L-Tryptophan Ingredients & Drug Interactions
What is this page for?
First and foremost: checking L-Tryptophan against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Tryptophan is a dietary supplement by Vitamin Research Products with 1 active ingredient. Its ingredients are commonly taken for sleep problems, low mood and depression, anxiety.Based on those ingredients, 394 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are L-Tryptophan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Tryptophan by Vitamin Research Products
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Tryptophan by Vitamin Research Products — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Tryptophan by Vitamin Research Products
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-tryptophan, an amino acid that your body uses to make serotonin, a neurotransmitter tied to mood and sleep. The capsule also holds hydroxypropylmethylcellulose, an inactive binder.
Does it work?
Not established
The evidence for L-tryptophan is mixed. For depression, it's rated possibly ineffective.
For anxiety, athletic performance, teeth grinding (bruxism), and premenstrual dysphoric disorder (PMDD), we don't have enough reliable evidence to say whether it works.
How safe is it?
Well-documented data
L-tryptophan is generally well tolerated when taken by mouth, though common side effects include belching, diarrhea, drowsiness, dry mouth, flatulence, headache, heartburn, lightheadedness, nausea, stomach pain, blurred vision, and vomiting. There is a history of contamination: in 1989, over 1,500 cases of eosinophilia-myalgia syndrome (EMS), a serious neurological disorder, were tied to L-tryptophan — but about 95% of those cases traced back to a single contaminated manufacturer in Japan, and the product was recalled and restricted by the FDA in 1990.
During pregnancy, safety data is conflicting — some evidence suggests it may be unsafe, so talk with your doctor or pharmacist about whether it's right for you. While breastfeeding, there isn't enough safety data, so it's best avoided unless you've cleared it with your healthcare provider.
Meds to double-check
Major interaction found
Before taking L-tryptophan, double-check with your doctor or pharmacist if you're on any CNS depressants (including alcohol, sedatives, and opioid painkillers) or serotonergic drugs such as antidepressants, migraine medications, or other mood-related prescriptions. These are the two main interaction risks.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
L-tryptophan may appeal to you if you're exploring options for mood or sleep support, but it's not a proven fix for depression and the evidence for other uses is sparse. If you take any sedatives, antidepressants, or migraine medications, you'll need to check with your own doctor or pharmacist before starting it — the interaction risks are real.
Pregnancy and breastfeeding also require a conversation with your provider.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Tryptophan, straight from the product label.
| Brand | Vitamin Research Products |
|---|---|
| Barcode (UPC) | 892727000124 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 25, 2014 |
| DSLD ID | 34051 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Tryptophan by Vitamin Research Products, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Tryptophan | 2 Gram(s) | -- |
Other ingredients: Hydroxypropylmethylcellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: Take 2-4 capsules one hour before bedtime on an empty stomach.
General Statements
Description: The amino acid L-Tryptophan helps boost levels of serotonin, a mood-enhancing neurotransmitter involved in promoting a sense of well being, calm, personal security, relaxation, confidence, concentration and appetite control.
This product is manufactured in a NSF GMP registered facility.
Since 1979
TESTED FOR QUALITY & PURITY
Code Number: 8901
Precautions
Caution: If you are under a physician's care or are taking medication, or if you are pregnant or nursing, consult your healthcare professional before using this product.
Keep out of reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Seals/Symbols
LABORATORY TESTED QUALITY & PURITY
VRP
General
300-VRP8901-F
FDA Statement of Identity
Dietary Supplement
Storage
Keep container tightly closed in a cool, dry and dark place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Tryptophan by Vitamin Research Products label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Tryptophan by Vitamin Research Products
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container23 Amounts shown are per serving.
L-Tryptophan
Interacts with394 drugs
L-tryptophan is an essential amino acid the body uses to make serotonin and melatonin, and people take it to support sleep and mood. The evidence for...
L-Tryptophan monograph & interactionsOther (inactive) ingredients: Hydroxypropylmethylcellulose. These complete the product’s ingredient list but are not active constituents.
L-Tryptophan by Vitamin Research Products Drug Interactions
HelloPharmacist Interaction Report
L-Tryptophan by Vitamin Research Products interacts with two major drug categories.
The most serious concern is with CNS depressants (sedatives, sleeping pills, alcohol, opioids) — combining L-tryptophan with these can add up to dangerous levels of drowsiness and sedation, since L-tryptophan itself causes fatigue and drowsiness.
Read the full breakdown — every affected drug type, severity by severity
The second concern is with serotonergic drugs (antidepressants like SSRIs, SNRIs, tricyclics; migraine medications; and others that work through serotonin). L-tryptophan is a building block for serotonin in your body, so pairing it with these medications could boost serotonergic effects beyond what's intended and raise the risk of serotonin syndrome — a potentially serious condition marked by agitation, confusion, muscle rigidity, and high fever.
Altogether, these interactions span 394 individual medications. Before you start L-tryptophan, check your exact prescriptions and over-the-counter medications with the tool on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Tryptophan?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Tryptophan interact with 394 drugs. Click any drug to see the details.
1 of the 1 ingredient in L-Tryptophan interact with drugs. Each result below shows which ingredient is responsible. L-Tryptophan
AcepromazineAtravet
How Acepromazine interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acepromazine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanSerotonergic Drugs, Cns Depressants Major
Interaction Summary
Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.
Read the full L-tryptophan + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanSerotonergic Drugs, Cns Depressants Major
Interaction Summary
Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.
Read the full L-tryptophan + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Dichlorophenazone, Isometheptane interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Hydrocodone interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants, Serotonergic Drugs Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Meperidine interactionAcetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR
How Acetaminophen, Oxycodone interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Oxycodone interactionAcetaminophen, PentazocineTalacen
How Acetaminophen, Pentazocine interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Pentazocine interactionAcetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
How Acetaminophen, Propoxyphene interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Propoxyphene interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetazolamide interactionAlfentanilAlfenta
How Alfentanil interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Alfentanil interactionAlprazolamNiravam, Xanax
How Alprazolam interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Alprazolam interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAminoglutethimideCytadren
How Aminoglutethimide interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Aminoglutethimide interactionAminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with L-Tryptophan — through 1 ingredient. Tap an ingredient for the detail:
L-tryptophanCns Depressants Major
Interaction Summary
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Aminophylline, Amobarbital, Ephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Tryptophan with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Tryptophan
Cns Depressants
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Clinical research shows that L-tryptophan can cause fatigue and drowsiness.
Serotonergic Drugs
Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.
L-tryptophan is a precursor to serotonin. Theoretically, combining serotonergic drugs with L-tryptophan might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Brand information
Manufacturer and brand details for L-Tryptophan, from the product label.
Vitamin Research Products
See all Vitamin Research Products products- Name
- VRP Brand, LLC
- Street Address
- 4610 Arrowhead Dr.
- City
- Carson City
- State
- NV
- ZipCode
- 89706
- Phone Number
- 1-800-877-2447
- Web Address
- www.vrp.com
L-Tryptophan by Vitamin Research Products: Common Questions
Does L-Tryptophan by Vitamin Research Products interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What does L-tryptophan actually do in my body?
Is L-tryptophan safe during pregnancy?
Can I take this while breastfeeding?
I've heard L-tryptophan caused serious illness in the past — is it still safe?
Does L-tryptophan actually help with depression?
What side effects might I notice?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Tryptophan is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Tryptophan’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Tryptophan's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 18 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
L-tryptophan 18 references
- Messiha FS. Fluoxetine: adverse effects and drug-drug interactions. J Toxicol Clin Toxicol 1993;31:603-30. PubMed
- Devoe LD, Castillo RA, Searle NS. Maternal dietary substrates and human fetal biophysical activity. The effects of tryptophan and glucose on fetal breathing movements. Am J Obstet Gynecol 1986;155:135-9. DOI
- Lieberman HR, Corkin S, Spring BJ. The effects of dietary neurotransmitter precursors on human behavior. Am J Clin Nutr 1985;42:366-70. PubMed
- U. S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Nutritional Products, Labeling, and Dietary Supplements. Information Paper on L-Tryptophan and 5-hydroxy-L-tryptophan, February 2001.
- Sullivan EA, Kamb ML, Jones JL, et al. The natural history of eosinophilia-myalgia syndrome in a tryptophan-exposed cohort in South Carolina. Arch Intern Med 1996;156:973-9. DOI
- Philen RM, Hill RH, Flanders WD, et al. Tryptophan contaminants associated with eosinophilia-myalgia syndrome. Am J Epidemiol 1993;138:154-9. PubMed
- Bohme A, Wolter M, Hoelzer D. L-tryptophan-related eosinophilia-myalgia syndrome possibly associated with a chronic B-lymphocytic leukemia. Ann Hematol 1998;77:235-8. PubMed
- Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
- Priori R, Conti F, Luan FL, et al. Chronic fatigue: a peculiar evolution of eosinophilia myalgia syndrome following treatment with L-tryptophan in four Italian adolescents. Eur J Pediatr 1994;153:344-6..
- Klein R, Berg PA. A comparative study on antibodies to nucleoli and 5-hydroxytryptamine in patients with fibromyalgia syndrome and tryptophan-induced eosinophilia-myalgia syndrome. Clin Investig 1994;72:541-9.. PubMed
- Simat TJ, Kleeberg KK, Muller B, Sierts A. Synthesis, formation, and occurrence of contaminants in biotechnologically manufactured L-tryptophan. Adv Exp Med Biol 1999;467:469-80.. PubMed
- Shaw K, Turner J, Del Mar C. Tryptophan and 5-hydroxytryptophan for depression. Cochrane Database Syst Rev 2002;(1):CD003198. PubMed
- Kilbourne EM, Philen RM, Kamb ML, Falk H. Tryptophan produced by Showa Denko and epidemic eosinophilia-myalgia syndrome. J Rheumatol Suppl 1996;46:81-8.
- Horwitz RI, Daniels SR. Bias or biology: evaluating the epidemiologic studies of L-tryptophan and the eosinophilia-myalgia syndrome. J Rheumatol Suppl 1996;46:60-72.
- Shapiro S. Epidemiologic studies of the association of L-tryptophan with the eosinophilia-myalgia syndrome: a critique. J Rheumatol Suppl 1996;46:44-58.
- Mayeno AN, Gleich GJ. The eosinophilia-myalgia syndrome: lessons from Germany. Mayo Clin Proc 1994;69:702-4. PubMed
- Carr L, Ruther E, Berg PA, Lehnert H. Eosinophilia-myalgia syndrome in Germany: an epidemiologic review. Mayo Clin Proc 1994;69:620-5. PubMed
- Ullrich SS, Fitzgerald PCE, Giesbertz P, Steinert RE, Horowitz M, Feinle-Bisset C. Effects of intragastric administration of tryptophan on the blood glucose response to a nutrient drink and energy intake, in lean and obese men. Nutrients 2018;10(4). pii: PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC