Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

MYcoMune 4X Ingredients & Drug Interactions

by Pure Essence MyPure

MYcoMune 4X label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking MYcoMune 4X against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

MYcoMune 4X is a dietary supplement by Pure Essence MyPure with 6 active ingredients. Its ingredients are commonly taken for immune support, antioxidant support, general wellness/tonic.Based on those ingredients, 662 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Chaga sclerotium extract, Lion's Mane Mushroom Fruiting Body Extract, Shiitake Mushroom Fruiting Body Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against MYcoMune 4X by Pure Essence MyPure

Ask about any prescription or over-the-counter medication and we check it for interactions with MYcoMune 4X by Pure Essence MyPure — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of MYcoMune 4X by Pure Essence MyPure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

MYcoMune 4X contains six active mushroom ingredients: organic chaga sclerotium extract, lion's mane mushroom fruiting body extract, royal red reishi mushroom fruiting body extract, shiitake mushroom fruiting body extract, cordyceps militaris mushroom fruiting body extract, and maitake mushroom fruiting body extract. These are combined in a capsule with hydroxypropyl methylcellulose, which is an inactive ingredient (capsule material).

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: Supports maximum performance and healthy immune response.
  • We looked for evidence on: Common cold, Influenza, Coronavirus disease 2019 (COVID-19), Allergic rhinitis (hay fever), Asthma, Chronic obstructive pulmonary disease (COPD) — and 4 related terms.
  • The closest evidence on file: Cordyceps is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever), Laryngeal cancer, Chronic fatigue syndrome (CFS), Chemotherapy-related fatigue, and more.

The evidence for these ingredients is limited. Chaga's effectiveness for cardiovascular disease, diabetes, and COVID-19 has insufficient reliable evidence to rate.

Lion's mane has insufficient evidence for Alzheimer's disease, anxiety, athletic performance, cancer, cognitive function, and cognitive impairment. Cordyceps is rated possibly ineffective for athletic performance and has insufficient evidence for sexual dysfunction, arrhythmia, asthma, lung cancer, and COPD.

Shiitake is rated possibly ineffective for dental plaque and has insufficient evidence for cancer-related side effects and atherosclerosis. Maitake has insufficient evidence for allergic rhinitis, chemotherapy-related anemia and diarrhea, laryngeal cancer, and chronic fatigue syndrome.

The product facts don't establish effectiveness for any specific condition based on the data we hold.

The evidence, ingredient by ingredient Chaga Lion's Mane Mushroom Shiitake Mushroom Cordyceps Maitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these mushroom ingredients are generally well tolerated as foods, but supplement safety — especially at concentrated doses — is less well studied. Chaga poses a specific risk: excessive consumption can cause kidney problems due to high oxalate content, with two cases of kidney failure and one case of acute inflammation reported.

Lion's mane commonly causes gastrointestinal discomfort, nausea, and sometimes skin rash. Shiitake can trigger shiitake dermatitis (a whiplash-like skin eruption) if raw mushroom is eaten, and has caused allergic reactions in people who handle it extensively.

Cordyceps may cause abdominal discomfort, constipation, or diarrhea, though these are uncommon. One case of liver inflammation (hepatitis) has been reported with cordyceps, though it's unclear if the supplement or a contaminant was responsible.

Maitake typically causes mild gastrointestinal effects like diarrhea and stomach pain, and rarely can trigger allergic rash. All four ingredients with safety information advise against use during pregnancy and breastfeeding due to insufficient data.

Side effects, ingredient by ingredient Chaga Lion's Mane Mushroom Shiitake Mushroom Cordyceps Maitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Maitake Mushroom, Cordyceps, Shiitake Mushroom, Chaga, Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 662 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this product if you use blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel), antidiabetes medications, immunosuppressants, blood pressure medications, or drugs metabolized by CYP2D6 such as certain antidepressants and beta-blockers. The mushroom ingredients theoretically increase bleeding risk, lower blood sugar, interfere with immune suppression, lower blood pressure, or alter how your liver processes these drugs — none of these interactions have been confirmed in humans, but the potential exists.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a concentrated mushroom blend marketed for immune support, but the evidence for its effectiveness is insufficient in our data. If you take blood thinners, drugs that lower blood sugar, blood pressure medications, immune-suppressing drugs, or medications processed by the liver enzyme CYP2D6, check your specific prescriptions with the tool on this page before starting.

Do not use during pregnancy or breastfeeding. Talk with your pharmacist if you have a history of kidney problems or extensive mushroom handling allergies.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about MYcoMune 4X, straight from the product label.

Brand Pure Essence MyPure
Barcode (UPC) 659670923029
Net contents 60 Vegi-Cap(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 327520
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for MYcoMune 4X by Pure Essence MyPure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
659670923029
IngredientAmount% DV
organic Chaga sclerotium extract50 mg--
Lion's Mane Mushroom Fruiting Body Extract50 mg--
Royal Red Reishi Mushroom Fruiting Body Extract200 mg--
Shiitake Mushroom Fruiting Body Extract100 mg--
Cordyceps militaris Mushroom Fruiting Body Extract40 mg--
Maitake Mushroom Fruiting Body Extract40 mg--

Other ingredients: Hydroxypropyl Methylcellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Non GMO Gluten free

Vegan

Organic Ingredients

Supports maximum performance & healthy immune response Over 4 times stronger

Every batch is lab tested for cleanliness, purity and potency. MyPure MYcoMune 4X supports: Healthy stress response Healthy immune function Brain health, memory, concentration & focus Nerve & Neuron growth

Does not contain: wheat, milk, tree nuts, peanuts, soy, eggs, fish, shellfish

Seals/Symbols

Vegan Purity & Potency 100% Guarantee 90 Day Money Back Guarantee

Made in USA

General Statements

2 months supply

Please recycle

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Copyright 2018 All Rights Reserved

Formula

MyPure MYcoMune 4X provides 500 mg of our premium blend of certified organic, fruiting body mushroom extracts to deliver the most potent mushroom nutrition you'll find.

Suggested/Recommended/Usage/Directions

Suggested use: One capsule daily.

Storage

Storage: Keep closed in a cool, dry place.

Precautions

Caution: Keep all supplements out of children's reach.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

MYcoMune 4X by Pure Essence MyPure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

MYcoMune 4X label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in MYcoMune 4X by Pure Essence MyPure

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Organic Chaga sclerotium extract

Interacts with
327 drugs
50 mg per serving

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for i...

Organic Chaga sclerotium extract monograph & interactions

Lion's Mane Mushroom Fruiting Body Extract

Interacts with
327 drugs
50 mg per serving Form: Beta-1,3-1,6-D-Glucan

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane Mushroom Fruiting Body Extract monograph & interactions

Royal Red Reishi Mushroom Fruiting Body Extract

200 mg per serving Form: Beta-1,3-1,6-D-Glucan

Shiitake Mushroom Fruiting Body Extract

Interacts with
312 drugs
100 mg per serving Form: Beta-1,3-1,6-D-Glucan

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have b...

Shiitake Mushroom Fruiting Body Extract monograph & interactions

Cordyceps militaris Mushroom Fruiting Body Extract

Interacts with
249 drugs
40 mg per serving Form: Beta-1,3-1,6-D-Glucan

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited an...

Cordyceps militaris Mushroom Fruiting Body Extract monograph & interactions

Maitake Mushroom Fruiting Body Extract

Interacts with
260 drugs
40 mg per serving Form: Beta-1,3-1,6-D-Glucan

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake Mushroom Fruiting Body Extract monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

MYcoMune 4X by Pure Essence MyPure Drug Interactions

Want to check YOUR meds against MYcoMune 4X?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
662Drugs
654 Moderate 8 Minor

Ingredients driving the most interactions

organic Chaga sclerotium extract 327
Lion's Mane Mushroom Fruiting Body Extract 327
Shiitake Mushroom Fruiting Body Extract 312
Maitake Mushroom Fruiting Body Extract 260
Cordyceps militaris Mushroom Fruiting Body Extract 249

Individual Drug Interactions

The ingredients in MYcoMune 4X interact with 662 drugs. Click any drug to see the details.

5 of the 6 ingredients in MYcoMune 4X interact with drugs. Each result below shows which ingredient is responsible. organic Chaga sclerotium extract Lion's Mane Mushroom Fruiting Body Extract Shiitake Mushroom Fruiting Body Extract Maitake Mushroom Fruiting Body Extract Cordyceps militaris Mushroom Fruiting Body Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in MYcoMune 4X with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Chaga sclerotium extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that chaga extract can inhibit platelet aggregation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that chaga might decrease blood glucose levels and increase insulin levels. This has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, chaga might interfere with immunosuppressive therapy.
In vitro research suggests that certain constituents of chaga stimulate immune function. This has not been reported in humans.

Likelihood Possible Evidence D
organic Chaga sclerotium extract full monograph & interactions

Lion's Mane Mushroom Fruiting Body Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane Mushroom Fruiting Body Extract full monograph & interactions

Shiitake Mushroom Fruiting Body Extract2 drug types · 312 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.

Likelihood Possible Evidence D
Shiitake Mushroom Fruiting Body Extract full monograph & interactions

Maitake Mushroom Fruiting Body Extract3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake Mushroom Fruiting Body Extract full monograph & interactions

Cordyceps militaris Mushroom Fruiting Body Extract3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Cordyceps militaris Mushroom Fruiting Body Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for MYcoMune 4X, from the product label.

Pure Essence MyPure

See all Pure Essence MyPure products
Name
Pure Essence Laboratories, Inc.
Street Address
P.O. Box 95397
City
Las Vegas
State
NV
ZipCode
89193
Web Address
PureEssenceLabs.com
Pharmacist Counseling Corner

MYcoMune 4X by Pure Essence MyPure: Common Questions

Does MYcoMune 4X by Pure Essence MyPure interact with any medications?
Yes. Based on its ingredients, MYcoMune 4X has a known interaction with 662 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
MYcoMune 4X contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety information advises against it. There isn't enough data on concentrated mushroom supplements during pregnancy or breastfeeding, so it's best avoided. Talk with your doctor or pharmacist about what's safe for your situation.
What does each mushroom in this product do?
The facts we have don't confirm that any of these mushrooms work for specific conditions — the evidence is insufficient to rate them. They're traditionally used for immune support and general wellness, but the product facts don't establish that claim based on reliable research.
Does lion's mane cause side effects?
Yes. Gastrointestinal discomfort and nausea are the most common, and some people report skin rash. These were noted in supplement use, though lion's mane is generally well tolerated as a food.
Is there a risk of kidney problems with this product?
Chaga, one of the ingredients, contains high concentrations of oxalate. Excessive chaga consumption has been linked to kidney failure and inflammation in rare cases. If you have kidney disease or have had kidney stones, ask your pharmacist before taking this.
What's in this besides the mushrooms?
The only other ingredient is hydroxypropyl methylcellulose, which is the capsule material — an inactive ingredient. There are no added fillers or binders.
Are there any safety concerns specific to shiitake in this blend?
Shiitake is generally safe as a cooked food, but concentrated supplements carry more risk. Raw shiitake can cause a distinctive rash called shiitake dermatitis. Allergic reactions are more common in people who handle the mushroom extensively.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if MYcoMune 4X is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

MYcoMune 4X label
Go deeper

The Full Monographs Behind MYcoMune 4X’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chaga

Interacts with 327 drugs

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for its benefits is very limited, and it may...

Read the full Chaga monograph → Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Shiitake Mushroom

Interacts with 312 drugs

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...

Read the full Shiitake Mushroom monograph → Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph → Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph →
Sources

Sources & How We Checked

MYcoMune 4X's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 104 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chaga 9 references
  1. Sun JE, Ao ZH, Lu ZM, et al. Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice. J Ethnopharmacol 2008;118(1):7-13. PubMed
  2. Hyun KW, Jeong SC, Lee DH, et al. Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus. Peptides 2006;27(6):1173-8. PubMed
  3. Kim YO, Han SB, Lee HW, et al. Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus. Life Sci 2005;77(19):2438-56. PubMed
  4. Kikuchi Y, Seta K, Ogawa Y, et al. Chaga mushroom-induced oxalate nephropathy. Clin Nephrol 2014;81(6):440-4. PubMed
  5. Lee S, Lee HY, Park Y, et al. Development of end stage renal disease after long-term ingestion of chaga mushroom: case report and review of literature. J Korean Med Sci. 2020;35(19):e122.
  6. Kwon O, Kim Y, Paek JH, et al. Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report. Medicine (Baltimore) 2022;101(10):e28997. PubMed
  7. Su L, Xin C, Yang J, et al. A polysaccharide from Inonotus obliquus ameliorates intestinal barrier dysfunction in mice with type 2 diabetes mellitus. Int J Biol Macromol 2022;214:312-323. PubMed
  8. Chen S, Ma Y, Li H, et al. Anti-diabetic e?ects of Inonotus obliquus extract in high fat diet combined streptozotocin-induced type 2 diabetic mice. Nutr Hosp 2022;39(6):1256-1263. PubMed
  9. Ye X, Wu K, Xu L, et al. Methanol extract of Inonotus obliquus improves type 2 diabetes mellitus through modifying intestinal flora. Front Endocrinol (Lausanne) 2023;13:1103972. PubMed

See these in context on the Chaga monograph →

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Shiitake Mushroom 67 references
  1. Hitosugi M, Kitamura O, Takatsu A, Yoshino Y. Autopsy case of duodenal obstruction from impacted mushroom. J Gastroenterol 1998;33:562-5. PubMed
  2. Hanada K, Hashimoto I. Flagellate mushroom (Shiitake) dermatitis and photosensitivity. Dermatol 1998;197:255-7. PubMed
  3. Levy AM, Kita H, Phillips SF, et al. Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms. J Allergy Clin Immunol 1998;101:613-20. PubMed
  4. Murakami M, Kawabe K, Hosoi Y, et al. Decreased pulmonary perfusion in hypersensitivity pneumonitis caused by Shiitake mushroom spores. J Intern Med 1997;241:85-8. PubMed
  5. Matsui S, Nakazawa T, Umegae Y, Mori M. Hypersensitivity pneumonitis induced by Shiitake mushroom spores. Intern Med 1992;31:1204-6.
  6. Nakamura T. Shiitake (Lentinus edodes) dermatitis. Contact Dermatitis 1992;27:65-70.
  7. Ueda A, Obama K, Aoyama K, et al. Allergic contact dermatitis in shiitake (Lentinus edodes (Berk) Sing) growers. Contact Dermatitis 1992;26:228-33.
  8. Burikhanov, R. B., Wakame, K., Igarashi, Y., Wang, S., and Matsuzaki, S. Suppressive effect of active hexose correlated compound (AHCC) on thymic apoptosis induced by dexamethasone in the rat. Endocr.Regul. 2000;34(4):181-188.
  9. Gao, Y., Zhang, D., Sun, B., Fujii, H., Kosuna, K., and Yin, Z. Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses. Cancer Immunol.Immunother. 2006;55(10):1258-1266. PubMed
  10. Ritz, B. W., Nogusa, S., Ackerman, E. A., and Gardner, E. M. Supplementation with active hexose correlated compound increases the innate immune response of young mice to primary influenza infection. J Nutr. 2006;136(11):2868-2873. PubMed
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Cordyceps 14 references
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Maitake Mushroom 8 references
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