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Dietary supplement

Noni 500 mg Extended Release Ingredients & Drug Interactions

by Nature's Plus Herbal Actives

Noni 500 mg Extended Release label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Noni 500 mg Extended Release against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Noni 500 mg Extended Release is a dietary supplement by Nature's Plus Herbal Actives with 1 active ingredient. Its ingredients are commonly taken for general wellness and energy, inflammation and joint pain, immune support.Based on those ingredients, 542 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Noni. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Noni 500 mg Extended Release by Nature's Plus Herbal Actives

Ask about any prescription or over-the-counter medication and we check it for interactions with Noni 500 mg Extended Release by Nature's Plus Herbal Actives — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Noni 500 mg Extended Release by Nature's Plus Herbal Actives

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: noni (500 mg per extended-release tablet). Noni is a tropical fruit with a long history in traditional medicine.

The tablet also contains several inactive ingredients — microcrystalline cellulose, di-calcium phosphate, hydroxypropyl methylcellulose, stearic acid, magnesium stearate, silica, Activessence, and pharmaceutical glaze — which are binders, fillers, and coating materials that help deliver the noni.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Noni's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: free radical defense nutritional support.
  • We looked for evidence on: Aging, Atherosclerosis, Cancer, Cardiovascular disease (CVD), Cataracts, Diabetes — and 3 related terms.
  • The closest evidence on file: Noni is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis (Natural Medicines).
  • Also on file: Noni is rated "Insufficient Reliable Evidence To Rate" for Cancer, Cardiovascular disease (CVD), Cataracts, Diabetes, and more.

The evidence for noni's effectiveness isn't established in the data we hold. Noni has been studied for asthma, atherosclerosis, athletic performance, burns, cancer, and cardiovascular disease, but for all of these conditions, there is insufficient reliable evidence to rate it.

That doesn't mean it doesn't work — it means the clinical evidence available so far isn't strong enough to draw a conclusion.

The evidence, ingredient by ingredient Noni

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Noni is generally well tolerated in moderate amounts, but there are real concerns. The most common side effects when taken by mouth are abdominal discomfort and nausea.

Rarely, noni has been linked to serious liver injury, including liver failure, though it's not always clear whether noni itself or contaminants in specific products caused the damage. Because of its traditional use to cause abortion, noni should not be used during pregnancy.

There isn't enough safety information available for breastfeeding, so it's best avoided then as well.

Side effects, ingredient by ingredient Noni

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Noni.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 543 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start noni, double-check with your doctor or pharmacist if you take warfarin or any blood thinner — noni may make it less effective. Also confirm use of any blood pressure or heart drug (especially ACE inhibitors, ARBs, potassium-sparing diuretics, or other antihypertensives), seizure medications like phenytoin, drugs that can damage the liver, or ranitidine for acid reflux.

Noni interacts with all of these.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Noni may be worth considering if you're interested in traditional remedies and have no major drug interactions — but you need to check your exact medications first because noni affects blood thinners, blood pressure drugs, diuretics, seizure medications, and several others. Anyone taking warfarin, ACE inhibitors, ARBs, potassium-sparing diuretics, phenytoin, or hepatotoxic drugs should talk with their doctor or pharmacist before adding this product.

Pregnant or breastfeeding people should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Noni 500 mg Extended Release, straight from the product label.

Brand Nature's Plus Herbal Actives
Barcode (UPC) 097467073449
Net contents 30 Tablet(s)
Market status On market
Date entered into DSLD Jan 25, 2017
DSLD ID 69163
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Noni 500 mg Extended Release by Nature's Plus Herbal Actives , sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Extended Release Tablet(s)
Maximum serving Sizes:
1 Extended Release Tablet(s)
UPC/BARCODE
097467073449
IngredientAmount% DV
Noni500 mg--

Other ingredients: Microcrystalline Cellulose, Di-Calcium Phosphate, Hydroxypropyl Methylcellulose, Stearic Acid, Magnesium Stearate, Silica, Activessence, Pharmaceutical Glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Nutritional Support for Free Radical Defense. Each Herbal Actives extended-release formula provides rapid and sustained results. Guaranteed Maximum Potency: Each Herbal Actives formula is scientifically standardized to the highest level of active principles. HerbaShield: An exclusive purity and safety system providing light-resistant bottle, airtight inner seal, moisture-absorbing packet, tamper-evident safety cap and tamper-proof full bottle seal.

This is not a prescription product. It is a dietary supplement made with the highest possible quality standards.

Extended realease

Prescription quality

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement offering the consistent benefits of exact potency, one tablet daily or as recommended by your health care professional

Precautions

Note: If you are pregnant or nursing, consult your health care professional before using any herbal product.

Printed HerbaShield inner seal and full bottle seal. Do not use if either seal is missing or broken.

Keep out of reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Activessence is a registered trademark of Triarco Industries, Inc. and protected by U.S. patents.

HerbaShield

Herbal Actives is a registered trademark of Natural Organics, Inc. in the US and/or other countries.

Natural organics

Formula

Noni 500 mg/10% Polysaccherides

Hypo-allergenic

Supplying the greatest concentration of active botanical principles, Herbal Actives Noni maximizes the synergistic benefits of the whole fruit, which naturally contains myristic acid, ursolic acid, rutin, and limonene.

Noni 500 mg/10% Polysaccharides

FDA Statement of Identity

Standardized Botanical Supplement

Seals/Symbols

Maximum guaranteed potency

Gluten free

Formulation

Gluten free

Vegetarian

Free from artificial colors and preservatives. Free from the common allergens yeast, wheat, soy and milk.

Hypo-allergenic

General

Product No. 7344 LBL. 1135867

Storage

Keep tightly closed in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Noni 500 mg Extended Release by Nature's Plus Herbal Actives label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Noni 500 mg Extended Release label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Noni 500 mg Extended Release by Nature's Plus Herbal Actives

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Extended Release Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Noni

Interacts with
542 drugs
500 mg per serving Form: Polysaccharides

Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claimed benefits...

Noni monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Di-Calcium Phosphate, Hydroxypropyl Methylcellulose, Stearic Acid, Magnesium Stearate, Silica, Activessence, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

Noni 500 mg Extended Release by Nature's Plus Herbal Actives Drug Interactions

Want to check YOUR meds against Noni 500 mg Extended Release?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
542Drugs
541 Moderate 1 Minor

Ingredients driving the most interactions

Noni 542

Individual Drug Interactions

The ingredients in Noni 500 mg Extended Release interact with 542 drugs. Click any drug to see the details.

1 of the 1 ingredient in Noni 500 mg Extended Release interact with drugs. Each result below shows which ingredient is responsible. Noni

Each ingredient & the kinds of drugs it affects

For each ingredient in Noni 500 mg Extended Release with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Noni8 drug types · 542 drugs

Ace Inhibitors (Aceis)

Theoretically, combining noni and ACE inhibitors might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ACE inhibitors, which can also increase potassium levels.

Likelihood Possible Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, combining noni and ARBs might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ARBs, which can also increase potassium levels.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Preliminary clinical research suggests that drinking noni juice can reduce blood pressure in individuals with hypertension.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
There is concern that noni might cause hepatotoxicity in some patients. Advise patients against combining noni with potentially hepatotoxic drugs.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, taking noni fruit juice concomitantly with phenytoin may lower phenytoin levels and increase the risk of seizures.
In one case report, an adult taking phenytoin for partial seizures experienced low serum phenytoin levels while taking noni juice 90-200 mL daily. Serum phenytoin levels increased after decreasing noni juice consumption; similarly, serum phenytoin levels decreased after increasing noni juice consumption. Some researchers believe noni juice may induce cytochrome P450 2C9 enzymes, which would decrease phenytoin levels, but this has not been well studied. Patients may need additional monitoring when starting or stopping noni juice supplementation.

Likelihood Possible Evidence D
Potassium-Sparing Diuretics

Theoretically, combing noni and a potassium-sparing diuretic might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with potassium-sparing diuretics, which can also increase potassium levels.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking noni juice concomitantly with warfarin might decrease the effectiveness of warfarin.
In one case, a 41-year-old patient stabilized on warfarin had a decreased international normalized ratio (INR) following consumption of a specific commercial noni juice product (Noni juice 4 Everything). While the patient was still taking noni juice, an increase in warfarin dose did not produce an increase in INR. However, it should be noted that this particular product contained extracts and derivatives from more than 115 components, many of which contained vitamin K. Furthermore, vitamin K was listed as a separate ingredient of the product, suggesting that the product was possibly fortified with vitamin K. It has not been verified that noni fruit alone contains a significant amount of vitamin K or interacts with warfarin.

Likelihood Possible Evidence D
Ranitidine (Zantac)

Taking noni fruit with ranitidine might increase the levels and clinical effects of ranitidine.
Clinical evidence shows that taking an aqueous extract of noni fruit 30 minutes prior to taking a single oral dose of ranitidine can increase the rate of absorption and plasma concentration of ranitidine.

Likelihood Possible Evidence B
Noni full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Noni 500 mg Extended Release, from the product label.

Nature's Plus Herbal Actives

See all Nature's Plus Herbal Actives products
Name
Natural Organics Laboratories, Inc. makers of Nature's Plus
Street Address
9500 New Horizons Blvd.
City
Amityville
State
New York
ZipCode
11701
Web Address
www.naturesplus.com
Pharmacist Counseling Corner

Noni 500 mg Extended Release by Nature's Plus Herbal Actives : Common Questions

Does Noni 500 mg Extended Release by Nature's Plus Herbal Actives interact with any medications?
Yes. Based on its ingredients, Noni 500 mg Extended Release has a known interaction with 542 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Noni 500 mg Extended Release contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take noni if I'm pregnant or breastfeeding?
No. Noni has been traditionally used to cause abortion, so it should not be used during pregnancy. There isn't enough safety information for breastfeeding either, so it's best avoided then too. Talk with your doctor about safer alternatives if you're interested in supplements during pregnancy or while nursing.
What are the most common side effects?
When taken by mouth, noni most often causes abdominal discomfort and nausea. Most people tolerate it in moderate amounts without serious problems, though high-quality safety studies haven't been done.
Is noni safe for my liver?
Noni is generally well tolerated, but there's a real concern about liver injury. While it's rare, noni has been linked to serious hepatotoxicity — including liver failure in some cases — though it's unclear whether the noni itself or contaminants in certain products caused the damage. If you have liver disease or take medications that stress the liver, talk with your pharmacist before starting it.
Does noni actually work for any health conditions?
The evidence we hold doesn't support a rating for noni on asthma, atherosclerosis, athletic performance, burns, cancer, or cardiovascular disease. There simply isn't enough reliable clinical evidence yet to say whether it works for these or other conditions.
Why does noni interact with so many blood pressure and heart medications?
Noni juice contains a lot of potassium — about 6 mEq per 100 mL. Several blood pressure and heart drugs (ACE inhibitors, ARBs, and potassium-sparing diuretics) also raise potassium levels, so combining them with noni could push your potassium dangerously high. Noni can also lower blood pressure on its own, which adds to the risk when combined with blood pressure medications.
What should I do before starting this product?
Use the medication checker on this page to look up every prescription and supplement you take. Noni touches a lot of drug types — blood thinners, blood pressure drugs, diuretics, seizure meds, and others — so you need to confirm it's safe for your specific situation with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Noni 500 mg Extended Release is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Noni 500 mg Extended Release label
Go deeper

The Full Monographs Behind Noni 500 mg Extended Release’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Noni

Interacts with 542 drugs

Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claimed benefits is limited. While moderate juice intake...

Read the full Noni monograph →
Sources

Sources & How We Checked

Noni 500 mg Extended Release's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Noni 16 references
  1. Mueller BA, Scott MK, Sowinski KM, Prag KA. Noni juice (Morinda citrifolia): hidden potential for hyperkalemia? Am J Kidney Dis 2000;35:310-2. PubMed
  2. Millonig G, Stadlmann S, Vogel W. Herbal hepatotoxicity: acute hepatitis caused by a Noni preparation (Morinda citrifolia). Eur J Gastroenterol Hepatol 2005;17:445-7. PubMed
  3. Stadlbauer V, Fickert P, Lackner C, et al. Hepatotoxicity of NONI juice: report of two cases. World J Gastroenterol 2005;11:4758-60. PubMed
  4. Carr ME, Klotz J, Bergeron M. Coumadin resistance and the vitamin supplement "Noni". Am J Hematol 2004;77:103. PubMed
  5. Jensen CJ, Westendorf J, Wang MY, Wadsworth DP. Noni juice protects the liver. Eur J Gastroenterol Hepatol 2006;18:575-7. PubMed
  6. Yuce B, Gulberg V, Diebold J, Gerbes AL. Hepatitis induced by noni juice from morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg? Digestion 2006;73:167-70.
  7. Koch E, Biber A. Treatment of rats with the Pelargonium sidoides extract EPs 7630 has no effect on blood coagulation parameters or on the pharmacokinetics of warfarin. Phytomedicine 2007;14 Suppl 6:40-5. PubMed
  8. Yu EL, Sivagnanam M, Ellis L, Huang JS. Acute hepatotoxicity after ingestion of Morinda citrifolia (noni berry) juice in a 14-year-old boy. J Pediatr Gastroenterol Nutr 2011;52:222-4.
  9. Stadlbauer V, Weiss S, Payer F, Stauber RE. Herbal does not at all mean innocuous: the sixth case of hepatotoxicity associated with morinda citrifolia (noni). Am J Gastroenterol 2008;103:2406-7. PubMed
  10. López-Cepero Andrada JM, Lerma Castilla S, Fernández Olvera MD, Amaya Vidal A. [Hepatotoxicity caused by a noni (Morinda citrifolia) preparation]. [Article in Spanish] Rev Esp Enferm Dig 2007;99:179-81.
  11. Nima S, Kasiwong S, Ridtitid W, et al. Gastrokinetic activity of Morinda citrifolia aqueous fruit extract and its possible mechanism of action in human and rat models. J Ethnopharmacol. 2012;142(2):354-61. PubMed
  12. Issell, B. F., Gotay, C. C., Pagano, I., and Franke, A. A. Using quality of life measures in a Phase I clinical trial of noni in patients with advanced cancer to select a Phase II dose. J.Diet.Suppl 2009;6(4):347-359. PubMed
  13. Palu AK, Santiago RA West B Kaluhiokalani N Jensen J. The Effects of Morillda citrifolia L. Noni on High Blood Pressure: A Mechanistic Investigation and Case Study. ACS SYMPOSIUM SERIES 993 2008;
  14. Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
  15. Bussmann RW, Hennig L, Giannis A, Ortwein J, Kutchan TM, Feng X. Anthraquinone Content in Noni (Morinda citrifolia L.). Evid Based Complement Alternat Med. 2013;2013:208378.
  16. Yu-Chan Kang, Ming-Hong Chen, Shung-Lon Lai. Potentially Unsafe Herb-drug Interactions Between a Commercial Product of Noni Juice and Phenytoin- A Case Report. Acta Neurol Taiwan. 2015 Jun;24(2):43-6.

See these in context on the Noni monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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