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Dietary supplement

Litchi Ingredients & Drug Interactions

by Hawaii Pharm

Litchi label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Litchi against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Litchi is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for general nutrition and antioxidant support, digestive complaints (traditional use), cough and sore throat (traditional use).Based on those ingredients, 207 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Litchi Seed Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Litchi by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Litchi by Hawaii Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Litchi by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: litchi seed extract in a concentrated liquid form. It also includes alcohol, water, and glycerin as inactive ingredients to preserve and deliver the extract.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Lychee product and its label doesn't state a use — see Lychee's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We don't have effectiveness data on file for litchi seed extract. The facts we hold don't include information on what this ingredient is proven to do for people.

The evidence, ingredient by ingredient Lychee

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lychee fruit eaten in normal food amounts is generally well tolerated, but concentrated extracts like this one haven't been well studied for safety. There's a concern with unripe fruit specifically—it carries risks we don't have full details on.

Orally, lychee can trigger allergic reactions ranging from hives and skin rashes to swelling of the tongue and lips, shortness of breath, and in rare cases anaphylaxis. There's also a documented link between lychee consumption and a serious condition called hypoglycemic encephalopathy in children, especially those who were malnourished—the association is supported by the presence of a specific compound (hypoglycin A) in affected children.

There isn't enough safety data on file for this extract during pregnancy or breastfeeding—talk with your doctor or pharmacist about whether it's right for you if you're pregnant or nursing.

Side effects, ingredient by ingredient Lychee

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lychee.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 207 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check your medications with the tool on this page if you take antidiabetes drugs (to watch for low blood sugar) or immunosuppressants (which this extract may weaken). These are the main medication interactions documented for this ingredient.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a concentrated herbal extract with very limited safety data—it's quite different from eating lychee fruit as food. If you take antidiabetes or immunosuppressant medications, or have a history of allergic reactions to lychee, check with your doctor or pharmacist before starting.

Anyone considering this product should discuss it with their own healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Litchi, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 840253633378
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 301406
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Litchi by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
840253633378
IngredientAmount% DV
Litchi Seed Extract, Dry983 mg--

Other ingredients: Alcohol, Water, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Hawaii Pharm Herbal Extract Highest quality since 2008

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.

Precautions

Warning: We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.

Keep out of the reach of children!

Storage

Store in a cool dry place.

Seals/Symbols

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

Organic Alcohol Based USA Made in United States of America

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Scan this QR-code to get 15% discount on your next purchase. Limited time deal.

Formula

Litchi chinensis

Organic Alcohol Based

Formulation

Only natural ingredients Purity is laboratory tested and verified

All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives

Not tested on animals

Organic Alcohol Based

Made in USA, Hawaii

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Litchi by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Litchi label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Litchi by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Litchi Seed Extract, Dry

Interacts with
207 drugs
983 mg per serving

Lychee is a sweet tropical fruit that is nutritious and a source of vitamin C and antioxidant plant compounds. While the fruit is a healthy food for m...

Litchi Seed Extract, Dry monograph & interactions

Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Litchi by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Litchi?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
207Drugs
86 Moderate 121 Minor

Ingredients driving the most interactions

Litchi Seed Extract, Dry 207

Individual Drug Interactions

The ingredients in Litchi interact with 207 drugs. Click any drug to see the details.

1 of the 1 ingredient in Litchi interact with drugs. Each result below shows which ingredient is responsible. Litchi Seed Extract, Dry

Each ingredient & the kinds of drugs it affects

For each ingredient in Litchi with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Litchi Seed Extract, Dry2 drug types · 207 drugs

Antidiabetes Drugs

Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lychee seed reduces fasting and 2-hour postprandial blood glucose and improves impaired glucose tolerance in rats with type 2 diabetes. Additionally, retrospective research in children has found an association between lychee consumption and increased odds of acute hypoglycemic encephalopathy.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, lychee might reduce the effectiveness of immunosuppressant drugs.
In vitro, flavonoids extracted from lychee show immunostimulant effects. So far, this effect has not been reported in humans.

Likelihood Possible Evidence D
Litchi Seed Extract, Dry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Litchi, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
Street Address
510 Sumner St. Ste. 613
City
Honolulu
State
HI
ZipCode
96817
Phone Number
888-854-2924
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Litchi by Hawaii Pharm: Common Questions

Does Litchi by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Litchi has a known interaction with 207 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Litchi contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have diabetes or take blood sugar medication?
Animal studies suggest lychee seed extract can lower blood glucose, so it may increase your risk of low blood sugar (hypoglycemia) when combined with antidiabetes drugs. Talk with your doctor or pharmacist before starting—they can help you decide if it's safe for you and monitor your blood sugar if you do take it.
Can I take this if I take an immunosuppressant?
Lychee seed extract may theoretically reduce how well immunosuppressant drugs work, based on lab studies showing it stimulates immune activity. Check with your doctor or pharmacist before combining them, so they can monitor whether your medication stays effective.
Is this safe for someone with a lychee allergy?
No. Lychee can cause allergic reactions ranging from hives and skin rashes to swelling of the tongue and lips, shortness of breath, and rarely anaphylaxis. Avoid this product if you've had any allergic reaction to lychee fruit.
Is this safe during pregnancy or breastfeeding?
There isn't enough safety data on file for this extract during pregnancy or breastfeeding. Talk with your doctor or pharmacist—they can give you personalized advice based on your situation.
Why is this a liquid with alcohol in it instead of a capsule?
This is a concentrated liquid extract with alcohol, water, and glycerin to preserve and deliver the active ingredient. The alcohol helps extract and stabilize the plant compounds—your doctor or pharmacist can advise if the alcohol content is a concern for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Litchi is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Litchi label
Go deeper

The Full Monographs Behind Litchi’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lychee

Interacts with 207 drugs

Lychee is a sweet tropical fruit that is nutritious and a source of vitamin C and antioxidant plant compounds. While the fruit is a healthy food for most people, supplement-strength extracts...

Read the full Lychee monograph →
Sources

Sources & How We Checked

Litchi's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lychee 12 references
  1. Niggemann B, Reibel S, Hipler C, Wahn U. Anaphylactic reaction to lychee in a 12-year-old girl: cross-reactivity to latex? Pediatr Allergy Immunol 2002;13(1):64-7. PubMed
  2. Giannattasio M, Serafini M, Guarrera P, et al. Contact urticaria from litchi fruit (Litchi chinensis Sonn.). Contact Dermatitis 1995;33(1):67.
  3. Raap U, Schaefer T, Kapp A, Wedi B. Exotic food allergy: anaphylactic reaction to lychee. J Investig Allergol Clin Immunol 2007;17(3):199-201.
  4. Guo JW. Effects of Litchi seed on enhancing insulin sensitivity in type 2 diabetic-insulin resistant rats. Chinese J New Drugs 2003;12:526-9.
  5. Zhao M, Yang B, Wang J, et al. Immunomodulatory and anticancer activities of flavonoids extracted from litchi (Litchi chinensis Sonn) pericarp. Int Immunopharmacol 2007;7(2):162-6. PubMed
  6. John TJ, Das M. Outbreaks of Hypoglycemic Encephalopathy in Muzaffarpur, India: Are These Caused by Toxins in Litchi Fruit?: The Point. Indian Pediatr. 2016;53(5):399.
  7. John TJ. Exploration of Association between Litchi Consumption and Seasonal Acute Encephalopathy Syndrome: Pediatric Infectious Disease Specialist's Viewpoint. Indian Pediatr. 2017;54(4):323-325. DOI
  8. Mathew JL. Exploration of Association between Litchi Consumption and Seasonal Acute Encephalopathy Syndrome: Evidence-based Medicine Viewpoint. Indian Pediatr. 2017;54(4):319-323. PubMed
  9. Shrivastava A, Kumar A, Thomas JD, et al. Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study. Lancet Glob Health. 2017;5(4):e458-e466.
  10. Spencer PS, Palmer VS, Mazumder R. Probable toxic cause for suspected lychee-linked viral encephalitis. Emerg Infect Dis. 2015;21(5):904-5. DOI
  11. Valsecchi R, Leghissa P. Contact allergy due to lychee. Acta Derm Venereol. 2013;93(1):90-1. PubMed
  12. Vashishtha VM. Outbreaks of Hypoglycemic Encephalopathy in Muzaffarpur, India: Are These Caused by Toxins in Litchi Fruit?: The Counterpoint. Indian Pediatr. 2016 May 8;53(5):399-402.

See these in context on the Lychee monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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