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Dietary supplement

Adrenal Cocktail + Wholefood Vitamin C Ingredients & Drug Interactions

by Jigsaw Health

Adrenal Cocktail + Wholefood Vitamin C label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Adrenal Cocktail + Wholefood Vitamin C against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Adrenal Cocktail + Wholefood Vitamin C is a dietary supplement by Jigsaw Health with 3 active ingredients. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 423 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin C, Sodium, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Adrenal Cocktail + Wholefood Vitamin C by Jigsaw Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Adrenal Cocktail + Wholefood Vitamin C by Jigsaw Health — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Adrenal Cocktail + Wholefood Vitamin C by Jigsaw Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Potassium” is listed as a grouped ingredient — the label gives one combined amount (380 mg) without saying how much of each component you get.

This powder has three active ingredients. Potassium bicarbonate and sodium work together as electrolytes to support your body's fluid and mineral balance — potassium bicarbonate is a form of potassium, while sodium is listed separately.

Vitamin C (from whole-food sources) is included as an antioxidant nutrient. The product contains no other inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support healthy adrenal gland function.
  • We looked for evidence on: Chronic fatigue syndrome (CFS), Athletic performance, Physical performance, Exercise-induced muscle damage, Exercise-induced respiratory infections, Adrenal fatigue — and 3 related terms.
  • The strongest evidence on file: Vitamin C is rated "Possibly Effective" for Exercise-induced respiratory infections (Natural Medicines).
  • Also on file: Vitamin C is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Chronic fatigue syndrome (CFS), Stress, Physical performance, and more.

Vitamin C in this product is effective for preventing vitamin C deficiency and possibly effective for anemia of chronic disease, atrial fibrillation, cataracts, and exercise-induced respiratory infections. The effectiveness data we hold doesn't cover potassium bicarbonate or sodium for any specific condition, so we can't speak to what this blend is designed to do overall.

The evidence, ingredient by ingredient Potassium Vitamin C Sodium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Potassium from food is safe, but supplements can raise blood potassium to dangerous levels in some people — especially those with kidney disease. Vitamin C is well-tolerated at normal doses, but high doses above 2 grams daily can cause abdominal cramps, diarrhea, nausea, kidney stones, and serious effects in rare cases.

Sodium is essential in small amounts, but too much is linked to high blood pressure and heart strain. For pregnancy, potassium from a normal diet and moderate vitamin C are considered likely safe; sodium in usual amounts is also likely safe.

For breastfeeding, check with your doctor before using potassium or high-dose vitamin C supplements, and avoid excess sodium.

Side effects, ingredient by ingredient Potassium Vitamin C Sodium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Potassium, Vitamin C, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; lithium.
  • For scale: 423 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take potassium-sparing diuretics, ACE inhibitors, or angiotensin receptor blockers (all Moderate — high blood potassium risk). Also flag estrogens like birth control or hormone therapy, warfarin, levothyroxine, blood pressure medications, lithium, and corticosteroids.

If you take chemotherapy drugs, discuss this product first.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product pairs electrolytes with vitamin C, but it's not for everyone. If you take a blood pressure medication, ACE inhibitor, ARB, diuretic, lithium, thyroid medication, warfarin, or hormonal contraceptive, you need to check your exact drugs before starting.

Talk to your pharmacist or doctor — especially if you have kidney disease or are pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Adrenal Cocktail + Wholefood Vitamin C, straight from the product label.

Brand Jigsaw Health
Barcode (UPC) 876634001696
Net contents 60 Packet(s); 8.5 Ounce(s); 240 Gram(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 334962
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Adrenal Cocktail + Wholefood Vitamin C by Jigsaw Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Gram(s)
Maximum serving Sizes:
4 Gram(s)
Servings per container
60
UPC/BARCODE
876634001696
IngredientAmount% DV
Potassium380 mg8%
Potassium Bicarbonate922 mg--
Vitamin C400 mg444%
Sodium440 mg19%

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Jigsaw Health It's fun to feel good.

SaltWorks is a registered trademark of SaltWorks, Inc.

Formulation

Non GMO Gluten free Soy free

Vegan

Energize and replenish your adrenal glands. Regulate important hormones. Promote healthy stress response.

Alergens: None.

We are committed to providing you with the highest quality nutritional supplements. Every batch of product is tested by an independent 3rd party lab to ensure purity and potency. If you are not completely satisfied with your purchase, we offer a 90-day, money-back guarantee - shipping included.

Seals/Symbols

Vegan Label Claim Verified

Product of the U.S.A. with select ingredients thoughtfully curated from around the world.

90 Day Money-Back Guarantee

Formula

Includes 400 mg of vitamin C from acerola fruit extract

Jigsaw Adrenal Cocktail combines 400 mg of Wholefood Vitamin C, potassium bicarbonate, and SaltWorks Sea Salt in a unique formulation designed to support healthy adrenal gland function. Vitamin C plays a critical role in adrenal performance, including the ability to produce numerous hormones. In fact, the highest concentration of vitamin C in your body is stored by your adrenal glands. Additionally, sodium and potassium are delicately balanced in your adrenals and are both vital minerals for normal adrenal function. Finally, stressed adrenals deplete your body's supply of magnesium. So complementing Jigsaw magnesium supplements with Jigsaw Adrenal Cocktail will help your body use magnesium more effectively.

FDA Statement of Identity

Nutritional Supplement Powder

General Statements

Since chiropractic school I've suffered with burnt out adrenals. Using this product makes me feel better! I have more energy, a clear mind, and wake up easier in the morning without feeling groggy. Now that I've personally experienced the benefits of Jigsaw's Adrenal Cocktail I recommend it to all my patients. - Ashley R.

What are the adrenal glands and what do they do in your body? Your adrenal glands are walnut-shaped organs that sit above your kidneys. These "tiny but mighty" glands are essential to life and responsible for secreting a range of critical hormones. When you're faced with a great deal of stress, your adrenal glands become overworked, exhausted, and depleted of the essential nutrients they need to function properly.

What's with the taste? If you're wondering about the extra salty flavor, please scan the QR code to watch a short explainer video. Need more? Call 1-888-352-5050 or visit JigsawHealth.com And the results are posted on our website for all to see; we believe that what's on the label is what should be in the product, and nothing else.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Suggested use: As a nutritional supplement, mix 1 packet in 8-16 fl oz of water or juice (or to taste) and mix thoroughly. Or use as directed by your healthcare professional.

Precautions

Should not be used if tamper-evident seal is broken.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Adrenal Cocktail + Wholefood Vitamin C by Jigsaw Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Adrenal Cocktail + Wholefood Vitamin C label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Adrenal Cocktail + Wholefood Vitamin C by Jigsaw Health

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Gram(s) Dosage formPowder Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Potassium

Interacts with
62 drugs
380 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Vitamin C

Interacts with
207 drugs
400 mg per serving Form: Acerola Fruit Extract

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...

Vitamin C monograph & interactions

Sodium

Interacts with
205 drugs
440 mg per serving Form: SaltWorks

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions
Interaction report

Adrenal Cocktail + Wholefood Vitamin C by Jigsaw Health Drug Interactions

Want to check YOUR meds against Adrenal Cocktail + Wholefood Vitamin C?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
423Drugs
317 Moderate 106 Minor

Ingredients driving the most interactions

Vitamin C 207
Sodium 205
Potassium 62

Individual Drug Interactions

The ingredients in Adrenal Cocktail + Wholefood Vitamin C interact with 423 drugs. Click any drug to see the details.

3 of the 3 ingredients in Adrenal Cocktail + Wholefood Vitamin C interact with drugs. Each result below shows which ingredient is responsible. Vitamin C Sodium Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Adrenal Cocktail + Wholefood Vitamin C with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin C13 drug types · 207 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Aluminum

Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.

Likelihood Probable Evidence B
Antitumor Antibiotics

Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Estrogens

Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.

Likelihood Probable Evidence B
Fluphenazine (Prolixin)

Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.

Likelihood Possible Evidence D
Indinavir (Crixivan)

Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.

Likelihood Probable Evidence B
Warfarin (Coumadin)

High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.

Likelihood Probable Evidence B
Aspirin

Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.

Likelihood Possible Evidence B
Choline Magnesium Trisalicylate (Trilisate)

Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Niacin

Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Salsalate (Disalcid)

Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Vitamin C full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Adrenal Cocktail + Wholefood Vitamin C, from the product label.

Jigsaw Health

See all Jigsaw Health products
Name
Jigsaw Health, LLC
Street Address
9035 E Pima Ctr Pkwy #4
City
Scottsdale
State
AZ
ZipCode
85258
Phone Number
1-888-352-5050
Pharmacist Counseling Corner

Adrenal Cocktail + Wholefood Vitamin C by Jigsaw Health: Common Questions

Does Adrenal Cocktail + Wholefood Vitamin C by Jigsaw Health interact with any medications?
Yes. Based on its ingredients, Adrenal Cocktail + Wholefood Vitamin C has a known interaction with 423 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Adrenal Cocktail + Wholefood Vitamin C contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is potassium in this product safe if I have kidney disease?
No — potassium supplements can cause dangerously high blood levels in people with kidney disease. Talk to your doctor or pharmacist before using this product if you have any kidney issues.
Can I take this with my birth control pill?
Vitamin C in supplements can increase estrogen levels from hormonal contraceptives by up to 55% in some cases. Check with your pharmacist to make sure it's okay for you specifically.
What are the common side effects of the potassium in this powder?
Taken by mouth, potassium most commonly causes abdominal pain, belching, diarrhea, flatulence, nausea, and vomiting. High doses can cause serious heart rhythm problems and mental confusion, though that's rare.
Is high-dose vitamin C safe during pregnancy?
Normal amounts from food and prenatal vitamins are fine, but avoid high-dose supplements unless your doctor advises it. Check with your provider before taking this product at full strength during pregnancy.
Will this interfere with my thyroid medication?
Vitamin C can actually increase how much levothyroxine your body absorbs, which may raise your thyroid hormone levels. Your doctor may need to adjust your dose — talk to your pharmacist before starting.
What is potassium bicarbonate in this product used for?
Potassium bicarbonate is a form of potassium, an electrolyte your body needs for nerve, muscle, and heart function. In this blend it works alongside sodium to support electrolyte balance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Adrenal Cocktail + Wholefood Vitamin C label
Go deeper

The Full Monographs Behind Adrenal Cocktail + Wholefood Vitamin C’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Vitamin C

Interacts with 207 drugs

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...

Read the full Vitamin C monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph →
Sources

Sources & How We Checked

Adrenal Cocktail + Wholefood Vitamin C's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 101 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
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See these in context on the Potassium monograph →

Vitamin C 51 references
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Sodium 38 references
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See these in context on the Sodium monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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