Liv.52 Ingredients & Drug Interactions
by Himalaya
What is this page for?
First and foremost: checking Liv.52 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Liv.52 is a dietary supplement by Himalaya with 7 active ingredients. Its ingredients are commonly taken for heart health and circulation, digestive problems (constipation, diarrhea), cholesterol support.Based on those ingredients, 934 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Arjuna, Caper Bush, Chicory. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Liv.52 by Himalaya
Ask about any prescription or over-the-counter medication and we check it for interactions with Liv.52 by Himalaya — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Liv.52 by Himalaya
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Liv.52 contains 7 ingredients, including a proprietary herbal blend made up of arjuna, yarrow, caper bush, chicory, black nightshade, tamarisk, and cassia occidentalis linn. The only inactive ingredient listed is vegetable cellulose in the capsule shell.
Does it work?
Insufficient evidence
The evidence for Liv.52's effectiveness is not well established in the data we hold. Arjuna is listed with insufficient reliable evidence for obesity, cholesterol levels, high blood pressure, and angina.
Yarrow, caper bush, chicory, and black nightshade all carry ratings of insufficient reliable evidence for their claimed uses. This means the research either doesn't exist, is too small or low-quality to be conclusive, or shows mixed results.
How safe is it?
Well-documented data
Arjuna is generally well tolerated in the short term, though long-term safety data are limited and can vary depending on the product quality you choose. The safety data advise against arjuna use during pregnancy and breastfeeding.
Yarrow may cause allergic skin reactions, especially when applied topically, and is likely unsafe in pregnancy because it may affect the uterus—avoid it if you're pregnant. Chicory is well tolerated in food amounts but may cause gas, bloating, and allergic reactions in sensitive people; it's possibly unsafe in pregnancy.
Black nightshade carries a likely unsafe rating for pregnancy and breastfeeding because unripe berries and green parts are toxic and safety data are lacking. We hold no pregnancy or breastfeeding data for caper bush, tamarisk, or cassia occidentalis linn.
Meds to double-check
Moderate interaction found
Before taking Liv.52, check with your doctor or pharmacist if you take any blood thinners or antiplatelet drugs, diabetes medications, or drugs processed through liver enzymes CYP2D6, CYP2C9, or CYP3A4 (these include many antidepressants, some heart medications, and certain pain relievers). Also check if you take chlorzoxazone, omeprazole, or lithium.
No interactions are documented for the ingredients we were unable to check.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Liv.52 is not well studied for effectiveness, and its ingredients interact with a significant number of medications, especially those processed by the liver and diabetes drugs. If you take any blood thinners, antidepressants, lithium, diabetes medications, or heartburn or muscle-relaxant drugs, check your exact medications with your doctor or pharmacist before taking this product.
Pregnant people and those breastfeeding should avoid it altogether.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 29, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Liv.52, straight from the product label.
| Brand | Himalaya |
|---|---|
| Barcode (UPC) | 605069105019 |
| Net contents | 90 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 29, 2014 |
| DSLD ID | 40463 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Liv.52 by Himalaya, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Herbal Blend | 375 mg | -- |
| Arjuna | 0 NP | -- |
| Yarrow | 0 NP | -- |
| Caper Bush | 0 NP | -- |
| Chicory | 0 NP | -- |
| Black Nightshade | 0 NP | -- |
| Tamarisk | 0 NP | -- |
| Cassia occidentalis Linn. | 0 NP | -- |
Other ingredients: Vegetable Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Pure Holistic Effective
MFG. LIC. NO. AUS-83 Product of INDIA
for Maintaining Liver Health*
Promotes Detox & Normal Liver Enzyme Levels*
HERBAL HEALTHCARE
Brand IP Statement(s)
Liv.52(R) is formulated to support healthy detoxification and normal liver cell regeneration. Liv.52(R) helps maintain healthy liver enzyme counts within normal levels while promoting protein metabolism and nutrient digestion.*
Suggested/Recommended/Usage/Directions
Recommendation: Take 1 capsule twice per day before meals.
Formulation
NO wheat, corn, soy, yeast, and dairy. NO ingredients of animal origin.
Additive Free - Gluten Free
Storage
Keep out of direct sunlight and away from children.
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Precautions
Keep out of direct sunlight and away from children.
Consult healthcare practitioner if pregnant or nursing.
FDA Disclaimer Statement
THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.
General
HUS-5024567
Seals/Symbols
{Recycle}
HOLISTIC HERBAL FORMULA
FDA Statement of Identity
HERBAL SUPPLEMENT
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Liv.52 by Himalaya label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Liv.52 by Himalaya
These are the 7 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Herbal Blend
- › Arjuna
- › Yarrow
- › Caper Bush
- › Chicory
- › Black Nightshade
- › Tamarisk
- › Cassia occidentalis Linn.
Other (inactive) ingredients: Vegetable Cellulose. These complete the product’s ingredient list but are not active constituents.
Liv.52 by Himalaya Drug Interactions
HelloPharmacist Interaction Report
Liv.52 by Himalaya interacts with medications through its arjuna, yarrow, caper bush, and chicory content.
The most serious concern is arjuna's potential to raise levels of drugs metabolized by the liver enzyme CYP2D6—including many antidepressants, some heart medications, and certain pain relievers—which could increase their effects and side effects.
Read the full breakdown — every affected drug type, severity by severity
Arjuna also inhibits two other major liver enzymes (CYP2C9 and CYP3A4), affecting a broad range of medications including blood thinners, some statins, and certain cancer drugs. Additionally, arjuna may increase bleeding risk when combined with blood thinners or antiplatelet drugs like aspirin.
Arjuna, caper bush, and chicory all may lower blood sugar when taken with diabetes medications, raising the risk of low blood sugar (hypoglycemia).
Arjuna specifically interacts with two individual medications: chlorzoxazone (a muscle relaxer) and omeprazole (a heartburn drug), both at Moderate severity. Yarrow may raise lithium levels in people taking it for bipolar disorder.
We were unable to check tamarisk and cassia occidentalis linn. for interactions. Altogether, these interactions span 935 individual medications.
Use the medication search tool below to check your exact prescriptions before starting Liv.52.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Liv.52?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Liv.52 interact with 934 drugs. Click any drug to see the details.
4 of the 7 ingredients in Liv.52 interact with drugs. Each result below shows which ingredient is responsible. Arjuna Caper Bush Chicory Yarrow
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 2c9 (cyp2c9) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2C9 substrates.
Read the full Arjuna + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Liv.52 — through 3 ingredients. Tap an ingredient for the detail:
ArjunaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Read the full Arjuna + Acarbose interactionChicoryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Chicory + Acarbose interactionCaper BushAntidiabetes Drugs Moderate
Interaction Summary
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Caper Bush + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
Read the full Arjuna + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Arjuna + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Arjuna + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Arjuna + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Arjuna + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Arjuna + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Arjuna + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Liv.52 — through 1 ingredient. Tap an ingredient for the detail:
ArjunaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
Read the full Arjuna + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Liv.52 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Arjuna
Anticoagulant/Antiplatelet Drugs
Theoretically, concomitant use of Terminalia arjuna with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients.
In vitro, Terminalia arjuna bark extract inhibits platelet aggregation, decreases platelet activation, and shows antithrombotic properties.
Antidiabetes Drugs
Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.
Animal and in vitro research shows that Terminalia bellirica and Terminalia chebula fruit and seed extract have hypoglycemic effects.
Chlorzoxazone (Parafon Forte, Paraflex)
Theoretically, use of Terminalia chebula may increase the risk of adverse effects from chlorzoxazone.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of chlorzoxazone increases blood levels of chlorzoxazone and decreases chlorzoxazone clearance. It is speculated that Terminalia chebula reduces the metabolism of chlorzoxazone by inhibiting cytochrome P450 2E1.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2C9 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP2C9 enzymes and reduces CYP2C9 substrate metabolism.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP2D6 enzymes and reduces CYP2D6 substrate metabolism.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP3A4 enzymes and reduces CYP3A4 substrate metabolism.
Omeprazole (Prilosec)
Theoretically, use of Terminalia chebula may increase the risk of adverse effects from omeprazole.
Animal research shows that enteral administration of Terminalia chebula for 15 days prior to administration of omeprazole increases blood levels of omeprazole and decreases omeprazole clearance. It is speculated that Terminalia chebula reduces the metabolism of omeprazole by inhibiting cytochrome P450 2C19.
Caper Bush
Antidiabetes Drugs
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs. However, other research does not support this effect. Until more is known, monitor blood glucose levels closely. Medication dose adjustments may be necessary.
Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.
Chicory
Antidiabetes Drugs
Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research shows that chicory extracts have antidiabetic effects.
Yarrow
Lithium
Theoretically, taking yarrow with lithium might increase the levels and adverse effects of lithium.
Animal research shows that yarrow has diuretic activity. Theoretically, due to these potential diuretic effects, yarrow might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for Liv.52, from the product label.
Liv.52 by Himalaya: Common Questions
Does Liv.52 by Himalaya interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is Liv.52 safe to take while pregnant?
Can I take Liv.52 if I'm breastfeeding?
Will Liv.52 help with my liver health?
Can yarrow in Liv.52 cause an allergic reaction?
Why does Liv.52 interact with so many medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Liv.52’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Terminalia
Interacts with 933 drugsTerminalia is a group of traditional Ayurvedic tree species (most notably Terminalia arjuna) used for heart, digestive, and general wellness purposes. Some small studies suggest possible ben...
Read the full Terminalia monograph → Herb & supplement monographYarrow
Interacts with 1 drugYarrow is a traditional herb long used for wounds, digestive complaints, and colds, but high-quality human studies are very limited, so its benefits are not well proven. It is generally used...
Read the full Yarrow monograph → Herb & supplement monographCapers
Interacts with 86 drugsCapers are the edible pickled flower buds of the Capparis spinosa shrub, used widely as food and in traditional medicine. They contain antioxidant plant compounds, but high-quality human stu...
Read the full Capers monograph → Herb & supplement monographChicory
Interacts with 86 drugsChicory is best known as a caffeine-free coffee substitute and as a source of inulin, a soluble prebiotic fiber that may support digestion and regularity. Strong human evidence for most othe...
Read the full Chicory monograph → Herb & supplement monographBlack Nightshade
Black nightshade is a wild plant whose cooked ripe berries and leaves are eaten as food in some cultures, but unripe berries and green parts can be poisonous. Human evidence for any health b...
Read the full Black Nightshade monograph →Sources & How We Checked
Liv.52's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 34 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Terminalia 9 references
- Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
- Rao, N. K. and Nammi, S. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats. BMC.Complement Altern.Med 2006;6:17. PubMed
- Murali, Y. K., Anand, P., Tandon, V., Singh, R., Chandra, R., and Murthy, P. S. Long-term effects of Terminalia chebula Retz. on hyperglycemia and associated hyperlipidemia, tissue glycogen content and in vitro release of insulin in streptozotocin induced
- Senthilkumar, G. P. and Subramanian, S. Evaluation of antioxidant potential of Terminalia chebula fruits studies in streptozotocin-induced diabetic rats. Pharmaceutical Biology (Netherlands) 2007;45:511-518.
- Malik N, Dhawan V, Bahl A, Kaul D. Inihbitory effects of Terminalia arjuna on platelet activation in vitro in healthy subjects and patients with coronary artery disease. Platelets. 2009;20(3):183-1190.
- Varghese A, Savai J, Pandita N, Gaud RS. In vitro modulatory effects of Terminalia arjuna, arjunic acid, arjunetin, and arjungenin on CYP3A4, CYP2D6, and CYP2C9 enzyme activity in human liver microsomes. Toxicology Reports. 2015(2):806-16. PubMed
- Wu G, Dong Z, Dong J, et al. Effects of mongolian medicine Terminalia chebula Retz. on 6 CYP450 enzymes in rats. Int J Clin Exp Pathol 2020;13(12):3128-3138.
- Das A, Naveen J, Sreerama YN, Gnanesh Kumar BS, Baskaran V. Low-glycemic foods with wheat, barley and herbs (Terminalia chebula, Terminalia bellerica and Emblica officinalis) inhibit a-amylase, a-glucosidase and DPP-IV activity in high fat and low dose st
- Eltimamy M, Elshamarka M, Aboelsaad M, Sayed M, Moawad H. Effects of alcoholic extract of Terminalia Chebula dried fruit on blood biochemical profile in diabetic rats. J Diabetes Metab Disord 2022;21(1):159-170. PubMed
Yarrow 8 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Uter, W., Nohle, M., Randerath, B., and Schwanitz, H. J. Occupational contact urticaria and late-phase bronchial asthma caused by compositae pollen in a florist. Am J Contact Dermat. 2001;12(3):182-184. DOI
- Schempp, C. M., Schopf, E., and Simon, J. C. [Plant-induced toxic and allergic dermatitis (phytodermatitis)]. Hautarzt 2002;53(2):93-97.
- Jovanovic, M., Poljacki, M., Duran, V., Vujanovic, L., Sente, R., and Stojanovic, S. Contact allergy to Compositae plants in patients with atopic dermatitis. Med Pregl. 2004;57(5-6):209-218. PubMed
- Becker LC, Bergfeld WF, Belsito DV, et al. Safety assessment of Achillea millefolium as used in cosmetics. Int J Toxicol. 2016;35(3 suppl):5S-15S.
- Zakeri S, Esmaeilzadeh S, Gorji N, Memariani Z, Moeini R, Bijani A. The effect of Achillea millefolium L. on vulvovaginal candidiasis compared with clotrimazole: A randomized controlled trial. Complement Ther Med. 2020;52:102483. PubMed
- de Souza P, Crestani S, da Silva Rde C, et al. Involvement of bradykinin and prostaglandins in the diuretic effects of Achillea millefolium L. (Asteraceae). J Ethnopharmacol. 2013 Aug 26;149(1):157-61. PubMed
- Miranzadeh S, Adib-Hajbaghery M, Soleymanpoor L, Ehsani M. Effect of adding the herb Achillea millefolium on mouthwash on chemotherapy induced oral mucositis in cancer patients: A double-blind randomized controlled trial. Eur J Oncol Nurs. 2015;19(3):207- PubMed
Capers 3 references
- Angelini G, Vena GA, Filotico R, et al. Allergic contact dermatitis from Capparis spinosa L. applied as wet compresses. Contact Dermatitis 1991;24:382-3.
- Huseini HF, Hasani-Rnjbar S, Nayebi N, et al. Capparis spinosa L. (Caper) fruit extract in treatment of type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Complement Ther Med. 2013;21(5):447-52. PubMed
- Vahid H, Bonakdaran S, Khorasani ZM, et al. Effect of Capparis spinosa extract on metabolic parameters in patients with type-2 diabetes: A randomized controlled trial. Endocr Metab Immune Disord Drug Targets. 2019;19(1):100-107. PubMed
Chicory 13 references
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Stone-Dorshow T, Levitt MD. Gaseous response to ingestion of a poorly absorbed fructo-oligosaccharide sweetener. Am J Clin Nutr 1987;46:61-5. PubMed
- Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
- Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
- Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
- Cadot, P., Kochuyt, A. M., van Ree, R., and Ceuppens, J. L. Oral allergy syndrome to chicory associated with birch pollen allergy. Int.Arch.Allergy Immunol. 2003;131(1):19-24. PubMed
- Friis, B., Hjorth, N., Vail, J. T., Jr., and Mitchell, J. C. Occupational contact dermatitis from Cichorium (chicory, endive) and Lactuca (lettuce). Contact Dermatitis 1975;1(5):311-313.
- Nemery, B. and Demedts, M. Occupational asthma in a chicory grower. Lancet 3-25-1989;1(8639):672-673. PubMed
- Pirson F, Detry B, Pilette C. Occupational rhinoconjunctivitis and asthma caused by chicory and oral allergy syndrome associated with bet v 1-related protein. J Investig Allergol Clin Immunol 2009;19(4):306-10.
- Willi R, Pfab F, Huss-Marp J, et al. Contact anaphylaxis and protein contact dermatitis in a cook handling chicory leaves. Contact Dermatitis 2009;60(4):226-7. PubMed
- Street RA, Sidana J, Prinsloo G. Cichorium intybus: traditional uses, phytochemistry, pharmacology, and toxicology. Evid Based Complement Alternat Med 2013;2013:579319.
- Bonnema AL, Kolberg LW, Thomas W, Slavin JL. Gastrointestinal tolerance of chicory inulin products. J Am Diet Assoc 2010;110(6):865-8. PubMed
- Devi Kt R, Sivalingam N. Cichorium intybus attenuates Streptozotocin-induced pancreatic ß-cell damage by inhibiting NF-?B activation and oxidative stress. J Appl Biomed 2020;18(2-3):70-9. PubMed
Black Nightshade 1 reference
- Dukes JA. CRC Handbook of Medicinal Herbs. first ed. Boca Raton, FL: CRC Press, Inc., 1985.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC