Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Legendary Pine Elixir 500 mg Ingredients & Drug Interactions

by Tonic Tinctures

Legendary Pine Elixir 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Legendary Pine Elixir 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Legendary Pine Elixir 500 mg is a dietary supplement by Tonic Tinctures with 3 active ingredients. Its ingredients are commonly taken for sexual health and impotence, energy and fatigue, kidney and reproductive support (in traditional medicine).Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Eurycoma. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Legendary Pine Elixir 500 mg by Tonic Tinctures

Ask about any prescription or over-the-counter medication and we check it for interactions with Legendary Pine Elixir 500 mg by Tonic Tinctures — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Legendary Pine Elixir 500 mg by Tonic Tinctures

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.

Legendary Pine Elixir contains 3 active ingredients. Cuscuta (also called dodder) is an herb traditionally used for skin and mood; Eurycoma longifolia is a plant root used for sexual function and athletic performance; and Pine is included in the blend, though we hold no detailed information on its role.

The capsule itself is made from vegetarian material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Male sexual health and vitality support.
  • We looked for evidence on: Age-related testosterone deficiency, Athletic performance, Erectile dysfunction (ED), Male Infertility, Muscle strength, Sexual desire — and 4 related terms.
  • The strongest evidence on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire (Natural Medicines).
  • Also on file: Eurycoma Longifolia is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Eurycoma Longifolia is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Muscle strength, Age-related testosterone deficiency, Male Infertility.

The evidence here is thin. Eurycoma shows possibly effective evidence for sexual desire, but possibly ineffective for athletic performance.

Cuscuta has insufficient evidence to support use for depression or eczema — we simply don't have reliable trial data. Pine's effectiveness is not established in the data we hold.

The evidence, ingredient by ingredient Dodder Eurycoma Longifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cuscuta is generally well tolerated at normal doses, though high doses may cause intestinal cramping and diarrhea. Eurycoma is generally tolerated short-term in studies, but long-term safety and product quality are uncertain.

One combination study reported loss of appetite, mild indigestion, and stomach heaviness, though it's unclear which ingredient caused it. The main concern: if Eurycoma raises testosterone beyond normal range, you could develop acne, insulin resistance, liver stress, and other hormone-related side effects.

Cuscuta should be avoided during pregnancy and breastfeeding — not enough safety data exists. Same with Eurycoma — the possible hormonal effects make it unsafe in pregnancy, and there's no reliable safety information for breastfeeding.

Side effects, ingredient by ingredient Dodder Eurycoma Longifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take propranolol (Inderal) — Eurycoma can reduce how well it works (Moderate severity). You should also flag any medications processed by your liver's CYP1A2, CYP2C19, or CYP2A6 enzymes, testosterone supplements or boosters, and any medications that raise testosterone levels (all Minor severity).

No interactions are documented for Cuscuta or Pine, though we hold no data on Pine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is geared toward sexual function and male vitality. If you take propranolol, heart medications, testosterone, or any prescription at all, check it with your pharmacist first — the interaction list is long.

Pregnant or breastfeeding? Skip this one.

Long-term use hasn't been well studied, so talk to your healthcare provider about how long you plan to take it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Legendary Pine Elixir 500 mg, straight from the product label.

Brand Tonic Tinctures
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Dec 26, 2020
DSLD ID 241267
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Legendary Pine Elixir 500 mg by Tonic Tinctures, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
60
IngredientAmount% DV
Cuscuta0 NP--
Eurycoma0 NP--
Pine0 NP--

Other ingredients: Vegetarian Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Artisan Made 2 capsules is equal to 1000 mgs

Gluten free, no hidden additives

Precautions

Keep out of reach of children.

Discontinue use if unusual symptoms occur.

FDA Disclaimer Statement

Caution: These products are not intended to diagnose, treat, cure or prevent any disease. These statements have not been evaluated by the FDA

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Use as directed, 2-4 capsules 1-3 times a day. Use within 60 days of opening.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Legendary Pine Elixir 500 mg by Tonic Tinctures label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Legendary Pine Elixir 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Legendary Pine Elixir 500 mg by Tonic Tinctures

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Cuscuta

No known
interactions
0 NP per serving

Dodder (Cuscuta) is a parasitic plant whose seeds are used in traditional Chinese and Middle Eastern medicine, mainly for sexual, kidney, and energy-r...

Cuscuta monograph & interactions

Eurycoma

Interacts with
248 drugs
0 NP per serving

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

Eurycoma monograph & interactions

Pine

0 NP per serving

Other (inactive) ingredients: Vegetarian Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Legendary Pine Elixir 500 mg by Tonic Tinctures Drug Interactions

Want to check YOUR meds against Legendary Pine Elixir 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
3 Moderate 245 Minor

Ingredients driving the most interactions

Eurycoma 248

Individual Drug Interactions

The ingredients in Legendary Pine Elixir 500 mg interact with 248 drugs. Click any drug to see the details.

1 of the 3 ingredients in Legendary Pine Elixir 500 mg interact with drugs. Each result below shows which ingredient is responsible. Eurycoma

Each ingredient & the kinds of drugs it affects

For each ingredient in Legendary Pine Elixir 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Eurycoma5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Eurycoma full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Legendary Pine Elixir 500 mg, from the product label.

Tonic Tinctures

See all Tonic Tinctures products
Name
Tonic Apothecary
Web Address
www.tonictinctures.com
Pharmacist Counseling Corner

Legendary Pine Elixir 500 mg by Tonic Tinctures: Common Questions

Does Legendary Pine Elixir 500 mg by Tonic Tinctures interact with any medications?
Yes. Based on its ingredients, Legendary Pine Elixir 500 mg has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Legendary Pine Elixir 500 mg contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No — both Cuscuta and Eurycoma should be avoided during pregnancy and breastfeeding. Cuscuta lacks enough safety data, and Eurycoma has possible hormonal effects that make it unsafe in pregnancy and uncertain during breastfeeding. Talk to your obstetrician or pharmacist for a safer option.
What's the main thing this product is for?
Eurycoma is the active ingredient here, and it shows possibly effective evidence for sexual desire. The other two ingredients don't have solid evidence for their listed uses — depression and eczema — so Eurycoma is really the workhorse.
What side effects might I notice?
At normal doses, these ingredients are generally well tolerated. High doses of Cuscuta may cause stomach cramping and diarrhea. The bigger concern: if Eurycoma raises your testosterone too high, you could develop acne, trouble with blood sugar control, or liver stress. If you notice those, stop and call your pharmacist or doctor.
Is this safe to take long-term?
The research on long-term use is limited. Studies show short-term safety, but we don't know much about using it for months or years. Check with your healthcare provider about how long you plan to take it.
Does Pine do anything in this blend?
Pine is listed as an ingredient, but we don't hold detailed information on its role or effects in this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Legendary Pine Elixir 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Legendary Pine Elixir 500 mg label
Go deeper

The Full Monographs Behind Legendary Pine Elixir 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Dodder

Dodder (Cuscuta) is a parasitic plant whose seeds are used in traditional Chinese and Middle Eastern medicine, mainly for sexual, kidney, and energy-related complaints. Human evidence for an...

Read the full Dodder monograph → Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph →
Sources

Sources & How We Checked

Legendary Pine Elixir 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Dodder 3 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Mehrbani M, Choopani R, Fekri A, Mehrabani M, Mosaddegh M, Mehrabani M. The efficacy of whey associated with dodder seed extract on moderate-to-severe atopic dermatitis in adults: A randomized, double-blind, placebo-controlled clinical trial. J Ethnopharm PubMed
  3. Firoozabadi A, Zarshenas MM, Salehi A, Jahanbin S, Mohagheghzadeh A. Effectiveness of Cuscuta planiflora Ten. and Nepeta menthoides Boiss. & Buhse in major depression: a triple-blind randomized controlled trial study. J Evid Based Complementary Altern Med

See these in context on the Dodder monograph →

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team