Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Lipo6 Stim-Free Ingredients & Drug Interactions

by Nutrex Research Basix Series

Lipo6 Stim-Free label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lipo6 Stim-Free against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lipo6 Stim-Free is a dietary supplement by Nutrex Research Basix Series with 5 active ingredients. Its ingredients are commonly taken for blood sugar support in type 2 diabetes, weight loss and appetite control, insulin sensitivity.Based on those ingredients, 1,067 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Black Pepper (fruit) extract, Synthetic 99% Guggulsterones Z&E, Chromium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Lipo6 Stim-Free by Nutrex Research Basix Series

Ask about any prescription or over-the-counter medication and we check it for interactions with Lipo6 Stim-Free by Nutrex Research Basix Series — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Lipo6 Stim-Free by Nutrex Research Basix Series

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Lipo6 Stim-Free contains 5 active ingredients. Chromium helps support normal blood sugar regulation.

N-Acetyl-L-Tyrosine is an amino acid form of tyrosine. Black pepper (fruit) extract provides piperine, a compound that may enhance absorption of other nutrients.

L-Carnitine HCl is an amino acid that plays a role in how your body uses fat for energy. Synthetic 99% Guggulsterones Z&E are plant-derived compounds from guggul resin.

The product also contains inactive ingredients—glycerin, vegetable cellulose, purified water, hypromellose, titanium dioxide, and polysorbate 80—that serve as capsule material and thickeners.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: weight loss and metabolic enhancement support.
  • We looked for evidence on: Obesity, Metabolic syndrome, L-carnitine deficiency, Chromium deficiency, overweight, lipid metabolism — and 1 related terms.
  • The strongest evidence on file: L-carnitine is rated "Effective" for L-carnitine deficiency (Natural Medicines).
  • Also on file: Chromium is rated "Likely Effective" for Chromium deficiency.
  • Also on file: Guggul is rated "Possibly Ineffective" for Obesity.

Chromium is rated Likely Effective for chromium deficiency, and Possibly Effective for diabetes management. For prediabetes and other conditions listed, the evidence is Possibly Ineffective or insufficient.

L-carnitine is Effective for L-carnitine deficiency and Possibly Effective for high cholesterol, congestive heart failure, and angina. For black pepper and guggulsterones, the evidence we hold does not establish effectiveness—the data shows Insufficient Reliable Evidence for most uses black pepper is studied for, and guggulsterones are rated Possibly Ineffective for obesity and Insufficient Reliable Evidence for other conditions.

The overall strength of evidence for this product's intended purpose isn't established in our data.

The evidence, ingredient by ingredient Chromium Black Pepper L-carnitine Guggul

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chromium is generally well tolerated at typical supplement doses; high or long-term doses may carry risks. Most common side effects are gastrointestinal irritation, headaches, insomnia, and mood changes, though serious effects like kidney or liver damage and blood disorders are rare.

Black pepper as a food spice is safe, but concentrated supplements should be used cautiously; common side effects include burning aftertaste and indigestion. L-carnitine is generally well tolerated, with most side effects being stomach upset, diarrhea, nausea, and a fish-like body odor at higher doses; seizures are rare.

Guggul may cause digestive upset, headaches, nausea, and skin reactions—the risk of skin rash increases at higher doses. Pregnancy and breastfeeding safety varies by ingredient: chromium is rated Likely Safe or Possibly Safe in pregnancy and Likely Safe while breastfeeding; black pepper is Likely Safe in pregnancy and lactation but also rated Possibly Unsafe in pregnancy (consult your doctor on this conflicting data); L-carnitine has insufficient pregnancy data and is Possibly Safe while breastfeeding; guggul is Likely Unsafe in pregnancy and should be avoided while breastfeeding due to limited safety data.

Side effects, ingredient by ingredient Chromium Black Pepper L-carnitine Guggul

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Guggul, Black Pepper, Chromium, L-carnitine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,068 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use insulin or diabetes medications (major low blood sugar risk from chromium), blood thinners like warfarin or antiplatelet drugs, thyroid hormone replacement, beta-blockers like propranolol or diltiazem, birth control pills or estrogen therapy, seizure medications like phenytoin, or antibiotics like rifampin. Also inform them if you take heart or transplant medications, statins for cholesterol, theophylline for breathing, or NSAIDs or aspirin regularly.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be considered by people looking to support blood sugar management or fat metabolism, but chromium and guggulsterones interact with many common medications—especially blood sugar drugs, blood thinners, thyroid hormone, heart medications, and birth control. Before starting Lipo6 Stim-Free, go through your complete medication list with your doctor or pharmacist to make sure it won't reduce a drug's effect or raise your risk of side effects.

If you're pregnant, breastfeeding, or managing a chronic condition, check with them first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 31, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lipo6 Stim-Free, straight from the product label.

Brand Nutrex Research Basix Series
Barcode (UPC) 853237000929
Net contents 120 Liqui-Cap(s)
Market status On market
Date entered into DSLD Aug 31, 2018
DSLD ID 176253
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lipo6 Stim-Free by Nutrex Research Basix Series, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Liqui-Cap(s)
Maximum serving Sizes:
2 Liqui-Cap(s)
Servings per container
60
UPC/BARCODE
853237000929
IngredientAmount% DV
Chromium200 mcg571%
N-Acetyl-L-Tyrosine150 mg--
Black Pepper (fruit) extract5 mg--
L-Carnitine HCl500 mg--
Synthetic 99% Guggulsterones Z&E20 mg--

Other ingredients: Glycerin, Vegetable Cellulose, purified Water, Hypromellose, Titanium Dioxide, Polysorbate 80

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Lipo-6 Stim-Free Product Highlights

Bioperine is a registered trademark of Sabinsa Corp.

Formulation

Powerful stimulant-free weight loss support

100% stimulant & caffeine free

Stimulant-free weight loss support

This product utilizes only natural vegetable capsules that are free of animal products.

General Statements

Maximum potency

Helps enhance metabolic activity Fast-acting liquid capsule

Regular exercise and proper nutrition are essential for achieving your weight loss goals. As individuals vary so may results from using this product.

Precautions

Warning: Lipo-6 Stim-Free is not for use for persons under the age of 18.

Do not use if pregnant or nursing.

Do not exceed recommended dosage.

If you are a diabetic and are taking any medication consult your doctor before use.

Keep out of reach of children.

Do not exceed 4 liqui-caps per day.

General

LBL-LIPO6SF-120CT-V2-US

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended Use: Take 2 liqui-caps in the morning and 2 more liqui-caps in the afternoon. For best results do not take with a meal. Be consistent and take daily. Do not exceed 4 liqui-caps per day.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lipo6 Stim-Free by Nutrex Research Basix Series label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lipo6 Stim-Free label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lipo6 Stim-Free by Nutrex Research Basix Series

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Liqui-Cap(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chromium

Interacts with
178 drugs
200 mcg per serving Form: Chromium Picolinate

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

N-Acetyl-L-Tyrosine

150 mg per serving

Black Pepper (fruit) extract

Interacts with
1,019 drugs
5 mg per serving

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to he...

Black Pepper (fruit) extract monograph & interactions

L-Carnitine HCl

Interacts with
19 drugs
500 mg per serving

L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most...

L-Carnitine HCl monograph & interactions

Synthetic 99% Guggulsterones Z&E

Interacts with
757 drugs
20 mg per serving

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are...

Synthetic 99% Guggulsterones Z&E monograph & interactions

Other (inactive) ingredients: Glycerin, Vegetable Cellulose, Purified Water, Hypromellose, Titanium Dioxide, Polysorbate 80. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lipo6 Stim-Free by Nutrex Research Basix Series Drug Interactions

Want to check YOUR meds against Lipo6 Stim-Free?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,067Drugs
998 Moderate 69 Minor

Ingredients driving the most interactions

Black Pepper (fruit) extract 1,019
Synthetic 99% Guggulsterones Z&E 757
Chromium 178
L-Carnitine HCl 19

Individual Drug Interactions

The ingredients in Lipo6 Stim-Free interact with 1,067 drugs. Click any drug to see the details.

4 of the 5 ingredients in Lipo6 Stim-Free interact with drugs. Each result below shows which ingredient is responsible. Black Pepper (fruit) extract Synthetic 99% Guggulsterones Z&E Chromium L-Carnitine HCl

Each ingredient & the kinds of drugs it affects

For each ingredient in Lipo6 Stim-Free with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Black Pepper (fruit) extract17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
Black Pepper (fruit) extract full monograph & interactions

Synthetic 99% Guggulsterones Z&E9 drug types · 757 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research and preliminary clinical studies suggest that guggul might have antiplatelet and anticoagulant effects.

Likelihood Possible Evidence B
Contraceptive Drugs

Theoretically, guggul might increase the risk of adverse effects when taken with contraceptive drugs.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, guggul might reduce the effects of CYP3A4 substrates.
In vitro research shows that guggul constituents known as guggulsterones can induce CYP3A4.

Likelihood Probable Evidence D
Diltiazem (Cardizem, Others)

Guggul might reduce the effects of diltiazem.
A small pharmacokinetic study shows that concomitant use of guggul with diltiazem reduces the bioavailability of diltiazem.

Likelihood Probable Evidence B
Estrogens

Theoretically, guggul might increase the risk of adverse effects when taken with estrogens.
In vitro research shows that guggul constituents known as guggulsterones have estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Propranolol (Inderal)

Guggul might reduce the effects of propranolol.
A small pharmacokinetic study shows that concomitant use of guggul with propranolol reduces the bioavailability of propranolol.

Likelihood Probable Evidence B
Rosuvastatin (Crestor)

Theoretically, guggul might increase the effects and adverse effects of rosuvastatin.
Animal research shows that guggul increases the bioavailability and hypolipidemic effects of rosuvastatin. The mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, guggul might interfere with tamoxifen therapy.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, guggul might increase the risk for adverse effects when taken with thyroid hormone therapy.
Animal research suggests that guggul has thyroid-stimulating effects.

Likelihood Probable Evidence B
Synthetic 99% Guggulsterones Z&E full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions

L-Carnitine HCl3 drug types · 19 drugs

Acenocoumarol (Sintrom)

Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation with concomitant use. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism.

Likelihood Probable Evidence B
Warfarin (Coumadin)

Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with L-carnitine and warfarin.

Likelihood Possible Evidence D
L-Carnitine HCl full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lipo6 Stim-Free, from the product label.

Nutrex Research Basix Series

See all Nutrex Research Basix Series products
Name
Nutrex Research, Inc.
City
Oviedo
State
FL
ZipCode
32765
Phone Number
1-888-368-8739
Web Address
Nutrex.com
Pharmacist Counseling Corner

Lipo6 Stim-Free by Nutrex Research Basix Series: Common Questions

Does Lipo6 Stim-Free by Nutrex Research Basix Series interact with any medications?
Yes. Based on its ingredients, Lipo6 Stim-Free has a known interaction with 1,067 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lipo6 Stim-Free contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is chromium safe if I have diabetes?
Chromium may lower blood sugar, which is helpful for blood sugar management in type 2 diabetes—but it can also add to the effect of your diabetes medications and raise your risk of low blood sugar. You must talk with your doctor before taking this product if you use insulin or diabetes drugs.
Can I take this with my thyroid medication?
Chromium may bind to levothyroxine and decrease how much your body absorbs, and L-carnitine may theoretically interfere with thyroid hormone's effects. Additionally, guggul has thyroid-stimulating properties. You should discuss this with your doctor or pharmacist before combining them.
What are the most common side effects?
The most common side effects from this product would likely come from chromium (gastrointestinal irritation, headaches, insomnia, mood changes) and guggul (belching, bloating, diarrhea, nausea, skin rashes). L-carnitine can cause stomach upset and, at higher doses, a fish-like body odor. Black pepper may cause a burning aftertaste.
Is this safe during pregnancy?
Guggul is rated Likely Unsafe in pregnancy and should be avoided. Chromium and black pepper have conflicting or insufficient safety data in pregnancy. L-carnitine has no established pregnancy rating in our data. Don't take this product while pregnant without talking to your doctor first.
Can I take this while breastfeeding?
Chromium is Likely Safe and black pepper is Likely Safe while breastfeeding. L-carnitine is Possibly Safe but not well studied. Guggul should be avoided—there isn't enough safety information. Talk with your doctor or pharmacist before starting if you're nursing.
Does black pepper in this product help it work better?
Black pepper extract (piperine) is included because it may increase the absorption and blood levels of other compounds. However, the evidence that this product itself is effective for its intended purpose is not established in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lipo6 Stim-Free is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lipo6 Stim-Free label
Go deeper

The Full Monographs Behind Lipo6 Stim-Free’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph → Herb & supplement monograph

L-carnitine

Interacts with 19 drugs

L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most clearly useful for people with a true ca...

Read the full L-carnitine monograph → Herb & supplement monograph

Guggul

Interacts with 757 drugs

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are mixed and often low-quality, and it can...

Read the full Guggul monograph →
Sources

Sources & How We Checked

Lipo6 Stim-Free's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 144 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chromium 53 references
  1. Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother 1998;32:428-31. PubMed
  2. Urberg M, Zemel MB. Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans. Metabolism 1987;36:896-9. PubMed
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  10. Bianchi A, Cantu P, Firenzuoli F, et al. Rhabdomyolysis caused by Commiphora mukul, a natural lipid-lowering agent. Ann Pharmacother 2004;38:1222-5.
  11. Gelfand JM, Crawford GH, Brod BA, Szazpary PO. Adverse cutaneous reactions to guggulipid. J Am Acad Dermatol 2005;52:533-4 PubMed
  12. Nohr, L. A., Rasmussen, L. B., and Straand, J. Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study. Complement Ther.Med. 2009;17(1):16-22. PubMed
  13. Gelfand, J. M., Crawford, G. H., Brod, B. A., and Szazpary, P. O. Adverse cutaneous reactions to guggulipid. J.Am.Acad.Dermatol. 2005;52(3 Pt 1):533-534. PubMed
  14. Kolonte, A., Guillot, B., and Raison-Peyron, N. Allergic contact dermatitis to guggul extract contained in an anticellulite gel-cream. Contact Dermatitis 2006;54(4):226-227. PubMed
  15. Salavert, M., Amarger, S., Le Bouedec, M. C., Roger, H., Souteyrand, P., and D'incan, M. Allergic contact dermatitis to guggul in a slimming cream. Contact Dermatitis 2007;56(5):286-287. PubMed
  16. Malhotra SC, Ahuja MM. Comparative hypolipidaemic effectiveness of gum guggulu (Commiphora mukul) fraction 'A', ethyl-P-chlorophenoxyisobutyrate and Ciba-13437-Su. Indian J Med Res 1971;59:1621-1632.
  17. Gaur SP, Garg RK, Kar AM, et al. Gugulipid, a new hypolipidaemic agent, in patients of acute ischaemic stroke: effect on clinical outcome, platelet function and serum lipids. Asia Pacif J Pharm 1997;12:65-69.
  18. Baldwa VS, Sharma RC, Ranka PC, et al. Effect of Commiphora mukul (guggul) on fibrinolytic activity and platelet aggregation in coronary artery disease. Rajas Med J 1980;19:84-86.
  19. Donato F, Raffetti E, Toninelli G, Festa A, Scarcella C, Castellano M; TRIGU Project Working Group. Guggulu and Triphala for the Treatment of Hypercholesterolaemia: A Placebo-Controlled, Double-Blind, Randomised Trial. Complement Med Res 2021;28(3):216-22 PubMed
  20. Mehdi Z, Fatemeh P, Roja R, et al. Efficacy and safety of Hemoheal cream in patients with hemorrhoids: a randomized double-blind placebo controlled clinical trial. J Tradit Chin Med 2021;41(2):301-307.
  21. Asad M, Asdaq SMB, Mohzari Y, et al. Pharmacokinetic and pharmacodynamic interaction of Rosuvastatin calcium with guggulipid extract in rats. Saudi J Biol Sci 2021;28(6):3490-3496. PubMed

See these in context on the Guggul monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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