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Dietary supplement

Methyl B12 5,000 mcg Methylcobalamin With Folic Acid Ingredients & Drug Interactions

by Protocol For Life Balance

Methyl B12 5,000 mcg Methylcobalamin With Folic Acid label
See full label image
Lozenge Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Methyl B12 5,000 mcg Methylcobalamin With Folic Acid against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Methyl B12 5,000 mcg Methylcobalamin With Folic Acid is a dietary supplement by Protocol For Life Balance with 2 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Methyl B12 5,000 mcg Methylcobalamin With Folic Acid by Protocol For Life Balance

Ask about any prescription or over-the-counter medication and we check it for interactions with Methyl B12 5,000 mcg Methylcobalamin With Folic Acid by Protocol For Life Balance — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Methyl B12 5,000 mcg Methylcobalamin With Folic Acid by Protocol For Life Balance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Folate” is listed as a grouped ingredient — the label gives one combined amount (680 mcg DFE) without saying how much of each component you get.

This lozenge contains 2 active ingredients: vitamin B12 (as methylcobalamin) at 5,000 mcg, and a folic acid blend. The B12 supports energy metabolism and nerve function; folate plays a role in DNA synthesis and cell division.

The remaining ingredients are inactive — fructose, sorbitol, cellulose, citric acid, stearic acid, natural flavors, and magnesium stearate — which help form and flavor the lozenge.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support nervous system and healthy homocysteine metabolism.
  • We looked for evidence on: Vitamin B12 deficiency, Peripheral neuropathy, Chemotherapy-induced peripheral neuropathy, Hyperhomocysteinemia, Diabetic neuropathy, Multiple sclerosis (MS) — and 4 related terms.
  • The strongest evidence on file: Vitamin B12 is rated "Effective" for Vitamin B12 deficiency (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Possibly Effective" for Hyperhomocysteinemia.
  • Also on file: Vitamin B12 is rated "Insufficient Reliable Evidence To Rate" for Amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), Chemotherapy-induced peripheral neuropathy, Diabetic neuropathy, Multiple sclerosis (MS), and more.

Vitamin B12 is effective for treating B12 deficiency and Imerslund-Grasbeck disease (a rare inherited condition affecting B12 absorption). It's likely effective for cyanide poisoning.

The data also rates it possibly effective for canker sores and nerve pain after shingles (postherpetic neuralgia). We don't hold effectiveness information on the folic acid blend or quatrefolic for any specific purpose.

The evidence, ingredient by ingredient Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B12 is generally very well tolerated. Your body removes excess B12 through the urine, so there's no established upper limit and toxicity from oral doses is not a concern.

Allergic reactions like rash or hives are rare but have been reported. In one case, someone with a cobalt allergy developed a skin reaction to oral methylcobalamin.

B12 is needed during pregnancy and breastfeeding and is considered safe at recommended amounts — follow your healthcare provider's guidance on dosing. We don't have safety data on file for the folic acid blend or quatrefolic.

Side effects, ingredient by ingredient Vitamin B12

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin B12.
  • The most serious interaction on file is rated Minor.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Metformin is the main medication to double-check before starting this product — it can lower your B12 levels, though the interaction is Minor. We could not verify interactions with the folic acid blend or quatrefolic.

If you take any other prescriptions, use the search tool on this page to see if they're affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This supplement is useful if you have B12 deficiency or want to prevent one, especially if you take metformin (which can lower B12 over time). It's generally very safe with no upper limit.

Before starting it, check with your doctor or pharmacist, particularly if you take any prescription medications or have a history of allergies to vitamins or minerals.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Methyl B12 5,000 mcg Methylcobalamin With Folic Acid, straight from the product label.

Brand Protocol For Life Balance
Barcode (UPC) 707359104969
Net contents 60 Lozenge(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 292268
Product type Vitamin
Supplement form Lozenge
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Methyl B12 5,000 mcg Methylcobalamin With Folic Acid by Protocol For Life Balance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Lozenge(s)
Maximum serving Sizes:
1 Lozenge(s)
Servings per container
60
UPC/BARCODE
707359104969
IngredientAmount% DV
Folate680 mcg DFE170%
Vitamin B125 mg208333%
Quatrefolic400 mcg--

Other ingredients: Fructose, Sorbitol, Hydroxypropyl Cellulose, Microcrystalline Cellulose, Citric Acid, Stearic Acid, Natural Flavors, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested usage: Take 1 lozenge daily with a meal, or as directed by your healthcare practitioner. Chew lozenge or hold in mouth until dissolved and swallow.

Formula

How it works: Vitamin B12 has the largest and most complex chemical structure of all the vitamins. Most of its functions are related to its co-enzyme activity, such as enzymes required for the production of DNA during cell division, as well as for the proper disposal of homocysteine. B12 is also necessary for the maintenance of a healthy nervous system.

MTHF= Methyltetrahydrofolate

Precautions

Cautions/interactions: A number of drugs can affect vitamin B12 levels or its utilization. If you are taking any prescription medications, consult your healthcare practitioner before taking this product.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Healthy homocystein metabolism Supports healthy nervous system

Vegetarian/vegan

Natural color variation may occur in this product.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

FDA Statement of Identity

A Dietary Supplement

Brand IP Statement(s)

Quatrefolic is a registered trademark of Gnosis S.p.A. and protected by U.S. Patent 7,947,662.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Methyl B12 5,000 mcg Methylcobalamin With Folic Acid by Protocol For Life Balance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Methyl B12 5,000 mcg Methylcobalamin With Folic Acid label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Methyl B12 5,000 mcg Methylcobalamin With Folic Acid by Protocol For Life Balance

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Lozenge(s) Dosage formLozenge Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Folate

680 mcg DFE per serving
  • › Quatrefolic

Vitamin B12

Interacts with
20 drugs
5 mg per serving Form: Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Other (inactive) ingredients: Fructose, Sorbitol, Hydroxypropyl Cellulose, Microcrystalline Cellulose, Citric Acid, Stearic Acid, Natural Flavors, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Methyl B12 5,000 mcg Methylcobalamin With Folic Acid by Protocol For Life Balance Drug Interactions

Want to check YOUR meds against Methyl B12 5,000 mcg Methylcobalamin With Folic Acid?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Minor

Ingredients driving the most interactions

Vitamin B12 20

Individual Drug Interactions

The ingredients in Methyl B12 5,000 mcg Methylcobalamin With Folic Acid interact with 20 drugs. Click any drug to see the details.

1 of the 2 ingredients in Methyl B12 5,000 mcg Methylcobalamin With Folic Acid interact with drugs. Each result below shows which ingredient is responsible. Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Methyl B12 5,000 mcg Methylcobalamin With Folic Acid with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Methyl B12 5,000 mcg Methylcobalamin With Folic Acid, from the product label.

Protocol For Life Balance

See all Protocol For Life Balance products
Name
Protocol For Life Balance
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
www.protocolforlife.com
Pharmacist Counseling Corner

Methyl B12 5,000 mcg Methylcobalamin With Folic Acid by Protocol For Life Balance: Common Questions

Does Methyl B12 5,000 mcg Methylcobalamin With Folic Acid by Protocol For Life Balance interact with any medications?
Yes. Based on its ingredients, Methyl B12 5,000 mcg Methylcobalamin With Folic Acid has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Methyl B12 5,000 mcg Methylcobalamin With Folic Acid contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my B12 deficiency?
Yes, vitamin B12 is effective for treating B12 deficiency. This product supplies 5,000 mcg per lozenge as methylcobalamin, a highly absorbable form. That said, if your deficiency is severe or caused by a condition that blocks absorption, you may need injections instead — check with your doctor.
I take metformin for diabetes. Can I use this?
Metformin can lower your B12 levels over time by interfering with absorption, so taking this supplement makes sense. The interaction is Minor, meaning metformin won't prevent you from getting the B12 — it just increases your risk of needing it. Talk it over with your doctor or pharmacist.
Is it safe during pregnancy or breastfeeding?
Yes, B12 is needed during both pregnancy and breastfeeding and is considered safe at recommended amounts. Follow your healthcare provider's guidance on whether you need this specific dose.
What about the folic acid — what does it do?
Folate (folic acid) supports DNA synthesis and cell division. We don't have specific effectiveness data on file for the folic acid blend or its ingredient quatrefolic in this product, so ask your pharmacist if you'd like to know more about its intended purpose here.
Can I take too much B12?
No — B12 is very safe, and your body removes excess through urine, so there's no established upper limit. Toxicity from oral supplements is not a concern.
Are there any side effects?
Oral B12 is generally well tolerated with minimal side effects. Allergic reactions like rash or hives are rare but possible, especially if you have a cobalt allergy. Serious effects are very uncommon.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Methyl B12 5,000 mcg Methylcobalamin With Folic Acid is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Methyl B12 5,000 mcg Methylcobalamin With Folic Acid label
Go deeper

The Full Monographs Behind Methyl B12 5,000 mcg Methylcobalamin With Folic Acid’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

Methyl B12 5,000 mcg Methylcobalamin With Folic Acid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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