Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Legs Relax Alcohol Free Ingredients & Drug Interactions

by Herbal Terra

Legs Relax Alcohol Free label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Legs Relax Alcohol Free against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Legs Relax Alcohol Free is a dietary supplement by Herbal Terra with 3 active ingredients. Its ingredients are commonly taken for cough and respiratory congestion, sore throat, digestive upset.Based on those ingredients, 1,141 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Valerian Root Extract, Dry, Quina Bark Extract, Dry, Thyme Leaf Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Legs Relax Alcohol Free by Herbal Terra

Ask about any prescription or over-the-counter medication and we check it for interactions with Legs Relax Alcohol Free by Herbal Terra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Legs Relax Alcohol Free by Herbal Terra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (1,156 mg) without saying how much of each component you get.

Legs Relax Alcohol Free contains three active ingredients. Thyme Leaf Extract is included for its traditional uses; Valerian Root Extract is used to support relaxation and sleep; and Quina Bark Extract (also called cinchona) is included for its traditional herbal purposes.

The product also contains two inactive ingredients — glycerin and water — which act as the base for the liquid formula.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: leg relaxation and restless legs support.
  • We looked for evidence on: Leg cramps, Muscle cramps, Restless legs syndrome (RLS), leg tension, muscle tension.
  • The closest evidence on file: Cinchona is rated "Insufficient Reliable Evidence To Rate" for Muscle cramps (Natural Medicines).
  • Also on file: Cinchona is rated "Insufficient Reliable Evidence To Rate" for Leg cramps.
  • Also on file: Valerian is rated "Insufficient Reliable Evidence To Rate" for Restless legs syndrome (RLS).

The evidence for the active ingredients in this product is limited. Valerian root is possibly effective for insomnia, but for restless legs syndrome — likely the condition this product targets — the evidence isn't established in our data.

Thyme leaf shows insufficient reliable evidence for bronchitis, aging skin, and common cold. Quina bark shows insufficient reliable evidence for muscle cramps, influenza, malaria, and other traditional uses.

None of the three ingredients have strong evidence backing the specific purpose suggested by the product name.

The evidence, ingredient by ingredient Thyme Valerian Cinchona

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Thyme leaf is generally well tolerated when used in food amounts, though medicinal doses have limited safety data. The most common side effects reported are allergic reactions, diarrhea, dizziness, headache, heartburn, nausea, or vomiting.

Topically, it may cause contact dermatitis or skin irritation. Valerian root is generally well tolerated short-term and causes dizziness, drowsiness, and mental slowness most commonly.

Long-term safety is not well studied. When you stop valerian after extended use, taper your dose slowly — stopping abruptly can trigger withdrawal symptoms like anxiety, irritability, and insomnia.

The safety data advises against valerian during pregnancy and while breastfeeding. Quina bark contains quinine, which carries serious risks.

High doses used long-term can cause severe side effects, and rare but dangerous blood and heart problems have been reported. The product is not dose-controlled, and the safety data advises against quina bark in pregnancy and while breastfeeding because quinine may harm the baby.

Side effects, ingredient by ingredient Thyme Valerian Cinchona

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Cinchona, Thyme, Valerian.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications.
  • For scale: 1,142 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Legs Relax Alcohol Free, double-check with your pharmacist if you take quinidine or quinine (Major severity), any QT interval-prolonging heart drugs (Major), seizure medications like phenobarbital or carbamazepine (Moderate), blood thinners or antiplatelet drugs (Moderate), estrogen or hormone therapies (Moderate), CNS depressants including alcohol and sleep aids (Moderate), or any drugs metabolized by the liver enzyme CYP2D6 (Moderate from cinchona; Minor from valerian). No interactions are documented for the Proprietary Extract Blend component itself — we hold no data for it since it is a group container.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product brings together three herbs with limited effectiveness evidence for leg-related symptoms and substantial medication interaction risks — especially if you take heart rhythm drugs, seizure medications, blood thinners, estrogen, sedatives, or many other common medications. Talk with your pharmacist or doctor before starting, and use the interaction checker on this page with your exact medication list.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Legs Relax Alcohol Free, straight from the product label.

Brand Herbal Terra
Barcode (UPC) 7439500427483
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 324321
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Legs Relax Alcohol Free by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
60
UPC/BARCODE
7439500427483
IngredientAmount% DV
Proprietary Extract Blend1156 mg--
Thyme Leaf Extract, Dry0 NP--
Valerian Root Extract, Dry0 NP--
Quina Bark Extract, Dry0 NP--

Other ingredients: Glycerin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz. of juice or water up to 4 times a day.

Precautions

We recommend to seek expert medical advice before taking. May have contraindications and cause adverse reaction.

Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications.

Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications. Keep out of the reach of children!

Do not use if you are allergic to any ingredients.

Storage

Store in a cool, dry, dark place.

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

Formulation

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

Sugar free

Expertly extracted 100% natural Premium product

No alcohol (ethyl), artificial ingredients, color additives, fillers or binders.

Natural Gluten free

FDA Statement of Identity

Herbal Supplement

General Statements

Extraction rate: about 1/3-4(up to 333 mg of dry raw material per 1 ml of extract).

Seals/Symbols

Made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Legs Relax Alcohol Free by Herbal Terra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Legs Relax Alcohol Free label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Legs Relax Alcohol Free by Herbal Terra

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Extract Blend

1156 mg per serving

Other (inactive) ingredients: Glycerin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Legs Relax Alcohol Free by Herbal Terra Drug Interactions

Want to check YOUR meds against Legs Relax Alcohol Free?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,141Drugs
3 Major 818 Moderate 320 Minor

Ingredients driving the most interactions

Valerian Root Extract, Dry 902
Quina Bark Extract, Dry 492
Thyme Leaf Extract, Dry 379

Individual Drug Interactions

The ingredients in Legs Relax Alcohol Free interact with 1,141 drugs. Click any drug to see the details.

3 of the 3 ingredients in Legs Relax Alcohol Free interact with drugs. Each result below shows which ingredient is responsible. Valerian Root Extract, Dry Quina Bark Extract, Dry Thyme Leaf Extract, Dry

Each ingredient & the kinds of drugs it affects

For each ingredient in Legs Relax Alcohol Free with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Valerian Root Extract, Dry6 drug types · 902 drugs

Alcohol (Ethanol)

Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.

Likelihood Possible Evidence B
Alprazolam (Xanax)

Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.

Likelihood Possible Evidence B
Cns Depressants

Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.

Likelihood Possible Evidence D
Glucuronidated Drugs

Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.

Likelihood Possible Evidence B
Valerian Root Extract, Dry full monograph & interactions

Quina Bark Extract, Dry11 drug types · 492 drugs

Quinidine

Theoretically, taking cinchona might increase plasma levels and adverse effects of quinidine.
Cinchona contains quinidine.

Likelihood Probable Evidence D
Quinine

Theoretically, taking cinchona might increase plasma levels and adverse effects of quinine.
Cinchona contains quinine.

Likelihood Probable Evidence D
Antacids

Theoretically, taking cinchona might decrease the effectiveness of antacids. Theoretically, taking antacids might also increase the risk of adverse effects from cinchona.
Some research shows that taking cinchona lowers stomach acid pH. In addition, some research shows that taking antacids might increase urinary pH. Theoretically, this may increase the amount of quinidine, a constituent of cinchona, reabsorbed in the renal tubules and increase the risk of quinidine toxicity.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, taking cinchona might increase the drug effects and risk of bleeding with anticoagulant and antiplatelet drugs.
In vitro evidence shows that the alkaloids quinine, quinidine, and cinchonine, constituents of cinchona, inhibit platelet aggregation.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, taking cinchona might increase the adverse effects of carbamazepine.
Clinical research shows that taking quinine, a constituent of cinchona, increases the peak plasma concentration and area under the curve of carbamazepine.

Likelihood Probable Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, taking cinchona might inhibit cytochrome P450 2D6 (CYP2D6) and increase levels of drugs metabolized by this enzyme.
Quinidine, a constituent of cinchona, inhibits CYP2D6-mediated metabolism in humans.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking cinchona might increase serum levels of digoxin.
Quinine and quinidine, which are constituents of cinchona, decrease clearance of digoxin and increase serum digoxin levels in humans.

Likelihood Possible Evidence D
Phenobarbital (Luminal)

Theoretically, taking cinchona might increase the adverse effects of phenobarbital.
Clinical research shows that taking quinine, a constituent of cinchona, increases the peak plasma concentration and area under the curve of phenobarbital.

Likelihood Probable Evidence D
Qt Interval-Prolonging Drugs

Theoretically, taking cinchona with other QT interval-prolonging drugs might cause an additive effect and increase the risk of ventricular arrhythmias.
Quinidine and quinine, which are constituents of cinchona, prolong the QT interval.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, taking cinchona might decrease the effectiveness of H2-blockers.
Some research shows that taking cinchona lowers stomach acid pH.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, taking cinchona might decrease the effectiveness of PPIs.
Some research shows that taking cinchona lowers stomach acid pH.

Likelihood Possible Evidence D
Quina Bark Extract, Dry full monograph & interactions

Thyme Leaf Extract, Dry4 drug types · 379 drugs

Anticholinergic Drugs

Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that thyme leaf extract has antiplatelet effects. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of cholinergic drugs and thyme essential oil might cause additive cholinergic effects.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, thyme might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that thyme has estrogen receptor-binding activity and phytoestrogen content. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Thyme Leaf Extract, Dry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Legs Relax Alcohol Free, from the product label.

Herbal Terra

See all Herbal Terra products
Name
Herbal Terra LLC
Phone Number
+18083857868
Web Address
herbalterra.com
Pharmacist Counseling Corner

Legs Relax Alcohol Free by Herbal Terra: Common Questions

Does Legs Relax Alcohol Free by Herbal Terra interact with any medications?
Yes. Based on its ingredients, Legs Relax Alcohol Free has a known interaction with 1,141 medications, including 3 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Legs Relax Alcohol Free contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this while I'm pregnant or breastfeeding?
No. The safety data advises against quina bark during pregnancy and breastfeeding because it contains quinine, which may harm the baby. Valerian is also advised against during pregnancy and while breastfeeding due to insufficient safety data. Thyme is rated likely safe in pregnancy and lactation, but since the product contains quina bark and valerian, it is not appropriate for use during pregnancy or while breastfeeding.
What are the most common side effects I might notice?
From thyme: allergic reactions, diarrhea, dizziness, headache, heartburn, nausea, or vomiting. From valerian: dizziness, drowsiness, and mental slowness. From quina bark: diarrhea, nausea, ringing ears, and vomiting. Keep in mind that serious side effects from quina bark, though rare, can include abnormal heartbeats and blood disorders.
Does this product actually work for restless legs?
The evidence isn't established in our data. Valerian is possibly effective for insomnia, but for restless legs syndrome specifically, we don't have reliable effectiveness data. Thyme and quina bark also lack established evidence for this use.
Can I take this long-term?
The safety data for valerian shows that long-term safety is not well studied, so caution is advised. Quina bark can cause severe side effects with prolonged high-dose use. It's best to discuss how long you plan to take this with your pharmacist or doctor.
Why does this product say 'alcohol free' if alcohol is one of the interaction concerns?
The product itself contains no alcohol — it's a liquid made with glycerin and water instead. The interaction with alcohol (ethanol) is a caution because if you drink alcohol while taking this product, you may feel more drowsy or sedated than expected, especially from the valerian.
What is quina bark, and why is it in this product?
Quina bark, also called cinchona, comes from the cinchona tree and has been used traditionally for various purposes including respiratory and muscle concerns. However, it contains quinine and quinidine — potent compounds that carry serious interaction and side-effect risks — and the bark used in supplements is not dose-controlled, making safety unpredictable.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Legs Relax Alcohol Free label
Go deeper

The Full Monographs Behind Legs Relax Alcohol Free’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Thyme

Interacts with 379 drugs

Thyme is a common kitchen herb that has long been used for coughs, sore throats, and digestive complaints. It is generally safe in the amounts found in food, and some cough products that com...

Read the full Thyme monograph → Herb & supplement monograph

Valerian

Interacts with 902 drugs

Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some people sleep but does not work reliably...

Read the full Valerian monograph → Herb & supplement monograph

Cinchona

Interacts with 492 drugs

Cinchona bark is the natural source of quinine and has been used for centuries to treat malaria and fever, but the bark itself is not standardized and can be unpredictable and risky. Modern...

Read the full Cinchona monograph →
Sources

Sources & How We Checked

Legs Relax Alcohol Free's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 70 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Thyme 18 references
  1. Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369-78. PubMed
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Okazaki K, Kawazoe K, Takaishi Y. Human platelet aggregation inhibitors from thyme (Thymus vulgaris L.). Phytother Res 2002;16:398-9. .
  4. Spiewak R, Skorska C, Dutkiewicz J. Occupational airborne contact dermatitis caused by thyme dust. Contact Dermatitis 2001;44:235-9. . PubMed
  5. Ernst E, Marz R, Sieder C. A controlled multi-centre study of herbal versus synthetic secretolytic drugs for acute bronchitis. Phytomedicine 1997;4:287-93. PubMed
  6. Yamamoto J, Yamada K, Naemura A, et al. Testing various herbs for antithrombotic effect. Nutrition 2005;21(5):580-7. PubMed
  7. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
  8. Mackiewicz, B., Skorska, C., Dutkiewicz, J., Michnar, M., Milanowski, J., Prazmo, Z., Krysinska-Traczyk, E., and Cisak, E. Allergic alveolitis due to herb dust exposure. Ann Agric Environ Med 1999;6(2):167-170.
  9. Martinez-Gonzalez, M. C., Goday Bujan, J. J., Martinez, Gomez W., and Fonseca, Capdevila E. Concomitant allergic contact dermatitis due to Rosmarinus officinalis (rosemary) and Thymus vulgaris (thyme). Contact Dermatitis 2007;56(1):49-50.
  10. Jukic, M., Politeo, O., Maksimovic, M., Milos, M., and Milos, M. In vitro acetylcholinesterase inhibitory properties of thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone. Phytother.Res 2007;21(3):259-261.
  11. Marzian, O. [Treatment of acute bronchitis in children and adolescents. Non-interventional postmarketing surveillance study confirms the benefit and safety of a syrup made of extracts from thyme and ivy leaves]. MMW.Fortschr.Med 6-28-2007;149(27-28 Suppl
  12. Cuzzolin, L. and Benoni, G. Attitudes and knowledge toward natural products safety in the pharmacy setting: an Italian study. Phytother.Res 2009;23(7):1018-1023. PubMed
  13. Berova, N., Stransky, L., and Krasteva, M. Studies on contact dermatitis in stomatological staff. Dermatol.Monatsschr. 1990;176(1):15-18.
  14. Smeenk, G., Kerckhoffs, H. P., and Schreurs, P. H. Contact allergy to a reaction product in Hirudoid cream: an example of compound allergy. Br.J Dermatol. 1987;116(2):223-231.
  15. Le Roy, R., Grosshans, E., and Foussereau, J. [Investigation of contact allergies in 100 cases of ulcus cruris (author's transl)]. Derm.Beruf.Umwelt. 1981;29(6):168-170.
  16. Lorenzi, S., Placucci, F., Vincenzi, C., Bardazzi, F., and Tosti, A. Allergic contact dermatitis due to thymol. Contact Dermatitis 1995;33(6):439-440. PubMed
  17. Bahadoran P, Rokni FK, Fahami F. Investigating the therapeutic effect of vaginal cream containing garlic and thyme compared to clotrimazole cream for the treatment of mycotic vaginitis. Iran J Nurs Midwifery Res 2010;15(Suppl 1):343-9.
  18. Erol S, Aydin B, Dilli D, Okumus N, Zenciroglu A, Gündüz M. An interesting newborn case of fructose 1-6 diphosphatase deficiency triggered after thyme juice ingestion. Clin Lab. 2014;60(1):151-3. PubMed

See these in context on the Thyme monograph →

Valerian 37 references
  1. Willey LB, Mady SP, Cobaugh DJ, Wax PM. Valerian overdose: a case report. Vet Hum Toxicol 1995;37:364-5.
  2. Kuhlmann J, Berger W, Podzuweit H, Schmidt U. The influence of valerian treatment on "reaction time, alertness and concentration" in volunteers. Pharmacopsychiatry 1999;32:235-41. PubMed
  3. Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
  4. Houghton PJ. The scientific basis for the reputed activity of Valerian. J Pharm Pharmacol 1999;51:505-12. PubMed
  5. Garges HP, Varia I, Doraiswamy PM. Cardiac complications and delirium associated with Valerian root withdrawal. [Letter to the Editor]. JAMA 1998;280:1566-7. PubMed
  6. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
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  24. Carrasco MC, Vallejo JR, Pardo-de-Santayana M, et al. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009 Dec;23:1795-6.
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See these in context on the Valerian monograph →

Cinchona 15 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
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See these in context on the Cinchona monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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