Mycozil Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Mycozil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Mycozil is a dietary supplement by Global Healing with 8 active ingredients. Its ingredients are commonly taken for sore throat and cough, heartburn and stomach upset, mouth ulcers and digestive complaints.Based on those ingredients, 1,264 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Licorice, Fulvic Acid, organic Anise. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Mycozil by Global Healing
Ask about any prescription or over-the-counter medication and we check it for interactions with Mycozil by Global Healing — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Mycozil by Global Healing
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Mycozil contains 8 active ingredients in a proprietary blend. Licorice, anise, and pau d'arco are herbal extracts; fulvic acid is a compound derived from organic material.
Beta-Glucanase and Hemicellulase are enzymes meant to break down cell wall material. Brevibacillus laterosporus is a probiotic-type organism.
The product also contains inactive ingredients — organic gum acacia and a vegetable capsule — that serve as a binder and capsule material. The proprietary blend format means the exact amount of each active ingredient isn't listed separately on the label.
This makes it harder to know the dose of licorice, anise, fulvic acid, or pau d'arco you're actually taking — important when considering interactions or side effects.
Does it work?
Couldn't assess
The evidence we hold shows that licorice is possibly effective for canker sores and atopic dermatitis (eczema). For anise, fulvic acid, and pau d'arco — the other active ingredients — we have insufficient evidence to rate their effectiveness for any condition.
Licorice has also been studied for Addison disease and asthma, but the evidence is too thin to say whether it helps. Because the ingredients are in a proprietary blend and we don't have their individual amounts, we can't tell you the product's strength for any of these uses.
How safe is it?
Well-documented data
Licorice is generally well tolerated in food amounts, but high doses or long-term use of its active component glycyrrhizin can cause serious problems — including electrolyte imbalances, high blood pressure, and low potassium. The most common side effects from licorice are headache, nausea, and vomiting.
Rare serious effects include pseudoaldosteronism (a condition mimicking hormonal disorders). Licorice is unsafe in pregnancy and should be avoided while breastfeeding due to insufficient safety data.
Fulvic acid appears well tolerated in the short term, though human safety data is limited. Common side effects are diarrhea, headache, and sore throat.
Avoid it in pregnancy and while breastfeeding due to lack of safety information. Anise is likely safe during pregnancy and breastfeeding, but medicinal amounts and essential oil should be avoided in pregnancy.
Anise may trigger allergic reactions including contact dermatitis, asthma, or in sensitive people, anaphylaxis. Pau d'arco may cause anemia and bleeding at higher doses (above 1.5 grams lapachol daily), and can trigger nausea, vomiting, or diarrhea.
It is possibly unsafe in pregnancy and should be avoided while breastfeeding.
Meds to double-check
Moderate interaction found
Before taking Mycozil, check with your doctor or pharmacist if you take heart medications (especially digoxin), blood thinners or antiplatelet drugs (warfarin, aspirin, others), diabetes medications, cancer chemotherapy (cisplatin, paclitaxel), thyroid hormone, antidepressants (fluoxetine, imipramine), sedatives (diazepam, midazolam), immunosuppressants, birth control or hormone therapy, loop diuretics (water pills), or caffeine. All are documented to interact with one or more of this product's ingredients.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Mycozil carries documented interactions with a wide range of medications — heart drugs, blood thinners, diabetes pills, antidepressants, sedatives, birth control, thyroid hormone, and others. Before you start it, check your exact medications using the tool on this page and confirm with your own doctor or pharmacist that this product won't interfere with your prescriptions or conditions.
If you're pregnant, breastfeeding, or taking any regular medication, ask your healthcare provider whether it's right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Mycozil, straight from the product label.
| Brand | Global Healing |
|---|---|
| Barcode (UPC) | 811839030645 |
| Net contents | 120 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 23, 2021 |
| DSLD ID | 250664 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Mycozil by Global Healing, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 1920 mg | -- |
| Beta-Glucanase | 0 NP | -- |
| Hemicellulase | 0 NP | -- |
| organic Licorice | 0 NP | -- |
| Fulvic Acid | 0 NP | -- |
| organic Anise | 0 NP | -- |
| wildcrafted Pau d'Arco | 0 NP | -- |
| wildcrafted Jatoba | 0 NP | -- |
| Brevibacillus laterosporus | 0 NP | -- |
Other ingredients: organic Gum Acacia, Vegetable Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use Take 3 capsules twice daily before meals or as recommended by your healthcare provider.
Formulation
Mycozil is a unique blend of herbs, enzymes, probiotics, and prebiotics formulated to support systemic cleansing and normal candida levels to encourage healthy flora balance.
Candida & flora balance support
GMO Free Gluten Free
Precautions
Warning: Keep out of reach of children.
Consult your healthcare provider before taking if you are pregnant or nursing, or have any other medical concerns.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Global Healing Since 1998
See bottle for best-by date & lot info.
No Animal Testing
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Mycozil by Global Healing label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Mycozil by Global Healing
These are the 8 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Capsule(s) Dosage formCapsule Servings per container40 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › Beta-Glucanase
- › Hemicellulase
- › Organic Licorice
- › Fulvic Acid
- › Organic Anise
- › Wildcrafted Pau d'Arco
- › Wildcrafted Jatoba
- › Brevibacillus laterosporus
Other (inactive) ingredients: Organic Gum Acacia, Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.
Mycozil by Global Healing Drug Interactions
HelloPharmacist Interaction Report
Mycozil by Global Healing interacts with medications through its licorice, fulvic acid, anise, and pau d'arco content.
The most serious documented interaction is moderate in severity: licorice may increase the risk of heart toxicity when combined with digoxin (Lanoxin), a heart medication, especially if licorice is overused or misused.
Read the full breakdown — every affected drug type, severity by severity
Licorice affects several drug types. It may raise levels of drugs broken down by your liver's CYP2B6 and CYP2C19 pathways (Moderate).
It can decrease how well warfarin (Coumadin), a blood thinner, works by speeding up its breakdown (Moderate). It may enhance the effects of loop diuretics — water pills like furosemide (Lasix) — in ways that could cause electrolyte problems (Moderate).
It may reduce the effectiveness of cancer drugs cisplatin (Platinol-AQ) and paclitaxel (Abraxane, Onxol) (Moderate each). It may lower midazolam (Versed), a sedative, to less-effective levels (Moderate).
Fulvic acid may decrease how well blood thinners (anticoagulants and antiplatelets) work, raising clotting risk (Moderate). It may blunt the effects of immunosuppressants used after transplant or for autoimmune disease (Moderate).
It may interfere with thyroid hormone therapy by raising thyroid-stimulating hormone (TSH) levels (Moderate). Anise may interfere with estrogen-based hormone replacement therapy or birth control pills (Moderate each).
It may increase low blood sugar (hypoglycemia) risk with diabetes medications (Moderate). It may reduce how well fluoxetine (Prozac) or imipramine (Tofranil) antidepressants work (Moderate each).
It may boost the sedative effect of diazepam (Valium) or the pain-relief effect of codeine (Moderate each). It may lower caffeine's effects (Moderate).
Pau d'arco may increase bleeding risk with blood thinners (Moderate).
We could not check Beta-Glucanase, Hemicellulase, or Jatoba — we hold no data for these ingredients. Altogether, these interactions span 1,265 individual medications.
Use the medication checker below to see if any of your exact drugs are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Mycozil?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Mycozil interact with 1,264 drugs. Click any drug to see the details.
4 of the 8 ingredients in Mycozil interact with drugs. Each result below shows which ingredient is responsible. organic Licorice Fulvic Acid organic Anise wildcrafted Pau d'Arco
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Mycozil — through 1 ingredient. Tap an ingredient for the detail:
Fulvic AcidImmunosuppressants Moderate
Interaction Summary
Theoretically, taking fulvic acid might decrease the effects of immunosuppressive therapy.
Read the full Fulvic Acid + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Mycozil — through 1 ingredient. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Fulvic AcidAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking fulvic acid may decrease the effectiveness of anticoagulant and antiplatelet drugs.
Read the full Fulvic Acid + Abciximab interactionWildcrafted Pau D'arcoAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Wildcrafted Pau D'arco + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Mycozil — through 1 ingredient. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Mycozil — through 1 ingredient. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Mycozil — through 1 ingredient. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Mycozil — through 3 ingredients. Tap an ingredient for the detail:
Fulvic AcidAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, taking fulvic acid may decrease the effectiveness of anticoagulant and antiplatelet drugs.
Read the full Fulvic Acid + Abrocitinib interactionOrganic LicoriceCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP2C9.
Read the full Organic Licorice + Abrocitinib interactionWildcrafted Pau D'arcoAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Wildcrafted Pau D'arco + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Mycozil — through 1 ingredient. Tap an ingredient for the detail:
Organic LicoriceP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
Read the full Organic Licorice + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Mycozil — through 1 ingredient. Tap an ingredient for the detail:
Organic AniseAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, anise seed might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Organic Anise + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Mycozil — through 1 ingredient. Tap an ingredient for the detail:
Organic LicoriceAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, licorice might reduce the effects of antihypertensive drugs.
Read the full Organic Licorice + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Wildcrafted Pau D'arcoAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Wildcrafted Pau D'arco + Acenocoumarol interactionFulvic AcidAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking fulvic acid may decrease the effectiveness of anticoagulant and antiplatelet drugs.
Read the full Fulvic Acid + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Mycozil — through 4 ingredients. Tap an ingredient for the detail:
Wildcrafted Pau D'arcoAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Wildcrafted Pau D'arco + Acetaminophen, Aspirin interactionFulvic AcidAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking fulvic acid may decrease the effectiveness of anticoagulant and antiplatelet drugs.
Read the full Fulvic Acid + Acetaminophen, Aspirin interactionOrganic AniseAcetaminophen (tylenol, Others) Minor
Interaction Summary
Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Read the full Organic Anise + Acetaminophen, Aspirin interactionOrganic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Mycozil — through 4 ingredients. Tap an ingredient for the detail:
Fulvic AcidAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking fulvic acid may decrease the effectiveness of anticoagulant and antiplatelet drugs.
Read the full Fulvic Acid + Acetaminophen, Aspirin, Caffeine interactionOrganic AniseCaffeine, Acetaminophen (tylenol, Others) Moderate
Interaction Summary
Theoretically, anise oil might decrease the efficacy of caffeine.
Read the full Organic Anise + Acetaminophen, Aspirin, Caffeine interactionWildcrafted Pau D'arcoAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Wildcrafted Pau D'arco + Acetaminophen, Aspirin, Caffeine interactionOrganic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Organic AniseAcetaminophen (tylenol, Others), Caffeine Moderate
Interaction Summary
Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Read the full Organic Anise + Acetaminophen, Butalbital, Caffeine interactionOrganic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Butalbital, Caffeine, Codeine interactionOrganic AniseAcetaminophen (tylenol, Others), Caffeine +1 Moderate
Interaction Summary
Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Read the full Organic Anise + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Organic AniseCodeine, Acetaminophen (tylenol, Others) Moderate
Interaction Summary
Theoretically, anise oil might increase the effects and adverse effects of codeine.
Read the full Organic Anise + Acetaminophen, Butalbital, Codeine interactionOrganic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Organic AniseAcetaminophen (tylenol, Others), Codeine Moderate
Interaction Summary
Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Read the full Organic Anise + Acetaminophen, Butalbital, Codeine Phosphate interactionOrganic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionOrganic AniseAcetaminophen (tylenol, Others), Caffeine Moderate
Interaction Summary
Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Read the full Organic Anise + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Organic AniseCaffeine, Codeine +1 Moderate
Interaction Summary
Theoretically, anise oil might decrease the efficacy of caffeine.
Read the full Organic Anise + Acetaminophen, Caffeine, Codeine interactionOrganic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Acetaminophen, Caffeine, Codeine, Salicylamide interactionOrganic AniseAcetaminophen (tylenol, Others), Caffeine +1 Moderate
Interaction Summary
Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Read the full Organic Anise + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Caffeine, Dihydrocodeine interactionOrganic AniseAcetaminophen (tylenol, Others), Caffeine Moderate
Interaction Summary
Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Read the full Organic Anise + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Organic AniseCaffeine, Acetaminophen (tylenol, Others) Moderate
Interaction Summary
Theoretically, anise oil might decrease the efficacy of caffeine.
Read the full Organic Anise + Acetaminophen, Caffeine, Isometheptene interactionOrganic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates, Diuretic Drugs +1 Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Acetaminophen, Caffeine, Pyrilamine interactionOrganic AniseAcetaminophen (tylenol, Others), Caffeine Moderate
Interaction Summary
Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Read the full Organic Anise + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionOrganic AniseAcetaminophen (tylenol, Others) Minor
Interaction Summary
Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Read the full Organic Anise + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Organic AniseAcetaminophen (tylenol, Others), Codeine Moderate
Interaction Summary
Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Read the full Organic Anise + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionOrganic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionOrganic AniseAcetaminophen (tylenol, Others) Minor
Interaction Summary
Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Read the full Organic Anise + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionOrganic AniseAcetaminophen (tylenol, Others) Minor
Interaction Summary
Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Read the full Organic Anise + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionOrganic AniseAcetaminophen (tylenol, Others) Minor
Interaction Summary
Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Read the full Organic Anise + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Organic Licorice + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionOrganic AniseAcetaminophen (tylenol, Others) Minor
Interaction Summary
Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Read the full Organic Anise + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Mycozil — through 2 ingredients. Tap an ingredient for the detail:
Organic LicoriceCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Licorice + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionOrganic AniseAcetaminophen (tylenol, Others) Minor
Interaction Summary
Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Read the full Organic Anise + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Mycozil with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
organic Licorice
Antihypertensive Drugs
Theoretically, licorice might reduce the effects of antihypertensive drugs.
In human research, licorice increases blood pressure in a dose-dependent manner.
Cisplatin (Platinol-Aq)
Theoretically, licorice might reduce the effects of cisplatin.
In animal research, licorice diminished the therapeutic efficacy of cisplatin.
Corticosteroids
Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Case reports suggest that concomitant use of licorice and oral corticosteroids, such as hydrocortisone, can potentiate the duration of activity and increase blood levels of corticosteroids. Additionally, in one case report, a patient with neurogenic orthostatic hypertension stabilized on fludrocortisone 0.1 mg twice daily developed pseudohyperaldosteronism after recent consumption of large amounts of black licorice.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, licorice might increase levels of drugs metabolized by CYP2B6.
In vitro research shows that licorice extract and glabridin, a licorice constituent, inhibit CYP2B6 isoenzymes. Licorice extract from the species G. uralensis seems to inhibit CYP2B6 isoenzymes to a greater degree than G. glabra extract in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2B6; however, these interactions have not yet been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, licorice might increase levels of drugs metabolized by CYP2C19.
In vitro, licorice extracts from the species G. glabra and G. uralensis inhibit CYP2C19 isoenzymes in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C19; however, this interaction has not yet been reported in humans.
Cytochrome P450 2C8 (Cyp2C8) Substrates
Theoretically, licorice might increase levels of drugs metabolized by CYP2C8.
In vitro, licorice extract from the species G. glabra and G. uralensis inhibits CYP2C8 isoenzymes. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C8; however, this interaction has not yet been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP2C9.
There is conflicting evidence about the effect of licorice on CYP2C9 enzyme activity. In vitro research shows that extracts from the licorice species G. glabra and G. uralensis moderately inhibit CYP2C9 isoenzymes. However, evidence from an animal model shows that licorice extract from the species G. uralensis can induce hepatic CYP2C9 activity. Until more is known, licorice should be used cautiously in people taking CYP2C9 substrates.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Pharmacokinetic research shows that the licorice constituent glycyrrhizin, taken in a dosage of 150 mg orally twice daily for 14 days, modestly decreases the area under the concentration-time curve of midazolam by about 20%. Midazolam is a substrate of CYP3A4, suggesting that glycyrrhizin modestly induces CYP3A4 activity. Animal research also shows that licorice extract from the species G. uralensis induces CYP3A4 activity. However, licorice extract from G. glabra species appear to inhibit CYP3A4-induced metabolism of testosterone in vitro. It is thought that the G. glabra inhibits CYP3A4 due to its constituent glabridin, which is a moderate CYP3A4 inhibitor in vitro and not present in other licorice species. Until more is known, licorice should be used cautiously in people taking CYP3A4 substrates.
Digoxin (Lanoxin)
Theoretically, concomitant use of licorice with digoxin might increase the risk of cardiac toxicity.
Overuse or misuse of licorice with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.
Diuretic Drugs
Theoretically, concomitant use of licorice with diuretic drugs might increase the risk of hypokalemia.
Overuse of licorice might compound diuretic-induced potassium loss. In one case report, a 72-year-old male with a past medical history of hypertension, type 2 diabetes, hyperlipidemia, arrhythmia, stroke, and hepatic dysfunction was hospitalized with severe hypokalemia and uncontrolled hypertension due to pseudohyperaldosteronism. This was thought to be provoked by concomitant daily consumption of a product containing 225 mg of glycyrrhizin, a constituent of licorice, and hydrochlorothiazide 12.5 mg for 1 month.
Estrogens
Theoretically, licorice might increase or decrease the effects of estrogen therapy.
Theoretically, licorice might interfere with estrogen therapy due to estrogenic and anti-estrogenic effects.
Loop Diuretics
Theoretically, loop diuretics might increase the mineralocorticoid effects of licorice.
Theoretically, loop diuretics might enhance the mineralocorticoid effects of licorice by inhibiting the enzyme that converts cortisol to cortisone; however, bumetanide (Bumex) does not appear to have this effect.
Midazolam (Versed)
Theoretically, licorice might decrease levels of midazolam.
In humans, the licorice constituent glycyrrhizin appears to moderately induce the metabolism of midazolam. This is likely due to induction of cytochrome P450 3A4 by licorice. Until more is known, licorice should be used cautiously in people taking midazolam.
P-Glycoprotein Substrates
Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
In vitro research shows that licorice can increase P-glycoprotein activity.
Paclitaxel (Abraxane, Onxol)
Theoretically, licorice might decrease plasma levels and clinical effects of paclitaxel.
Multiple doses of licorice taken concomitantly with paclitaxel might reduce the effectiveness of paclitaxel. Animal research shows that licorice 3 grams/kg given orally for 14 days before intravenous administration of paclitaxel decreases the exposure to paclitaxel and increases its clearance. Theoretically, this occurs because licorice induces cytochrome P450 3A4 enzymes, which metabolize paclitaxel. Notably, a single dose of licorice did not affect exposure or clearance of paclitaxel.
Warfarin (Coumadin)
Theoretically, licorice might decrease plasma levels and clinical effects of warfarin.
Licorice seems to increase metabolism and decrease levels of warfarin in animal models. This is likely due to induction of cytochrome P450 2C9 (CYP2C9) metabolism by licorice. Advise patients taking warfarin to avoid taking licorice.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that licorice induces CYP1A2 enzymes.
Methotrexate (Trexall, Others)
Theoretically, licorice might increase levels of methotrexate.
Animal research suggests that intravenous administration of glycyrrhizin, a licorice constituent, and high-dose methotrexate may delay methotrexate excretion and increase systemic exposure, leading to transient elevations in liver enzymes and total bilirubin. This interaction has not yet been reported in humans.
Fulvic Acid
Anticoagulant/Antiplatelet Drugs
Theoretically, taking fulvic acid may decrease the effectiveness of anticoagulant and antiplatelet drugs.
In vitro evidence shows that fulvic acid, formed from the oxidation and polymerization of protocatechuic acid, can shorten prothrombin time in human plasma, increasing the risk of clot formation.
Immunosuppressants
Theoretically, taking fulvic acid might decrease the effects of immunosuppressive therapy.
Animal research shows that fulvic acid stimulates immune function.
Thyroid Hormone
Theoretically, taking fulvic acid with thyroid hormone therapy might interfere with the ability to normalize thyroid function.
Animal research shows that fulvic acid increases the plasma level of thyroid-stimulating hormone (TSH) and decreases the thyroxine (T4):triiodothyronine (T3) ratio.
organic Anise
Antidiabetes Drugs
Theoretically, anise seed might increase the risk of hypoglycemia when taken with antidiabetes drugs.
A small clinical study shows that anise seed powder decreases fasting blood glucose levels by 36% when compared to baseline.
Caffeine
Theoretically, anise oil might decrease the efficacy of caffeine.
Animal research shows that taking anise oil with caffeine decreases the bioavailability of caffeine. Whether this interaction will occur in humans is unclear.
Codeine
Theoretically, anise oil might increase the effects and adverse effects of codeine.
Animal research shows that anise oil increases the analgesic effects of codeine, possibly by inducing its phase I metabolism and increasing conversion to morphine. Whether this interaction occurs in humans is unclear.
Contraceptive Drugs
Theoretically, anise might interfere with contraceptive drug therapy.
Some in vitro research suggests that anise has estrogenic effects, while other in vitro research suggests that anise has antiestrogenic effects.
Diazepam (Valium)
Theoretically, anise oil might increase the effects and adverse effects of diazepam.
Animal research shows that taking anise oil with diazepam increases the motor impairment associated with diazepam, possibly by inhibiting its breakdown by cytochrome P450 3A4. Whether this interaction occurs in humans is unclear.
Estrogens
Theoretically, anise might interfere with estrogen-based hormone replacement therapy.
Some in vitro research suggests that anise has estrogenic effects, while other in vitro research suggests that anise has antiestrogenic effects.
Fluoxetine (Prozac)
Theoretically, anise oil might decrease the efficacy of fluoxetine.
Animal research shows that taking anise oil with fluoxetine reduces the antidepressant effects of fluoxetine, possibly by promoting its breakdown by cytochrome P450 2D6. Whether this interaction occurs in humans is unclear.
Imipramine (Tofranil)
Theoretically, anise oil might decrease the efficacy of imipramine.
Animal research shows that taking anise oil with imipramine reduces the antidepressant effects of imipramine, possibly by promoting its breakdown by cytochrome P450 2D6. Whether this interaction occurs in humans is unclear.
Midazolam (Versed)
Theoretically, anise oil might increase the effects and adverse effects of midazolam.
Animal research shows that taking anise oil with midazolam increases the motor impairment associated with midazolam, possibly by inhibiting its breakdown by cytochrome P450 3A4. Whether this interaction occurs in humans is unclear.
Tamoxifen (Nolvadex)
Theoretically, anise might interfere with tamoxifen therapy.
Some in vitro research suggests that anise has estrogenic effects, while other in vitro research suggests that anise has antiestrogenic effects.
Acetaminophen (Tylenol, Others)
Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Animal research shows that taking anise oil with acetaminophen decreases peak plasma levels of acetaminophen but does not reduce overall bioavailability. Whether this interaction will occur in humans is unclear.
wildcrafted Pau d'Arco
Anticoagulant/Antiplatelet Drugs
Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that pau d'arco reduces platelet aggregation and may interfere with vitamin K. One clinical study shows that taking the lapachol constituent of pau d'arco in doses above 1.5 grams daily increases the risk of bleeding. The effects of whole pau d'arco or pau d'arco extract in humans are unclear.
Brand information
Manufacturer and brand details for Mycozil, from the product label.
Global Healing
See all Global Healing products- Name
- Global Healing Center, LP.
- City
- Houston
- State
- TX
- ZipCode
- 77018
- Phone Number
- 1.800.476.0016
- Web Address
- globalhealing.com
Mycozil by Global Healing: Common Questions
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Why can't you check Beta-Glucanase, Hemicellulase, Jatoba, and Brevibacillus laterosporus for interactions?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Mycozil’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Licorice
Interacts with 1,040 drugsLicorice root is a traditional remedy used for sore throats, coughs, and digestive complaints, but solid human evidence is limited for most uses. Regular licorice contains glycyrrhizin, whic...
Read the full Licorice monograph → Herb & supplement monographFulvic Acid
Interacts with 257 drugsFulvic acid is a natural compound formed when plants and microbes break down in soil, and it is sold as a supplement for energy, gut, and overall wellness. Human research is very limited, so...
Read the full Fulvic Acid monograph → Herb & supplement monographAnise
Interacts with 245 drugsAnise is a fragrant, licorice-flavored seed used for centuries to ease digestion and soothe coughs. Most of its health claims are based on tradition and small or laboratory studies rather th...
Read the full Anise monograph → Herb & supplement monographPau D'arco
Interacts with 122 drugsPau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activity in lab studies. However, strong human...
Read the full Pau D'arco monograph →Sources & How We Checked
Mycozil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 113 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Licorice 92 references
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- Sigurjonsdottir HA, Ragnarsson J, Franzson L, Sigurdsson G. Is blood pressure commonly raised by moderate consumption of liquorice? J Hum Hypertens 1995;9:345-8.
- Armanini D, Lewicka S, Pratesi C, et al. Further studies on the mechanism of the mineralocorticoid action of licorice in humans. J Endocrinol Invest 1996;19:624-9. PubMed
- Zhang YD, Lorenzo B, Reidenberg MM. Inhibition of 11 beta hydroxysteroid dehydrogenase obtained from guinea pig kidney by furosemide, naringenin and some other compounds. J Steroid Biochem Mol Biol 1994;49:81-5.
- Strandberg TE, Jarvenpaa AL, Vanhanen H, McKeigue PM. Birth outcome in relation to licorice consumption during pregnancy. Am J Epidemiol 2001;153:1085-8. PubMed
- Sigurjonsdottir HA, Franzson L, Manhem K, et al. Liquorice-induced rise in blood pressure: a linear dose-response relationship. J Hum Hypertens 2001;15:549-52. PubMed
- Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause 2002;9:145-50. PubMed
- Kent UM, Aviram M, Rosenblat M, Hollenberg PF. The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9. Drug Metab Dispos 2002;30:709-15.. PubMed
- Yoshida S, Takayama Y. Licorice-induced hypokalemia as a treatable cause of dropped head syndrome. Clin Neurol Neurosurg 2003;105:286-7.. PubMed
- Strandberg TE, Andersson S, Jarvenpaa AL, et al. Preterm birth and licorice consumption during pregnancy. Am J Epidemiol 2002;156:803-5.. PubMed
- Hussain RM. The sweet cake that reaches parts other cakes can't! Postgrad Med J 2003;79:115-6.. PubMed
- Morris DJ, Davis E, Latif SA. Licorice, tobacco chewing, and hypertension. N Engl J Med 1990;322:849-50. PubMed
- Quinkler M, Stewart PM. Hypertension and the cortisol-cortisone shuttle. J Clin Endocrinol Metab 2003;88:2384-92. PubMed
- Westman EC, Guthrie GP. Licorice, tobacco chewing, and hypertension. N Engl J Med 1990;322:850. PubMed
- Mu Y, Zhang J, Zhang S, et al. Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. J Pharmacol Exp Ther 2006;316:1369-77. PubMed
- Yasue H, Itoh T, Mizuno Y, Harada E. Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hypertensive patient taking herbal medicines containing licorice. Intern Med 2007;46:575-8. PubMed
- Brayley J, Jones J. Life-threatening hypokalemia associated with excessive licorice ingestion (letter). Am J Psychiatry 1994;151:617-8. PubMed
- de Klerk GJ, Nieuwenhuis G, Beutler JJ. Hypokalaemia and hypertension associated with use of liquorice flavoured chewing gum. BMJ 1997;314:731-2.
- Dellow EL, Unwin RJ, Honour JW. Pontefract cakes can be bad for you: refractory hypertension and liquorice excess. Nephol Dial Transplant 1999;14:218-20. PubMed
- Elinav E, Chajek-Shaul T. Licorice consumption causing severe hypokalemic paralysis. Mayo Clin Proc 2003;78:767-8. PubMed
- Eriksson JW, Carlberg B, Hillom V. Life-threatening ventricular tachycardia due to liquorice-induced hypokalemia. J Intern Med 1999;245:307-10.
- Janse A, van Iersel M, Hoefnagels WH, Olde Rikker MG. The old lady who liked liquorice: hypertension due to chronic intoxication in a memory-impaired patient. Neth J Med 2005;63:149-50.
- Lin SH, Yang SS, Chau T, Halperin ML. An unusual cause of hypokalemic paralysis: chronic licorice ingestion. Am J Med Sci 2003;325:153-6. PubMed
- van den Bosch AE, van der Klooster JM, Zuidgeest DM, et al. Severe hypokalemic paralysis and rhabdomyolysis due to ingestion of liquorice. Neth J Med 2005;63:146-8.
- van Uum SH. Liquorice and hypertension. Neth J Med 2005;63:119-20.
- Russo S, Mastropasqua M, Mosetti MA, et al. Low doses of liquorice can induce hypertension encephalopathy. Am J Nephrol 2000;20:145-8. PubMed
- Stormer FC, Reistad R, Alexander J. Glycyrrhizic acid in liquorice - evaluation of health hazard. Food Chem Toxicol 1993;31:303-12. PubMed
- Sontia B, Mooney J, Gaudet L, Touyz RM. Pseudohyperaldosteronism, liquorice, and hypertension. J Clin Hypertens (Greenwich) 2008;10:153-7. PubMed
- Francini-Pesenti F, Puato M, Piccoli A, Brocadello F. Liquorice-induced hypokalaemia and water retention in the absence of hypertension. Phytother Res 2008;22:563-5. PubMed
- Lapi F, Gallo E, Bernasconi S, et al. Myopathies associated with red yeast rice and liquorice: spontaneous reports from the Italian Surveillance System of Natural Health Products. Br J Clin Pharmacol 2008;66:572-4. PubMed
- Chen MF, Shimada F, Kato H, Yano S, Kanaoka M. Effect of glycyrrhizin on the pharmacokinetics of prednisolone following low dosage of prednisolone hemisuccinate. Endocrinol Jpn 1990;37:331-41. PubMed
- Teelucksingh S, Mackie AD, Burt D, McIntyre MA, Brett L, Edwards CR. Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid. Lancet 1990;335(8697):1060-3. PubMed
- Heidemann HT, Kreuzfelder E. Hypokalemic rhabdomyolysis with myoglobinuria due to licorice ingestion and diuretic treatment. Klin Wochenschr 1983;61:303-5. PubMed
- Hukkanen J, Ukkola O, Savolainen MJ. Effects of low-dose liquorice alone or in combination with hydrochlorothiazide on the plasma potassium in healthy volunteers. Blood Press 2009;18:192-5. PubMed
- Bisogni V, Rossi GP, Calò LA. Apparent mineralcorticoid excess syndrome, an often forgotten or unrecognized cause of hypokalemia and hypertension: case report and appraisal of the pathophysiology. Blood Press. 2014 Jun;23(3):189-92. PubMed
- Dehours E, Vallé B, Rougé-Bugat ME, Florent B, Bounes V, Franchitto N. Suspected hypokalaemia following liquorice ingestion on board ship. J Telemed Telecare. 2013 Jun;19(4):227-8. PubMed
- Kormann R, Languille E, Amiot HM, Hertig A. Dying for a cup of tea. BMJ Case Rep. 2012 Oct 19;2012. PubMed
- Panduranga P, Al-Rawahi N. Licorice-induced severe hypokalemia with recurrent torsade de pointes. Ann Noninvasive Electrocardiol. 2013 Nov;18(6):593-6. PubMed
- Räikkönen K, Seckl JR, Heinonen K, Pyhälä R, Feldt K, Jones A, Pesonen AK, Phillips DI, Lahti J, Järvenpää AL, Eriksson JG, Matthews KA, Strandberg TE, Kajantie E. Maternal prenatal licorice consumption alters hypothalamic-pituitary-adrenocortical axis fu
- Robles BJ, Sandoval AR, Dardon JD, Blas CA. Lethal liquorice lollies (liquorice abuse causing pseudohyperaldosteronism). BMJ Case Rep. 2013 Sep 19;2013. PubMed
- Chamberlain, J. J. and Abolnik, I. Z. Pulmonary edema following a licorice binge. West J Med 1997;167(3):184-185.
- Barrella, M., Lauria, G., Quatrale, R., and Paolino, E. Hypokaliemic rhabdomyolysis associated with liquorice ingestion: report of an atypical case. Ital.J Neurol.Sci 1997;18(4):217-220. PubMed
- Fugh-Berman, A. Herb-drug interactions. Lancet 2000;355(9198):134-138. PubMed
- Hasegawa, J., Suyama, Y., Kinugawa, T., Morisawa, T., and Kishimoto, Y. Echocardiographic findings of the heart resembling dilated cardiomyopathy during hypokalemic myopathy due to licorice-induced pseudoaldosteronism. Cardiovasc.Drugs Ther 1998;12(6):59 PubMed
- van Rossum, T. G., Vulto, A. G., Hop, W. C., Brouwer, J. T., Niesters, H. G., and Schalm, S. W. Intravenous glycyrrhizin for the treatment of chronic hepatitis C: a double-blind, randomized, placebo-controlled phase I/II trial. J Gastroenterol Hepatol 199 PubMed
- Lozano, P., Flores, D., Martinez, S., Artigues, I., Rimbau, E. M., and Gomez, F. Upper limb ischemia induced by chronic licorice ingestion. J Cardiovasc.Surg (Torino) 2000;41(4):631-632.
- Brouwers, A. J. and van der, Meulen J. ['Licorice hypertension' also caused by licorice tea]. Ned.Tijdschr Geneeskd. 4-14-2001;145(15):744-747.
- van Rossum, T. G., Vulto, A. G., Hop, W. C., and Schalm, S. W. Glycyrrhizin-induced reduction of ALT in European patients with chronic hepatitis C. Am J Gastroenterol 2001;96(8):2432-2437. PubMed
- Sigurjonsdottir, H. A., Manhem, K., Axelson, M., and Wallerstedt, S. Subjects with essential hypertension are more sensitive to the inhibition of 11 beta-HSD by liquorice. J Hum Hypertens 2003;17(2):125-131.
- Shintani, S., Murase, H., Tsukagoshi, H., and Shiigai, T. Glycyrrhizin (licorice)-induced hypokalemic myopathy. Report of 2 cases and review of the literature. Eur Neurol 1992;32(1):44-51. PubMed
- Chen, M. F., Shimada, F., Kato, H., Yano, S., and Kanaoka, M. Effect of oral administration of glycyrrhizin on the pharmacokinetics of prednisolone. Endocrinol Jpn 1991;38(2):167-174. PubMed
- Lee, C. K., Park, K. K., Lim, S. S., Park, J. H., and Chung, W. Y. Effects of the licorice extract against tumor growth and cisplatin-induced toxicity in a mouse xenograft model of colon cancer. Biol Pharm Bull 2007;30(11):2191-2195. PubMed
- Isaia, G. C., Pellissetto, C., Ravazzoli, M., and Tamone, C. Acute adrenal crisis and hypercalcemia in a patient assuming high liquorice doses. Minerva Med 2008;99(1):91-94.
- Bocker, D. and Breithardt, G. [Induction of arrhythmia by licorice abuse]. Z Kardiol 1991;80(6):389-391.
- Tacconi, P., Paribello, A., Cannas, A., and Marrosu, M. G. Carpal tunnel syndrome triggered by excessive licorice consumption. J Peripher.Nerv.Syst. 2009;14(1):64-65. PubMed
- Tu, J. H., He, Y. J., Chen, Y., Fan, L., Zhang, W., Tan, Z. R., Huang, Y. F., Guo, D., Hu, D. L., Wang, D., and Hong-Hao Zhou. Effect of glycyrrhizin on the activity of CYP3A enzyme in humans. Eur J Clin Pharmacol 2010;66(8):805-810. PubMed
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