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Dietary supplement

MPS-X10 Rainbow Unicorn Ingredients & Drug Interactions

by Vital Pharmaceuticals

MPS-X10 Rainbow Unicorn label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking MPS-X10 Rainbow Unicorn against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

MPS-X10 Rainbow Unicorn is a dietary supplement by Vital Pharmaceuticals with 2 active ingredients.Based on those ingredients, 407 medications have a known interaction with it, the most serious rated major. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against MPS-X10 Rainbow Unicorn by Vital Pharmaceuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with MPS-X10 Rainbow Unicorn by Vital Pharmaceuticals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of MPS-X10 Rainbow Unicorn by Vital Pharmaceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 9 active ingredients.
  • “Essential Amino Acids” is listed as a grouped ingredient — the label gives one combined amount (10,000 mg) without saying how much of each component you get.
  • “Branched Chain Amino Acids” is listed as a grouped ingredient — the label gives one combined amount (7,500 mg) without saying how much of each component you get.
  • “Other Essential Amino Acids” is listed as a grouped ingredient — the label gives one combined amount (2,500 mg) without saying how much of each component you get.

MPS-X10 Rainbow Unicorn is a powder blend of nine amino acids — the building blocks your body uses to make proteins. The product contains L-leucine, L-isoleucine, L-methionine, L-lysine hydrochloride, L-phenylalanine, L-valine, L-histidine hydrochloride, L-threonine, and L-tryptophan, plus several inactive ingredients (malic acid, natural flavors, citric acid, and sucralose) that add taste and texture.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Supports lean muscle mass, strength, and recovery.
  • We looked for evidence on: Athletic performance, Muscle strength, Wound healing, Muscle protein synthesis, Post-workout recovery, Muscle hypertrophy — and 1 related terms.
  • The closest evidence on file: Methionine is rated "Insufficient Reliable Evidence To Rate" for Wound healing (Natural Medicines).
  • Also on file: Lysine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Muscle strength.
  • Also on file: L-tryptophan is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

The evidence for these amino acids is mixed. L-lysine is possibly effective for cold sores (herpes labialis).

L-methionine is possibly effective for preventing neural tube birth defects (though food sources and prenatal vitamins are the standard). L-histidine is possibly effective for cholera.

L-phenylalanine is possibly ineffective for ADHD. L-tryptophan and L-threonine are possibly ineffective for the conditions studied (depression and ALS, respectively).

For most other uses listed — athletic performance, anxiety, multiple sclerosis, kidney failure, rheumatoid arthritis — the evidence in our data is insufficient to rate effectiveness.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-methionine is generally well tolerated in food amounts, but high-dose supplements may cause dizziness, drowsiness, headache, nausea, and vomiting; it should be used only under medical guidance. L-lysine is generally well tolerated at typical doses, though some people report abdominal pain, diarrhea, or stomach upset; long-term safety is not well studied.

L-phenylalanine is generally tolerated in food amounts but can cause anxiety, constipation, headache, heartburn, insomnia, nausea, and sedation at higher doses. L-tryptophan is generally well tolerated but may cause drowsiness, nausea, headache, heartburn, and diarrhea; it has a past history of contaminated products associated with a serious neurological condition (though the risk was traced to one manufacturer).

L-threonine may cause headache and minor digestive upset (diarrhea, constipation, gas). L-histidine side effects are not documented in our data.

L-valine, L-isoleucine, and L-leucine safety data are not on file.

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 6 matched ingredients can interact with medications — Lysine, L-tryptophan, Phenylalanine, Threonine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 407 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take levodopa (Parkinson disease medication) — phenylalanine can reduce its effectiveness. Also double-check if you take baclofen (muscle relaxant), an MAOI antidepressant, CNS depressants (such as sedatives, sleep aids, or opioids), serotonergic antidepressants (SSRIs), or NMDA antagonists (such as memantine).

Run your complete medication list through the checker below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product is a branched and essential amino acid blend. If you take levodopa (Parkinson disease), baclofen (muscle spasticity), an MAOI antidepressant, a CNS depressant (sedative or opioid), an SSRI or other serotonergic drug, or an NMDA antagonist (like memantine), check your exact medications with the tool on this page before starting.

Talk to your pharmacist if you have questions about how this fits your medications or health.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about MPS-X10 Rainbow Unicorn, straight from the product label.

Brand Vital Pharmaceuticals
Barcode (UPC) 610764024008
Net contents 0.79 lb(s); 358 Gram(s)
Market status On market
Date entered into DSLD Sep 24, 2021
DSLD ID 252325
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for MPS-X10 Rainbow Unicorn by Vital Pharmaceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
12.8 Gram(s)
Maximum serving Sizes:
12.8 Gram(s)
Servings per container
28
UPC/BARCODE
610764024008
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
L-Leucine3000 mg--
L-Isoleucine3000 mg--
L-Methionine0 NP--
L-Lysine Hydrochloride0 NP--
L-Phenylalanine0 NP--
L-Valine1500 mg--
L-Histidine Hydrochloride0 NP--
L-Threonine0 NP--
L-Tryptophan0 NP--
Essential Amino Acids10000 mg--
Branched Chain Amino Acids7500 mg--
Other Essential Amino Acids2500 mg--

Other ingredients: Malic Acid, Natural Flavors, Citric Acid, Sucralose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Lean mass MPS & recovery

Muscle protein synthesizer Multifunctional Pre, intra & post-workout - Supports lean muscle mass, strength, and recovery - Supports increased muscle protein synthesis - Full spectrum essential amino acids

Strength

GMP Compliant facility

Gluten free

Vegan friendly

Formula

10,000 EAAs

MPS-X10 contains a full spectrum of Essential Amino Acids (EAAs), which are the building blocks of muscle. EAAs are necessary for increasing muscle protein synthesis and have a muscle-sparing effect on the muscle tissue. Recent research suggests that EAAs are superior to Branched Chain Amino Acids (BCAAs) for increasing muscle protein synthesis. What separates MPS-X10 from every other amino acid supplement on the market is the 2:2:1 Leucine, Isoleucine, Valine ratio of BCAAs. Many supplement companies erroneously have increased Leucine content in the BCAA profile, however this is scientifically flawed. The latest studies conclude that there is a "leucine threshold" and further increasing leucine will have no further increase in muscle protein synthesis. Consuming the 2:2:1 BCAA ratio in MPS-X10 in conjunction with other essential amino acids allows you to maximize protein synthesis, but also increase insulin sensitivity.

Rainbow Unicorn Natural flavors

Product contains heat and moisture sensitive materials which can cause clumping and settling.

General Statements

Jack Owoc CEO, VPX/Redline/Bang Tiktok Instagram Bangenergy.ceo LinkedIn Jackowoc 100% Money back guarantee I am so confident in our products' effectiveness that I guarantee them. If you are not satisfied with the product, please send it back to us in the original packaging within 40 days of purchase for a full refund.

Bang Potent brain and body fuel

VPX_Sports

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Precautions

Allergen warning: Produced in a facility that may also process ingredients containing milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, and soybeans.

Warnings: This product is only intended for healthy adults, 18 years of age or older.

Do not use if pregnant or nursing.

Consult with a licensed, qualified healthcare professional before taking this or any dietary supplement product. Use only as directed. Do not use if safety seal is broken or missing.

Keep out of reach of children.

Do not purchase if safety seal is broken or missing.

To report a serious adverse event or obtain product information, contact (954) 641-0570 ext 3508

Suggested/Recommended/Usage/Directions

Recommended use: Mix one scoop of MPS-X10 2:2:1 with 10 oz. of water or your favorite beverage. For advanced athletes and bodybuilders, drink Bang Master Blaster prior to training, MPS-X10 2:2:1 during training and 40 grams of Pristine Protein Zero Carb Whey Protein Isolate after training, or any athletic event. Always consume at least 1/2 an ounce of water for each pound of body weight. For best results use 2 to 3 servings of MPS-X10 2:2:1 daily including non-training days.

Storage

Store in a cool dry place.

Protect from heat, light and moisture.

Store at 59 degrees F - 77 degrees F (15 degrees C - 25 degrees C)

Brand IP Statement(s)

Copyright 2020 Vital Pharmaceuticals, Inc. All rights reserved.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

MPS-X10 Rainbow Unicorn by Vital Pharmaceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

MPS-X10 Rainbow Unicorn label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in MPS-X10 Rainbow Unicorn by Vital Pharmaceuticals

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size12.8 Gram(s) Dosage formPowder Servings per container28 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Essential Amino Acids

10000 mg per serving
  • › Branched Chain Amino Acids
  • › Other Essential Amino Acids

Other (inactive) ingredients: Malic Acid, Natural Flavors, Citric Acid, Sucralose. These complete the product’s ingredient list but are not active constituents.

Interaction report

MPS-X10 Rainbow Unicorn by Vital Pharmaceuticals Drug Interactions

Want to check YOUR meds against MPS-X10 Rainbow Unicorn?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
407Drugs
256 Major 151 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in MPS-X10 Rainbow Unicorn interact with 407 drugs. Click any drug to see the details.

0 of the 2 ingredients in MPS-X10 Rainbow Unicorn interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in MPS-X10 Rainbow Unicorn with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for MPS-X10 Rainbow Unicorn, from the product label.

Vital Pharmaceuticals

See all Vital Pharmaceuticals products
Name
Vital Pharmaceuticals, Inc.
Street Address
1600 North Park Dr.
City
Weston
State
FL
ZipCode
33326
Phone Number
(954) 641-0570 EXT (3508)
Web Address
bang-energy.com
Pharmacist Counseling Corner

MPS-X10 Rainbow Unicorn by Vital Pharmaceuticals: Common Questions

Does MPS-X10 Rainbow Unicorn by Vital Pharmaceuticals interact with any medications?
Yes. Based on its ingredients, MPS-X10 Rainbow Unicorn has a known interaction with 407 medications, including 256 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
MPS-X10 Rainbow Unicorn contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe during pregnancy?
It depends on the ingredient. L-methionine and L-histidine are likely safe in pregnancy. L-phenylalanine and L-tryptophan should be avoided — safety data does not support their use in pregnancy. For L-lysine and L-threonine, supplemental doses have not been well studied in pregnancy, so check with your doctor first. Talk to your obstetrician or pharmacist before taking any supplement while pregnant.
Can I take this while breastfeeding?
L-methionine is likely safe. L-phenylalanine and L-tryptophan should be avoided — safety data does not support use while breastfeeding. L-lysine, L-threonine, and L-histidine have not been well studied during breastfeeding, so caution is advised — ask your doctor or pharmacist before starting.
What's L-tryptophan for, and why does the label mention a safety scare?
L-tryptophan is an amino acid your body uses to make serotonin, which affects mood and sleep. In 1989–1990, a contaminated batch from a single Japanese manufacturer caused a rare neurological condition (eosinophilia-myalgia syndrome) in over 1,500 people in the US. Modern products are regulated more carefully now, but the ingredient does have a documented safety history you should know about.
Will this help me build muscle or improve athletic performance?
These are amino acids, which your body needs for muscle, but the evidence in our data doesn't show that L-tryptophan or L-threonine are effective for athletic performance. If muscle building is your goal, talk to your doctor or a sports nutritionist about whether amino acid supplements are right for you.
What are the main side effects I should watch for?
Common side effects may include headache, nausea, diarrhea, constipation, heartburn, and drowsiness. L-phenylalanine in particular can cause anxiety and insomnia. If you're sensitive to any amino acid, start with a small dose and watch for stomach upset or mood changes.
Can I take this if I have phenylketonuria (PKU)?
No. L-phenylalanine is not safe for people with PKU. Talk to your doctor before taking any supplement if you have this condition.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if MPS-X10 Rainbow Unicorn is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

MPS-X10 Rainbow Unicorn label
Sources

Sources & How We Checked

MPS-X10 Rainbow Unicorn's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 67 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Methionine 12 references
  1. La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
  2. Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
  3. Cottington EM, LaMantia C, Stabler SP, et al. Adverse event associated with methionine loading test: a case report. Arterioscler Thromb Vasc Biol 2002;22:1046-50.. PubMed
  4. Anon. Should methionine be added to paracetamol formulations? Drug Ther Perspect 1997;10:11-3. DOI
  5. Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
  6. McAuley, D. F., Hanratty, C. G., McGurk, C., Nugent, A. G., and Johnston, G. D. Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation. J.Toxicol.Clin.Toxicol. 1999;37(4):435-440. PubMed
  7. Hanratty, C. G., McGrath, L. T., McAuley, D. F., Young, I. S., and Johnston, G. D. The effects of oral methionine and homocysteine on endothelial function. Heart 2001;85(3):326-330. PubMed
  8. Ward, M., McNulty, H., McPartlin, J., Strain, J. J., Weir, D. G., and Scott, J. M. Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. Int.J.Vitam.Nutr.Res. 2001;71(1):82-86. PubMed
  9. Yaghmai, R., Kashani, A. H., Geraghty, M. T., Okoh, J., Pomper, M., Tangerman, A., Wagner, C., Stabler, S. P., Allen, R. H., Mudd, S. H., and Braverman, N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient
  10. Talukdar R, Murthy HV, Reddy DN. Role of methionine containing antioxidant combination in the management of pain in chronic pancreatitis: a systematic review and meta-analysis. Pancreatology 2015;15(2):136-44. PubMed
  11. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226 DOI
  12. Khairan P, Sobue T, Eshak ES, et al. Association of B Vitamins and Methionine Intake with the Risk of Gastric Cancer: The Japan Public Health Center-based Prospective Study. Cancer Prev Res (Phila) 2022;15(2):101-110. PubMed

See these in context on the Methionine monograph →

Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
  3. DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
  4. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  5. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
  6. Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
  7. Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.

See these in context on the Lysine monograph →

Phenylalanine 23 references
  1. Rouse B, Azen C, Koch R, et al. Maternal phenylketonuria collaborative Study (MPKUCS) offspring: facial anomalies, malformations, and early neurological sequelae. Am J Med Genet 1997;69:89-95. DOI
  2. Sturtevant FM. Use of aspartame in pregnancy. Int J Fertil 1985;30:85-7.
  3. Silkaitis RP, Mosnaim AD. Pathways linking L-phenylalanine and 2-phenylethylamine with p-tyramine in rabbit brain. Brain Res 1976;114:105-15.
  4. Lehmann WD, Theobald N, Fischer R, Heinrich HC. Stereospecificity of phenylalanine plasma kinetics and hydroxylation in man following oral application of a stable isotope-labelled pseudo-racemic mixture of L- and D-phenylalanine. Clin Chim Acta 1983;128 PubMed
  5. Mosnik DM, Spring B, Rogers K, Baruah S. Tardive dyskinesia exacerbated after ingestion of phenylalanine by schizophrenic patients. Neuropsychopharmacology 1997;16:136-46. PubMed
  6. Siddiqui AH, Stolk LM, Bhaggoe R, et al. L-phenylalanine and UVA irradiation in the treatment of vitiligo. Dermatology 1994;88:215-8. PubMed
  7. Birkmayer W, Riederer P, Linauer W, Knoll J. L-deprenyl plus L-phenylalanine in the treatment of depression. J Neural Transm 1984;59:81-7. PubMed
  8. Nutt JG, Woodward WR, Hammerstad JP, et al. The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport. N Engl J Med 1984;310:483-8. PubMed
  9. Baruzzi A, Contin M, Riva R, et al. Influence of meal ingestion time on pharmacokinetics of orally administered levodopa in parkinsonian patients. Clin Neuropharmacol 1987;10:527-37. PubMed
  10. Juncos JL, Fabbrini G, Mouradian MM, et al. Dietary influences on the antiparkinsonian response to levodopa. Arch Neurol 1987;44:1003-5. PubMed
  11. Eriksson T, Granerus AK, Linde A, et al. "On-off" phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma. Neurology 1988;38:1245-8. PubMed
  12. Baker GB, Bornstein RA, Rouget AC, et al. Phenylethylaminergic mechanisms in attention-deficit disorder. Biol Psychiatry 1991;29:15-22.. PubMed
  13. Wood DR, Reimherr FW, Wender PH. Treatment of attention deficit disorder with DL-phenylalanine. Psychiatry Res 1985;16:21-6.. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, DC: National Academy Press, 2002. Available at: http://www.n
  15. Cederbaum S. Phenylketonuria: an update. Curr Opin Pediatr 2002;14:702-6. PubMed
  16. Cejudo-Ferragud, E., Nacher, A., Polache, A., Cercos-Fortea, T., Merino, M., and Casabo, V. G. Evidence of competitive inhibition for the intestinal absorption of baclofen by phenylalanine. Int J of Pharm (Amsterdam) 1996;132:63-69. DOI
  17. Fischer, E., Heller, B., Nachon, M., and Spatz, H. Therapy of depression by phenylalanine. Preliminary note. Arzneimittelforschung. 1975;25(1):132.
  18. Beckmann, H., Strauss, M. A., and Ludolph, E. Dl-phenylalanine in depressed patients: an open study. J.Neural Transm. 1977;41(2-3):123-134. PubMed
  19. Sabelli, H. C., Fawcett, J., Gusovsky, F., Javaid, J. I., Wynn, P., Edwards, J., Jeffriess, H., and Kravitz, H. Clinical studies on the phenylethylamine hypothesis of affective disorder: urine and blood phenylacetic acid and phenylalanine dietary supplem
  20. Cotzias, G. C., Van Woert, M. H., and Schiffer, L. M. Aromatic amino acids and modification of parkinsonism. N Engl.J Med 2-16-1967;276(7):374-379. PubMed
  21. Kravitz, H. M., Sabelli, H. C., and Fawcett, J. Dietary supplements of phenylalanine and other amino acid precursors of brain neuroamines in the treatment of depressive disorders. J Am Osteopath.Assoc 1984;84(1 Suppl):119-123. DOI
  22. Mann, J., Peselow, E. D., Snyderman, S., and Gershon, S. D-phenylalanine in endogenous depression. Am.J.Psychiatry 1980;137(12):1611-1612. PubMed
  23. Katoulis AC, Alevizou A, Bozi E, et al. A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines. Clin Exp Dermatol 2010;35(5):473-6. PubMed

See these in context on the Phenylalanine monograph →

Histidine 3 references
  1. Histidine — MedlinePlus (U.S. National Library of Medicine) Source
  2. Amino Acids — MedlinePlus (U.S. National Library of Medicine) Source
  3. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Histidine monograph →

Threonine 4 references
  1. Tandan R, Bromberg MB, Forshew D, et al. A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data. Neurology 1996;47:1220-6. PubMed
  2. Lee A, Patterson V. A double blind study of L-threonine in patients with spinal spasticity. Acta Neurol Scand 1993;88:334-8. PubMed
  3. Blin O, Pouget J, Aubrespy G, et al. A double-blind placebo controlled trial of L-threonine in amyotrophic lateral sclerosis. J Neurol 1992;239:79-81.
  4. Roufs JB. L-threonine as a symptomatic treatment for amyotrophic lateral sclerosis (ALS). Med Hypotheses 1991;34:20-3. PubMed

See these in context on the Threonine monograph →

L-tryptophan 18 references
  1. Messiha FS. Fluoxetine: adverse effects and drug-drug interactions. J Toxicol Clin Toxicol 1993;31:603-30. PubMed
  2. Devoe LD, Castillo RA, Searle NS. Maternal dietary substrates and human fetal biophysical activity. The effects of tryptophan and glucose on fetal breathing movements. Am J Obstet Gynecol 1986;155:135-9. DOI
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See these in context on the L-tryptophan monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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