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Dietary supplement

Motherwort Ingredients & Drug Interactions

by Village Vitality

Motherwort label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Motherwort against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Motherwort is a dietary supplement by Village Vitality with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, heart palpitations, menstrual discomfort.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are certified organic Motherwort. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Motherwort by Village Vitality

Ask about any prescription or over-the-counter medication and we check it for interactions with Motherwort by Village Vitality — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Motherwort by Village Vitality

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: certified organic motherwort. The liquid also includes grain alcohol and deionized water as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Motherwort's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports heart, menstrual, and sleep wellness.
  • We looked for evidence on: Anxiety, Arrhythmia, Dysmenorrhea, Insomnia, Menopausal symptoms, Heart palpitations — and 2 related terms.
  • The closest evidence on file: Motherwort is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Motherwort is rated "Insufficient Reliable Evidence To Rate" for Arrhythmia, Insomnia, Menopausal symptoms, Dysmenorrhea.

The evidence supporting motherwort is mixed. It's rated possibly effective for bleeding.

For anxiety, amenorrhea (absent periods), asthma, and alcohol use disorder, the data we hold show insufficient evidence to rate it — meaning we don't have enough reliable research to confirm whether it works for these uses.

The evidence, ingredient by ingredient Motherwort

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Motherwort appears to be generally well tolerated when taken by mouth. The most common side effects are diarrhea and stomach irritation.

Amounts larger than 3 grams taken orally can cause uterine bleeding. Topically, it may cause contact dermatitis or photosensitivity (a skin reaction to sunlight).

The safety data advises against motherwort in pregnancy because it's traditionally thought to stimulate the uterus. There isn't enough safety information available for breastfeeding, and human safety data overall are limited.

Talk with your doctor or pharmacist before using it if you're pregnant, nursing, or planning to become pregnant.

Side effects, ingredient by ingredient Motherwort

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Motherwort.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against motherwort if you take any central nervous system (CNS) depressants — sedatives, sleep aids, anti-anxiety drugs, or certain pain relievers — because motherwort may increase drowsiness and sedation.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Motherwort may be worth considering if you're interested in herbal support for bleeding and you've checked with your pharmacist about your medications — especially if you take sedatives or sleep aids. Pregnant and nursing women should avoid it.

Because safety data are limited and CNS depressants are a real concern, run your medication list through the checker before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Motherwort, straight from the product label.

Brand Village Vitality
Barcode (UPC) 788332042812
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 216268
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Motherwort by Village Vitality, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 mL
Maximum serving Sizes:
1.33 mL
Servings per container
30
UPC/BARCODE
788332042812
IngredientAmount% DV
certified organic Motherwort333 mg--

Other ingredients: Grain Alcohol, deionized Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: 15-40 drops in water or juice, 2-3 times daily, or as needed. Shake well before using.

Precautions

Warnings: Do not take during pregnancy.

Keep out of the reach of children.

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Motherwort by Village Vitality label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Motherwort label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Motherwort by Village Vitality

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.5 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Certified organic Motherwort

Interacts with
248 drugs
333 mg per serving

Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human ev...

Certified organic Motherwort monograph & interactions

Other (inactive) ingredients: Grain Alcohol, Deionized Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Motherwort by Village Vitality Drug Interactions

Want to check YOUR meds against Motherwort?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

certified organic Motherwort 248

Individual Drug Interactions

The ingredients in Motherwort interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Motherwort interact with drugs. Each result below shows which ingredient is responsible. certified organic Motherwort

Each ingredient & the kinds of drugs it affects

For each ingredient in Motherwort with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

certified organic Motherwort1 drug type · 248 drugs

Cns Depressants

Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Motherwort has been reported to cause CNS depression and sedation.

Likelihood Possible Evidence D
certified organic Motherwort full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Motherwort, from the product label.

Village Vitality

See all Village Vitality products
Name
Woodstock Apothecary
Street Address
79 Tinker Street
City
Woodstock
State
NY
ZipCode
12498
Pharmacist Counseling Corner

Motherwort by Village Vitality: Common Questions

Does Motherwort by Village Vitality interact with any medications?
Yes. Based on its ingredients, Motherwort has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Motherwort contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is motherwort used for?
Motherwort is rated possibly effective for bleeding. For anxiety, amenorrhea, asthma, and alcohol use disorder, the evidence we have is insufficient to say whether it works.
Can I take motherwort while pregnant?
No. The safety data advise against motherwort in pregnancy because it's traditionally thought to stimulate the uterus. Talk with your doctor or pharmacist if you're pregnant or planning to become pregnant.
Is motherwort safe to breastfeed with?
There isn't enough safety information available to know either way. Talk with your doctor or pharmacist for personalized advice if you're breastfeeding.
What are the side effects of motherwort?
Taken by mouth, the most common side effects are diarrhea and stomach irritation. Amounts over 3 grams can cause uterine bleeding. Applied to the skin, it may cause contact dermatitis or a photosensitivity reaction (a rash triggered by sunlight).
Can I take motherwort with sleep aids or sedatives?
Talk with your pharmacist first. Motherwort can cause drowsiness on its own, and taking it with CNS depressants like sleep aids or sedatives may increase that effect.
How much motherwort is safe to take?
The safety data note that use above 3 grams orally can cause uterine bleeding. Human safety data are limited overall, so talk with your pharmacist or doctor about the right dose for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Motherwort is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Motherwort label
Go deeper

The Full Monographs Behind Motherwort’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Motherwort

Interacts with 248 drugs

Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human evidence is very limited. It should be avo...

Read the full Motherwort monograph →
Sources

Sources & How We Checked

Motherwort's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Motherwort 6 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wojtyniak K, Szymanski M, Matlawska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res 2013;27(8):1115-20.
  5. Xia WT, Zhou H, Wang Y, et al. Motherwort injection in preventing post-abortion hemorrhage after induced abortion: A multi-center, prospective, randomized controlled trial. Explore (NY). 2019. pii: S1550-8307(19)30447-1. PubMed
  6. Cao Shan DOSOGC, Zhang W, Zhao Z, et al. Post-marketing safety surveillance and reevaluation of Motherwort injection: A clinical study of 10 094 cases. J Tradit Chin Med. 2018 Aug;38(4):625-635. DOI

See these in context on the Motherwort monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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