condition in preemies), the evidence points to likely ineffective, so this product wouldn't be a good choice for those goals.

The evidence, ingredient by ingredient Lactoferrin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactoferrin is generally well tolerated at typical doses, but long-term safety data are limited — we don't have great information on what happens if you take it for months or years. In pregnancy, some research exists but safety isn't fully established, so use only under medical supervision.

While lactoferrin naturally occurs in breast milk, safety of supplements while breastfeeding hasn't been well studied, so talk it over with your doctor or pharmacist first. At standard doses, side effects are uncommon.

Higher doses — 7.2 grams daily, well above what's in one capsule — can trigger constipation, diarrhea, nausea, loss of appetite, or fatigue. Diarrhea has been reported even at lower doses in some people.

In newborns given lactoferrin in trials, rare cases of jaundice, bloody stool, bowel obstruction, and intestinal perforation occurred, though cause wasn't established.

Side effects, ingredient by ingredient Lactoferrin

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for lactoferrin with any medications. That said, confirm with your own doctor or pharmacist before combining it with any prescription or other supplement — especially anything related to iron metabolism or gut health — to make sure it's right for your specific medicines.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

Lactoferrin-250 might be worth considering if you're looking at immune support or managing iron deficiency in pregnancy under a doctor's watch. Because long-term safety data are sparse, this isn't a supplement to take open-ended without checking in.

Talk with your own doctor or pharmacist about whether it fits your situation and how long you should use it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lactoferrin-250, straight from the product label.

Brand AOR Advanced Orthomolecular Research Advanced
Barcode (UPC) 624917081107
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 214556
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lactoferrin-250 by AOR Advanced Orthomolecular Research Advanced, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
624917081107
IngredientAmount% DV
Lactoferrin1500 mg, 250 mg--

Other ingredients: Capsule, Sodium Stearyl Fumarate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

GMP Manufacturing Quality assured Independent testing

Supports iron absorption and immune modulation

Vegetarian

Non-GMO Gluten free

AOR guarantees that all ingredients have been declared on the label.

Made without wheat, gluten, corn, nuts, peanuts, sesame seeds, sulfites, mustard, soy, eggs, fish or shellfish.

Precautions

Do not use if safety seal is broken

Warning: Consult your physician if you are pregnant or lactating or if you have a medical condition, or if you’re taking any medication.

Keep out of reach of children.

Contains: milk (bovine).

Storage

Store tightly sealed in a cool, dry place

Formula

Discussion: Lactoferrin is an iron transporter glycoprotein originally isolated from bovine milk. Lactoferrin is a multitasking protein with various biological roles including binding to iron, which contributes to its beneficial immune effects.

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule 1-6 times daily with meals and a few hours before or after taking other medications, or as directed by a qualified health care practitioner.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

Product of Canada

Brand IP Statement(s)

To report a serious adverse event or obtain product information, call 1-866-215-0450

See for yourself

Lactoferrin-250 by AOR Advanced Orthomolecular Research Advanced label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Lactoferrin-250 by AOR Advanced Orthomolecular Research Advanced

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Lactoferrin

No known
interactions
1500 mg per serving

Lactoferrin is an iron-binding protein found naturally in milk and other body fluids, and supplements are usually made from cow's milk or rice. It is...

Lactoferrin monograph & interactions

Other (inactive) ingredients: Capsule, Sodium Stearyl Fumarate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lactoferrin-250 by AOR Advanced Orthomolecular Research Advanced Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Lactoferrin-250. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Lactoferrin-250, from the product label.

AOR Advanced Orthomolecular Research Advanced

See all AOR Advanced Orthomolecular Research Advanced products
Name
AOR Inc.
Street Address
30 Industrial West
City
Clifton
State
NJ
ZipCode
07012
Phone Number
1-866-215-0450
Pharmacist Counseling Corner

Lactoferrin-250 by AOR Advanced Orthomolecular Research Advanced: Common Questions

Does Lactoferrin-250 by AOR Advanced Orthomolecular Research Advanced interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Lactoferrin-250. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Lactoferrin-250 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is lactoferrin safe to take while pregnant?
The safety data for lactoferrin in pregnancy aren't fully established. It's rated likely safe to possibly safe depending on the context, but you should use it only under medical supervision if you're pregnant. Talk with your own doctor or pharmacist before starting.
Can I take this while breastfeeding?
Lactoferrin occurs naturally in breast milk, and the rating here is likely safe — but the safety of supplements while breastfeeding hasn't been well studied. Confirm with your own doctor or pharmacist before taking it so they can weigh what you're doing.
What are the most common side effects?
At typical doses, lactoferrin is well tolerated and side effects are uncommon. Diarrhea has been reported in some people, and at higher doses (well above one capsule) constipation, nausea, loss of appetite, and fatigue are possible.
Does this product actually work?
Evidence is mixed. It's rated possibly effective for sepsis and for iron deficiency in pregnancy — meaning some studies show benefit, but it's not definitive. For preventing complications in premature infants, the evidence leans toward it not working.
How much lactoferrin is in each capsule?
Each capsule contains 250 mg of lactoferrin.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lactoferrin-250 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lactoferrin-250 label
Go deeper

The Full Monographs Behind Lactoferrin-250’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Lactoferrin-250's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactoferrin 6 references
  1. Food and Drug Administration, CFSAN/Office of Food Additive Safety. Agency Response Letter GRAS Notice No. GRN 000130. 2003. Available at: http://www.cfsan.fda.gov/~rdb/opa-g130.html (Accessed 29 June 2005).
  2. Okada S, Tanaka K, Sato T, et al. Dose-response trial of lactoferrin in patients with chronic hepatitis C. Jpn J Cancer Res 2002;93:1063-9. PubMed
  3. Abu Hashim H, Foda O, Ghayaty E. Lactoferrin or ferrous salts for iron deficiency anemia in pregnancy: A meta-analysis of randomized trials. Eur J Obstet Gynecol Reprod Biol. 2017;219:45-52. PubMed
  4. Tarnow-Mordi WO, Abdel-Latif ME, Martin A, et al. The effect of lactoferrin supplementation on death or major morbidity in very low birthweight infants (LIFT): a multicentre, double-blind, randomised controlled trial. Lancet Child Adolesc Health. 2020 Jun PubMed
  5. ELFIN trial investigators group. Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial. Lancet. 2019 Feb 2;393(10170):423-433. doi: 10.1016/S0140-6736(18)32221-9.
  6. Lepanto MS, Rosa L, Cutone A, Conte MP, Paesano R, Valenti P. Efficacy of lactoferrin oral administration in the treatment of anemia and anemia of inflammation in pregnant and non-pregnant women: An interventional study. Front Immunol. 2018 Sep 21;9:2123. PubMed

See these in context on the Lactoferrin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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