Modified Citrus Pectin Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Modified Citrus Pectin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Modified Citrus Pectin is a dietary supplement by Douglas Laboratories with 2 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,031 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, PectaSol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Modified Citrus Pectin by Douglas Laboratories
Ask about any prescription or over-the-counter medication and we check it for interactions with Modified Citrus Pectin by Douglas Laboratories — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Modified Citrus Pectin by Douglas Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: PectaSol, a form of pectin — a natural fiber extracted from citrus fruit. Pectin works by binding to substances in your digestive tract and is primarily used to help manage cholesterol levels.
The product has no other inactive ingredients listed.
Does it work?
Strong evidence
Research shows pectin is possibly effective for high cholesterol (hypercholesterolemia). For blood sugar control in prediabetes and for reducing damage from radiation exposure, the evidence we hold is insufficient to establish whether it works.
If you're considering this supplement for one of those uses, talk with your doctor about what the current research shows for your specific situation.
How safe is it?
Well-documented data
Pectin from food and typical supplement amounts is generally well tolerated. The most common side effects are digestive — diarrhea, gas, loose stools, and mild cramps.
Allergic reactions, including anaphylaxis in sensitive individuals, are rare but can happen; one documented case involved a young child with a history of oral allergy syndrome who experienced anaphylaxis after exposure to pectin. If you have a known citrus allergy or oral allergy syndrome, be cautious.
During pregnancy, pectin in food amounts is fine, but safety data for concentrated supplements has not been well studied — check with your doctor for personalized advice. The same applies to breastfeeding: dietary amounts are likely okay, but supplement safety while nursing hasn't been well studied.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your doctor or pharmacist if you take lovastatin, tetracycline antibiotics (such as doxycycline), or digoxin. All three interactions are Moderate severity and may reduce how well your medication works.
Do not start or stop this supplement on your own around any of these drugs.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Modified Citrus Pectin may help manage cholesterol, though evidence is still emerging. The main caution is that it can reduce absorption of lovastatin, tetracycline antibiotics, and digoxin.
If you take any of those medications, talk with your doctor or pharmacist before starting this product. It's generally easy on the digestive system, though some people experience mild gas or loose stools.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Modified Citrus Pectin, straight from the product label.
| Brand | Douglas Laboratories |
|---|---|
| Barcode (UPC) | 310539000472 |
| Net contents | 1 Pound(s); 454 g |
| Market status | On market |
| Date entered into DSLD | Jun 25, 2012 |
| DSLD ID | 10078 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Modified Citrus Pectin by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Carbohydrates | 5 g | 2% |
| Dietary Fiber | 5 g | 20% |
| PectaSol | 5 g | -- |
Other ingredients: None
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
PectaSol(R) Modified Citrus Pectin is a complex polysaccharide rich in galactosyl residues.
PectaSol(R) was developed by a research and development team working with the world's leading pectin scientists.
PectaSol(R) is manufactured to GMP/ISO-9001 standards. Meets requirements of GRAS, CAS, WHO, EC, FCC.
PectaSol(R) is a registered trademark of EcoNugenics(R), Inc. PectaSol(R) is protected under US Patent No. #6,274,566, #6,462,029 and #7,026,302.
General Statements
Ordinary pectin is a complex carbohydrate molecule found in almost all plants, which is not absorbed due to its long molecular chain. PectaSol(R)'s exclusive formulation and processing result in a shorter molecular chain that is readily absorbed, thus allowing the body to utilize the essential polysaccharide compounds.
A Natural Product Made from Citrus Fruit: Variations in color, texture or flavor may occur.
Formulation
This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives or flavoring.
Suggested/Recommended/Usage/Directions
Suggested Usage: As a dietary supplement, adults take 15 grams daily. Stirring briskly, dissolve 2 level teaspoons (approx 5 grams) of powder in water, juice or other liquid drink, 3 timer per day, or as directed by your healthcare professional.
Precautions
KEEP OUT OF REACH OF CHILDREN.
Tamper resistant package, do not use if outer seal is missing.
Storage
For optimal storage conditions, store in a cool, dry place. (59(0)-77(0)F/15(0)-25(0)C) (35-65% relative humidity)
General
Formula #82047
FDA Statement of Identity
A Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Modified Citrus Pectin by Douglas Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Modified Citrus Pectin by Douglas Laboratories
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size5 Gram(s) Dosage formPowder Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Dietary Fiber
Interacts with2,025 drugs
Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...
Dietary Fiber monograph & interactionsPectaSol
Interacts with23 drugs
Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly he...
PectaSol monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
Modified Citrus Pectin by Douglas Laboratories Drug Interactions
HelloPharmacist Interaction Report
Modified Citrus Pectin by Douglas Laboratories can interact with several medications through its pectin content.
The most serious interactions documented are Moderate severity and affect three drug types: lovastatin (a cholesterol medication), tetracycline antibiotics, and digoxin (a heart medication). Pectin may reduce how your body absorbs these drugs, potentially making them less effective.
Read the full breakdown — every affected drug type, severity by severity
With lovastatin, case reports suggest pectin can lower the cholesterol-lowering effect, possibly by reducing intestinal absorption. With tetracycline antibiotics, a small clinical study found that pectin (in a suspension with other compounds) reduced tetracycline absorption by roughly one-third.
With digoxin, a small study showed pectin-containing suspension reduced digoxin absorption by about 62%. In both antibiotic and heart medication cases, it's unclear whether pectin alone or a combination of ingredients caused the effect.
Altogether, these interactions span 23 individual medications. If you take any of these drug types, check your exact medications with the tool below before adding this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Modified Citrus Pectin?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Modified Citrus Pectin interact with 2,031 drugs. Click any drug to see the details.
2 of the 2 ingredients in Modified Citrus Pectin interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber PectaSol
Metformin, SitagliptinJanumet, Janumet XR
How Metformin, Sitagliptin interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Dietary Fiber + Metformin, Sitagliptin interactionMetronidazole, Tetracyline, Bismuth Subcitrate PotassiumPylera
How Metronidazole, Tetracyline, Bismuth Subcitrate Potassium interacts with Modified Citrus Pectin — through 2 ingredients. Tap an ingredient for the detail:
PectasolTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Pectasol + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium interactionMinocyclineAcnamino MR, Aknemin, Amzeeq, Arestin Miscrosperes, Dynacin, Minocin +6 more
How Minocycline interacts with Modified Citrus Pectin — through 2 ingredients. Tap an ingredient for the detail:
PectasolTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Pectasol + Minocycline interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Minocycline interactionMinocycline HydrochlorideMinolira, Ximino
How Minocycline Hydrochloride interacts with Modified Citrus Pectin — through 2 ingredients. Tap an ingredient for the detail:
PectasolTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Pectasol + Minocycline Hydrochloride interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Minocycline Hydrochloride interactionNiacin, LovastatinAdvicor
How Niacin, Lovastatin interacts with Modified Citrus Pectin — through 2 ingredients. Tap an ingredient for the detail:
PectasolLovastatin (mevacor) Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Read the full Pectasol + Niacin, Lovastatin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Niacin, Lovastatin interactionOlanzapineZyprexa
How Olanzapine interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Olanzapine (zyprexa) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Olanzapine interactionOmadacycline (iv)Nuzyra
How Omadacycline (iv) interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
PectasolTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Pectasol + Omadacycline (iv) interactionOmadacycline (oral)Nuzyra
How Omadacycline (oral) interacts with Modified Citrus Pectin — through 2 ingredients. Tap an ingredient for the detail:
PectasolTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Pectasol + Omadacycline (oral) interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Omadacycline (oral) interactionOxytetracyclineTerramycin
How Oxytetracycline interacts with Modified Citrus Pectin — through 2 ingredients. Tap an ingredient for the detail:
PectasolTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Pectasol + Oxytetracycline interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Oxytetracycline interactionOxytetracycline, Phenazopyridine, SulfamethizoleUrobiotic
How Oxytetracycline, Phenazopyridine, Sulfamethizole interacts with Modified Citrus Pectin — through 2 ingredients. Tap an ingredient for the detail:
PectasolTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Pectasol + Oxytetracycline, Phenazopyridine, Sulfamethizole interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Oxytetracycline, Phenazopyridine, Sulfamethizole interactionRetapamulinAltabax, Altargo
How Retapamulin interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
PectasolTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Pectasol + Retapamulin interactionSaxagliptin, Metformin XrKombiglyze
How Saxagliptin, Metformin Xr interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Saxagliptin, Metformin Xr interactionSitagliptin, MetforminZituvimet
How Sitagliptin, Metformin interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Sitagliptin, Metformin interactionTetracyclineAchromycin, Achromycin V, Nor-Tet, Robitet, Sumycin, Sumycin 250 +6 more
How Tetracycline interacts with Modified Citrus Pectin — through 2 ingredients. Tap an ingredient for the detail:
PectasolTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Pectasol + Tetracycline interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Tetracycline interactionTigecyclineTygacil
How Tigecycline interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
PectasolTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Pectasol + Tigecycline interactionPioglitazone, MetforminActoPlus Met
How Pioglitazone, Metformin interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Pioglitazone, Metformin interaction"phentolamineOraVerse, Rogitine, Ryzumvi
How "phentolamine interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + "phentolamine interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + 6-mercaptopurine interactionAbacavirZiagen
How Abacavir interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Abacavir interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acalabrutinib interactionAcamprosateCampral
How Acamprosate interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acamprosate interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Modified Citrus Pectin — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acebutolol interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Modified Citrus Pectin with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Dietary Fiber
Carbamazepine (Tegretol)
Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.
Lithium
Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.
Metformin (Glucophage)
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
Olanzapine (Zyprexa)
Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.
Digoxin (Lanoxin)
Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.
Ethinyl Estradiol
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.
Oral Drugs
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.
PectaSol
Digoxin (Lanoxin)
Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
A small clinical study shows that taking digoxin with a kaolin-pectin suspension reduces the absorption of digoxin by about 62%. It is unclear if these effects are due to pectin, kaolin, or the combination.
Lovastatin (Mevacor)
Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Case reports suggest that concomitant use of pectin and lovastatin might reduce the cholesterol-lowering effect of lovastatin, possibly due to reduced intestinal absorption of lovastatin.
Tetracycline Antibiotics
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
A small clinical study shows that taking tetracycline with bismuth subsalicylate in a kaolin-pectin suspension reduces the absorption of tetracycline by about 34%. It is unclear if these effects are due to pectin, kaolin, bismuth subsalicylate, or the combination.
Brand information
Manufacturer and brand details for Modified Citrus Pectin, from the product label.
Douglas Laboratories
See all Douglas Laboratories products- Name
- Douglas Laboratories
- Street Address
- 600 Boyce Road
- City
- Pittsburgh
- State
- PA
- ZipCode
- 15205
- Web Address
- www.douglaslabs.com
Modified Citrus Pectin by Douglas Laboratories: Common Questions
Does Modified Citrus Pectin by Douglas Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
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What exactly is PectaSol?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Modified Citrus Pectin is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Modified Citrus Pectin’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Black Psyllium
Interacts with 2,025 drugsBlack psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...
Read the full Black Psyllium monograph → Herb & supplement monographPectin
Interacts with 23 drugsPectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly help with cholesterol, blood sugar, and di...
Read the full Pectin monograph →Sources & How We Checked
Modified Citrus Pectin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 29 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Psyllium 18 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
- Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
- Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
- Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
- Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
- Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
- Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
- Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
- Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
- Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
- Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
- Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
- Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
- Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed
Pectin 11 references
- Jaakkola MS, et al. Asthma caused by occupational exposure to pectin. J Allergy Clin Immunol 1997;100:575-6. PubMed
- Westphal W, et al. [Exogenous allergic asthma following pectin exposure-a new occupational allergen]. Pneumologie 1990;44(Suppl 1):337-8.
- Baldwin JL, et al. Pectin-induced occupational asthma. Chest 1993;104:1936-7. PubMed
- Cohen AJ, Forse MS, Tarlo SM. Occupational asthma caused by pectin inhalation during the manufacture of jam. Chest 1993;103:309-11.
- Kraut A, et al. Christmas candy maker's asthma. IgG4-mediated pectin allergy. Chest 1992;102:1605-7. PubMed
- Richter WO, Jacob BG, Schwandt P. Interaction between fibre and lovastatin. Lancet 1991;338:706.
- Albert KS, Ayres JW, DiSanto AR, et al. Influence of kaolin-pectin suspension on digoxin bioavailability. J Pharm Sci 1978;67:1582-6. PubMed
- Albert KS, Welch RD, DeSante KA, et al. Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture. J Pharm Sci 1979;68:586-8. PubMed
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Federal Register April 17,2003. Anti-Diarrheal Products for over-the-counter human use; final monograph. Available at: http://www.fda.gov/OHRMS/DOCKETS/98fr/03-9380.pdf (Accessed 27 December 2004).
- Washio K, Nakamura M, Sato N, et al. Anaphylaxis in a pectin- and cashew nut-allergic child caused by a citrus bath. Allergol Int 2022;71(1):155-157. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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