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Dietary supplement

Lobelia & Calamus Combination Ingredients & Drug Interactions

by TerraVita

Lobelia & Calamus Combination label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lobelia & Calamus Combination against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lobelia & Calamus Combination is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for asthma and breathing problems, cough and bronchitis, smoking cessation aid.Based on those ingredients, 1,119 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lobelia & Calamus Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lobelia & Calamus Combination by TerraVita

Ask about any prescription or over-the-counter medication and we check it for interactions with Lobelia & Calamus Combination by TerraVita — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lobelia & Calamus Combination by TerraVita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Lobelia & Calamus Glycerite Liquid Extract” is listed as a grouped ingredient — the label gives one combined amount (0.13 mL) without saying how much of each component you get.

This liquid combination contains 2 active ingredients: lobelia glycerite liquid extract and calamus glycerite liquid extract. Both are delivered as glycerite extracts — a liquid preparation using glycerin as the solvent.

Glycerin is also listed as an inactive ingredient (the carrier that makes this a drinkable liquid).

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold is limited. Lobelia is rated possibly ineffective for smoking cessation.

For calamus, effectiveness data isn't established — the facts note insufficient reliable evidence for bronchitis, anorexia nervosa, asthma, and cancer. Neither ingredient has a solid evidence base for the uses this combination may be marketed toward.

The evidence, ingredient by ingredient Lobelia Calamus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both ingredients carry serious safety concerns. Lobelia can cause nausea, vomiting, diarrhea, dizziness, tremors, and throat irritation at doses as low as 50 mg; higher doses (600 mg or more) can trigger toxicity with symptoms including rapid heart rate (tachycardia), dangerously low blood pressure (hypotension), convulsions, and even death.

Calamus is likely unsafe — it may increase cancer risk because some forms contain beta-asarone, a possible carcinogen banned from food by the FDA. Calamus can also cause nausea, vomiting, and in rare cases intestinal paralysis and rapid heart rate.

The safety data advises strongly against lobelia during pregnancy and breastfeeding due to toxicity concerns. Calamus is also rated unsafe in pregnancy and lactation — it may affect the uterus and contains potentially toxic compounds.

Do not use this product if you are pregnant or nursing.

Side effects, ingredient by ingredient Lobelia Calamus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lobelia, Calamus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 1,120 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, confirm your exact medications with your doctor or pharmacist. The most serious interaction is with CNS depressants (sedating medications), which could dangerously increase sedation.

Also double-check blood pressure medications, drugs for depression (especially MAOIs), heartburn medications (H2-blockers), anticholinergic drugs (for overactive bladder or other conditions), cholinergic drugs, lithium, and any medication your liver metabolizes through the CYP2D6 or CYP3A4 pathways — a category that includes many common drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product has two ingredients with broad interactions and serious safety flags. Lobelia carries toxicity concerns even at modest doses, and calamus poses a potential cancer risk and interacts with a very large number of medications.

If you take any prescription medications — especially for depression, anxiety, heart rhythm, blood pressure, or digestion — check them against this product with your own doctor or pharmacist before starting. Pregnancy and breastfeeding are contraindications for both ingredients.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lobelia & Calamus Combination, straight from the product label.

Brand TerraVita
Barcode (UPC) 064435226725
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 279672
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lobelia & Calamus Combination by TerraVita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
227
UPC/BARCODE
064435226725
IngredientAmount% DV
Lobelia Glycerite Liquid Extract0 NP--
Lobelia & Calamus Glycerite Liquid Extract0.13 mL--
Calamus Glycerite Liquid Extract0 NP--

Other ingredients: Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2018 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Formula

Glycerite liquid extract (1:5)

Formulation

Alcohol free No flavor

Suggested/Recommended/Usage/Directions

Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.

Precautions

Keep away from children.

Do not use if safety seal around cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lobelia & Calamus Combination by TerraVita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lobelia & Calamus Combination label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lobelia & Calamus Combination by TerraVita

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.

Lobelia & Calamus Glycerite Liquid Extract

Interacts with
1 drug
0.13 mL per serving

Lobelia is a traditional herb once used for breathing problems and to help people quit smoking, but reliable evidence supporting these uses is lacking...

Lobelia & Calamus Glycerite Liquid Extract monograph & interactions

Other (inactive) ingredients: Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lobelia & Calamus Combination by TerraVita Drug Interactions

Want to check YOUR meds against Lobelia & Calamus Combination?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,119Drugs
1,100 Moderate 19 Minor

Ingredients driving the most interactions

Lobelia & Calamus Glycerite Liquid Extract 1

Individual Drug Interactions

The ingredients in Lobelia & Calamus Combination interact with 1,119 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lobelia & Calamus Combination interact with drugs. Each result below shows which ingredient is responsible. Lobelia & Calamus Glycerite Liquid Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lobelia & Calamus Combination with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lobelia & Calamus Glycerite Liquid Extract1 drug type · 1 drug

Lithium

Lobelia is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, lobelia might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Lobelia & Calamus Glycerite Liquid Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lobelia & Calamus Combination, from the product label.

TerraVita

See all TerraVita products
Name
ZooScape LLC
Phone Number
844-449-0444
Web Address
www.ZooScape.com
Pharmacist Counseling Corner

Lobelia & Calamus Combination by TerraVita: Common Questions

Does Lobelia & Calamus Combination by TerraVita interact with any medications?
Yes. Based on its ingredients, Lobelia & Calamus Combination has a known interaction with 1,119 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lobelia & Calamus Combination contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. Both lobelia and calamus are rated unsafe in pregnancy and lactation. Lobelia carries toxicity concerns and lack of safety data, and calamus may affect the uterus and contains potentially toxic compounds. Do not use this product if you are pregnant or nursing.
What side effects might I experience?
Lobelia commonly causes nausea, vomiting, diarrhea, dizziness, tremors, and throat irritation — even at low doses. At higher doses (600 mg or more), it can cause toxicity with rapid heart rate, dangerously low blood pressure, seizures, and life-threatening effects. Calamus typically causes nausea and vomiting, and rarely can cause intestinal paralysis.
Does this product work for smoking cessation?
Lobelia is rated possibly ineffective for smoking cessation based on the evidence we hold. For the other uses this combination may address, effectiveness data isn't established in our records.
Why is calamus considered unsafe?
Calamus is likely unsafe because some forms contain beta-asarone, a possible carcinogen that the FDA banned from food. Additionally, it contains other potentially toxic compounds and has very limited safety data.
I take blood pressure medication. Can I use this?
Calamus may lower blood pressure further and could dangerously reduce your blood pressure if combined with antihypertensive drugs. Talk with your doctor or pharmacist before adding this product to confirm it's safe with your specific medication.
What is the difference between lobelia and calamus in this combination?
Both are herbal extracts delivered as glycerites. Lobelia's main interaction concern is with lithium; calamus interacts with a much broader range of drug types including CNS depressants, blood pressure medications, and drugs metabolized by major liver enzymes.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lobelia & Calamus Combination label
Go deeper

The Full Monographs Behind Lobelia & Calamus Combination’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lobelia

Interacts with 1 drug

Lobelia is a traditional herb once used for breathing problems and to help people quit smoking, but reliable evidence supporting these uses is lacking. It can be toxic in higher amounts, cau...

Read the full Lobelia monograph → Herb & supplement monograph

Calamus

Interacts with 1,119 drugs

Calamus is a swamp plant with a long history in Ayurvedic and traditional Chinese medicine, mostly for digestive and nervous-system complaints. However, it contains beta-asarone, a compound...

Read the full Calamus monograph →
Sources

Sources & How We Checked

Lobelia & Calamus Combination's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lobelia 6 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. McChargue DE, Collins FL Jr, Cohen LM. Effect of non-nicotinic moist snuff replacement and lobeline on withdrawal symptoms during 48-h smokeless tobacco deprivation. Nicotine Tob Res 2002;4:195-200. PubMed
  5. Stead LF, Hughes JR. Lobeline for smoking cessation. Cochrane Database Syst Rev 2000;2:CD000124. PubMed
  6. Plakun, A. L., Ambrus, J., Bross, I., Graham, S., Levin, M. L., and Ross, C. A. Clinical factors in smoking withdrawal: preliminary report. Am J Public Health Nations.Health 1966;56(3):434-441. PubMed

See these in context on the Lobelia monograph →

Calamus 13 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. Sandy, OR: Eclectic Medical Publ, 1997.
  4. Shoba, F. G. and Thomas, M. Study of antidiarrhoeal activity of four medicinal plants in castor-oil induced diarrhoea. J Ethnopharmacol 2001;76(1):73-76. PubMed
  5. Koo, B. S., Park, K. S., Ha, J. H., Park, J. H., Lim, J. C., and Lee, D. U. Inhibitory effects of the fragrance inhalation of essential oil from Acorus gramineus on central nervous system. Biol Pharm.Bull. 2003;26(7):978-982. PubMed
  6. Oh, M. H., Houghton, P. J., Whang, W. K., and Cho, J. H. Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity. Phytomedicine 2004;11(6):544-548. PubMed
  7. Panchal, G. M., Venkatakrishna-Bhatt, H., Doctor, R. B., and Vajpayee, S. Pharmacology of Acorus calamus L. Indian J Exp.Biol 1989;27(6):561-567.
  8. Vargas, C. P., Wolf, L. R., Gamm, S. R., and Koontz, K. Getting to the root (Acorus calamus) of the problem. J Toxicol Clin Toxicol 1998;36(3):259-260.
  9. Pandit S, Mukherjee PK, Ponnusankar S, Venkatesh M, Srikanth N. Metabolism mediated interaction of a-asarone and Acorus calamus with CYP3A4 and CYP2D6. Fitoterapia 2011;82(3):369-74.
  10. Sharma V, Singh I, Chaudhary P. Acorus calamus (The Healing Plant): a review on its medicinal potential, micropropagation and conservation. Nat Prod Res. 2014;28(18):1454-66.
  11. Björnstad K, Helander A, Hultén P, Beck O. Bioanalytical investigation of asarone in connection with Acorus calamus oil intoxications. J Anal Toxicol 2009;33(9):604-9. PubMed
  12. Federal Register. Volume 33, Page 6967. U.S. Government Publishing Office. http://api.fdsys.gov/link?collection=fr&volume=33&page=6967. Accessed May 23, 2018.
  13. Electronic Code of Federal Regulations. Title 21. Part 189 - Substances Prohibited From Use in Human Food. Available at: https://www.ecfr.gov/cgi-bin/text-idx?SID=259fa8a1284cad42676075c8425c7333&mc=true&node=pt21.3.189&rgn=div5.

See these in context on the Calamus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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