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Dietary supplement

NO Cofactors Ingredients & Drug Interactions

by NutriCology

NO Cofactors label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking NO Cofactors against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

NO Cofactors is a dietary supplement by NutriCology with 6 active ingredients. Its ingredients are commonly taken for high blood pressure, erectile dysfunction, athletic performance.Based on those ingredients, 1,042 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Beet (root) powder, L-Arginine, L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against NO Cofactors by NutriCology

Ask about any prescription or over-the-counter medication and we check it for interactions with NO Cofactors by NutriCology — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of NO Cofactors by NutriCology

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 4 of its 6 active ingredients.
  • “Setria Performance Blend” is a proprietary blend — the label gives one combined amount (1.10 Gram(s)) without saying how much of each component you get.

NO Cofactors contains six active ingredients. L-arginine and L-citrulline are amino acids that work through nitric oxide to relax blood vessels and improve circulation.

Beet (root) powder is a vegetable extract rich in nitrates that also support blood flow. L-taurine is an amino acid that helps heart and liver function.

L-glutathione is an antioxidant made naturally by your cells. Propionyl-L-carnitine is a form of carnitine that supports heart muscle energy and exercise performance.

The capsule also contains inactive ingredients — microcrystalline cellulose, hydroxypropyl methylcellulose (the capsule shell), rice hull concentrate, gum arabic, and sunflower oil — which are fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: arterial flexibility, endothelial function, and healthy blood flow.
  • We looked for evidence on: Angina, Angioplasty, Cardiovascular disease (CVD), Congestive heart failure (CHF), Coronary heart disease (CHD), Dyslipidemia — and 4 related terms.
  • The strongest evidence on file: Beet is rated "Possibly Effective" for Exercise-induced muscle soreness (Natural Medicines).
  • Also on file: Propionyl-l-carnitine is rated "Possibly Effective" for Angina, Cardiovascular disease (CVD), Congestive heart failure (CHF).
  • Also on file: Taurine is rated "Possibly Effective" for Congestive heart failure (CHF).

The evidence is mixed. Beet and L-citrulline are possibly effective for athletic performance, meaning there's some promising research but it's not definitive.

Propionyl-L-carnitine is possibly effective for congestive heart failure (CHF), angina, and cardiovascular disease — again, the research is encouraging but not conclusive. L-arginine's effectiveness hasn't been rated in our data.

For other uses — like diabetes, heart failure prevention, or cognitive health — the evidence is insufficient to draw firm conclusions, or research suggests the ingredient may not work (L-citrulline for sarcopenia and beet for COPD, both rated possibly ineffective).

The evidence, ingredient by ingredient L-arginine Beet Taurine Propionyl-l-carnitine L-citrulline Glutathione

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-arginine is generally well tolerated short-term but lowers blood pressure and isn't safe for everyone — use only under medical supervision. Common side effects include abdominal pain, bloating, nausea, diarrhea, headache, insomnia, and flushing.

L-citrulline is generally well tolerated in healthy adults but long-term safety isn't fully studied; most common side effects are gastrointestinal discomfort and heartburn. Beet is widely eaten as food and well tolerated, but concentrated supplements lack full safety data.

Rare side effects include red or black stools (harmless color changes) and, at very high doses, calcium loss and kidney damage. L-Taurine is generally well tolerated short-term, with constipation, diarrhea, or indigestion most common; long-term safety is less certain.

L-Glutathione appears well tolerated orally short-term, but pregnancy and breastfeeding safety aren't well established. Propionyl-L-carnitine is well tolerated and may cause diarrhea, stomach pain, nausea, or vomiting.

For pregnancy: L-arginine is possibly safe, but L-citrulline, L-glutathione, and propionyl-L-carnitine lack enough data — safety data for beet and taurine in pregnancy isn't on file. For breastfeeding: L-citrulline, L-glutathione, and propionyl-L-carnitine lack enough safety data, while beet and taurine safety data during lactation isn't on file.

Side effects, ingredient by ingredient L-arginine Beet Taurine Propionyl-l-carnitine L-citrulline Glutathione

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Beet, Propionyl-l-carnitine, L-arginine, Taurine, L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,043 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take blood pressure drugs (antihypertensive medications), blood thinners or antiplatelet drugs, diabetes medications, ACE inhibitors or ARBs, potassium-sparing diuretics, warfarin or acenocoumarol, thyroid hormone, or lithium. All of these have documented moderate interactions with one or more ingredients.

Use the medication checker on this page with your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is aimed at people looking to support circulation, athletic performance, and heart health, but it's not for self-treatment. Every active ingredient lowers blood pressure or affects how your body handles potassium, blood thinners, or other drugs — so if you're on any prescription medication, you must check it against this product with your pharmacist first.

Talk to your doctor before starting, especially if you take blood pressure drugs, blood thinners, diabetes meds, or thyroid hormone.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NO Cofactors, straight from the product label.

Brand NutriCology
Barcode (UPC) 713947574809
Net contents 180 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2020
DSLD ID 234773
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NO Cofactors by NutriCology, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
60
UPC/BARCODE
713947574809
IngredientAmount% DV
L-Arginine125 mg--
L-Citrulline0 NP--
Beet (root) powder250 mg--
L-Taurine25 mg--
L-Glutathione0 NP--
Propionyl L-Carnitine250 mg--
Setria Performance Blend1.1 Gram(s)--

Other ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Rice hull concentrate, Gum Arabic, Sunflower Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Targets arterial flexibility, endothelial function, and healthy blood flow with nutrients that support nitric oxide production.

Variations in product color may occur.

Hypoallergenic

Suggested/Recommended/Usage/Directions

Suggested Use As a dietary supplement, 3 capsules two times daily with or without food, or as directed by a healthcare practitioner.

Precautions

Caution: If pregnant or nursing, consult your healthcare practitioner before use. If taking nitrates or anti-hypertensive medications, use under the direct supervision of a qualified healthcare practitioner.

Keep out of reach of children.

Storage

Keep in a cool, dry place, tightly capped.

Brand IP Statement(s)

Setria Performance Blend Setria is a registered trademark of Kyowa Hakko Bio Co., Ltd.

General Statements

NutriCology Innovative Nutrition

Formula

Nitric oxide performance blend

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

NO Cofactors by NutriCology label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

NO Cofactors label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in NO Cofactors by NutriCology

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Arginine

Interacts with
403 drugs
125 mg per serving

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...

L-Arginine monograph & interactions

Beet (root) powder

Interacts with
861 drugs
250 mg per serving

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some peopl...

Beet (root) powder monograph & interactions

L-Taurine

Interacts with
173 drugs
25 mg per serving

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements,...

L-Taurine monograph & interactions

Propionyl L-Carnitine

Interacts with
19 drugs
250 mg per serving

Propionyl-l-carnitine is a form of the amino acid derivative carnitine that the body uses to help turn fat into energy, and it is studied mostly for c...

Propionyl L-Carnitine monograph & interactions

Setria Performance Blend

1.1 Gram(s) per serving

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Rice hull concentrate, Gum Arabic, Sunflower Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

NO Cofactors by NutriCology Drug Interactions

Want to check YOUR meds against NO Cofactors?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,042Drugs
974 Moderate 68 Minor

Ingredients driving the most interactions

Beet (root) powder 861
L-Arginine 403
L-Citrulline 178
L-Taurine 173
Propionyl L-Carnitine 19

Individual Drug Interactions

The ingredients in NO Cofactors interact with 1,042 drugs. Click any drug to see the details.

5 of the 6 ingredients in NO Cofactors interact with drugs. Each result below shows which ingredient is responsible. Beet (root) powder L-Arginine L-Citrulline L-Taurine Propionyl L-Carnitine

Each ingredient & the kinds of drugs it affects

For each ingredient in NO Cofactors with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Beet (root) powder3 drug types · 861 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.

Likelihood Possible Evidence D
Antihypertensive Drugs

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Beet (root) powder full monograph & interactions

L-Arginine9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine full monograph & interactions

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions

L-Taurine2 drug types · 173 drugs

Antihypertensive Drugs

Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Some clinical evidence suggests that taurine can reduce both systolic and diastolic blood pressure.

Likelihood Probable Evidence D
Lithium

Theoretically, taurine might reduce excretion and increase plasma levels of lithium.
Taurine is thought to have diuretic properties, which might reduce the excretion of lithium.

Likelihood Probable Evidence D
L-Taurine full monograph & interactions

Propionyl L-Carnitine3 drug types · 19 drugs

Acenocoumarol (Sintrom)

Theoretically, propionyl-L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine, the parent compound of propionyl-L-carnitine, might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation when L-carnitine was taken with acenocoumarol. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product. It is unclear if such an interaction would also occur with propionyl-L-carnitine.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, acetyl-L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism. It is unclear if such an interaction would occur with propionyl-L-carnitine.

Likelihood Possible Evidence B
Warfarin (Coumadin)

Theoretically, propionyl-L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine, the parent compound of propionyl-L-carnitine, might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with propionyl-L-carnitine and warfarin.

Likelihood Possible Evidence D
Propionyl L-Carnitine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for NO Cofactors, from the product label.

NutriCology

See all NutriCology products
Name
NutriCology
City
South Salt Lake
State
UT
ZipCode
84115
Phone Number
800.545.9960
Web Address
www.allergyresearchgroup.com
Pharmacist Counseling Corner

NO Cofactors by NutriCology: Common Questions

Does NO Cofactors by NutriCology interact with any medications?
Yes. Based on its ingredients, NO Cofactors has a known interaction with 1,042 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NO Cofactors contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product help with athletic performance?
Two of the ingredients — beet and L-citrulline — are rated possibly effective for athletic performance, meaning there's some research support but it's not definitive. L-carnitine supports heart and muscle energy in certain conditions, but we don't have an effectiveness rating for athletic performance specifically.
What's the most common side effect?
Most of these ingredients cause some gastrointestinal upset — bloating, nausea, diarrhea, heartburn, or stomach discomfort — in some people. L-arginine can also cause headache, insomnia, and flushing. Beet may cause red or black stools, which is harmless.
Can I take this while pregnant or breastfeeding?
L-arginine is possibly safe in pregnancy, but L-citrulline, L-glutathione, and propionyl-L-carnitine lack enough safety data — talk to your doctor. For breastfeeding, the safety of L-citrulline, L-glutathione, and propionyl-L-carnitine isn't well studied either. Safety data for beet and taurine during pregnancy and lactation isn't on file. Check with your doctor or pharmacist for personalized advice.
Is this safe to use long-term?
The data focuses on short-term use and generally shows good tolerance there. Long-term safety for most of these ingredients — especially L-citrulline, taurine, and L-glutathione — hasn't been fully studied, so use only under medical guidance if you plan to take it long-term.
What does each ingredient do?
L-arginine and L-citrulline boost nitric oxide to relax blood vessels and improve blood flow. Beet provides nitrates for similar effects. L-taurine supports heart and liver function. L-glutathione is an antioxidant your cells make naturally. Propionyl-L-carnitine fuels heart muscle and exercise performance.
Can this lower my blood pressure too much?
Yes — L-arginine, L-citrulline, beet, and L-taurine all lower blood pressure theoretically, especially when combined with blood pressure medications. This is why medical supervision is important. If you're on a blood pressure drug, your doctor may need to monitor you or adjust your dose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NO Cofactors label
Go deeper

The Full Monographs Behind NO Cofactors’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

Beet

Interacts with 861 drugs

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but s...

Read the full Beet monograph → Herb & supplement monograph

Taurine

Interacts with 173 drugs

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements, and short-term use appears generally sa...

Read the full Taurine monograph → Herb & supplement monograph

Propionyl-l-carnitine

Interacts with 19 drugs

Propionyl-l-carnitine is a form of the amino acid derivative carnitine that the body uses to help turn fat into energy, and it is studied mostly for circulation problems like peripheral arte...

Read the full Propionyl-l-carnitine monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Glutathione

Glutathione is a powerful antioxidant your body makes naturally, and many people take it as a supplement hoping for skin, detox, or anti-aging benefits. However, strong human evidence is lim...

Read the full Glutathione monograph →
Sources

Sources & How We Checked

NO Cofactors's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 122 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
  6. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
  7. Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
  8. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  9. Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
  10. Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. J Am Coll Nutr 2002;21:422-7.. PubMed
  11. Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004;83:103-7.
  12. Resnick DJ, Softness B, Murphy AR, et al. Case report of an anaphylactoid reaction to arginine. Ann Allergy Asthma Immunol 2002;88:67-8. PubMed
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L-citrulline 8 references
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Taurine 21 references
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Glutathione 1 reference
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Propionyl-l-carnitine 12 references
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