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Dietary supplement

Lithium Orotate Ingredients & Drug Interactions

by Vitamin Research Products

Lithium Orotate label
See full label image
Capsule Category: Mineral
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lithium Orotate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Lithium Orotate is a dietary supplement by Vitamin Research Products with 1 active ingredient. Its ingredients are commonly taken for mood support, bipolar disorder (prescription), healthy mental function.Based on those ingredients, 515 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are LIthium Orotate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lithium Orotate by Vitamin Research Products

Ask about any prescription or over-the-counter medication and we check it for interactions with Lithium Orotate by Vitamin Research Products — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lithium Orotate by Vitamin Research Products

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “LIthium Orotate” is listed as a grouped ingredient — the label gives one combined amount (130 mg) without saying how much of each component you get.

This product contains one active ingredient: elemental lithium in the form of lithium orotate. The capsule itself includes two inactive ingredients — hydroxypropylmethylcellulose and microcrystalline cellulose — which help form and fill the capsule.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Lithium product and its label doesn't state a use — see Lithium's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold shows insufficient reliable data to rate lithium orotate for any condition — including alcohol use disorder, Alzheimer disease, ALS, and anorexia nervosa. That doesn't mean it doesn't work; it means studies haven't yet established what it does or doesn't do for these uses.

The evidence, ingredient by ingredient Lithium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Prescription lithium is generally well tolerated at therapeutic doses, but it has a narrow safety margin and requires blood monitoring to prevent toxicity. It's unclear how lower supplement doses alter the risk.

Common side effects with prescription forms include tremor, fatigue, muscle weakness, weight gain, increased thirst and urination, digestive upset, swelling, skin problems, and dizziness. For pregnancy, the safety data advises against lithium — it can cross the placenta and has been linked to birth defects.

For breastfeeding, the data rates it likely unsafe because lithium passes into breast milk and may affect your infant. Unless your doctor directs and monitors you throughout, avoid it during pregnancy or while nursing.

Abruptly stopping lithium can trigger a return of bipolar symptoms, so if you're taking prescription lithium, it should be tapered gradually over at least two weeks — never stop suddenly.

Side effects, ingredient by ingredient Lithium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lithium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 515 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting this product, check with your doctor or pharmacist if you take serotonergic drugs (antidepressants like SSRIs), diuretics (water pills), NSAIDs like ibuprofen, antipsychotics, muscle relaxants, ACE inhibitors or calcium channel blockers for blood pressure, or anticonvulsants. The interactions with serotonergic drugs and diuretics are the most serious.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Lithium orotate is marketed as a mood and brain supplement, but we don't have reliable evidence it works for that. More importantly, it interacts with many common medications — especially antidepressants, water pills, and blood pressure drugs — in ways that could be serious.

Because lithium requires blood monitoring in prescription form and supplements aren't well studied, talk with your doctor or pharmacist before taking this, especially if you're on any regular medications or have a history of mood or thyroid issues.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lithium Orotate, straight from the product label.

Brand Vitamin Research Products
Barcode (UPC) 892727000650
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2014
DSLD ID 34048
Product type Mineral
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lithium Orotate by Vitamin Research Products, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
892727000650
IngredientAmount% DV
elemental Lithium4.8 mg--
LIthium Orotate130 mg--

Other ingredients: Hydroxypropylmethylcellulose, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Keep container tightly closed in a cool, dry and dark place.

Precautions

Keep out of reach of children.

Caution: Individuals with renal or cardiovascular disease or who are taking diuretics or ACE inhibitors, should consult their healthcare professionals before use. Lithium should not be used by pregnant or nursing women.

General Statements

This product is manufactured in accordance with current Good Manufacturing Practices (GMP).

9090

Since 1979

TESTED FOR QUALITY & PURITY

Seals/Symbols

LABORATORY TESTED QUALITY & PURITY

VRP

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule twice per day with meals or as directed by your healthcare professional.

FDA Statement of Identity

Dietary Supplement

General

300-VRP7241-J

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lithium Orotate by Vitamin Research Products label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lithium Orotate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lithium Orotate by Vitamin Research Products

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

LIthium Orotate

Interacts with
515 drugs
130 mg per serving

Lithium is a naturally occurring metal that, in prescription form (lithium carbonate or citrate), is an FDA-approved, well-proven treatment for bipola...

LIthium Orotate monograph & interactions

Other (inactive) ingredients: Hydroxypropylmethylcellulose, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lithium Orotate by Vitamin Research Products Drug Interactions

Want to check YOUR meds against Lithium Orotate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
515Drugs
259 Major 256 Moderate

Ingredients driving the most interactions

LIthium Orotate 515

Individual Drug Interactions

The ingredients in Lithium Orotate interact with 515 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lithium Orotate interact with drugs. Each result below shows which ingredient is responsible. LIthium Orotate

Each ingredient & the kinds of drugs it affects

For each ingredient in Lithium Orotate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

LIthium Orotate11 drug types · 515 drugs

Diuretic Drugs

Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Thiazide diuretics and loop diuretics might reduce lithium excretion, particularly in sodium-restricted patients. If lithium is clinically indicated and other treatment options are unavailable or inadequate in patients using diuretics, lithium treatment can be initiated with extreme caution. Serum lithium should be measured frequently and the doses used should be the lowest dose ordinarily tolerated. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
In a case report, a 67-year-old female with depression and bipolar disorder using lithium in combination with selective serotonin reuptake inhibitors (SSRIs) and other medications developed serotonin syndrome with symptoms of deep tendon hyperreflexia, muscle rigidity, tremor, and hyperthermia. However, agitation, one classical symptom of serotonin syndrome, was lacking. This was thought to be due to masking by lithium toxicity. Lithium can increase serotonin levels, thus, combining serotonergic drugs with lithium might increase the risk of serotonergic side effects including serotonin syndrome and cerebral vasoconstrictive disorders. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Ace Inhibitors (Aceis)

Theoretically, taking lithium supplements with ACEIs might increase levels and adverse effects of lithium.
Concomitant administration of ACEIs with lithium may increase lithium concentrations. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Possible Evidence D
Anticonvulsants

Theoretically, taking lithium supplements with anticonvulsants might increase the risk of neurotoxicity.
Drugs such as carbamazepine and phenytoin seem to increase the risk of neurotoxicity. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.

Likelihood Possible Evidence D
Antipsychotic Drugs

Theoretically, taking lithium supplements with antipsychotic drugs might increase the risk of encephalopathic syndrome.
Encephalopathic syndrome has been reported in multiple patients taking prescription lithium and antipsychotics concomitantly. Symptoms have included weakness and lethargy, fever, confusion, and extrapyramidal symptoms. In some patients, resulting brain damage was irreversible. Although there is no established causal relationship between these symptoms and the combination of lithium and antipsychotic medications, there is a theoretical relationship. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.

Likelihood Possible Evidence D
Calcium Channel Blockers

Theoretically, taking lithium supplements with calcium channel blockers might reduce lithium levels and might also increase the risk of certain adverse effects.
Calcium channel blockers might reduce lithium concentrations. Monitor lithium levels with concurrent use. Calcium channel blockers might also increase the adverse neurological and gastrointestinal adverse effects of lithium. It is unclear if these interactions would occur with the smaller doses found in lithium supplements.

Likelihood Possible Evidence D
Methyldopa (Aldomet)

Theoretically, taking lithium supplements with methyldopa might increase the risk of lithium toxicity.
Concurrent use of methyldopa with lithium increases the risk of lithium toxicity. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Methylxanthines

Theoretically, taking lithium supplements with methylxanthines might decrease lithium levels.
Xanthines such as aminophylline, caffeine, and theophylline (Theo-Dur, Theo-24, others) might increase the clearance of lithium. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

Theoretically, taking lithium supplements with NSAIDs might increase lithium levels and adverse effects.
NSAIDs can decrease the renal clearance of lithium and increase lithium levels. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Phenothiazines

Theoretically, taking lithium supplements with phenothiazines might decrease the levels and clinical effects of phenothiazines.
Concomitant use of lithium with phenothiazines might reduce lithium concentrations. Lithium might also reduce phenothiazine concentrations, making the pharmacokinetic effect unpredictable. It is unclear if these interactions would occur with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Skeletal Muscle Relaxants

Theoretically, taking lithium supplements with skeletal muscle relaxants might prolong neuromuscular blockade.
Lithium might prolong neuromuscular blockade. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
LIthium Orotate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lithium Orotate, from the product label.

Vitamin Research Products

See all Vitamin Research Products products
Name
VRP Brand, LLC
Street Address
4610 Arrowhead Dr.
City
Carson City
State
NV
ZipCode
89706
Phone Number
1-800-877-2447
Web Address
www.vrp.com
Pharmacist Counseling Corner

Lithium Orotate by Vitamin Research Products: Common Questions

Does Lithium Orotate by Vitamin Research Products interact with any medications?
Yes. Based on its ingredients, Lithium Orotate has a known interaction with 515 medications, including 259 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lithium Orotate contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on an antidepressant?
Not without checking first. Lithium with SSRIs or other serotonergic antidepressants carries a Major interaction risk — there's a theoretical concern about serotonin syndrome, and a case report documented this happening. Talk to your doctor or pharmacist before combining them.
What are the common side effects?
With prescription lithium, the most common include a fine tremor, fatigue, muscle weakness, weight gain, increased thirst and urination, digestive upset, swelling, and skin problems. We don't know how often these occur at the lower doses in supplements, since supplements aren't well studied that way.
Is it safe during pregnancy or breastfeeding?
No. Lithium can cross the placenta and has been linked to birth defects, so the data advises against it in pregnancy unless your doctor directs and monitors you. It's also rated likely unsafe while breastfeeding because it passes into milk and may affect your infant. Talk to your doctor or pharmacist about what's right for your situation.
Does this actually work for mood or brain health?
We don't have reliable evidence establishing that lithium orotate works for any condition — including mood support, Alzheimer disease, or others it's marketed for. That doesn't mean it can't help, just that the research hasn't shown it yet.
Why does lithium need blood monitoring?
Lithium has a narrow safety margin — the dose that's helpful is very close to a dose that causes toxicity. Prescription forms require blood tests to keep levels in the safe range. Supplements aren't well studied, so it's unclear whether they'd need the same oversight.
What happens if I stop taking it suddenly?
Abruptly stopping lithium — especially if you're on prescription lithium — can trigger a return of bipolar or mood symptoms. If you're taking prescription lithium, it should be tapered gradually over at least two weeks, never stopped cold. Talk with your doctor before making any changes.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lithium Orotate label
Go deeper

The Full Monographs Behind Lithium Orotate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lithium

Interacts with 515 drugs

Lithium is a naturally occurring metal that, in prescription form (lithium carbonate or citrate), is an FDA-approved, well-proven treatment for bipolar disorder. Low-dose supplement forms li...

Read the full Lithium monograph →
Sources

Sources & How We Checked

Lithium Orotate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lithium 26 references
  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  3. Perlis RH, Sachs GS, Lafer B, et al. Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data. Am J Psychiatry 2002;159:1155-9.. PubMed
  4. Pinelli JM, Symington AJ, Cunningham KA, Paes BA. Case report and review of the perinatal implications of maternal lithium use. Am J Obstet Gynecol 2002;187:245-9.. PubMed
  5. Sawagashira R, Sasagawa Y, Matsukura M, Takamaru Y. Case of myxedema coma induced by lithium carbonate in a patient with schizophrenia. Psychiatry Clin Neurosci. 2018;72(2):131. PubMed
  6. Foulser P, Abbasi Y, Mathilakath A, Nilforooshan R. Do not treat the numbers: lithium toxicity. BMJ Case Rep. 2017;2017. pii: bcr-2017-220079. PubMed
  7. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/017812s028,018421s027lbl.pdf. Accessed Nov. 21, 2018
  8. Fornaro M, Maritan E, Ferranti R, et al. Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes. Am J Psychiatry. 2020;177(1):76-92. DOI
  9. Rauf A, Gul S, Nasir M, Arif U, Oyenuga M. A Rare Case of Lithium-induced Partial Nephrogenic Diabetes Insipidus. Cureus. 2020;12(4):e7877. PubMed
  10. Hanna RM, Hasnain H, Sangalang MD, et al. Three Patients with Lithium-Associated Hyperparathyroidism: Literature Review Regarding Medical and Surgical Management. Case Rep Nephrol Dial. 2019;9(2):108-118. PubMed
  11. Rana P, Alba Aponte P, Babar G. An Adolescent Female with Bipolar Disorder Presenting with Lithium-Induced Hyperthyroidism. Case Rep Endocrinol. 2020;2020:1283464. PubMed
  12. Nwabufor PC, Omoniyi ON, Oyibo SO. A Case of Lithium-Associated Hypocalciuric Hypercalcemia. Cureus. 2020;12(9):e10606. PubMed
  13. Landa E, Wagner S, Makkar A, Liu A, Jung D. An atypical presentation of serotonin syndrome. Cureus. 2021;13(2):e13377. PubMed
  14. Benjelloun R, Motaib I, Otheman Y. Lithium-associated hypercalcemia presenting with neuropsychiatric manifestations in a patient with bipolar disorder. Case Rep Psychiatry. 2020;2020:6630838. PubMed
  15. Nombora O, Samico A, Venâncio Â. Lithium-Induced Dysgeusia and Hyposmia: A Case Report and a Literature Review. Clin Neuropharmacol 2023;46(1):31-33. PubMed
  16. Zhang P, Gandhi H, Kassis N. Lithium-induced nephropathy; One medication with multiple side effects: a case report. BMC Nephrol 2022;23(1):309. PubMed
  17. Kawada T. Lithium use and the risk of chronic kidney disease. Basic Clin Pharmacol Toxicol 2023;132(4):295-296. PubMed
  18. Yang Q, Cheng X, Su Z, Sun L, Li M. Electroconvulsive therapy combined with lithium developed reversible pure anomic aphasia: a case report. BMC Psychiatry 2022;22(1):663. PubMed
  19. Itoh M, Fukuya Y, Endo C, et al. Lithium carbonate-induced Stevens-Johnson syndrome: the first case report. Int J Dermatol 2023;62(3):e165-e167. PubMed
  20. Ono R, Nishiguchi S, Kitagawa I. Lithium intoxication-associated mild encephalitis/encephalopathy with a reversible splenial lesion: A case report. Bipolar Disord 2022;24(5):551-552. PubMed
  21. Li JJ, Tan S, Kawashita T, Tagle CA, Farmand F. Central Diabetes Insipidus in the Background of Lithium Use: Consider Central Causes Despite Nephrogenic as the Most Common. Am J Case Rep 2023;24:e939034. PubMed
  22. Yamada Y, Fujiwara M, Tsujino S, et al. Late-Onset Neutropenia With Clozapine Associated With Lithium Carbonate-Related Hyperthyroidism: A Case Report. J Clin Psychopharmacol 2023;43(1):76-77. PubMed
  23. Bocchetta A, Ambrosiani L, Sanna F, et al. Renal function at follow-up in a cohort of patients who had shown reduced glomerular filtration rate during long-term treatment with lithium. J Nephrol 2023;36(4):1079-1081. PubMed
  24. Sarangi A, Javed S, Paul T, Amor W. Lithium-Induced Sinoatrial Node Dysfunction. Cureus 2021;13(7):e16778. PubMed
  25. Aydin D, Tural Hesapcioglu S, Ceylan MF. Oropharyngeal Dysphagia as a Clinical Presentation of Lithium Intoxication: A Case Report. J Am Acad Child Adolesc Psychiatry 2021;60(12):1443-1445. PubMed
  26. Sogawa R, Tobita S, Monji A, et al. Deep Vein Thrombosis after Lithium Toxicity: A Report of Two Cases and Literature Review. Case Rep Psychiatry 2021;2021:9934037. PubMed

See these in context on the Lithium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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