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Dietary supplement

Mood & Stress Probiotic Ingredients & Drug Interactions

by Renew Life

Mood & Stress Probiotic label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mood & Stress Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mood & Stress Probiotic is a dietary supplement by Renew Life with 2 active ingredients. Its ingredients are commonly taken for digestive health and regularity, irritable bowel syndrome (ibs), diarrhea (including antibiotic-related).Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium longum, Lactobacillus helveticus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Mood & Stress Probiotic by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Mood & Stress Probiotic by Renew Life — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Mood & Stress Probiotic by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Mood & Stress Probiotic Culture Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product contains 2 active ingredients: Bifidobacterium longum and Lactobacillus helveticus, both live probiotic bacteria designed to support your gut microbiome and potentially help with mood and stress. The inactive ingredients are potato starch, magnesium stearate, and a capsule shell.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: mood and stress support with digestive comfort.
  • We looked for evidence on: Generalized anxiety disorder (GAD), Depression, Irritable bowel syndrome (IBS), Diarrhea, Antibiotic-associated diarrhea, Abdominal pain — and 2 related terms.
  • The closest evidence on file: Bifidobacterium Longum is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Bifidobacterium Longum is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD), Depression, Diarrhea, Irritable bowel syndrome (IBS), and more.

The evidence for both Bifidobacterium longum and Lactobacillus helveticus is limited. For Bifidobacterium longum, there isn't enough reliable evidence to rate it for age-related cognitive decline, allergic rhinitis (hay fever), antibiotic-associated diarrhea, generalized anxiety disorder (GAD), asthma, or athletic performance.

Similarly, Lactobacillus helveticus shows insufficient reliable evidence for allergic rhinitis, antibiotic-associated diarrhea, cognitive function, depression, rotaviral diarrhea, or exercise-induced respiratory infections. The bottom line: we don't yet have strong data to confirm what this product can do for the conditions it targets.

The evidence, ingredient by ingredient Bifidobacterium Longum Lactobacillus Helveticus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both probiotics are generally well tolerated in healthy people, but if you're seriously ill or have a weakened immune system, talk with your doctor before taking this product — the safety data for those situations are limited. Rare gastrointestinal side effects have been reported with Bifidobacterium longum, including abdominal discomfort, flatulence, constipation, and distension.

There's also a rare case report of a dry cough. In very rare and serious cases, both bacteria have been isolated in bloodstream infections, mostly in critically ill or premature infants — a reminder that probiotics carry a small risk in vulnerable populations.

Lactobacillus helveticus is rated possibly safe in pregnancy and lactation, but safety data are limited, so check with your doctor before use.

Side effects, ingredient by ingredient Bifidobacterium Longum Lactobacillus Helveticus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Bifidobacterium Longum, Lactobacillus Helveticus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product alongside antibiotic drugs. Both Bifidobacterium longum and Lactobacillus helveticus can lose effectiveness if antibiotics kill the live organisms — timing them separately (usually a few hours apart) can help prevent that.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may appeal to you if you're looking to support gut health alongside mood and stress — but the evidence that it works for these purposes isn't yet strong. If you take antibiotics, you'll need to space them away from this product so the antibiotics don't kill off the live bacteria.

If you're seriously ill, immunocompromised, pregnant, or breastfeeding, talk with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mood & Stress Probiotic, straight from the product label.

Brand Renew Life
Barcode (UPC) 631257120144
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2022
DSLD ID 272943
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mood & Stress Probiotic by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
631257120144
IngredientAmount% DV
Bifidobacterium longum0 NP--
Lactobacillus helveticus0 NP--
Mood & Stress Probiotic Culture Blend0 NP--

Other ingredients: Potato Starch, Capsule, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Helps moderate everyday stress and reduce GI-related discomfort

Gluten free

Quality, purity and potency guaranteed through expiration.

Made in Canada of global ingredients.

Helps support healthy levels of cortisol

Free of gluten

Formula

3 billion live cultures 2 probiotic strains

Contains a blend of strains to reflect the natural diversity of your gut

FDA Statement of Identity

Probiotic Supplement

Suggested/Recommended/Usage/Directions

Directions: For best results, take one (1) capsule with food daily.

Precautions

Contains soy and milk traces from culture media.

Keep out of reach of children.

Consult your physician prior to using this or any product if you are pregnant, nursing, taking any medication or have a medical condition.

Storage

Store at 77 degrees F (25 degrees C) or below. Best if refrigerated.

Brand IP Statement(s)

Copyright 2018 Patents: www.renewlife.com/patents

General Statements

Questions or comments? 1-800-830-1800 or www.renewlife.com Please recycle this box At Renew Life, we're probiotic pioneers With double decades of experience and innovation on our side to help keep you and your gut healthy and happy. Visit RenewLife.com for help finding the right probiotic for you. Did you know your gut is home to 70% of your immune system? It's also home to trillions of bacteria. And stress, diet, antibiotics and just growing older can throw them out of balance. Renew Life probiotics help restore digestive harmony and support immune health so your gut works smarter. Helping you feel lighter, brighter and more energized to take on the day.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mood & Stress Probiotic by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mood & Stress Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mood & Stress Probiotic by Renew Life

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Mood & Stress Probiotic Culture Blend

0 NP per serving

Other (inactive) ingredients: Potato Starch, Capsule, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mood & Stress Probiotic by Renew Life Drug Interactions

Want to check YOUR meds against Mood & Stress Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium longum 182
Lactobacillus helveticus 182

Individual Drug Interactions

The ingredients in Mood & Stress Probiotic interact with 182 drugs. Click any drug to see the details.

2 of the 2 ingredients in Mood & Stress Probiotic interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium longum Lactobacillus helveticus

Each ingredient & the kinds of drugs it affects

For each ingredient in Mood & Stress Probiotic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium longum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum full monograph & interactions

Lactobacillus helveticus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus helveticus with antibiotic drugs might decrease the effectiveness of L. helveticus.
Lactobacillus helveticus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. helveticus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus helveticus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mood & Stress Probiotic, from the product label.

Renew Life

Name
Renew Life Formulas, Inc.
City
Palm Harbor
State
FL
ZipCode
34683
Phone Number
1-800-830-1800
Web Address
www.renewlife.com
Pharmacist Counseling Corner

Mood & Stress Probiotic by Renew Life: Common Questions

Does Mood & Stress Probiotic by Renew Life interact with any medications?
Yes. Based on its ingredients, Mood & Stress Probiotic has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mood & Stress Probiotic contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this work for anxiety or depression?
The evidence isn't strong enough yet to say. While Lactobacillus helveticus has been studied for depression and Bifidobacterium longum for generalized anxiety, we don't hold reliable data showing either one works. If you're interested in trying it, talk with your doctor about whether it's right for you alongside any other treatments you're using.
Can I take this while I'm on antibiotics?
You can, but timing matters. Antibiotics can kill the live bacteria in this product, making it less effective. Your doctor or pharmacist can help you space out when you take the antibiotic and the probiotic — usually a few hours apart works.
Is it safe to take while breastfeeding?
Lactobacillus helveticus is rated possibly safe in pregnancy and lactation, but safety data are limited. Bifidobacterium longum has safety notes but no pregnancy/lactation rating on file. Check with your doctor or pharmacist before using while breastfeeding to make sure it's right for you.
What side effects have been reported?
Both bacteria are generally well tolerated, but rare gastrointestinal effects like abdominal discomfort, flatulence, and constipation have been reported with Bifidobacterium longum. One person reported a dry cough in a trial. Very rare but serious infections have occurred in critically ill patients — so let your doctor know if you're seriously ill or immunocompromised.
What are these bacteria supposed to do?
Bifidobacterium longum and Lactobacillus helveticus are live probiotic bacteria meant to support your gut microbiome's balance, which in theory may help with mood, stress, digestion, and immune function — but we don't have strong evidence yet that this product delivers those benefits.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mood & Stress Probiotic label
Go deeper

The Full Monographs Behind Mood & Stress Probiotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Lactobacillus Helveticus

Interacts with 182 drugs

Lactobacillus helveticus is a lactic acid bacterium used as a probiotic, often combined with other strains in mood, gut, and general wellness products. Early research is interesting—especial...

Read the full Lactobacillus Helveticus monograph →
Sources

Sources & How We Checked

Mood & Stress Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Lactobacillus Helveticus 2 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed

See these in context on the Lactobacillus Helveticus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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