Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Lipitrol Ingredients & Drug Interactions

by Ortho Molecular Products

Lipitrol label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lipitrol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lipitrol is a dietary supplement by Ortho Molecular Products with 6 active ingredients. Its ingredients are commonly taken for constipation and bowel regularity, diarrhea (as a stool bulking agent), lowering cholesterol.Based on those ingredients, 2,138 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Guar Gum, Guggul, Artichoke leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Lipitrol by Ortho Molecular Products

Ask about any prescription or over-the-counter medication and we check it for interactions with Lipitrol by Ortho Molecular Products — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Lipitrol by Ortho Molecular Products

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 4 of its 6 active ingredients.
  • “Proprietary Blend (Sytrinol)” is a proprietary blend — the label gives one combined amount (300 mg) without saying how much of each component you get.

Lipitrol contains 6 active ingredients: guar gum, chromium, artichoke leaf extract, guggul, polymethoxylated flavones, and tocotrienols. These are paired with inactive ingredients — the capsule itself, microcrystalline cellulose, magnesium stearate, calcium silicate, and stearic acid — which are standard binders and fillers.

The active ingredients work on cholesterol, blood sugar, digestion, and inflammation through different pathways.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Cholesterol and lipid support.
  • We looked for evidence on: Hypercholesterolemia, Hyperlipidemia, Beta blocker-induced dyslipidemia, Metabolic syndrome, Nonalcoholic fatty liver disease (NAFLD), Triglyceride management — and 1 related terms.
  • The strongest evidence on file: Artichoke is rated "Possibly Effective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Guar Gum is rated "Possibly Effective" for Hypercholesterolemia.
  • Also on file: Tocotrienols is rated "Possibly Ineffective" for Hypercholesterolemia.

Guar gum is possibly effective for high cholesterol, high blood pressure, and irritable bowel syndrome, and possibly helps with constipation. Chromium shows possibly effective evidence for chromium deficiency and diabetes, but possibly ineffective for prediabetes, schizophrenia, and high blood pressure.

Artichoke leaf extract is possibly effective for high cholesterol and indigestion, but evidence for fatty liver disease is insufficient. Guggul's evidence is insufficient or shows it possibly ineffective for the conditions tested.

Tocotrienols are possibly effective for diabetes but possibly ineffective for high cholesterol. Overall, the strongest evidence is for guar gum on cholesterol and blood pressure, and for chromium on diabetes and deficiency.

The evidence, ingredient by ingredient Guar Gum Chromium Artichoke Guggul Tocotrienols

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Guar gum is generally well tolerated but must be taken with plenty of water to avoid choking or blockage in the throat or small intestine — a rare but serious risk. Common side effects include bloating, gas, diarrhea, and abdominal discomfort; these tend to improve if you start with a small dose and increase gradually.

Chromium is generally well tolerated at typical doses, though high or long-term use may pose risks; common side effects are headaches, insomnia, irritability, and gastrointestinal irritation. Artichoke is generally well tolerated short-term and can cause abdominal pain, diarrhea, gas, and nausea; it may trigger allergic reactions in people sensitive to ragweed or related plants.

Guggul commonly causes bloating, nausea, diarrhea, and unpleasant taste, and can cause skin reactions that are dose-dependent — higher doses carry higher risk. Tocotrienols appear well tolerated; no serious side effects have been reported in trials, though topical formulas have caused mild itching.

Pregnancy and lactation data vary by ingredient: guar gum and chromium are possibly safe in pregnancy but should be used cautiously; artichoke should be avoided during pregnancy and lactation; guggul is likely unsafe in pregnancy and should be avoided while breastfeeding; and tocotrienol safety in pregnancy and lactation is not established.

Side effects, ingredient by ingredient Guar Gum Chromium Artichoke Guggul Tocotrienols

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Guggul, Artichoke, Guar Gum, Chromium, Tocotrienols.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications.
  • For scale: 2,139 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking if you use diabetes medications or insulin (risk of low blood sugar), blood thinners or antiplatelet drugs (risk of bleeding or reduced effect), thyroid medication like levothyroxine (reduced absorption), blood pressure drugs (risk of low blood pressure or reduced effect), estrogen-based birth control (theoretical interaction), or any other oral medications (guar gum may reduce absorption — allow 30–60 minutes between doses).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Lipitrol may be worth considering if you're working on cholesterol or blood sugar and want a multi-ingredient approach, but it has a significant interaction profile — especially with diabetes medications, blood thinners, thyroid medication, and birth control. If you take any prescription drugs, check them against the interaction tool here before starting, or talk it over with your doctor or pharmacist to make sure it fits your regimen.

Take it with plenty of water, start low, and watch for digestive upset or skin reactions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lipitrol, straight from the product label.

Brand Ortho Molecular Products
Barcode (UPC) 615033015305
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Mar 23, 2018
DSLD ID 175136
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lipitrol by Ortho Molecular Products, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
615033015305
IngredientAmount% DV
Guar Gum225 mg--
Chromium200 mcg167%
Artichoke leaf extract150 mg--
Guggul500 mg--
Proprietary Blend (Sytrinol)300 mg--
Polymethoxylated flavones0 NP--
Tocotrienols0 NP--

Other ingredients: natural Vegetable Capsules, Microcrystalline Cellulose, Magnesium Stearate, Calcium Silicate, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: 2 capsules per day or as recommended by your health care professional.

Precautions

For best results, consult your health care professional about using Fiber Plus with Lipitrol.

Do not consume this product if you are pregnant or nursing. Consult your physician for further information.

As with all dietary supplements, some individuals may not tolerate or may be allergic to the ingredients used. Please read the ingredient panel carefully prior to ingestion. Cease taking this product and consult your physician if you have negative reactions upon ingestion.

Keep out of reach of children.

This product was sealed for your protection. Do not use if outer logoed neck seal or inner-seal is missing or damaged.

Do not accept if label shows signs of tampering

Formulation

Formulated To Be Free Of Allergens Derived From: Gluten, yeast, artificial colors and flavors.

Storage

Keep container tightly closed. Store at room temperature.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Vcaps

General

Product #530060 Label ID L-OMP100-530060-F V1

General Statements

Learn more

Cardiovascular health

Professional Strength: Not for sale through Amazon.com

Brand IP Statement(s)

VitaSecure

Because efficacy matters

ChromeMate brand niacin-bound chromium. ChromeMate is a registered trademark of InterHealth N.I. Sytrinol is a registered trademark of KGK Synergize. Use and composition of this proprietary formula is protected by U.S. patents #6,239,114, #6,251,400. Tocomin is a registered trademark of Carotech BHD.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lipitrol by Ortho Molecular Products label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lipitrol label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lipitrol by Ortho Molecular Products

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Guar Gum

Interacts with
2,025 drugs
225 mg per serving

Guar gum is a soluble, gel-forming fiber from the guar bean that may modestly help with cholesterol, blood sugar, and bowel regularity. It is generall...

Guar Gum monograph & interactions

Chromium

Interacts with
178 drugs
200 mcg per serving Form: O-Polynicotinate

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

Artichoke leaf extract

Interacts with
363 drugs
150 mg per serving Form: Cynarin

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, th...

Artichoke leaf extract monograph & interactions

Guggul

Interacts with
757 drugs
500 mg per serving Form: Guggulsterones

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are...

Guggul monograph & interactions

Proprietary Blend (Sytrinol)

300 mg per serving

Other (inactive) ingredients: Natural Vegetable Capsules, Microcrystalline Cellulose, Magnesium Stearate, Calcium Silicate, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lipitrol by Ortho Molecular Products Drug Interactions

Want to check YOUR meds against Lipitrol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,138Drugs
2,135 Moderate 3 Minor

Ingredients driving the most interactions

Guar Gum 2,025
Guggul 757
Artichoke leaf extract 363
Chromium 178
Tocotrienols 122

Individual Drug Interactions

The ingredients in Lipitrol interact with 2,138 drugs. Click any drug to see the details.

5 of the 6 ingredients in Lipitrol interact with drugs. Each result below shows which ingredient is responsible. Guar Gum Guggul Artichoke leaf extract Chromium Tocotrienols

Each ingredient & the kinds of drugs it affects

For each ingredient in Lipitrol with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Guar Gum5 drug types · 2,025 drugs

Ethinyl Estradiol

Theoretically, guar gum might reduce the absorption of ethinyl estradiol, potentially decreasing its effectiveness.
Animal research shows that taking guar gum with ethinyl estradiol decreases ethinyl estradiol absorption. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Metformin (Glucophage)

Guar gum might reduce the absorption of metformin, potentially decreasing its effectiveness.
A small study in healthy volunteers shows that guar gum reduces the absorption rate of metformin.

Likelihood Probable Evidence B
Oral Drugs

Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Clinical research shows that guar gum reduces or slows absorption of medications such as penicillin and metformin. To avoid changes in absorption, take guar gum 30-60 minutes after oral medications.

Likelihood Possible Evidence B
Penicillin

Guar gum might reduce the absorption of penicillin, potentially decreasing its effectiveness.
A small clinical study in healthy volunteers shows that taking guar gum with penicillin results in decreased penicillin absorption and reduced penicillin levels.

Likelihood Probable Evidence B
Digoxin (Lanoxin)

Guar gum might slow digoxin absorption, but it does not seem to impact how much digoxin is absorbed overall.
Two small studies in healthy volunteers show no change in the overall extent of digoxin absorption, although early absorption was slowed, when taken with guar gum.

Likelihood Possible Evidence B
Guar Gum full monograph & interactions

Guggul9 drug types · 757 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research and preliminary clinical studies suggest that guggul might have antiplatelet and anticoagulant effects.

Likelihood Possible Evidence B
Contraceptive Drugs

Theoretically, guggul might increase the risk of adverse effects when taken with contraceptive drugs.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, guggul might reduce the effects of CYP3A4 substrates.
In vitro research shows that guggul constituents known as guggulsterones can induce CYP3A4.

Likelihood Probable Evidence D
Diltiazem (Cardizem, Others)

Guggul might reduce the effects of diltiazem.
A small pharmacokinetic study shows that concomitant use of guggul with diltiazem reduces the bioavailability of diltiazem.

Likelihood Probable Evidence B
Estrogens

Theoretically, guggul might increase the risk of adverse effects when taken with estrogens.
In vitro research shows that guggul constituents known as guggulsterones have estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Propranolol (Inderal)

Guggul might reduce the effects of propranolol.
A small pharmacokinetic study shows that concomitant use of guggul with propranolol reduces the bioavailability of propranolol.

Likelihood Probable Evidence B
Rosuvastatin (Crestor)

Theoretically, guggul might increase the effects and adverse effects of rosuvastatin.
Animal research shows that guggul increases the bioavailability and hypolipidemic effects of rosuvastatin. The mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, guggul might interfere with tamoxifen therapy.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, guggul might increase the risk for adverse effects when taken with thyroid hormone therapy.
Animal research suggests that guggul has thyroid-stimulating effects.

Likelihood Probable Evidence B
Guggul full monograph & interactions

Artichoke leaf extract4 drug types · 363 drugs

Antidiabetes Drugs

Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Artichoke leaf extract full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions

Tocotrienols1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding. However, this has not been reported in humans.
Taking tocotrienols orally inhibits experimentally-induced platelet aggregation in humans. Theoretically tocotrienols might increase the risk of bleeding if taken with antiplatelet or anticoagulant drugs. However, tocotrienols 400-800 mg daily have been used with aspirin and/or clopidogrel for 1 year with no clear cumulative antiplatelet effects and no reports of bleeding.

Likelihood Unlikely Evidence B
Tocotrienols full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lipitrol, from the product label.

Ortho Molecular Products

See all Ortho Molecular Products products
Name
Ortho Molecular Products, Inc.
Street Address
1991 Duncan Place
City
Woodstock
State
IL
ZipCode
60098
Web Address
OrthoMolecularProducts.com
Pharmacist Counseling Corner

Lipitrol by Ortho Molecular Products: Common Questions

Does Lipitrol by Ortho Molecular Products interact with any medications?
Yes. Based on its ingredients, Lipitrol has a known interaction with 2,138 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lipitrol contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on metformin?
Guar gum in this product can reduce how much metformin your body absorbs. Talk with your doctor or pharmacist before combining them — they may suggest spacing the doses 30–60 minutes apart, or they may recommend against it for your situation.
Is it safe during pregnancy?
Safety varies by ingredient. Guar gum and chromium are possibly safe in small amounts (like from food), but concentrated supplement doses haven't been well studied. Artichoke and guggul should be avoided. There isn't enough data on the others. Talk with your doctor before taking this during pregnancy.
What are the most common side effects?
Bloating, gas, diarrhea, and abdominal discomfort are most likely, coming mainly from guar gum. Chromium and guggul can add headaches and nausea. Most people who experience mild GI upset find it improves if they start with a smaller dose and build up slowly.
Does this actually lower cholesterol?
Guar gum and artichoke extract show 'possibly effective' evidence for high cholesterol, meaning some clinical studies support it but more research is needed. Guggul's evidence is too weak to rate it effective. Results vary by person.
Why do I need to take this with lots of water?
Guar gum absorbs water and swells in your digestive tract — that's how it works. Without enough water, it can clump and block your throat or small intestine, which is rare but serious. Drink a full glass of water with each dose.
Can I take this with my blood pressure medication?
Both guar gum and artichoke leaf extract may lower blood pressure. Taking them with your medication could drop your pressure too far. Check with your doctor or pharmacist before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lipitrol is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lipitrol label
Go deeper

The Full Monographs Behind Lipitrol’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Guar Gum

Interacts with 2,025 drugs

Guar gum is a soluble, gel-forming fiber from the guar bean that may modestly help with cholesterol, blood sugar, and bowel regularity. It is generally safe in food amounts, but concentrated...

Read the full Guar Gum monograph → Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Artichoke

Interacts with 363 drugs

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...

Read the full Artichoke monograph → Herb & supplement monograph

Guggul

Interacts with 757 drugs

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are mixed and often low-quality, and it can...

Read the full Guggul monograph → Herb & supplement monograph

Tocotrienols

Interacts with 122 drugs

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early research is interesting but far from conclusi...

Read the full Tocotrienols monograph →
Sources

Sources & How We Checked

Lipitrol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 120 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Guar Gum 26 references
  1. Gin H, Orgerie MB, Aubertin J. The influence of Guar gum on absorption of metformin from the gut in healthy volunteers. Horm Metab Res 1989;21:81-3.
  2. Huupponen R, Seppala P, Iisalo E. Effect of guar gum, a fibre preparation, on digoxin and penicillin absorption in man. Eur J Clin Pharmacol 1984;26:279-81. PubMed
  3. Malo JL, Cartier A, L'Archeveque J, et al. Prevalence of occupational asthma and immunologic sensitization to guar gum among employees at a carpet-manufacturing plant. J Allergy Clin Immunol 1990;86:562-9. PubMed
  4. Lagier F, Cartier A, Somer J, et al. Occupational asthma caused by guar gum. J Allergy Clin Immunol 1990;85:785-90.
  5. Lewis JH. Esophageal and small bowel obstruction from guar gum-containing diet pills: analysis of 26 cases reported to the FDA. Am J Gastroenterol 1992;87:1424-8.
  6. Vuorinen-Markkola H, Sinisalo M, Koivisto VA. Guar gum in insulin-dependent diabetes: effects on glycemic control and serum lipoproteins. Am J Clin Nutr 1992;56:1056-1060. PubMed
  7. Superko HR, Haskell WL, Sawrey-Kubicek L, Farquhar JW. Effects of solid and liquid guar gum on plasma cholesterol and triglyceride concentrations in moderate hypercholesterolemia. Am J Cardiol 1988;62:51-5. PubMed
  8. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  9. Groop PH, Aro A, Stenman S, Groop L. Long-term effects of guar gum in subjects with non-insulin-dependent diabetes mellitus. Am J Clin Nutr 1993;58:513-8. PubMed
  10. Chuang LM, Jou TS, Yang WS, et al. Therapeutic effect of guar gum in patients with non-insulin-dependent diabetes mellitus. J Formos Med Assoc 1992;91:15-9.
  11. Ebeling P, Yki-Jarvinen H, Aro A, et al. Glucose and lipid metabolism and insulin sensitivity in type 1 diabetes: the effect of guar gum. Am J Clin Nutr 1988;48:98-103. PubMed
  12. Scheen AJ. Clinical pharmacokinetics of metformin. Clin Pharmacokinet 1996;30:359-71. PubMed
  13. Knopp RH, Superko HR, Davidson M, et al. Long-term blood cholesterol-lowering effects of a dietary fiber supplement. Am J Prev Med 1999;17:18-23. PubMed
  14. Patrick PG, Gohman SM, Marx SC, et al. Effect of supplements of partially hydrolyzed guar gum on the occurrence of constipation and use of laxative agents. J Am Diet Assoc 1998;98:912-4. PubMed
  15. Osterlund P, Ruotsalainen T, Korpela R, et al. Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study. Br J Cancer 2007;97:1028-34. PubMed
  16. Lembcke B, Hasler K, Kramer P, et al. Plasma digoxin concentrations during administration of dietary fibre (guar gum) in man. Z Gastroenterol 1982;20;164-7.
  17. Riikonen, S., Savonius, H., Gylling, H., Nikkila, K., Tuomi, A. M., and Miettinen, T. A. Oral guar gum, a gel-forming dietary fiber relieves pruritus in intrahepatic cholestasis of pregnancy. Acta Obstet.Gynecol.Scand. 2000;79(4):260-264. DOI
  18. Kovacs, E. M., Westerterp-Plantenga, M. S., Saris, W. H., Goossens, I., Geurten, P., and Brouns, F. The effect of addition of modified guar gum to a low-energy semisolid meal on appetite and body weight loss. Int.J.Obes.Relat Metab Disord. 2001;25(3):307 PubMed
  19. Halama, W. H. and Mauldin, J. L. Distal esophageal obstruction due to a guar gum preparation (Cal-Ban 3000). South.Med.J. 1992;85(6):642-645. PubMed
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Artichoke 16 references
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Guggul 21 references
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Tocotrienols 4 references
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