Interactions on record — worth a quick check against your medications. Based on 2 of 6 ingredients. Check your meds →
Dietary supplement

Margarite Acne Pills Ingredients & Drug Interactions

by Plum Flower

Margarite Acne Pills label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Margarite Acne Pills against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Margarite Acne Pills is a dietary supplement by Plum Flower with 6 active ingredients. Its ingredients are commonly taken for kidney and adrenal support, anemia and blood building (traditional), inflammatory conditions.Based on those ingredients, 375 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rehmannia glutinosa extract, Lonicera japonica extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Margarite Acne Pills by Plum Flower

Ask about any prescription or over-the-counter medication and we check it for interactions with Margarite Acne Pills by Plum Flower — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Margarite Acne Pills by Plum Flower

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (850 mg) without saying how much of each component you get.

Margarite Acne Pills contains 6 active ingredients. The main active component is a proprietary extract blend whose individual parts are listed separately: rehmannia (a traditional root used in Asian medicine), honeysuckle flower extract, cristaria plicata pearl extract, bos taurus domesticus bezoar (a type of animal-derived material), and zostera marina extract (from seagrass).

The product also contains inactive ingredients — hydrated magnesium silicate, dextrin, activated carbon, and china wax — that serve as binders and fillers in the tablet.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Chronic kidney disease (CKD) — rated "Possibly Effective" (Rehmannia) (Natural Medicines).

The evidence for this product isn't established in our data. Among the individual ingredients, rehmannia is rated possibly effective for chronic kidney disease; for everything else listed — aplastic anemia, atopic disease, osteoporosis, diabetes, and diabetic nephropathy — the evidence is insufficient.

Honeysuckle and the other ingredients lack effectiveness ratings in our system. To understand what this acne product is intended to do and whether it works for your specific concern, talk with your doctor or pharmacist.

The evidence, ingredient by ingredient Rehmannia Honeysuckle

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 1 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rehmannia and honeysuckle are both used in traditional medicine, but human safety data are limited and product quality varies. Neither ingredient should be taken during pregnancy or while breastfeeding — there isn't enough safety information in either case.

Honeysuckle has been linked to rare allergic reactions; one documented case involved a rash and swelling after taking 30 grams over 24 hours, which resolved after stopping the supplement and using antihistamines and steroids. Topical use has also been associated with contact dermatitis.

We hold no safety data for cristaria plicata pearl extract, bos taurus domesticus bezoar, or zostera marina extract.

Side effects, ingredient by ingredient Rehmannia Honeysuckle

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Honeysuckle, Rehmannia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 375 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Margarite Acne Pills, double-check these medication types with your doctor or pharmacist: blood thinners and antiplatelet drugs (moderate risk of increased bleeding from honeysuckle), blood pressure medications (moderate risk of low blood pressure from rehmannia), and diabetes drugs (moderate risk of low blood sugar from rehmannia).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and some safety-information gaps remain.

This supplement combines traditional ingredients whose effectiveness for acne isn't established in our data. If you take a blood thinner, diabetes medication, or blood pressure medication, you'll need to check with your doctor or pharmacist first — the rehmannia and honeysuckle here may affect how those drugs work.

Avoid it during pregnancy or while breastfeeding. Talk it over with your own doctor or pharmacist to see if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Margarite Acne Pills, straight from the product label.

Brand Plum Flower
Barcode (UPC) 739934839522
Net contents 105 Pill(s); 0.63 Oz(s); 17.9 Gram(s)
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 229644
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Margarite Acne Pills by Plum Flower, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Pill(s)
Maximum serving Sizes:
5 Pill(s)
Servings per container
21
UPC/BARCODE
739934839522
IngredientAmount% DV
Proprietary Extract Blend850 mg--
Rehmannia glutinosa extract0 NP--
Cristaria plicata pearl extract0 NP--
Lonicera japonica extract0 NP--
Bos taurus domesticus bezoar0 NP--
Zostera marina extract0 NP--
Bubalus bubalis extract0 NP--

Other ingredients: hydrated Magnesium Silicate, Dextrin, Activated Carbon, China Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

GMP quality

Plum Flower quality guarantee

No pharmaceuticals or dyes Unsulfured Preservative free herbs when available

Scientifically authenticated herbs, microbial and heavy metal tested, produced at a Good Manufacturing Practices (GMP) certified factory

FDA Statement of Identity

Herbal Dietary Supplement

Suggested/Recommended/Usage/Directions

Take 5 pills 3 times daily after meals or as directed by your health care practitioner

Precautions

Not for use during pregnancy

Keep out of reach of children

General Statements

U.S. owned and operated since 1969 Made in China

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Margarite Acne Pills by Plum Flower label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Margarite Acne Pills label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Margarite Acne Pills by Plum Flower

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size5 Pill(s) Dosage formTablet Or Pill Servings per container21 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Extract Blend

850 mg per serving

Other (inactive) ingredients: Hydrated Magnesium Silicate, Dextrin, Activated Carbon, China Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Margarite Acne Pills by Plum Flower Drug Interactions

Want to check YOUR meds against Margarite Acne Pills?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
375Drugs
375 Moderate

Ingredients driving the most interactions

Rehmannia glutinosa extract 258
Lonicera japonica extract 122

Individual Drug Interactions

The ingredients in Margarite Acne Pills interact with 375 drugs. Click any drug to see the details.

2 of the 6 ingredients in Margarite Acne Pills interact with drugs. Each result below shows which ingredient is responsible. Rehmannia glutinosa extract Lonicera japonica extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Margarite Acne Pills with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Rehmannia glutinosa extract2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that rehmannia may have hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that rehmannia may have hypotensive effects. Laboratory research shows that formulations of dried and processed rehmannia root inhibit angiotensin-converting enzyme (ACE).

Likelihood Possible Evidence D
Rehmannia glutinosa extract full monograph & interactions

Lonicera japonica extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, honeysuckle might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that polyphenols extracted from honeysuckle can inhibit platelet aggregation.

Likelihood Possible Evidence D
Lonicera japonica extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Margarite Acne Pills, from the product label.

Plum Flower

Name
Mayway Herbs
City
Oakland
State
CA
Phone Number
(800) 262-9929
Web Address
plumflowerherbs.com
Pharmacist Counseling Corner

Margarite Acne Pills by Plum Flower: Common Questions

Does Margarite Acne Pills by Plum Flower interact with any medications?
Yes. Based on its ingredients, Margarite Acne Pills has a known interaction with 375 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Margarite Acne Pills contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
No. The safety data for both rehmannia and honeysuckle in this product are too limited, so they should be avoided during pregnancy. Talk with your doctor about whether this supplement is right for you before you become pregnant or if you're already pregnant.
Can I breastfeed while taking it?
No. Both rehmannia and honeysuckle lack enough safety information for breastfeeding, so they're best avoided. Ask your doctor or pharmacist about safer options while you're nursing.
What is the proprietary extract blend, and why don't you list its amounts?
The proprietary blend contains the rehmannia, honeysuckle, cristaria plicata, bos taurus, and zostera marina extracts listed separately on the label. Manufacturers keep the exact amounts proprietary — they're not required to disclose them — so we can't see the individual doses in each ingredient.
Has honeysuckle caused any side effects?
Allergic reactions are rare but reported. One documented case involved a rash and facial swelling after taking 30 grams over 24 hours; symptoms cleared once the supplement was stopped and antihistamines and steroids were used. Applying honeysuckle to skin has also been linked to contact dermatitis in a case report.
Why can't you check three of the ingredients?
We don't hold safety or interaction data for cristaria plicata pearl extract, bos taurus domesticus bezoar, or zostera marina extract in our current monographs. That doesn't mean they're unsafe — it means we simply haven't reviewed them yet. If you have concerns about those ingredients, ask your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Margarite Acne Pills is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Margarite Acne Pills label
Go deeper

The Full Monographs Behind Margarite Acne Pills’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rehmannia

Interacts with 258 drugs

Rehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health. Human evidence for most modern uses is limited, so i...

Read the full Rehmannia monograph → Herb & supplement monograph

Honeysuckle

Interacts with 122 drugs

Honeysuckle, especially Japanese honeysuckle flower (Lonicera japonica), is a staple of traditional Chinese medicine used mainly for colds, sore throat, and inflammation. Modern human eviden...

Read the full Honeysuckle monograph →
Sources

Sources & How We Checked

Margarite Acne Pills's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rehmannia 3 references
  1. Zhang R, Zhou J, Jia Z, et al. Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism. J Ethnopharmacol 2004;90:39-43. PubMed
  2. Zhang RX, Li MX, Jia ZP. Rehmannia glutinosa: review of botany, chemistry and pharmacology. J Ethnopharmacol 2008;117(2):199-214. PubMed
  3. Chao CH, Hsu JL, Chen MF, et al. Anti-hypertensive effects of Radix Rehmanniae and its active ingredients. Nat Prod Res. 2020;34(11):1547-1552.

See these in context on the Rehmannia monograph →

Honeysuckle 3 references
  1. Chang WC, Hsu FL. Inhibition of platelet activation and endothelial cell injury by polyphenolic compounds isolated from Lonicera japonica Thunb. Prostaglandins Leukot Essent Fatty Acids 1992;45:307-12. PubMed
  2. Webster RM. Honeysuckle contact dermatitis. Cutis 1993;51:424.
  3. Zhou LF, Lu R. Compound-honeysuckle-induced drug eruption with special manifestations: A case report. World J Clin Cases 2022;10(22):8018-8024. PubMed

See these in context on the Honeysuckle monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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