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Dietary supplement

Artichoke 250 mg Ingredients & Drug Interactions

by Nature's Plus Herbal Actives

Artichoke 250 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Artichoke 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Artichoke 250 mg is a dietary supplement by Nature's Plus Herbal Actives with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, indigestion and heartburn, constipation and bloating.Based on those ingredients, 363 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Artichoke. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Artichoke 250 mg by Nature's Plus Herbal Actives

Ask about any prescription or over-the-counter medication and we check it for interactions with Artichoke 250 mg by Nature's Plus Herbal Actives — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Artichoke 250 mg by Nature's Plus Herbal Actives

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: artichoke leaf extract at 250 mg per capsule. Artichoke is the globe vegetable you may have seen at the farmer's market, and the extract concentrates compounds believed to support digestive and liver health.

The capsule also contains several inactive ingredients—microcrystalline cellulose, vegetable cellulose, magnesium stearate, and purified water—which are fillers and binding materials that hold the supplement together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Artichoke's overall clinical evidence instead.

Moderate

Some clinical evidence supports Artichoke for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Dyspepsia — rated "Possibly Effective" (Natural Medicines).
  • On file: Hyperlipidemia — rated "Possibly Effective" (Natural Medicines).

Artichoke has possibly effective evidence for high cholesterol (hyperlipidemia) and indigestion (dyspepsia). The research supporting these uses is limited but promising enough to suggest it may help.

For nonalcoholic fatty liver disease (NAFLD), the evidence isn't established enough in our data to rate it one way or the other. If you're considering artichoke for that reason, talk it over with your doctor to see whether the available research makes sense for your situation.

The evidence, ingredient by ingredient Artichoke

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Artichoke extract is generally well tolerated when used short-term, though quality and dosing vary widely between products. The most common side effects are mild: abdominal pain, diarrhea, gas, increased hunger, and nausea.

Allergic reactions are possible, especially if you're sensitive to plants in the daisy family (ragweed, chrysanthemums, marigolds, daisies, and similar herbs). Severe allergic reactions including anaphylaxis have been reported rarely in people with sensitivity to artichoke inulin.

During pregnancy, there isn't enough safety information, so the data advises against it in supplement form. The same holds for breastfeeding—safety hasn't been established, so it's best avoided.

Side effects, ingredient by ingredient Artichoke

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Artichoke.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 363 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check these medication types before taking artichoke: blood pressure medications (antihypertensive drugs), diabetes medications, and any drugs your liver breaks down via the CYP2C19 or CYP2B6 pathways. If you're unsure whether your medications fall into these groups, ask your doctor or pharmacist to review your list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Artichoke may help with high cholesterol and indigestion, but it can lower blood pressure and blood sugar, which matters if you take medications for either. If you're on blood pressure or diabetes drugs, or if you take medications broken down by your liver, check with your doctor or pharmacist before starting.

It's not suitable during pregnancy or breastfeeding based on available safety data.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Artichoke 250 mg, straight from the product label.

Brand Nature's Plus Herbal Actives
Barcode (UPC) 097467071049
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Dec 23, 2016
DSLD ID 69015
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Artichoke 250 mg by Nature's Plus Herbal Actives, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
097467071049
IngredientAmount% DV
Artichoke250 mg--

Other ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Magnesium Stearate, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Nutritional support for general well-being.

Guaranteed maximum potency: Each Herbal Actives formula is scientifically standardized to the highest level of active principles. Herbashield: An exclusive purity and safety system including light-resistant bottle, airtight inner seal, moisture-absorbing packet, tamper-evident safety cap and tamper-proof full bottle seal.

This is not a prescription product. It is a dietary supplement made with the highest possible quality standards.

Prescription quality

Formula

Each Herbal Actives Artichoke capsule, providing the greatest concentration of active botanical principles, maximizes the synergistic benefits of the whole flower, which naturally contains sesquiterpene lactones and highly active flavonoids (scolymoside, inulin and taraxasterol).

Artichoke 250 mg/2.5-5% Caffeylquinic Acids

Hypo-allergenic

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement offering the consistent benefit of exact potency, one capsule daily or as recommended by your health care professional.

Precautions

Note: If you are pregnant or nursing, consult your health care professional before using any herbal product.

Printed Herbashield inner seal and full bottle seal. Do not use if either seal is missing or broken.

Keep out of reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Herbashield

Maximum potency guaranteed

Gluten free

VCaps

Brand IP Statement(s)

The energy supplements

VCaps is a trademark of Capsugel

Natural Organics

FDA Statement of Identity

Standardized Botanical Supplement

Formulation

Gluten free

Free from artificial colors and preservatives. Free from the common allergens yeast, wheat, corn, soy and milk. Hypo-allergenic

Storage

Keep tightly closed in a cool, dry place.

General

PRODUCT NO. 7104 LBL. 1134023

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Artichoke 250 mg by Nature's Plus Herbal Actives label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Artichoke 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Artichoke 250 mg by Nature's Plus Herbal Actives

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Artichoke

Interacts with
363 drugs
250 mg per serving Form: Caffeylquinic Acids

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, th...

Artichoke monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Magnesium Stearate, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Artichoke 250 mg by Nature's Plus Herbal Actives Drug Interactions

Want to check YOUR meds against Artichoke 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
363Drugs
363 Moderate

Ingredients driving the most interactions

Artichoke 363

Individual Drug Interactions

The ingredients in Artichoke 250 mg interact with 363 drugs. Click any drug to see the details.

1 of the 1 ingredient in Artichoke 250 mg interact with drugs. Each result below shows which ingredient is responsible. Artichoke

Each ingredient & the kinds of drugs it affects

For each ingredient in Artichoke 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Artichoke4 drug types · 363 drugs

Antidiabetes Drugs

Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Artichoke full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Artichoke 250 mg, from the product label.

Nature's Plus Herbal Actives

Name
Natural Organics Laboratories, Inc. makers of Nature's Plus
Street Address
9500 New Horizons Blvd.
City
Amityville
State
New York
ZipCode
11701
Web Address
www.naturesplus.com
Pharmacist Counseling Corner

Artichoke 250 mg by Nature's Plus Herbal Actives: Common Questions

Does Artichoke 250 mg by Nature's Plus Herbal Actives interact with any medications?
Yes. Based on its ingredients, Artichoke 250 mg has a known interaction with 363 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Artichoke 250 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does artichoke actually do?
Artichoke has possibly effective evidence for high cholesterol and indigestion. The research is modest but suggests it may help with these conditions. It doesn't appear to have strong evidence for other uses we track.
Are there common side effects?
Most people tolerate artichoke well. The most common side effects are mild—belly pain, diarrhea, gas, hunger, and nausea. Allergic reactions are rare but possible if you're sensitive to plants in the daisy family.
Can I take this if I have high blood pressure?
Not without checking first. Artichoke can lower blood pressure on its own, and combining it with your blood pressure medication could push your pressure too low. Talk to your doctor or pharmacist before starting it.
Is it safe during pregnancy or breastfeeding?
No. There isn't enough safety information during pregnancy, so the data advises against using artichoke in supplement form. Safety during breastfeeding hasn't been established either. Talk with your doctor if you're pregnant or breastfeeding and interested in artichoke.
Why does this product interact with so many medications?
The 363 number includes all individual medications affected across the four drug categories artichoke interacts with—blood pressure drugs, diabetes drugs, and two groups of liver-metabolized drugs. One person won't be on all of them; that's a comprehensive list of possibilities across the whole population.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Artichoke 250 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Artichoke 250 mg label
Go deeper

The Full Monographs Behind Artichoke 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Artichoke

Interacts with 363 drugs

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...

Read the full Artichoke monograph →
Sources

Sources & How We Checked

Artichoke 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Artichoke 16 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study. Phytother Res 2001;15:58-61. PubMed
  3. Pittler MH, White AR, Stevinson C, Ernst E. Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial. CMAJ 2003;169:1269-73.
  4. Romano, C., Ferrara, A., and Falagiani, P. A case of allergy to globe artichoke and other clinical cases of rare food allergy. J Investig.Allergol.Clin Immunol. 2000;10(2):102-104.
  5. Miralles, J. C., Garcia-Sells, J., Bartolome, B., and Negro, J. M. Occupational rhinitis and bronchial asthma due to artichoke (Cynara scolymus). Ann Allergy Asthma Immunol. 2003;91(1):92-95. PubMed
  6. Franck, P., Moneret-Vautrin, D. A., Morisset, M., Kanny, G., Megret-Gabeaux, M. L., and Olivier, J. L. Anaphylactic reaction to inulin: first identification of specific IgEs to an inulin protein compound. Int Arch Allergy Immunol 2005;136(2):155-158. PubMed
  7. Meding, B. Allergic contact dermatitis from artichoke, Cynara scolymus. Contact Dermatitis 1983;9(4):314.
  8. Quirce, S., Tabar, A. I., Olaguibel, J. M., and Cuevas, M. Occupational contact urticaria syndrome caused by globe artichoke (Cynara scolymus). J Allergy Clin Immunol. 1996;97(2):710-711. PubMed
  9. Held C. Von der 1. Deutsche-Ungarischen Phytopharmakon-Konferenz, Budapest, 20. November 1991. Z Klin Med 1992;47:92-93.
  10. Barrat E, Zaïr Y, Ogier N, et al. A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomized placebo-controlled trial. Int J Food Sci Nutr. 2013;64(7):882-9. PubMed
  11. Huber R, Müller M, Naumann J, Schenk T, Lüdtke R. Artichoke leave extract for chronic hepatitis C - a pilot study. Phytomedicine. 2009 Sep;16(9):801-4. PubMed
  12. Caputo F, Barranco R, Bonsignore A, Fraternali Orcioni G, Ventura F. A rare case of fatal bowel obstruction secondary to a colonic bezoar. Am J Forensic Med Pathol. 2018;39(1):38-40. PubMed
  13. Elsebai MF, Abass K, Hakkola J, Atawia AR, Farag MA. The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials. Food Funct. 2016;7(7):3006-16. PubMed
  14. Moradi M, Sohrabi G, Golbidi M, et al. Effects of artichoke on blood pressure: a systematic review and meta-analysis. Complement Ther Med 2021;57:102668. PubMed
  15. Jalili C, Moradi S, Babaei A, et al. Effects of Cynara scolymus L. on glycemic indices: a systematic review and meta-analysis of randomized clinical trials. Complement Ther Med 2020;52:102496. PubMed
  16. Gallo R, Oddenino G, Trave I, Gasparini G, Guadagno A, Parodi A. Contact sensitivity to sesquiterpene lactone mix and artichoke in a patient with severe recurrent dermatitis: A puzzling case. Contact Dermatitis 2023;88(2):156-158. PubMed

See these in context on the Artichoke monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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