Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Lithium Orotate Natural Lemon Lime Flavor Ingredients & Drug Interactions

by KAL

Liquid Category: Mineral
Most serious interaction: Major
The interaction bottom line Most serious interaction: Major

Lithium Orotate Natural Lemon Lime Flavor is a dietary supplement by KAL with 1 active ingredient. Its ingredients are commonly taken for mood support, bipolar disorder (prescription), healthy mental function.Based on those ingredients, 515 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Lithium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Lithium Orotate Natural Lemon Lime Flavor by KAL

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: lithium, supplied as lithium orotate in liquid form. The inactive ingredients are purified water, glycerin, natural lemon and lime flavors, xanthan gum, potassium sorbate, and sodium benzoate.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Lithium product and its label doesn't state a use — see Lithium's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The effectiveness of lithium for the conditions listed in this product—including alcohol use disorder, Alzheimer disease, ALS, and anorexia nervosa—is rated as insufficient evidence in our data. This means the evidence to support its use for these purposes hasn't been reliably established in the studies available to us.

The evidence, ingredient by ingredient Lithium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lithium is generally well tolerated at prescription doses when blood levels are monitored, but supplements containing lithium are not well studied in the same way. Lithium has a narrow safety window—meaning the difference between a helpful dose and a harmful one is small—so blood monitoring is important with prescription forms.

The safety data advises against use during pregnancy, as lithium can cross the placenta and has been linked to birth defects, and against use while breastfeeding, as lithium passes into breast milk and may affect your infant. If you are pregnant, planning to become pregnant, or breastfeeding, do not take this product without direct medical supervision.

Side effects, ingredient by ingredient Lithium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lithium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 515 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you're on any serotonergic drugs (including SSRIs and other antidepressants)—that's a Major severity interaction. Also flag any water pills, NSAIDs, antipsychotics, blood pressure medications (ACE inhibitors or calcium channel blockers), seizure medications, or skeletal muscle relaxants you may be taking.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a supplement that carries real interaction risks, especially with antidepressants, water pills, pain relievers, and heart or blood pressure medications. Because lithium requires careful monitoring and has a narrow safety margin, it's not something to start without talking it over with your own doctor or pharmacist first.

They can help you decide if it's right for you and whether your current medications make it safe.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lithium Orotate Natural Lemon Lime Flavor, straight from the product label.

Brand KAL
Barcode (UPC) 021245768982
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 254601
Product type Mineral
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lithium Orotate Natural Lemon Lime Flavor by KAL, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
60
UPC/BARCODE
021245768982
IngredientAmount% DV
Lithium4 mg--

Other ingredients: purified Water, Glycerin, natural Lemon and Lime flavors, Xanthan Gum, Potassium Sorbate, Sodium Benzoate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

KAL Innovative Quality Since 1932

drop ins Clear quality

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

1 Daily

Directions: Use only as directed. Take 1 mL daily. Simply "DropIn" to your mouth.

Formulation

Fast-acting

Precautions

Warning: Do not use if safety seal is broken or missing.

Keep out of reach of children.

Keep your licensed health care practitioner informed when using this product.

Storage

Store in cool, dark place. Refrigerate after opening. Stated levels valid only while product is unopened and properly stored.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

See for yourself

Lithium Orotate Natural Lemon Lime Flavor by KAL label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Lithium Orotate Natural Lemon Lime Flavor by KAL

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Lithium

Interacts with
515 drugs
4 mg per serving Form: Lithium Orotate

Lithium is a naturally occurring metal that, in prescription form (lithium carbonate or citrate), is an FDA-approved, well-proven treatment for bipola...

Lithium monograph & interactions

Other (inactive) ingredients: Purified Water, Glycerin, Natural Lemon and Lime flavors, Xanthan Gum, Potassium Sorbate, Sodium Benzoate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lithium Orotate Natural Lemon Lime Flavor by KAL Drug Interactions

Want to check YOUR meds against Lithium Orotate Natural Lemon Lime Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
515Drugs
259 Major 256 Moderate

Ingredients driving the most interactions

Lithium 515

Each ingredient & the kinds of drugs it affects

For each ingredient in Lithium Orotate Natural Lemon Lime Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lithium11 drug types · 515 drugs

Diuretic Drugs

Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Thiazide diuretics and loop diuretics might reduce lithium excretion, particularly in sodium-restricted patients. If lithium is clinically indicated and other treatment options are unavailable or inadequate in patients using diuretics, lithium treatment can be initiated with extreme caution. Serum lithium should be measured frequently and the doses used should be the lowest dose ordinarily tolerated. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Serotonergic Drugs

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
In a case report, a 67-year-old female with depression and bipolar disorder using lithium in combination with selective serotonin reuptake inhibitors (SSRIs) and other medications developed serotonin syndrome with symptoms of deep tendon hyperreflexia, muscle rigidity, tremor, and hyperthermia. However, agitation, one classical symptom of serotonin syndrome, was lacking. This was thought to be due to masking by lithium toxicity. Lithium can increase serotonin levels, thus, combining serotonergic drugs with lithium might increase the risk of serotonergic side effects including serotonin syndrome and cerebral vasoconstrictive disorders. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Ace Inhibitors (Aceis)

Theoretically, taking lithium supplements with ACEIs might increase levels and adverse effects of lithium.
Concomitant administration of ACEIs with lithium may increase lithium concentrations. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Possible Evidence D
Anticonvulsants

Theoretically, taking lithium supplements with anticonvulsants might increase the risk of neurotoxicity.
Drugs such as carbamazepine and phenytoin seem to increase the risk of neurotoxicity. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.

Likelihood Possible Evidence D
Antipsychotic Drugs

Theoretically, taking lithium supplements with antipsychotic drugs might increase the risk of encephalopathic syndrome.
Encephalopathic syndrome has been reported in multiple patients taking prescription lithium and antipsychotics concomitantly. Symptoms have included weakness and lethargy, fever, confusion, and extrapyramidal symptoms. In some patients, resulting brain damage was irreversible. Although there is no established causal relationship between these symptoms and the combination of lithium and antipsychotic medications, there is a theoretical relationship. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.

Likelihood Possible Evidence D
Calcium Channel Blockers

Theoretically, taking lithium supplements with calcium channel blockers might reduce lithium levels and might also increase the risk of certain adverse effects.
Calcium channel blockers might reduce lithium concentrations. Monitor lithium levels with concurrent use. Calcium channel blockers might also increase the adverse neurological and gastrointestinal adverse effects of lithium. It is unclear if these interactions would occur with the smaller doses found in lithium supplements.

Likelihood Possible Evidence D
Methyldopa (Aldomet)

Theoretically, taking lithium supplements with methyldopa might increase the risk of lithium toxicity.
Concurrent use of methyldopa with lithium increases the risk of lithium toxicity. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Methylxanthines

Theoretically, taking lithium supplements with methylxanthines might decrease lithium levels.
Xanthines such as aminophylline, caffeine, and theophylline (Theo-Dur, Theo-24, others) might increase the clearance of lithium. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

Theoretically, taking lithium supplements with NSAIDs might increase lithium levels and adverse effects.
NSAIDs can decrease the renal clearance of lithium and increase lithium levels. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Phenothiazines

Theoretically, taking lithium supplements with phenothiazines might decrease the levels and clinical effects of phenothiazines.
Concomitant use of lithium with phenothiazines might reduce lithium concentrations. Lithium might also reduce phenothiazine concentrations, making the pharmacokinetic effect unpredictable. It is unclear if these interactions would occur with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
Skeletal Muscle Relaxants

Theoretically, taking lithium supplements with skeletal muscle relaxants might prolong neuromuscular blockade.
Lithium might prolong neuromuscular blockade. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Lithium Orotate Natural Lemon Lime Flavor, from the product label.

KAL

See all KAL products
Name
KAL
City
Park City
State
UT
ZipCode
84060
Phone Number
800-538-5888
Web Address
www.kalvitamins.com
Pharmacist Counseling Corner

Lithium Orotate Natural Lemon Lime Flavor by KAL: Common Questions

Does Lithium Orotate Natural Lemon Lime Flavor by KAL interact with any medications?
Yes. Based on its ingredients, Lithium Orotate Natural Lemon Lime Flavor has a known interaction with 515 medications, including 259 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lithium Orotate Natural Lemon Lime Flavor contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No—the safety data advises against it. Lithium can cross the placenta and has been linked to birth defects, and it passes into breast milk and may affect your infant. If you are pregnant, planning to become pregnant, or breastfeeding, do not use this product without direct supervision from your doctor.
What are the most common side effects?
With prescription lithium at monitored doses, the most common effects include tremor, fatigue, muscle weakness, weight gain, excessive thirst and urination, swelling, stomach symptoms, dizziness, and skin problems. It's unclear how the lower doses in supplements may change these risks.
Why does lithium interact with so many medications?
Lithium can raise levels of other drugs in your body (through effects on your kidneys and how drugs are cleared), mask or worsen certain drug effects (especially with serotonergic antidepressants), and combine with other medications to increase toxicity risk. That's why monitoring and careful coordination with your healthcare provider is essential.
Does this product actually work for the conditions listed?
The evidence to reliably support lithium for alcohol use disorder, Alzheimer disease, ALS, anorexia nervosa, and asthma hasn't been established in our data. That doesn't mean it never works, but we don't have solid proof from research at this time.
If I'm already on prescription lithium, can I add this supplement?
No—do not add a lithium supplement if you're already on prescription lithium without explicit direction and ongoing monitoring from your doctor. Prescription lithium requires regular blood tests to keep levels safe; adding a supplement could push you into the toxic range.
What's the difference between this supplement and prescription lithium?
Prescription lithium is carefully dosed and requires regular blood monitoring to stay in a safe, effective range. This supplement delivers a lower dose and isn't routinely monitored the same way, so the effects and risks are less well understood. Lithium has a very narrow safety margin, which is why the oversight matters.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lithium Orotate Natural Lemon Lime Flavor is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lithium Orotate Natural Lemon Lime Flavor label
Go deeper

The Full Monographs Behind Lithium Orotate Natural Lemon Lime Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Lithium Orotate Natural Lemon Lime Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lithium 26 references
  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  3. Perlis RH, Sachs GS, Lafer B, et al. Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data. Am J Psychiatry 2002;159:1155-9.. PubMed
  4. Pinelli JM, Symington AJ, Cunningham KA, Paes BA. Case report and review of the perinatal implications of maternal lithium use. Am J Obstet Gynecol 2002;187:245-9.. PubMed
  5. Sawagashira R, Sasagawa Y, Matsukura M, Takamaru Y. Case of myxedema coma induced by lithium carbonate in a patient with schizophrenia. Psychiatry Clin Neurosci. 2018;72(2):131. PubMed
  6. Foulser P, Abbasi Y, Mathilakath A, Nilforooshan R. Do not treat the numbers: lithium toxicity. BMJ Case Rep. 2017;2017. pii: bcr-2017-220079. PubMed
  7. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/017812s028,018421s027lbl.pdf. Accessed Nov. 21, 2018
  8. Fornaro M, Maritan E, Ferranti R, et al. Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes. Am J Psychiatry. 2020;177(1):76-92. DOI
  9. Rauf A, Gul S, Nasir M, Arif U, Oyenuga M. A Rare Case of Lithium-induced Partial Nephrogenic Diabetes Insipidus. Cureus. 2020;12(4):e7877. PubMed
  10. Hanna RM, Hasnain H, Sangalang MD, et al. Three Patients with Lithium-Associated Hyperparathyroidism: Literature Review Regarding Medical and Surgical Management. Case Rep Nephrol Dial. 2019;9(2):108-118. PubMed
  11. Rana P, Alba Aponte P, Babar G. An Adolescent Female with Bipolar Disorder Presenting with Lithium-Induced Hyperthyroidism. Case Rep Endocrinol. 2020;2020:1283464. PubMed
  12. Nwabufor PC, Omoniyi ON, Oyibo SO. A Case of Lithium-Associated Hypocalciuric Hypercalcemia. Cureus. 2020;12(9):e10606. PubMed
  13. Landa E, Wagner S, Makkar A, Liu A, Jung D. An atypical presentation of serotonin syndrome. Cureus. 2021;13(2):e13377. PubMed
  14. Benjelloun R, Motaib I, Otheman Y. Lithium-associated hypercalcemia presenting with neuropsychiatric manifestations in a patient with bipolar disorder. Case Rep Psychiatry. 2020;2020:6630838. PubMed
  15. Nombora O, Samico A, Venâncio Â. Lithium-Induced Dysgeusia and Hyposmia: A Case Report and a Literature Review. Clin Neuropharmacol 2023;46(1):31-33. PubMed
  16. Zhang P, Gandhi H, Kassis N. Lithium-induced nephropathy; One medication with multiple side effects: a case report. BMC Nephrol 2022;23(1):309. PubMed
  17. Kawada T. Lithium use and the risk of chronic kidney disease. Basic Clin Pharmacol Toxicol 2023;132(4):295-296. PubMed
  18. Yang Q, Cheng X, Su Z, Sun L, Li M. Electroconvulsive therapy combined with lithium developed reversible pure anomic aphasia: a case report. BMC Psychiatry 2022;22(1):663. PubMed
  19. Itoh M, Fukuya Y, Endo C, et al. Lithium carbonate-induced Stevens-Johnson syndrome: the first case report. Int J Dermatol 2023;62(3):e165-e167. PubMed
  20. Ono R, Nishiguchi S, Kitagawa I. Lithium intoxication-associated mild encephalitis/encephalopathy with a reversible splenial lesion: A case report. Bipolar Disord 2022;24(5):551-552. PubMed
  21. Li JJ, Tan S, Kawashita T, Tagle CA, Farmand F. Central Diabetes Insipidus in the Background of Lithium Use: Consider Central Causes Despite Nephrogenic as the Most Common. Am J Case Rep 2023;24:e939034. PubMed
  22. Yamada Y, Fujiwara M, Tsujino S, et al. Late-Onset Neutropenia With Clozapine Associated With Lithium Carbonate-Related Hyperthyroidism: A Case Report. J Clin Psychopharmacol 2023;43(1):76-77. PubMed
  23. Bocchetta A, Ambrosiani L, Sanna F, et al. Renal function at follow-up in a cohort of patients who had shown reduced glomerular filtration rate during long-term treatment with lithium. J Nephrol 2023;36(4):1079-1081. PubMed
  24. Sarangi A, Javed S, Paul T, Amor W. Lithium-Induced Sinoatrial Node Dysfunction. Cureus 2021;13(7):e16778. PubMed
  25. Aydin D, Tural Hesapcioglu S, Ceylan MF. Oropharyngeal Dysphagia as a Clinical Presentation of Lithium Intoxication: A Case Report. J Am Acad Child Adolesc Psychiatry 2021;60(12):1443-1445. PubMed
  26. Sogawa R, Tobita S, Monji A, et al. Deep Vein Thrombosis after Lithium Toxicity: A Report of Two Cases and Literature Review. Case Rep Psychiatry 2021;2021:9934037. PubMed

See these in context on the Lithium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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