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Dietary supplement

Mushroom Blend Ingredients & Drug Interactions

by Natural Grocers by Vitamin Cottage

Mushroom Blend label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mushroom Blend against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mushroom Blend is a dietary supplement by Natural Grocers by Vitamin Cottage with 8 active ingredients. Its ingredients are commonly taken for immune support, used alongside cancer care, gut and digestive health.Based on those ingredients, 704 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Reishi Mushroom, Chaga Mushroom, Lion's Mane Mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Mushroom Blend by Natural Grocers by Vitamin Cottage

Ask about any prescription or over-the-counter medication and we check it for interactions with Mushroom Blend by Natural Grocers by Vitamin Cottage — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Mushroom Blend by Natural Grocers by Vitamin Cottage

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 8 of its 8 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This blend contains 8 active mushroom ingredients: turkey tail, chaga, reishi, cordyceps, agaricus, maitake, lion's mane, and shiitake mushroom. Each has been traditionally used to support immune function and overall wellness, though the strength of evidence varies by mushroom and condition.

The capsules also contain inactive ingredients—hypromellose, magnesium stearate, and silica—which are typical binders and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

  • Cancer via Turkey Tail Mushroom Possibly Effective
Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Cancer — rated "Possibly Effective" (Turkey Tail Mushroom) (Natural Medicines).

The evidence for this blend is mixed. Turkey tail mushroom is rated possibly effective for cancer support.

For everything else in the blend—including reishi for high cholesterol, cordyceps for athletic performance, shiitake for dental plaque, and the other mushrooms for conditions like diabetes, cognitive function, and chronic fatigue—the evidence is rated insufficient to draw solid conclusions. Most of these mushrooms are well studied in traditional medicine, but reliable clinical data in humans remains limited.

The evidence, ingredient by ingredient Turkey Tail Mushroom Chaga Reishi Mushroom Cordyceps Agaricus Mushroom Maitake Mushroom Lion's Mane Mushroom Shiitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These mushroom ingredients are generally well tolerated as foods and short-term supplements. The most common side effects reported are mild gastrointestinal ones: nausea, diarrhea, abdominal discomfort, and stomach upset.

Rare serious effects have been reported in specific cases—liver problems with agaricus and cordyceps, kidney issues with excess chaga consumption, and allergic reactions including rashes and respiratory symptoms with several mushrooms. Because safety data for concentrated supplements are limited compared to eating mushrooms as food, especially long-term, check with your healthcare provider before starting.

Turkey tail, chaga, reishi, cordyceps, agaricus, maitake, and lion's mane should be avoided during pregnancy and breastfeeding due to insufficient safety data; shiitake as a food is likely fine, but concentrated supplement doses aren't well studied in pregnancy or while breastfeeding.

Side effects, ingredient by ingredient Turkey Tail Mushroom Chaga Reishi Mushroom Cordyceps Agaricus Mushroom Maitake Mushroom Lion's Mane Mushroom Shiitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 8 of the 8 matched ingredients can interact with medications — Maitake Mushroom, Cordyceps, Turkey Tail Mushroom, Shiitake Mushroom, Reishi Mushroom, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 704 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this blend, check with your doctor or pharmacist if you take any of these: blood thinners or antiplatelet drugs (such as warfarin), diabetes medications, blood pressure drugs, immunosuppressants like cyclosporine, chemotherapy drugs (especially cyclophosphamide), testosterone supplements, or any medication metabolized by the liver enzymes CYP2D6 or CYP2C9. Moderate-severity interactions are documented for all of these drug types across the blend's ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This blend may appeal to people looking for general immune support through traditional mushroom ingredients, but the clinical evidence for most conditions is still developing. If you take blood thinners, diabetes medications, blood pressure drugs, immunosuppressants, or chemotherapy, you need to discuss this product with your doctor or pharmacist before starting—several ingredients interact with these drug types.

Pregnant or breastfeeding? Talk with your provider first; safety data aren't solid enough to know either way for most of these mushrooms in concentrated form.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mushroom Blend, straight from the product label.

Brand Natural Grocers by Vitamin Cottage
Barcode (UPC) 849327005318
Net contents 60 Veg Capsule(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 306258
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mushroom Blend by Natural Grocers by Vitamin Cottage, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
849327005318
IngredientAmount% DV
Turkey Tail Mushroom70 mg--
Chaga Mushroom70 mg--
Reishi Mushroom70 mg--
Cordyceps Mushroom70 mg--
Agaricus Mushroom70 mg--
Maitake Mushroom70 mg--
Lion's Mane Mushroom70 mg--
Shiitake Mushroom70 mg--

Other ingredients: Hypromellose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Made without: Sugar, salt, dairy, yeast, wheat, gluten, corn, soy, artificial preservatives, artificial colors or flavors.

Immune support

GF (Gluten free)

Vegetarian

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take one (1) veg capsule daily, or as directed by a health care professional.

Storage

Store in a cool, dry place and away from direct light.

Precautions

Caution: Consult your physician before use if you are pregnant, nursing, have a medical condition, taking any medications, or are planning any medical or surgical procedures.

Keep out of reach of children.

For serious adverse event reporting call (877)455-2826.

Seals/Symbols

Made in a U.S. facility from global ingredients.

GMP Good Manufacturing Practice

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Natural Grocers by Vitamin Cottage good4u

Formula

Made with 8 varieties of mushrooms

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mushroom Blend by Natural Grocers by Vitamin Cottage label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mushroom Blend label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mushroom Blend by Natural Grocers by Vitamin Cottage

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Turkey Tail Mushroom

Interacts with
187 drugs
70 mg per serving Form: Trametes versicolor

Turkey tail is a woodland mushroom rich in polysaccharides like beta-glucans, and it is mainly used to support the immune system. Some of its purified...

Turkey Tail Mushroom monograph & interactions

Chaga Mushroom

Interacts with
327 drugs
70 mg per serving Form: Inonotus obliquus

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for i...

Chaga Mushroom monograph & interactions

Reishi Mushroom

Interacts with
375 drugs
70 mg per serving Form: Ganoderma lucidum, Ganoderma lucidum

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Reishi Mushroom monograph & interactions

Cordyceps Mushroom

Interacts with
249 drugs
70 mg per serving Form: Cordyceps sinensis

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited an...

Cordyceps Mushroom monograph & interactions

Agaricus Mushroom

Interacts with
86 drugs
70 mg per serving Form: Agaricus blazei, Agaricus blazei

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects...

Agaricus Mushroom monograph & interactions

Maitake Mushroom

Interacts with
260 drugs
70 mg per serving Form: Grifola frondosa, Grifola frondosa

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake Mushroom monograph & interactions

Lion's Mane Mushroom

Interacts with
327 drugs
70 mg per serving Form: Hericium erinaceus, Hericium erinaceus

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane Mushroom monograph & interactions

Shiitake Mushroom

Interacts with
312 drugs
70 mg per serving Form: Lentinula edodes, Lentinula edodes

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have b...

Shiitake Mushroom monograph & interactions

Other (inactive) ingredients: Hypromellose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mushroom Blend by Natural Grocers by Vitamin Cottage Drug Interactions

Want to check YOUR meds against Mushroom Blend?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
704Drugs
654 Moderate 50 Minor

Ingredients driving the most interactions

Reishi Mushroom 375
Chaga Mushroom 327
Lion's Mane Mushroom 327
Shiitake Mushroom 312
Maitake Mushroom 260

Individual Drug Interactions

The ingredients in Mushroom Blend interact with 704 drugs. Click any drug to see the details.

8 of the 8 ingredients in Mushroom Blend interact with drugs. Each result below shows which ingredient is responsible. Reishi Mushroom Chaga Mushroom Lion's Mane Mushroom Shiitake Mushroom Maitake Mushroom Cordyceps Mushroom Turkey Tail Mushroom Agaricus Mushroom

Each ingredient & the kinds of drugs it affects

For each ingredient in Mushroom Blend with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Reishi Mushroom3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi Mushroom full monograph & interactions

Chaga Mushroom3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that chaga extract can inhibit platelet aggregation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that chaga might decrease blood glucose levels and increase insulin levels. This has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, chaga might interfere with immunosuppressive therapy.
In vitro research suggests that certain constituents of chaga stimulate immune function. This has not been reported in humans.

Likelihood Possible Evidence D
Chaga Mushroom full monograph & interactions

Lion's Mane Mushroom3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane Mushroom full monograph & interactions

Shiitake Mushroom2 drug types · 312 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.

Likelihood Possible Evidence D
Shiitake Mushroom full monograph & interactions

Maitake Mushroom3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake Mushroom full monograph & interactions

Cordyceps Mushroom3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Cordyceps Mushroom full monograph & interactions

Turkey Tail Mushroom4 drug types · 187 drugs

Antidiabetes Drugs

Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that turkey tail mushroom and a polysaccharide component can have hypoglycemic effects.

Likelihood Possible Evidence D
Cyclophosphamide

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might increase exposure to cyclophosphamide.
Some animal research shows that the PSP component of turkey tail mushroom can increase the area under the concentration-time curve (AUC) of cyclophosphamide by 44% to 50% and the half-life by 34% to 43%. This interaction could potentially increase the effects and adverse effects of cyclophosphamide. However, it is not known whether PSP affects the levels of the active metabolites of cyclophosphamide that are responsible for its clinical activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might interfere with the absorption of tamoxifen.
Animal research suggests that PSP increases the time to reach maximum concentration of a single dose of tamoxifen by about 9.5 hours, or 228%. When repeated doses of tamoxifen were given, the time to reach maximum concentration was increased by about 5.6 hours, or 93%. However, PSP did not affect the maximum concentration or the area under the curve of tamoxifen.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might inhibit CYP2C9.
Laboratory research suggests that the PSP component of turkey tail mushroom dose-dependently inhibits CYP2C9. Theoretically, taking PSP with drugs metabolized by CYP2C9 might increase drug levels and the risk of adverse effects. However, this has not been reported in humans.

Likelihood Possible Evidence D
Turkey Tail Mushroom full monograph & interactions

Agaricus Mushroom1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.

Likelihood Possible Evidence D
Agaricus Mushroom full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mushroom Blend, from the product label.

Natural Grocers by Vitamin Cottage

See all Natural Grocers by Vitamin Cottage products
Name
Vitamin Cottage Natural Food Markets, Inc.
City
Lakewood
State
CO
ZipCode
80228
Phone Number
877-455-2826
Web Address
www.naturalgrocers.com
Pharmacist Counseling Corner

Mushroom Blend by Natural Grocers by Vitamin Cottage: Common Questions

Does Mushroom Blend by Natural Grocers by Vitamin Cottage interact with any medications?
Yes. Based on its ingredients, Mushroom Blend has a known interaction with 704 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mushroom Blend contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin?
Not without checking first. Maitake mushroom in this blend has limited evidence of increasing warfarin's blood-thinning effects, and several other mushrooms (turkey tail, chaga, cordyceps, lion's mane) theoretically increase bleeding risk with blood thinners. Talk with your doctor or pharmacist before adding this to your routine.
Will this help with my diabetes?
The evidence isn't established enough for us to say either way. Several mushrooms in the blend, like maitake, theoretically lower blood sugar, which is why we flag it as a concern if you're already on diabetes medication. But clinical evidence that it actually helps diabetes is insufficient in our data.
Is this safe during pregnancy?
The safety data advises against it. Most of these mushrooms—turkey tail, chaga, reishi, cordyceps, agaricus, maitake, and lion's mane—don't have enough safety information in pregnancy, so concentrated supplements are best avoided. Talk with your doctor or midwife about whether this blend is right for you.
What's in this that might give me stomach upset?
Gastrointestinal side effects like nausea, diarrhea, and abdominal discomfort have been reported with several of these mushrooms—turkey tail, cordyceps, agaricus, maitake, lion's mane, and shiitake. These tend to be mild and sometimes go away if you take the blend with food.
Can this interfere with my immunosuppressant medication?
Yes, theoretically. Chaga, cordyceps, lion's mane, and shiitake all contain compounds that stimulate immune function in lab and animal research, which could work against your medication. You'll want to discuss this with your doctor or pharmacist before starting.
Is there any mushroom in here with no known interactions?
Lion's mane is the only one we hold no interaction data for—that doesn't mean it has no interactions, just that our monograph doesn't document any. The other seven mushrooms all have documented interactions with various medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Mushroom Blend is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mushroom Blend label
Go deeper

The Full Monographs Behind Mushroom Blend’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Turkey Tail Mushroom

Interacts with 187 drugs

Turkey tail is a woodland mushroom rich in polysaccharides like beta-glucans, and it is mainly used to support the immune system. Some of its purified extracts (PSK and PSP) have been studie...

Read the full Turkey Tail Mushroom monograph → Herb & supplement monograph

Chaga

Interacts with 327 drugs

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for its benefits is very limited, and it may...

Read the full Chaga monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph → Herb & supplement monograph

Agaricus Mushroom

Interacts with 86 drugs

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...

Read the full Agaricus Mushroom monograph → Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph → Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Shiitake Mushroom

Interacts with 312 drugs

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...

Read the full Shiitake Mushroom monograph →
Sources

Sources & How We Checked

Mushroom Blend's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 141 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Turkey Tail Mushroom 15 references
  1. Nakazato H, Koike A, Saji S, et al. Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Study Group of Immunochemotherapy with PSK for Gastric Cancer. Lancet 1994;343:1122-6. PubMed
  2. Mitomi T, Tsuchiya S, Iijima N, et al. Randomized, controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer. The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum (Kanag DOI
  3. Torisu M, Hayashi Y, Ishimitsu T, et al. Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer. Cancer Immunol Immunother 1990;31:261-8. PubMed
  4. Tsujitani, S., Kakeji, Y., Orita, H., Watanabe, A., Kohnoe, S., Baba, H., Anai, H., Maehara, Y., and Sugimachi, K. Postoperative adjuvant immunochemotherapy and infiltration of dendritic cells for patients with advanced gastric cancer. Anticancer Res 199
  5. Kojima, J., Kamata, T., and Monna, T. [Evaluation of immunochemotherapy in patients with primary liver cancer. Osaka Research Society for Liver, Gallbladder and Pancreas]. Gan To Kagaku Ryoho 1987;14(1):179-187.
  6. Fukuo, Y., Terashi, A., Hayashi, Y., Yano, Y., and Atarashi, J. [A clinical trial of cis-platinum (II) in combination with PSK and FT-207 in advanced stomach cancer]. Gan To Kagaku Ryoho 1985;12(4):960-965.
  7. Imaizumi, M., Kondo, T., Kamei, H., and Ichihashi, H. [Cooperative studies on surgical adjuvant immunochemotherapy for prevention of postoperative recurrence of gastric cancer]. Gan To Kagaku Ryoho 1984;11(1):60-68.
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Chaga 9 references
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Reishi Mushroom 17 references
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Cordyceps 14 references
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Agaricus Mushroom 5 references
  1. Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2
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Maitake Mushroom 8 references
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Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
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Shiitake Mushroom 67 references
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See these in context on the Shiitake Mushroom monograph →

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© 2021 Therapeutic Research Center, LLC

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