Interactions on record — worth a quick check against your medications. Based on 8 of 11 ingredients. Check your meds →
Dietary supplement

Multi Collagen Gut Restore Ingredients & Drug Interactions

by Ancient Nutrition

Multi Collagen Gut Restore label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Multi Collagen Gut Restore against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Multi Collagen Gut Restore is a dietary supplement by Ancient Nutrition with 11 active ingredients. Its ingredients are commonly taken for skin health and wrinkles, joint pain and osteoarthritis, bone health.Based on those ingredients, 2,197 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Slippery Elm, Fermented, Organic, Ginger, Fermented, Peppermint, Fermented. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Multi Collagen Gut Restore by Ancient Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Multi Collagen Gut Restore by Ancient Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Multi Collagen Gut Restore by Ancient Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 11 active ingredients.
  • “Multi Collagen Complex” is a proprietary blend — the label gives one combined amount (874 mg) without saying how much of each component you get.
  • “Gut Restore Blend” is a proprietary blend — the label gives one combined amount (1.10 Gram(s)) without saying how much of each component you get.

Multi Collagen Gut Restore contains 11 ingredients including three fermented forms — ginger, slippery elm, and peppermint — plus live probiotics (Bacillus subtilis and Bacillus coagulans), apple cider vinegar, a multi-collagen complex made up of hydrolyzed collagen peptides from bovine hide and fish, eggshell membrane collagen, and chicken bone broth protein concentrate. The product also contains xylooligosaccharide as a prebiotic fiber.

Two inactive ingredients are used: bovine gelatin (the capsule) and wax.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy gut, skin, nails, and joints.
  • We looked for evidence on: Abdominal pain, Acne, Aging skin, Atopic dermatitis (eczema), Back pain, Brittle nails — and 4 related terms.
  • The strongest evidence on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Collagen Peptides is rated "Possibly Effective" for Aging skin, Dry skin.
  • Also on file: Bacillus Subtilis is rated "Possibly Effective" for Antibiotic-associated diarrhea.

The collagen peptides in this product are possibly effective for aging skin and dry skin, though they appear to be ineffective for building muscle strength. Peppermint is likely effective for irritable bowel syndrome and possibly effective for general digestive discomfort and nausea.

Bacillus coagulans is possibly effective for constipation and irritable bowel syndrome, and Bacillus subtilis is possibly effective for antibiotic-associated diarrhea. Ginger is possibly effective for pregnancy-related nausea and menstrual cramps.

Evidence is insufficient for apple cider vinegar, slippery elm, eggshell membrane, and chicken bone broth protein for the conditions listed in our data.

The evidence, ingredient by ingredient Collagen Peptides Eggshell Membrane Apple Cider Vinegar Bacillus Subtilis Bacillus Coagulans Ginger Slippery Elm Peppermint

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The collagen peptides and peppermint are generally well tolerated. Apple cider vinegar is well tolerated in food amounts, but long-term use in larger doses may be unsafe — a documented case involved hypokalemia, elevated renin, and osteoporosis from 250 mL daily over 6 years.

Ginger is generally well tolerated at typical supplement doses, though doses above 5 grams daily increase side-effect risk; common mild effects include abdominal discomfort, heartburn, and diarrhea. Bacillus subtilis and Bacillus coagulans are generally well tolerated in healthy adults, though safety data are limited.

Slippery elm is generally well tolerated short-term but carries limited safety data for long-term use. Eggshell membrane should be avoided by anyone with an egg allergy and is not studied enough in pregnancy or breastfeeding to recommend use.

Pregnancy and breastfeeding safety data are not on file for apple cider vinegar, Bacillus species, ginger, slippery elm, or the collagen peptides — talk to your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Collagen Peptides Eggshell Membrane Apple Cider Vinegar Bacillus Subtilis Bacillus Coagulans Ginger Slippery Elm Peppermint

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 8 matched ingredients can interact with medications — Peppermint, Apple Cider Vinegar, Ginger, Slippery Elm, Bacillus Coagulans, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications.
  • For scale: 2,198 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check if you use anticoagulants or antiplatelet drugs such as warfarin, nifedipine, or phenprocoumon (Moderate risk of bleeding), antidiabetes medications or insulin (Moderate risk of low blood sugar), diuretic drugs (Moderate risk of low potassium), digoxin heart medication (Moderate risk of heart toxicity), antibiotics (Moderate risk these may reduce probiotic effectiveness), or medications broken down by your liver's CYP3A4, CYP2C9, or CYP2C19 enzyme systems (Moderate risk of altered drug levels). Slippery elm may slow absorption of any oral drug, so separate it from medications by 2 hours if possible.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines probiotics, fermented botanicals, and collagen peptides marketed for gut and digestive support. It's reasonable to consider if you're not taking antibiotics, blood thinners, or medications metabolized by your liver, and if you tolerate these ingredients well.

If you take any prescription medications — especially blood thinners, diabetes drugs, diuretics, or heart medications — run them through the interaction checker below before starting. Talk to your pharmacist about whether the dose and form are right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Multi Collagen Gut Restore, straight from the product label.

Brand Ancient Nutrition
Barcode (UPC) 816401025142
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 305791
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Multi Collagen Gut Restore by Ancient Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
816401025142
IngredientAmount% DV
Apple Cider Vinegar0 NP--
Xylooligosaccharide0 NP--
Bacillus subtilis0 NP--
Bacillus coagulans0 NP--
Multi Collagen Complex874 mg--
Chicken Bone Broth Protein concentrate0 NP--
Bovine Hide Collagen Peptides, Hydrolyzed0 NP--
Fish Collagen Peptides, Hydrolyzed0 NP--
Ginger, Fermented0 NP--
Gut Restore Blend1.1 Gram(s)--
Slippery Elm, Fermented, Organic0 NP--
Peppermint, Fermented0 NP--
Eggshell Membrane Collagen, Fermented0 NP--

Other ingredients: Bovine Gelatin, organic Copernicia cerifera Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Gut Skin Nails Joints Supports a healthy gut, skin, nails, and joints

Color and odor may vary from lot to lot.

IGEN Non-GMO tested

Formula

10 types of collagen

FDA Statement of Identity

Whole Food Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Adults take 3 capsules per day.

Precautions

Contains: Egg, fish (haddock, cod, pollock).

Produced on equipment that also processes peanuts, tree nuts, milk, soybean, wheat, sesame, shellfish, fish, egg. Warning: If you are pregnant, nursing, allergic, have a medical condition, or taking any medications, consult a doctor before using this or any other dietary supplement.

Warning: If you are pregnant, nursing, allergic, have a medical condition, or taking any medications, consult a doctor before using this or any other dietary supplement.

Do not use if inner safety seal is broken or missing.

Keep out of reach of children.

Notice: Use this product as a food supplement only. Do not use for weight reduction.

Storage

Store in a cool, dry place.

Seals/Symbols

IGEN Non-GMO tested

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Multi Collagen Gut Restore by Ancient Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Multi Collagen Gut Restore label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Multi Collagen Gut Restore by Ancient Nutrition

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Multi Collagen Complex

874 mg per serving

Gut Restore Blend

1.1 Gram(s) per serving

Other (inactive) ingredients: Bovine Gelatin, Organic Copernicia cerifera Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Multi Collagen Gut Restore by Ancient Nutrition Drug Interactions

Want to check YOUR meds against Multi Collagen Gut Restore?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,197Drugs
2,193 Moderate 4 Minor

Ingredients driving the most interactions

Slippery Elm, Fermented, Organic 2,022
Ginger, Fermented 1,007
Peppermint, Fermented 796
Bacillus subtilis 182
Bacillus coagulans 182

Individual Drug Interactions

The ingredients in Multi Collagen Gut Restore interact with 2,197 drugs. Click any drug to see the details.

6 of the 11 ingredients in Multi Collagen Gut Restore interact with drugs. Each result below shows which ingredient is responsible. Slippery Elm, Fermented, Organic Ginger, Fermented Peppermint, Fermented Bacillus subtilis Bacillus coagulans Apple Cider Vinegar

Each ingredient & the kinds of drugs it affects

For each ingredient in Multi Collagen Gut Restore with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Slippery Elm, Fermented, Organic1 drug type · 2,022 drugs

Oral Drugs

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.

Likelihood Possible Evidence D
Slippery Elm, Fermented, Organic full monograph & interactions

Ginger, Fermented14 drug types · 1,007 drugs

Anticoagulant/Antiplatelet Drugs

Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Laboratory research suggests that ginger inhibits thromboxane synthetase and decreases platelet aggregation. However, this has not been demonstrated unequivocally in humans, with mixed results from clinical trials. Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Animal and human research suggests that ginger might increase insulin levels and/or decrease blood glucose levels.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Ginger might increase or decrease the levels of CYP3A4 substrates.
In vitro research and some case reports suggest that ginger inhibits CYP3A4 activity. Three case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are CYP3A4 substrates (imatinib, dabrafenib, and crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Conversely, other in vitro research suggests that ginger induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Losartan (Cozaar)

Theoretically, ginger might increase levels of losartan and the risk of hypotension.
In animal research, ginger increased the levels and hypotensive effects of a single dose of losartan. It is not clear if ginger alters the concentration or effects of losartan when taken continuously. Additionally, this interaction has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Ginger may have antiplatelet effects and increase the risk of bleeding if used with nifedipine.
Clinical research shows that combined treatment with ginger 1 gram plus nifedipine 10 mg significantly inhibits platelet aggregation when compared to nifedipine or ginger alone.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
In vitro research and case reports suggest that ginger inhibits drug efflux by P-gp, potentially increasing absorption and serum levels of P-gp substrates. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are P-gp substrates (trametinib, crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.

Likelihood Possible Evidence D
Phenprocoumon (Marcoumar, Others)

Ginger might increase the risk of bleeding with phenprocoumon.
Phenprocoumon, a warfarin-related anticoagulant, might increase the international normalized ratio (INR) when taken with ginger. There is one case report of a 76-year-old woman with a stable INR on phenprocoumon that increased to greater than 10 when she began consuming dried ginger and ginger tea.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Ginger might increase the risk of bleeding with warfarin.
Laboratory research suggests that ginger might inhibit thromboxane synthetase and decrease platelet aggregation. In one case report, ginger increased the INR when taken with phenprocoumon, which has similar pharmacological effects as warfarin. In another case report, ginger increased the INR when taken with a combination of warfarin, hydrochlorothiazide, and acetaminophen. A longitudinal analysis suggests that taking ginger increases the risk of bleeding in patients taking warfarin for at least 4 months. However, research in healthy people suggests that ginger has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. Until more is known, monitor INRs closely in patients taking large amounts of ginger.

Likelihood Possible Evidence B
Calcium Channel Blockers

Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Some animal and in vitro research suggests that ginger has hypotensive and calcium channel-blocking effects. Another animal study shows that concomitant administration of ginger and the calcium channel blocker amlodipine leads to greater reductions in blood pressure when compared with amlodipine alone.

Likelihood Unlikely Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, when taken prior to cyclosporine, ginger might decrease cyclosporine levels.
In an animal model, ginger juice taken 2 hours prior to cyclosporine administration reduced the maximum concentration and area under the curve of cyclosporine by 51% and 40%, respectively. This effect was not observed when ginger juice and cyclosporine were administered at the same time.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ginger might increase the levels of CYP1A2 substrates.
In vitro research shows that ginger inhibits CYP1A2 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, ginger might increase the levels of CYP2B6 substrates.
In vitro research shows that ginger inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, ginger might increase the levels of CYP2C9 substrates.
In vitro research shows that ginger inhibits CYP2C9 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Metronidazole (Flagyl)

Theoretically, ginger might increase levels of metronidazole.
In an animal model, ginger increased the absorption and plasma half-life of metronidazole. In addition, the elimination rate and clearance of metronidazole was significantly reduced.

Likelihood Possible Evidence D
Ginger, Fermented full monograph & interactions

Peppermint, Fermented5 drug types · 796 drugs

Cyclosporine (Neoral, Sandimmune)

Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.

Likelihood Possible Evidence B
Peppermint, Fermented full monograph & interactions

Bacillus subtilis1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
Bacillus subtilis full monograph & interactions

Bacillus coagulans1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Bacillus coagulans full monograph & interactions

Apple Cider Vinegar4 drug types · 162 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of apple cider vinegar with digoxin might increase the risk of cardiac toxicity.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar could decrease potassium levels, increasing the risk of toxicity with digoxin.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. There is some concern that people taking apple cider vinegar along with potassium depleting diuretics might have an increased risk for hypokalemia.

Likelihood Possible Evidence D
Insulin

Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar concomitantly with insulin might increase the risk of hypokalemia.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Apple cider vinegar might reduce fasting and postprandial blood glucose levels and decrease gastric emptying in people with diabetes. However, not all research agrees. Theoretically, it might have additive effects on glucose levels when used with antidiabetes drugs.

Likelihood Possible Evidence B
Apple Cider Vinegar full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Multi Collagen Gut Restore, from the product label.

Ancient Nutrition

See all Ancient Nutrition products
Name
Ancient Nutrition, LLC
Street Address
3480 Summertown Hwy
City
Summertown
State
TN
ZipCode
38483
Web Address
www.AncientNutrition.com
Pharmacist Counseling Corner

Multi Collagen Gut Restore by Ancient Nutrition: Common Questions

Does Multi Collagen Gut Restore by Ancient Nutrition interact with any medications?
Yes. Based on its ingredients, Multi Collagen Gut Restore has a known interaction with 2,197 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Multi Collagen Gut Restore contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have any serious side effects?
Most ingredients are well tolerated in typical amounts. However, long-term use of high-dose apple cider vinegar has caused low potassium, elevated renin, and osteoporosis in one documented case. Ginger and peppermint may cause mild digestive upset — heartburn, diarrhea, or abdominal discomfort — in some people. If you notice unusual symptoms, stop and talk to your pharmacist.
Can I take this while pregnant or breastfeeding?
Safety data during pregnancy and breastfeeding aren't on file for most ingredients in this product. Eggshell membrane specifically should be avoided in both — there isn't enough data to recommend it. If you're pregnant or nursing, talk with your doctor or pharmacist before starting, especially if you're considering this for morning sickness.
Is the peppermint in here enough to help my IBS?
Peppermint is likely effective for irritable bowel syndrome, but we don't know the exact dose in this product. If you're buying it mainly for IBS relief, ask your pharmacist whether the amount present is therapeutic or just incidental.
Will this help my gut health?
The probiotics Bacillus coagulans and Bacillus subtilis are possibly effective for constipation and antibiotic-associated diarrhea. Peppermint is likely effective for IBS. However, evidence is insufficient for apple cider vinegar, slippery elm, and collagen peptides to support general gut health — the data we have doesn't show they work for those claims.
I'm allergic to eggs — is this safe for me?
This product contains eggshell membrane collagen, which should be avoided if you have an egg allergy. Check with your pharmacist or allergist before taking it.
Can I take this with my antibiotics?
The live probiotics in this product may be killed by antibiotics, reducing their effectiveness. If you're on antibiotics, separate the timing — take antibiotics and probiotics at least 2 hours apart — and ask your pharmacist for the best schedule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Multi Collagen Gut Restore label
Go deeper

The Full Monographs Behind Multi Collagen Gut Restore’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Collagen Peptides

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is still developing and results vary. They...

Read the full Collagen Peptides monograph → Herb & supplement monograph

Eggshell Membrane

Eggshell membrane is a natural source of collagen, hyaluronic acid, and other connective-tissue compounds that is marketed mainly for joint comfort and osteoarthritis. Some small studies sug...

Read the full Eggshell Membrane monograph → Herb & supplement monograph

Apple Cider Vinegar

Interacts with 162 drugs

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of these uses is limited and mixed, and the...

Read the full Apple Cider Vinegar monograph → Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph → Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph → Herb & supplement monograph

Ginger

Interacts with 1,007 drugs

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...

Read the full Ginger monograph → Herb & supplement monograph

Slippery Elm

Interacts with 2,022 drugs

Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...

Read the full Slippery Elm monograph → Herb & supplement monograph

Peppermint

Interacts with 796 drugs

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartbu...

Read the full Peppermint monograph →
Sources

Sources & How We Checked

Multi Collagen Gut Restore's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 154 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Apple Cider Vinegar 11 references
  1. Lhotta K, Hofle G, Gasser R, Finkenstedt G. Hypokalemia, hyperreninemia, and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80:242-3. PubMed
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Bacillus Subtilis 10 references
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Bacillus Coagulans 20 references
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Collagen Peptides 2 references
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Ginger 64 references
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Peppermint 41 references
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See these in context on the Peppermint monograph →

Eggshell Membrane 3 references
  1. Osteoarthritis — MedlinePlus (NIH) Source
  2. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  3. Using Dietary Supplements Wisely — NIH NCCIH Source

See these in context on the Eggshell Membrane monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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