Interactions on record — worth a quick check against your medications. Based on 6 of 7 ingredients. Check your meds →
Dietary supplement

Liver X Ingredients & Drug Interactions

by MRM Nutrition

Liver X label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Liver X against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Liver X is a dietary supplement by MRM Nutrition with 7 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 964 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin E, Jiaogulan Leaf Extract, Alpha-Lipoic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Liver X by MRM Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Liver X by MRM Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Liver X by MRM Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • “BioSorb” is listed as a grouped ingredient — the label gives one combined amount (300 mg) without saying how much of each component you get.

Liver X contains 7 ingredients, including vitamin B12, choline bitartrate, alpha-lipoic acid, betaine anhydrous, vitamin E, silymarin, and jiaogulan leaf extract. Vitamin B12 supports nerve function and red blood cell formation.

Choline bitartrate aids in cell membrane function and brain health. Alpha-lipoic acid is an antioxidant compound.

Betaine anhydrous supports liver and heart metabolism. Vitamin E is a fat-soluble antioxidant.

Silymarin (from milk thistle) and jiaogulan leaf extract support liver function and overall health. The product also contains inactive ingredients: cellulose and magnesium stearate, which are common fillers and binders used in capsules.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: liver support and detoxification.
  • We looked for evidence on: Alcohol-related liver disease, Fatty liver disease, Hepatic function, Drug-induced liver injury.
  • The closest evidence on file: Alpha-lipoic Acid is rated "Possibly Ineffective" for Alcohol-related liver disease (Natural Medicines).
  • Also on file: Jiaogulan is rated "Insufficient Reliable Evidence To Rate" for Nonalcoholic fatty liver disease (NAFLD).
  • Also on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Nonalcoholic fatty liver disease (NAFLD).

Evidence for this product's ingredients varies. Vitamin B12 is effective for B12 deficiency and is likely effective for cyanide poisoning; it's possibly effective for canker sores and postherpetic neuralgia (nerve pain after shingles).

Alpha-lipoic acid is possibly effective for diabetic nerve damage and high cholesterol, and possibly effective for obesity. Jiaogulan is possibly effective for diabetes.

For choline bitartrate, betaine anhydrous, and silymarin, the evidence we hold either rates as insufficient to draw firm conclusions or shows insufficient reliable evidence — meaning we don't have strong data on how well they work for their intended purposes. Talk with your doctor about whether this product is right for your specific health goals.

The evidence, ingredient by ingredient Vitamin B12 Choline Alpha-lipoic Acid Betaine Anhydrous Vitamin E Jiaogulan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B12 is generally very well tolerated and is considered safe during pregnancy and breastfeeding at normal recommended amounts. Choline bitartrate is generally safe in food amounts, though high-dose supplements can cause side effects like a fishy body odor, nausea, diarrhea, and vomiting—especially at doses above 3.5 grams daily.

It's important during pregnancy and breastfeeding but should be used only at doses advised by your doctor. Alpha-lipoic acid is generally well tolerated but can lower blood sugar and is best used under medical guidance; the safety data advises against use during pregnancy and breastfeeding.

Betaine anhydrous is generally well tolerated at studied doses and may cause body odor, nausea, diarrhea, or GI distress. Vitamin E is generally well tolerated at usual dietary amounts, but high-dose long-term supplements may raise bleeding risk.

Jiaogulan is generally well tolerated for short-term use but is advised against during pregnancy and breastfeeding because safety isn't established.

Side effects, ingredient by ingredient Vitamin B12 Choline Alpha-lipoic Acid Betaine Anhydrous Vitamin E Jiaogulan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Jiaogulan, Choline, Alpha-lipoic Acid, Vitamin B12, Vitamin E.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications.
  • For scale: 965 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Liver X, double-check with your doctor or pharmacist if you take anticoagulant or antiplatelet drugs (blood thinners like warfarin, heparin, or aspirin), because alpha-lipoic acid, vitamin E, and jiaogulan may increase bleeding risk. Moderate caution is also needed if you take antidiabetes medications, chemotherapy drugs (alkylating agents or antitumor antibiotics), thyroid hormones, immunosuppressants, cyclosporine, or niacin.

If you take metformin for diabetes, B12 levels may need monitoring. No interactions are documented for silymarin in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Liver X may appeal to someone looking to support liver function with antioxidants and choline. However, if you take blood thinners, diabetes medications, thyroid hormones, chemotherapy drugs, or immunosuppressants, you should check with your doctor or pharmacist before starting this product.

The same goes if you're pregnant or breastfeeding. Talk it over with your own healthcare provider to make sure Liver X fits your individual health situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Liver X, straight from the product label.

Brand MRM Nutrition
Barcode (UPC) 60949261005
Net contents 60 Vegan Capsule(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 305041
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Liver X by MRM Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
60949261005
IngredientAmount% DV
Vitamin B1240 mcg1670%
Choline Bitartrate200 mg--
Alpha-Lipoic Acid100 mg--
Betaine Anhydrous800 mg--
Vitamin E54 mg360%
Silymarin60 mg--
Jiaogulan Leaf Extract50 mg--
BioSorb300 mg--

Other ingredients: Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested usage: Take 2 capsules per day with or without a meal or as directed by your qualified healthcare provider.

Formulation

Daily liver support & detoxification

GF

Vegan

Detoxification

Contains no added milk, egg, peanut, tree nut, fish, shellfish, soy, wheat, gluten or yeast ingredients.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Made from recycled materials

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Liver X is a registered trademark of Chemi-Source Inc. Chemi-Source Inc. Novel Nutritional Intermediates

Formula

Biosorb milk thistle complex gets absorbed 5x better than crude milk thistle extracts

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Liver X by MRM Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Liver X label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Liver X by MRM Nutrition

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B12

Interacts with
20 drugs
40 mcg per serving Form: Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Choline Bitartrate

Interacts with
16 drugs
200 mg per serving

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline Bitartrate monograph & interactions

Alpha-Lipoic Acid

Interacts with
263 drugs
100 mg per serving

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain,...

Alpha-Lipoic Acid monograph & interactions

Betaine Anhydrous

No known
interactions
800 mg per serving

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

Betaine Anhydrous monograph & interactions

Vitamin E

Interacts with
764 drugs
54 mg per serving Form: D-Alpha-Tocopherol

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Jiaogulan Leaf Extract

Interacts with
327 drugs
50 mg per serving

Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support. Early human and...

Jiaogulan Leaf Extract monograph & interactions

BioSorb

300 mg per serving Form: Milk Thistle Seed Extract
  • › Silymarin

Other (inactive) ingredients: Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Liver X by MRM Nutrition Drug Interactions

Want to check YOUR meds against Liver X?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
964Drugs
948 Moderate 16 Minor

Ingredients driving the most interactions

Vitamin E 764
Jiaogulan Leaf Extract 327
Alpha-Lipoic Acid 263
Vitamin B12 20
Choline Bitartrate 16

Individual Drug Interactions

The ingredients in Liver X interact with 964 drugs. Click any drug to see the details.

5 of the 7 ingredients in Liver X interact with drugs. Each result below shows which ingredient is responsible. Vitamin E Jiaogulan Leaf Extract Alpha-Lipoic Acid Vitamin B12 Choline Bitartrate

Each ingredient & the kinds of drugs it affects

For each ingredient in Liver X with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions

Jiaogulan Leaf Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, jiaogulan might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research suggests that jiaogulan has antiplatelet effects.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, jiaogulan might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that jiaogulan can lower blood glucose levels.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, jiaogulan might decrease the effectiveness of immunosuppressive therapy.
Clinical and animal studies suggest that jiaogulan can stimulate the immune system.

Likelihood Possible Evidence D
Jiaogulan Leaf Extract full monograph & interactions

Alpha-Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Alpha-Lipoic Acid full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions

Choline Bitartrate1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline Bitartrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Liver X, from the product label.

MRM Nutrition

See all MRM Nutrition products
Name
MRM
Street Address
2665 Vista Pacific Dr
City
Oceanside
State
CA
ZipCode
92056
Phone Number
1-800-948-6296
Web Address
www.mrmnutrition.com
Pharmacist Counseling Corner

Liver X by MRM Nutrition: Common Questions

Does Liver X by MRM Nutrition interact with any medications?
Yes. Based on its ingredients, Liver X has a known interaction with 964 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Liver X contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Liver X if I'm on blood thinners like warfarin or aspirin?
Not without checking first. Alpha-lipoic acid, vitamin E, and jiaogulan all carry Moderate interactions with blood thinners and may increase your bleeding risk. Talk with your doctor or pharmacist before starting this product if you're on any anticoagulant or antiplatelet drug.
Is Liver X safe during pregnancy?
It depends on the ingredient. Jiaogulan is advised against during pregnancy because safety isn't established. Alpha-lipoic acid also advises against use. Vitamin B12 is considered safe, but the safety data for betaine anhydrous and choline aren't strong enough to recommend use unless your doctor advises it. Talk with your doctor before taking any supplement in pregnancy.
Will Liver X lower my blood sugar?
Jiaogulan and alpha-lipoic acid can theoretically lower blood glucose levels, which means they may increase the risk of hypoglycemia (low blood sugar) if you're already taking antidiabetes medications. If you use diabetes drugs, check with your doctor or pharmacist first.
What's silymarin and does it interact with my medications?
Silymarin is a compound from milk thistle that's traditionally used for liver support. We don't hold interaction data for it, so we can't tell you whether it interacts with your specific medications—run your prescriptions through the checker on this page or ask your pharmacist.
Can I take Liver X while breastfeeding?
Vitamin B12 is considered safe while breastfeeding. Vitamin E is likely safe at normal dietary amounts. However, jiaogulan is advised against while breastfeeding because safety isn't well established, and safety data for betaine anhydrous aren't strong enough. Talk with your doctor or pharmacist about whether this product is right for you while nursing.
What are the most common side effects?
Most ingredients are generally well tolerated, but alpha-lipoic acid may cause headache, heartburn, nausea, or vomiting. Choline bitartrate at high doses can cause fishy body odor, nausea, diarrhea, and vomiting. Jiaogulan may cause diarrhea, nausea, or dry mouth. If you notice any of these, stop and talk with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Liver X is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Liver X label
Go deeper

The Full Monographs Behind Liver X’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph → Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph → Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph → Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Jiaogulan

Interacts with 327 drugs

Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support. Early human and animal studies are promising for some u...

Read the full Jiaogulan monograph →
Sources

Sources & How We Checked

Liver X's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 175 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
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Choline 14 references
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Alpha-lipoic Acid 48 references
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Betaine Anhydrous 11 references
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Vitamin E 64 references
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See these in context on the Vitamin E monograph →

Jiaogulan 8 references
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See these in context on the Jiaogulan monograph →

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