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Dietary supplement

Lion's Mane Ingredients & Drug Interactions

by Intelligent Labs

Lion's Mane label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane is a dietary supplement by Intelligent Labs with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane Mushroom Fruiting Body Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lion's Mane by Intelligent Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane by Intelligent Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lion's Mane by Intelligent Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Lion's Mane by Intelligent Labs is a single-ingredient supplement: Lion's Mane Mushroom Fruiting Body Extract. It's a concentrated form of the mushroom itself, not a cultured mycelium product.

The capsule also contains methylcellulose, an inactive ingredient used to form and fill the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: focus memory and cognitive health support.
  • We looked for evidence on: Memory, Cognitive function, Cognitive impairment, Dementia, Alzheimer disease, Parkinson disease — and 2 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Cognitive impairment, Dementia, Memory, and more.

The evidence for lion's mane is limited. Our data shows insufficient reliable evidence to rate it for Alzheimer disease, anxiety, athletic performance, cancer, cognitive function, or cognitive impairment.

That doesn't mean it doesn't work — it means high-quality human studies backing any of these uses aren't established yet in the data we hold.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane is generally well tolerated when taken by mouth. The most common side effects reported in trials are gastrointestinal discomfort, nausea, and skin rash — though these occur in a small number of people.

The main caution is that long-term safety as a supplement hasn't been well studied. During pregnancy and breastfeeding, there isn't enough safety data, so the guidance is to avoid it; talk with your doctor or pharmacist about whether it's right for you in those situations.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you're on blood thinners (anticoagulants or antiplatelet drugs) — lion's mane may increase bleeding risk. Also confirm if you take diabetes medications or drugs that suppress your immune system, as lion's mane may intensify their effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane is a single-ingredient mushroom extract that may appeal to you if you're curious about cognitive or immune support, but the human evidence isn't established yet. If you take blood thinners, diabetes medications, or immunosuppressants, check with your doctor or pharmacist before starting it.

The same goes if you're pregnant or nursing — there's not enough safety data to be certain either way.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane, straight from the product label.

Brand Intelligent Labs
Barcode (UPC) X002V2WSUV
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 313155
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane by Intelligent Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
X002V2WSUV
IngredientAmount% DV
Lion's Mane Mushroom Fruiting Body Extract1000 mg--

Other ingredients: Methylcellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take two (2) capsules of Lion's Mane Mushroom Extract daily, or as directed by a physician or healthcare provider.

Formulation

This product contains no: wheat, eggs, soy, salt, animal derivatives, maltodextrin, magnesium stearate, artificial flavors or preservatives.

Focus, Memory, and Immunity Support

Non-GMO, no fillers & binders

Storage

Two-year shelf life at room temperature.

Store in a cool and dry place. Avoid excessive heat. Tighten cap when not in use.

Formula

Intelligent Labs Lion's Mane Mushroom Extract from H. Erinaceus fruiting bodies may help support mental and cognitive health. It is standardized to contain a minimum of 25% Beta-glucans; these are bioactive compounds.

Extracted from whole fruiting bodies

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Made in USA with Global Ingredients GMP Good Manufacturing Practice Quality Product

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Do not exceed the stated dose. Discontinue use if any adverse reactions occur.

Consult your physician if you are pregnant or nursing, are taking medications, or have any medical conditions.

Keep out of the reach of children.

Do not use if the seal is damaged or missing.

General Statements

Two-month supply.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane by Intelligent Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane by Intelligent Labs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Lion's Mane Mushroom Fruiting Body Extract

Interacts with
327 drugs
1000 mg per serving Form: Beta-Glucan

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane Mushroom Fruiting Body Extract monograph & interactions

Other (inactive) ingredients: Methylcellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lion's Mane by Intelligent Labs Drug Interactions

Want to check YOUR meds against Lion's Mane?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane Mushroom Fruiting Body Extract 327

Individual Drug Interactions

The ingredients in Lion's Mane interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lion's Mane interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane Mushroom Fruiting Body Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane Mushroom Fruiting Body Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane Mushroom Fruiting Body Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane, from the product label.

Intelligent Labs

See all Intelligent Labs products
Name
Intelligent Labs
Street Address
4283 Express Lane Suite 447-067
City
Sarasota
State
FL
ZipCode
34238
Web Address
https://www.intelligentlabs.org
Pharmacist Counseling Corner

Lion's Mane by Intelligent Labs: Common Questions

Does Lion's Mane by Intelligent Labs interact with any medications?
Yes. Based on its ingredients, Lion's Mane has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Lion's Mane if I'm pregnant or breastfeeding?
Not enough safety data exists to know either way. The guidance in the data we hold advises against it in pregnancy and while breastfeeding. Talk with your doctor or pharmacist for personalized advice on whether it's right for you.
What are the most common side effects?
Gastrointestinal discomfort, nausea, and skin rash show up most often in people taking it by mouth. These occur in a small number of users, and most people tolerate it well.
Does this actually work for brain health or memory?
The evidence isn't established yet. Our data shows insufficient reliable evidence to rate it for cognitive function, cognitive impairment, Alzheimer disease, or anxiety. More high-quality human studies are needed.
Is there anything else in the capsule besides the mushroom?
Yes — methylcellulose is added as an inactive ingredient to form and fill the capsule. There's one active ingredient: the Lion's Mane Mushroom Fruiting Body Extract.
How long have people been using lion's mane safely?
Lion's mane is eaten as a food and generally well tolerated. However, as a supplement, long-term safety hasn't been well studied, so that's something to keep in mind.
Why does this interact with so many medications?
The 327 medications we've identified span three drug categories: blood thinners, diabetes drugs, and immunosuppressants. Lion's mane's effects on bleeding, blood sugar, and immune function mean it can potentially interact with drugs across those categories — but that doesn't mean you can't take it if you're on one of them. Check your exact medications with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane label
Go deeper

The Full Monographs Behind Lion's Mane’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Lion's Mane's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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