Melatonin 5 mg Strawberry Flavor Ingredients & Drug Interactions
by Solimo
What is this page for?
First and foremost: checking Melatonin 5 mg Strawberry Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Melatonin 5 mg Strawberry Flavor is a dietary supplement by Solimo with 2 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 1,467 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Melatonin, Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Melatonin 5 mg Strawberry Flavor by Solimo
Ask about any prescription or over-the-counter medication and we check it for interactions with Melatonin 5 mg Strawberry Flavor by Solimo — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Melatonin 5 mg Strawberry Flavor by Solimo
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 2 active ingredients: melatonin and sodium. Melatonin is the primary sleep aid—it's a hormone your body naturally makes to help regulate sleep-wake cycles.
The sodium comes from sodium citrate and other compounds in the formulation. The gummy also contains several inactive ingredients (tapioca syrup, sugar, pectin, citric acid, natural flavors, carrot juice concentrate, sunflower oil, and carnauba wax) that give it texture, taste, and shelf stability.
Does it work?
Strong evidence
Melatonin is likely effective for non-24-hour sleep-wake disorder and delayed sleep phase syndrome—specific sleep conditions where your internal clock is out of sync. It's possibly effective for pre-procedural anxiety (nervousness before medical procedures) and may help with high blood pressure in some people, though the evidence is less robust.
Sodium's effectiveness ratings in our data relate to cystic fibrosis (where it's likely effective) and prevention of kidney damage from amphotericin B (possibly effective)—uses that don't apply to this sleep product.
How safe is it?
Well-documented data
Melatonin is generally well tolerated for short-term use, though long-term safety is less established. The most common side effects are dizziness, drowsiness, headache, and nausea.
Rarely, melatonin may increase seizure risk, affect mood (including depression or mood dips), or cause hallucinations. There's also a case report of gynecomastia (breast enlargement) and reports of reduced sperm quality in men using melatonin long-term, though the latter improved after stopping.
Sodium is essential in normal amounts but too much raises blood pressure and strains the heart. Serious adverse effects are rare when sodium is kept to normal dietary levels; however, high intake is linked to worsened cardiovascular disease, high blood pressure, and kidney disease.
The pregnancy and lactation data for this product is incomplete—melatonin has no pregnancy/lactation rating on file, and sodium carries conflicting ratings (one entry says likely safe; another says possibly unsafe). Talk with your doctor or pharmacist before using this product if you're pregnant or breastfeeding.
Meds to double-check
Moderate interaction found
Check your exact medications against this product if you take blood thinners or warfarin (anticoagulants)—melatonin may increase bleeding risk. Also double-check if you're on blood pressure medications, diabetes drugs, seizure medications (anticonvulsants), lithium, corticosteroids, immune-suppressing drugs, or the HIV medicine didanosine.
Sodium in this gummy can interfere with how these work or raise your sodium levels too high.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This melatonin gummy is an option if you have a specific sleep disorder like delayed sleep phase syndrome or non-24-hour sleep-wake disorder. Be cautious if you take blood pressure medications, blood thinners, diabetes drugs, seizure medications, or lithium—the interactions here are real and deserve a medication check.
Talk to your pharmacist before starting, especially if you're on multiple prescriptions or have high blood pressure or kidney concerns.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Melatonin 5 mg Strawberry Flavor, straight from the product label.
| Brand | Solimo |
|---|---|
| Net contents | 120 Gummy(ies) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2025 |
| DSLD ID | 337396 |
| Product type | Other Combinations |
| Supplement form | Gummy Or Jelly |
| Dietary claims / uses | All Other |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Melatonin 5 mg Strawberry Flavor by Solimo, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 15 Calorie(s) | -- |
| Total Carbohydrates | 4 Gram(s) | 1% |
| Sodium | 5 mg | 1% |
| Added Sugars | 3 Gram(s) | 6% |
| Total Sugars | 3 Gram(s) | -- |
| Melatonin | 5 mg | -- |
Other ingredients: Tapioca Syrup, Sugar, Pectin, Citric Acid, Sodium Citrate, Natural Flavors, Black Carrot Juice Concentrate, Sunflower Oil, Carnauba Wax
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Strawberry flavor with other natural flavors
Formulation
Vegan
Gluten-free
Gummy colors may change over time due to natural colors. This does not alter the potency of the product. Any clouding of bottle is normal.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Adults - Chew 2 gummies daily or as needed 30 minutes before bedtime. Chew completely before swallowing.
Precautions
Keep out of the reach of children. Not for use by individuals under the age of 16.
Safety-sealed. For your protection, do not use if printed seal under cap is cut, torn, or missing. Warning: Do not exceed recommended dosage. Do not take with alcoholic beverages or while driving a motor vehicle or operating machinery.
Consult a doctor if you have a medical condition, depressive or endocrine disorder, autoimmune condition, or are taking prescription medications or planning any medical procedure.
Storage
Store in a cool, dry place.
General Statements
See bottom of bottle for expiration date and lot information.
Brand IP Statement(s)
Copyright 2018 Amazon.com, Inc. or its affiliates. All rights reserved. Solimo and all related logos are trademarks of Amazon.com, Inc. or its affiliates.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Melatonin 5 mg Strawberry Flavor by Solimo label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Melatonin 5 mg Strawberry Flavor by Solimo
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Gummy(ies) Dosage formGummy Or Jelly Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sodium
Interacts with205 drugs
Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...
Sodium monograph & interactionsMelatonin
Interacts with1,461 drugs
Melatonin is a hormone your body makes naturally to help control your sleep-wake cycle, and the supplement form is widely used to help with sleep timi...
Melatonin monograph & interactionsOther (inactive) ingredients: Tapioca Syrup, Sugar, Pectin, Citric Acid, Sodium Citrate, Natural Flavors, Black Carrot Juice Concentrate, Sunflower Oil, Carnauba Wax. These complete the product’s ingredient list but are not active constituents.
Melatonin 5 mg Strawberry Flavor by Solimo Drug Interactions
HelloPharmacist Interaction Report
Solimo Melatonin 5 mg Strawberry Flavor contains two active ingredients—melatonin and sodium—and both have documented interactions with medications.
The most serious concern is sodium's potential to worsen blood pressure control and complicate lithium therapy. Sodium can reduce how well blood pressure medications (antihypertensive drugs) work by raising blood pressure; it can also dangerously alter lithium levels, either reducing its effectiveness or causing toxicity depending on how much sodium you take.
Read the full breakdown — every affected drug type, severity by severity
Melatonin interacts with several drug types. It may reduce the effectiveness of certain blood pressure medications (specifically extended-release nifedipine) and anticonvulsants, and it could increase bleeding risk if you take blood thinners (anticoagulants) or warfarin.
Additionally, melatonin may affect blood sugar control with diabetes medications, interfere with immune-suppressing drugs, increase the risk of low blood pressure with blood pressure medications, and theoretically worsen side effects of methamphetamine.
Sodium also carries moderate interactions with corticosteroids (a class of anti-inflammatory steroids), the HIV medication didanosine, sodium phosphate laxatives, and tolvaptan—all involving a risk of elevated sodium levels in the blood. It may also interact with other sodium-containing drugs.
Altogether, these interactions span 1,451 individual medications. Because this product touches so many drug classes, use the medication checker on this page with your exact prescriptions before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Melatonin 5 mg Strawberry Flavor?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Melatonin 5 mg Strawberry Flavor interact with 1,467 drugs. Click any drug to see the details.
2 of the 2 ingredients in Melatonin 5 mg Strawberry Flavor interact with drugs. Each result below shows which ingredient is responsible. Melatonin Sodium
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninImmunosuppressants Moderate
Interaction Summary
Theoretically, melatonin might interfere with immunosuppressive therapy.
Read the full Melatonin + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, melatonin may have anticoagulant effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Melatonin + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninAnticoagulant/antiplatelet Drugs, Immunosuppressants +1 Moderate
Interaction Summary
Theoretically, melatonin may have anticoagulant effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Melatonin + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking melatonin with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Melatonin + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Melatonin 5 mg Strawberry Flavor — through 2 ingredients. Tap an ingredient for the detail:
MelatoninAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.
Read the full Melatonin + Acebutolol interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, melatonin may have anticoagulant effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Melatonin + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCns Depressants Moderate
Interaction Summary
Theoretically, taking melatonin might increase the sedative effects of CNS depressants.
Read the full Melatonin + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.
Read the full Melatonin + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.
Read the full Melatonin + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, melatonin may have anticoagulant effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Melatonin + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCytochrome P450 1a2 (cyp1a2) Substrates, Seizure Threshold Lowering Drugs Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.
Read the full Melatonin + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.
Read the full Melatonin + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.
Read the full Melatonin + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCaffeine, Cns Depressants +4 Moderate
Interaction Summary
Theoretically, taking caffeine with melatonin might increase levels of melatonin.
Read the full Melatonin + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninSeizure Threshold Lowering Drugs, Cns Depressants +2 Moderate
Interaction Summary
Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.
Read the full Melatonin + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants +2 Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.
Read the full Melatonin + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates +4 Moderate
Interaction Summary
Theoretically, taking melatonin might increase the sedative effects of CNS depressants.
Read the full Melatonin + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCytochrome P450 3a4 (cyp3a4) Substrates, Caffeine +4 Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.
Read the full Melatonin + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +4 Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.
Read the full Melatonin + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCns Depressants, Caffeine +4 Moderate
Interaction Summary
Theoretically, taking melatonin might increase the sedative effects of CNS depressants.
Read the full Melatonin + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCytochrome P450 3a4 (cyp3a4) Substrates, Caffeine +1 Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.
Read the full Melatonin + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.
Read the full Melatonin + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninSeizure Threshold Lowering Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.
Read the full Melatonin + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants +3 Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.
Read the full Melatonin + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninSeizure Threshold Lowering Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.
Read the full Melatonin + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.
Read the full Melatonin + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCytochrome P450 2d6 (cyp2d6) Substrates, Seizure Threshold Lowering Drugs +2 Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP2D6.
Read the full Melatonin + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.
Read the full Melatonin + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninSeizure Threshold Lowering Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.
Read the full Melatonin + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Melatonin 5 mg Strawberry Flavor — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCytochrome P450 3a4 (cyp3a4) Substrates, Seizure Threshold Lowering Drugs +1 Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.
Read the full Melatonin + Acetaminophen, Chlorpheniramine, Phenylephrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Melatonin 5 mg Strawberry Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Melatonin
Anticoagulant/Antiplatelet Drugs
Theoretically, melatonin may have anticoagulant effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There are isolated case reports of minor bleeding and decreased prothrombin activity in people taking melatonin with warfarin (Coumadin). The mechanism, if any, of this interaction is unknown. Taking melatonin orally seems to decrease coagulation activity within one hour of dosing in healthy men.
Anticonvulsants
Theoretically, melatonin may reduce the effects of anticonvulsants. Some clinical research suggests that melatonin may increase the frequency of seizures in certain patients, particularly children with neurological impairment.
Antidiabetes Drugs
Theoretically, taking melatonin with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that melatonin reduces levels of fasting blood glucose and improves glycemic control. However, other research suggests that melatonin might impair glucose utilization and increase insulin resistance, while other research has found no effect on glucose levels. Until more is known, use melatonin cautiously in combination with antidiabetes drugs.
Antihypertensive Drugs
Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.
Some clinical research suggests that taking melatonin decreases blood pressure in healthy adults. Also, melatonin seems to lower systolic and diastolic blood pressure in individuals with high blood pressure at nighttime or untreated essential hypertension. However, melatonin seems to worsen blood pressure in patients who are taking antihypertensive medications. Immediate-release melatonin 5 mg at night in combination with nifedipine GITS (Procardia XL) increases systolic blood pressure an average of 6.5 mmHg, diastolic blood pressure by an average of 4.9 mmHg, and heart rate by 3.9 bpm. Also, results from animal research suggest that melatonin reduces the effectiveness of certain antihypertensive drugs, including methoxamine and clonidine.
Caffeine
Theoretically, taking caffeine with melatonin might increase levels of melatonin.
Some evidence suggests that caffeine consumption can decrease endogenous melatonin levels, while other evidence suggests that caffeine increases endogenous melatonin levels. When administered in combination with melatonin supplements, caffeine seems to increase melatonin effects and levels. The reason for this discrepancy is not completely clear. Part of the discrepancy may result from the fact that caffeine can inhibit melatonin synthesis as well as inhibit melatonin metabolism. By functioning as an adenosine receptor antagonist, caffeine may indirectly inhibit the synthesis of melatonin. Conversely, because melatonin and caffeine are both metabolized by cytochrome P450 1A2 (CYP1A2) enzyme, concomitant use of melatonin and caffeine may reduce the metabolism of melatonin, resulting in higher serum levels.
Cns Depressants
Theoretically, taking melatonin might increase the sedative effects of CNS depressants.
Melatonin has sedative effects. Theoretically, concomitant use of melatonin with alcohol, benzodiazepines, or other sedative drugs might cause additive sedation.
Contraceptive Drugs
Theoretically, taking contraceptive drugs with melatonin might increase the effects and adverse effects of melatonin.
Contraceptive drugs can increase the levels of endogenous melatonin. Theoretically, these drugs may increase the effects and adverse effects of oral melatonin.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2. Also, other CYP1A2 substrates might decrease the metabolism of melatonin, increasing melatonin levels.
Melatonin is metabolized in the liver primarily by the CYP2C19 and CYP1A2 enzymes. Theoretically, combined administration of melatonin with drugs metabolized by the CYP1A2 enzyme might reduce the metabolism of these drugs, resulting in increased serum levels. Conversely, some drugs metabolized by CYP1A2 may inhibit the metabolism of melatonin, resulting in increased serum levels of melatonin. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, melatonin might increase levels of drugs metabolized by CYP2C19. Also, other CYP2C19 substrates might decrease the metabolism of melatonin, increasing melatonin levels.
Melatonin is metabolized in the liver primarily by the CYP2C19 and CYP1A2 enzymes. Theoretically, combined administration of melatonin with certain drugs metabolized by the CYP2C19 enzyme may reduce the metabolism of these drugs, resulting in increased serum levels. Conversely, some drugs metabolized by CYP2C19 may inhibit the metabolism of melatonin, resulting in increased serum levels of melatonin. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.
Fluvoxamine (Luvox)
Theoretically, taking fluvoxamine with melatonin might increase levels of melatonin.
Fluvoxamine can significantly increase melatonin levels. In some cases, fluvoxamine might increase bioavailability of exogenously administered melatonin by up to 20 times. Some researchers think this might be a beneficial interaction and be potentially useful for cases of refractory insomnia. However, this interaction might also cause unwanted excessive drowsiness and possibly other adverse effects. Fluvoxamine is known to increase endogenous melatonin secretion. It seems to increase serum levels of exogenously administered melatonin possibly by decreasing melatonin metabolism by inhibiting cytochrome P450 (CYP450) 1A2 and 2C19 or by inhibiting melatonin elimination. This effect has been found in healthy people taking fluvoxamine 50-75 mg and melatonin 5 mg.
Immunosuppressants
Theoretically, melatonin might interfere with immunosuppressive therapy.
Melatonin can stimulate immune function. Theoretically, melatonin might interfere with immunosuppressive therapy.
Methamphetamine (Desoxyn)
Theoretically, taking melatonin with methamphetamine may increase the adverse effects of methamphetamine.
Animal research suggests that melatonin exacerbates the adverse effects of methamphetamine, resulting in greater depression of tryptophan hydroxylase (TPH) and tyrosine hydroxylase (TH) activity, as well as a significant reduction in dopamine levels. This has not been shown in humans.
Nifedipine Gits (Procardia Xl)
Theoretically, taking melatonin with extended release nifedipine reduces the effects of nifedipine.
Melatonin can decrease the effectiveness of extended release nifedipine (GITS). Immediate-release melatonin 5 mg at night in combination with nifedipine GITS 30-60 mg daily increases systolic and blood pressure by an average of 6.5 mmHg and 4.9 mmHg, respectively. Concomitant use with melatonin also increases heart rate by 3.9 bpm. The mechanism of this interaction is not known.
Seizure Threshold Lowering Drugs
Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.
Some clinical evidence suggests that melatonin may increase the frequency of seizures in certain patients, particularly children with neurological disabilities.
Warfarin (Coumadin)
Theoretically, melatonin may have antiplatelet effects and may increase the risk of bleeding with warfarin.
Three cases of increased prothrombin time have been reported for patients aged 48-72 years who took melatonin orally in combination with warfarin. However, three cases of decreased prothrombin time have also been reported for patients aged 51-84 years who took melatonin orally in combination with warfarin. Until more is known, use melatonin cautiously in patients taking warfarin.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, melatonin might increase levels of drugs metabolized by CYP2D6.
Laboratory research suggests that certain lots of melatonin inhibit CYP2D6. Theoretically, combined administration of melatonin with certain drugs metabolized by the CYP2D6 enzyme may reduce the metabolism of these drugs, resulting in increased serum levels. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.
Laboratory research shows that certain lots of melatonin inhibit CYP3A4. Theoretically, combined administration of melatonin with certain drugs metabolized by CYP3A4 may reduce the metabolism of these drugs, resulting in increased serum levels. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.
Flumazenil (Romazicon)
Theoretically, taking flumazenil with melatonin might reduce the effects of melatonin.
Animal research shows that flumazenil may inhibit the effect of melatonin.
Sodium
Antihypertensive Drugs
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.
Corticosteroids
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.
Didanosine (Videx)
Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.
Lithium
Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.
Sodium Phosphates
Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.
Sodium-Containing Drugs
Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.
Tolvaptan (Samsca)
Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.
Brand information
Manufacturer and brand details for Melatonin 5 mg Strawberry Flavor, from the product label.
Solimo
See all Solimo products- Name
- Amazon.com Services, Inc.
- Street Address
- 410 Terry Ave N
- City
- Seattle
- State
- WA
- ZipCode
- 98109
- Web Address
- www.Amazon.com
Melatonin 5 mg Strawberry Flavor by Solimo: Common Questions
Does Melatonin 5 mg Strawberry Flavor by Solimo interact with any medications?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Melatonin 5 mg Strawberry Flavor’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sodium
Interacts with 205 drugsSodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...
Read the full Sodium monograph → Herb & supplement monographMelatonin
Interacts with 1,461 drugsMelatonin is a hormone your body makes naturally to help control your sleep-wake cycle, and the supplement form is widely used to help with sleep timing problems and jet lag. The evidence is...
Read the full Melatonin monograph →Sources & How We Checked
Melatonin 5 mg Strawberry Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 156 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
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