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Dietary supplement

Advanced Total Body + Refresh Ingredients & Drug Interactions

by Schiff MegaRed

Advanced Total Body + Refresh label
See full label image
Softgel Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Advanced Total Body + Refresh against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Advanced Total Body + Refresh is a dietary supplement by Schiff MegaRed with 2 active ingredients. Its ingredients are commonly taken for digestive upset, antimicrobial and antifungal, skin and wound care.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Advanced Total Body + Refresh by Schiff MegaRed

Ask about any prescription or over-the-counter medication and we check it for interactions with Advanced Total Body + Refresh by Schiff MegaRed — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Advanced Total Body + Refresh by Schiff MegaRed

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (375 mg) without saying how much of each component you get.
  • “DHA, EPA” is listed as a grouped ingredient — the label gives one combined amount (314 mg) without saying how much of each component you get.
  • “Proprietary Omega-3 Blend” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

This softgel contains three active ingredients. Zeaxanthin and lutein are carotenoids (plant pigments) that concentrate in the eye and may support vision health.

The product also includes total omega-3 fatty acids (delivered as docosahexaenoic acid ethyl ester and other omega-3 components in a proprietary blend), which are fats thought to support heart and brain function. The remaining ingredients are inactive: gelatin, glycerin, sunflower oil, water, sorbitol solution, vanilla, mixed tocopherols, and colorants.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Eye health and macular support.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Zeaxanthin is possibly effective for age-related macular degeneration (AMD)—the slow vision loss that can happen as you age—but the evidence for it helping age-related cognitive decline or Alzheimer disease is too weak to rate. Lutein is also possibly effective for AMD and possibly effective for cataracts.

The data we hold doesn't establish effectiveness ratings for the omega-3 component of this product.

The evidence, ingredient by ingredient Tagetes Zeaxanthin Lutein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Zeaxanthin and lutein are generally well tolerated at typical supplement doses. Dietary amounts from food are safe without question, but the product's pregnancy safety label notes caution: supplement-dose safety in pregnancy hasn't been well studied, so discuss it with your doctor or pharmacist first.

The same caution applies to breastfeeding. Lutein at doses up to 20 mg daily hasn't caused adverse effects in trials.

We hold no safety data on docosahexaenoic acid ethyl ester.

Side effects, ingredient by ingredient Tagetes Zeaxanthin Lutein

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against the tool below if you take any antidiabetes drugs—the zeaxanthin here may increase the risk of low blood sugar. We couldn't verify one ingredient (docosahexaenoic acid ethyl ester), so mention this product to your pharmacist when you review your full medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're concerned about age-related vision changes, this product's zeaxanthin and lutein may be worth discussing with your pharmacist—both have some evidence. But if you take any blood sugar medication, check your specific drugs against the interaction tool first, since zeaxanthin may increase the risk of low blood sugar.

Anyone pregnant or breastfeeding should talk it over with their doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Advanced Total Body + Refresh, straight from the product label.

Brand Schiff MegaRed
Barcode (UPC) 020525107138
Net contents 65 Softgel(s)
Market status On market
Date entered into DSLD Dec 26, 2020
DSLD ID 241106
Product type Botanical With Nutrients
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Qualified Health, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Advanced Total Body + Refresh by Schiff MegaRed, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
020525107138
IngredientAmount% DV
Calories10 Calorie(s)--
Zeaxanthin0 NP--
Total Fat1 Gram(s)1%
Total Omega-3 Fatty Acids375 mg--
Lutein0 NP--
Docosahexaenoic Acid Ethyl Ester0 NP--
DHA, EPA314 mg--
Proprietary Omega-3 Blend500 mg--
Marigold flower extract30 mg--

Other ingredients: Gelatin, Glycerin, Sunflower Oil, Water, Sorbitol Solution, natural Vanilla, Mixed Tocopherols, Caramel color, Carmine color, Mica, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Actual bottle size

Value pack Join, earn points & get rewards MegaRed rewards www.megaredrewards.com See cap sticker for details Valid for US residents only. Schiff since 1936

Supportive, but not conclusive research shows that consumption of EPA and DHA Omega-3 fatty acids may reduce the risk of coronary heart disease.

Formulation

Eco-friendly. Krill is one of earth's most abundant and sustainable organisms. MegaRed sources krill from the Antarctic where krill is most abundant.

This product comes from a fishery that has been independently certified to the MSC’s standard for a well-managed and sustainable fishery. www.msc.org Schiff Sure Dissolve softgels are formulated to disintegrate within one hour.

Guaranteed: No salt (sodium chloride), yeast, wheat, or milk.

Guaranteed for purity, freshness, and labeled potency.

+ easily absorbed krill oil

Heart Brain Joints Eyes + Sleep Stress Skin

With powerful Omega-3s to support 4 vital health areas: Heart May reduce the risk of coronary heart disease Joint Promotes joint comfort Brain Supports brain health Eye Building block for eye health And a natural antioxidant clinically proven to: Sleep Help support restful sleep Stress Help reduce everyday stress Skin Support skin hydration, firming, and skin tone

Seals/Symbols

MSC-C-52013 Certified Sustainable Seafood MSC www.msc.org

Brand IP Statement(s)

Superba is a trademark of Aker BioMarine Antarctic

2020 RB Health rb Health Hygiene Home Patents: www. rb.com/patents

Formula

Lutemax Lutein & Zeaxanthin 2020 Plus

Omega-3s + a powerful natural antioxidant

Gelatin is derived from bovine sources.

What is MegaRed Advanced Total Body + Refresh? MegaRed Advanced Total Body + Refresh is a powerful Omega-3 and natural antioxidant blend that provides multi-benefit support to help your body thrive.

What are Omega-3 fatty acids, EPA and DHA? EPA and DHA are two different types of Omega-3s. Omega-3s are critical to human health and provide the building blocks for all your cells. What is Krill? Krill are tiny crustaceans that carry their Omega-3s in phospholipid form which helps absorption in the human body. What are antioxidants? Antioxidants, often found in fruits and vegetables, support general health and wellness by neutralizing free radicals that can harm your body's cells. Marigold flower extract contains antioxidants leutin and zeaxanthin.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults take one (1) softgel daily.

Precautions

Contains fish (anchovy, sardine, mackerel), shellfish (krill), and soy. This product contains sulfites.

Caution: If you are pregnant, breastfeeding, allergic to seafood, have existing medical conditions, taking medications (including blood thinners) or are planning a medical or surgical procedure, consult a healthcare professional before use.

Caution: If you are pregnant, breastfeeding, allergic to seafood, have existing medical conditions, taking medications (including blood thinners) or are planning a medical or surgical procedure, consult a healthcare professional before use.

Keep out of reach of children.

Protected with a tamper evident seal. Do not use if seal under cap is broken or missing.

Storage

Store in a cool, dry place with lid tightly closed. Do not remove freshness pack from bottle.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Advanced Total Body + Refresh by Schiff MegaRed label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Advanced Total Body + Refresh label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Advanced Total Body + Refresh by Schiff MegaRed

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Omega-3 Blend

500 mg per serving Form: Fish Oil concentrate, Krill Oil
  • › Total Omega-3 Fatty Acids

Marigold flower extract

No known
interactions
30 mg per serving

Tagetes (marigold) is a group of flowering plants used in traditional medicine and as a source of plant pigments like lutein. Human evidence for most...

Marigold flower extract monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Sunflower Oil, Water, Sorbitol Solution, Natural Vanilla, Mixed Tocopherols, Caramel color, Carmine color, Mica, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Advanced Total Body + Refresh by Schiff MegaRed Drug Interactions

Want to check YOUR meds against Advanced Total Body + Refresh?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Advanced Total Body + Refresh interact with 86 drugs. Click any drug to see the details.

0 of the 2 ingredients in Advanced Total Body + Refresh interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Advanced Total Body + Refresh with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Advanced Total Body + Refresh, from the product label.

Schiff MegaRed

See all Schiff MegaRed products
Name
RB Health (US) LLC
City
Parsippany
State
NJ
ZipCode
07054-0224
Phone Number
1-800-526-6251
Web Address
www.megared.com
Pharmacist Counseling Corner

Advanced Total Body + Refresh by Schiff MegaRed: Common Questions

Does Advanced Total Body + Refresh by Schiff MegaRed interact with any medications?
Yes. Based on its ingredients, Advanced Total Body + Refresh has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Advanced Total Body + Refresh contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is this product supposed to do?
The two main ingredients—zeaxanthin and lutein—are plant pigments that settle in your eye and may help slow age-related macular degeneration and cataracts. The omega-3 fatty acids are included to support heart and brain health, though we don't have effectiveness ratings for them in our data.
Is it safe to take while pregnant or breastfeeding?
Both zeaxanthin and lutein are labeled as likely safe in pregnancy and lactation, but the safety notes caution that supplement-dose safety hasn't been well studied in these situations. Talk with your doctor or pharmacist about whether to take it during pregnancy or while breastfeeding—they can give you personalized advice.
What are the side effects?
Zeaxanthin and lutein are generally well tolerated. Lutein at doses up to 20 mg daily hasn't produced adverse effects in trials. We don't hold adverse-effect data for the other ingredients.
Does this work for macular degeneration?
Both zeaxanthin and lutein are possibly effective for age-related macular degeneration—meaning there's some evidence, but it's not definitive. Talk to your eye doctor about whether this fits into your overall vision-care plan.
I take diabetes medication—is this safe?
Zeaxanthin may theoretically increase the risk of low blood sugar when you take antidiabetes drugs. Run your specific medications through the checker on this page before starting, and let your pharmacist know.
Are there any fillers in this?
Yes. The inactive ingredients include gelatin, glycerin, sunflower oil, water, sorbitol solution, vanilla, mixed tocopherols, and colorants. If you have allergies or dietary restrictions, check that list carefully.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Advanced Total Body + Refresh is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Advanced Total Body + Refresh label
Go deeper

The Full Monographs Behind Advanced Total Body + Refresh’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tagetes

Tagetes (marigold) is a group of flowering plants used in traditional medicine and as a source of plant pigments like lutein. Human evidence for most health benefits is very limited, and the...

Read the full Tagetes monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph → Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph →
Sources

Sources & How We Checked

Advanced Total Body + Refresh's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Tagetes 1 reference
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

See these in context on the Tagetes monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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