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Dietary supplement

Goji 1000 mg Extended Release Ingredients & Drug Interactions

by Nature's Plus Herbal Actives

Goji 1000 mg Extended Release label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Goji 1000 mg Extended Release against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Goji 1000 mg Extended Release is a dietary supplement by Nature's Plus Herbal Actives with 1 active ingredient. Its ingredients are commonly taken for general antioxidant support, eye health, immune support.Based on those ingredients, 1,000 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Goji. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Goji 1000 mg Extended Release by Nature's Plus Herbal Actives

Ask about any prescription or over-the-counter medication and we check it for interactions with Goji 1000 mg Extended Release by Nature's Plus Herbal Actives — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Goji 1000 mg Extended Release by Nature's Plus Herbal Actives

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 1 active ingredient: goji berry at 1000 mg in an extended-release form. Goji is a fruit used in traditional herbal medicine.

The tablet also contains several inactive ingredients — microcrystalline cellulose, di-calcium phosphate, hydroxypropyl methylcellulose, stearic acid, magnesium stearate, silica, Activessence, and pharmaceutical glaze — which are fillers, binders, and coating materials.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Goji product and its label doesn't state a use — see Goji's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for goji's effectiveness in the conditions we have data for isn't established enough to rate. Sunburn, cardiovascular disease, high blood pressure, obesity, and quality of life all show insufficient reliable evidence in the studies we hold.

That doesn't mean goji won't help — it means the research so far isn't solid enough to say one way or the other.

The evidence, ingredient by ingredient Goji

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Goji berries are generally well tolerated as a food, but concentrated supplements like this one have less safety data than the whole fruit. A small number of case reports link goji to liver inflammation (autoimmune hepatitis and acute hepatitis), though it's unclear in some cases whether goji alone or other ingredients caused the injury.

Several allergic reactions have also been reported, ranging from mouth and throat itching and swelling to anaphylaxis — a serious whole-body allergic reaction. During pregnancy, avoid medicinal amounts of goji due to limited safety data and traditional reports of effects on the uterus.

While breastfeeding, there isn't enough reliable data on supplement use, so caution is advised — talk with your pharmacist or doctor about whether it's right for you.

Side effects, ingredient by ingredient Goji

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Goji.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,001 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your pharmacist if you're on warfarin (a blood thinner) — that's the most serious documented interaction. Also check if you take heart rhythm medications like flecainide, any blood pressure medications, blood sugar medications, or any drug that depends on liver enzymes CYP2D6, CYP2C19, CYP2C9, or CYP3A4 for breakdown — goji may raise their levels in your blood.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is worth a careful check before you start, especially if you take warfarin or any regular medications. The interaction with blood thinners is well documented, and goji may slow how your liver clears many other drugs.

Run your exact medications through the search tool on this page first, and talk to your pharmacist if you have any questions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Goji 1000 mg Extended Release, straight from the product label.

Brand Nature's Plus Herbal Actives
Barcode (UPC) 097467732629
Net contents 30 Tablet(s)
Market status On market
Date entered into DSLD Dec 23, 2016
DSLD ID 69012
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Goji 1000 mg Extended Release by Nature's Plus Herbal Actives, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Extended Release Tablet(s)
Maximum serving Sizes:
1 Extended Release Tablet(s)
UPC/BARCODE
097467732629
IngredientAmount% DV
Goji1000 mg--

Other ingredients: Microcrystalline Cellulose, Di-Calcium Phosphate, Hydroxypropyl Methylcellulose, Stearic Acid, Magnesium Stearate, Silica, Activessence, Pharmaceutical Glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Guaranteed maximum potency: Each Herbal Actives formula is scientifically standardized to the highest level of active principles.

This is not a prescription product. It is a dietary supplement made with the highest possible quality standards.

Extended release

Prescription quality

HerbaShield: An exclusive purity and safety system providing light-resistant bottle, airtight inner seal, moisture-absorbing packet, tamper-evident safety cap and tamper-proof full bottle seal.

Nutritional support for free radical defense.

Each Herbal Actives extended-release formula provides rapid and sustained results. Supplying the greatest concentration of active botanical principles, Herbal Actives Goji maximizes the synergistic benefits of the whole fruit, which naturally contains polysaccharides, beta carotene, zeaxanthin, and other antioxidant nutrients.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement offering the consistent benefits of exact potency, one tablet daily or as recommended by your health care professional.

Precautions

Note: If you are pregnant or nursing, consult your health care professional before using any herbal product.

Printed HerbaShield inner seal and full bottle seal. Do not use if either seal is missing or broken.

Keep out of reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Activessence is a registered trademark of Triarco Industries, Inc. and protected by U.S. patents.

The Energy Supplements

Natural Organics

Herbal Actives is a registered trademark of Natural Organics, Inc. in the US and/or other countries.

Seals/Symbols

HerbaShield

Maximum Guaranteed Potency

Gluten free

FDA Statement of Identity

Standardized Botanical Supplement

Formulation

Free from artificial colors and preservatives. Free from the common allergens yeast, wheat, soy and milk.

Vegetarian

Gluten free

Formula

Hypo-allergenic

50% Polysaccharides

Storage

Keep tightly closed in a cool, dry place.

General

Product No. 73262 LBL. 1135569

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Goji 1000 mg Extended Release by Nature's Plus Herbal Actives label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Goji 1000 mg Extended Release label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Goji 1000 mg Extended Release by Nature's Plus Herbal Actives

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Extended Release Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Goji

Interacts with
1,000 drugs
1000 mg per serving Form: Polysaccharides

Goji berries are a nutritious fruit rich in antioxidants, vitamins, and plant polysaccharides, and they are safe for most people as a food. While they...

Goji monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Di-Calcium Phosphate, Hydroxypropyl Methylcellulose, Stearic Acid, Magnesium Stearate, Silica, Activessence, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

Goji 1000 mg Extended Release by Nature's Plus Herbal Actives Drug Interactions

Want to check YOUR meds against Goji 1000 mg Extended Release?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,000Drugs
2 Major 930 Moderate 68 Minor

Ingredients driving the most interactions

Goji 1,000

Individual Drug Interactions

The ingredients in Goji 1000 mg Extended Release interact with 1,000 drugs. Click any drug to see the details.

1 of the 1 ingredient in Goji 1000 mg Extended Release interact with drugs. Each result below shows which ingredient is responsible. Goji

Each ingredient & the kinds of drugs it affects

For each ingredient in Goji 1000 mg Extended Release with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Goji8 drug types · 1,000 drugs

Warfarin (Coumadin)

Goji can increase the effects of warfarin and possibly increase the risk of bleeding.
There are at least 5 case reports of increased international normalized ratio (INR) in patients stabilized on warfarin who began drinking goji juice, concentrated goji tea, or goji wine. Goji may inhibit the metabolism of warfarin by cytochrome P450 2C9 (CYP2C9).

Likelihood Probable Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Animal and in vitro research suggest that goji root bark has hypotensive effects. However, goji fruit juice does not appear to reduce systolic or diastolic blood pressure in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, goji berry might inhibit CYP2C19 and reduce metabolism of CYP2C19 substrates.
In vitro research shows that goji berry tincture and juice inhibit CYP2C19 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP2C19 substrates. However, this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, goji berry might inhibit CYP2C9 and reduce metabolism of CYP2C9 substrates.
In vitro research shows that goji berry tincture and juice inhibit CYP2C9 enzymes. Additionally, multiple case reports suggest that goji berry concentrated tea and juice inhibit the metabolism of warfarin, a CYP2C9 substrate. Concomitant use with goji may decrease metabolism and increase levels of CYP2C9 substrates.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
In vitro research shows that goji berry juice inhibits CYP2D6 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP2D6 substrates. However, this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
In vitro research shows that goji berry juice inhibits CYP3A4 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP3A4 substrates. However, this has not been reported in humans.

Likelihood Possible Evidence D
Flecainide (Tambocor)

Theoretically, goji berry might increase the levels and clinical effects of flecainide.
In one case report, a 75-year-old patient stable on flecainide and warfarin presented to the emergency room with fainting and pleomorphic arrhythmia caused by flecainide toxicity. Flecainide toxicity was attributed to drinking 1-2 glasses of concentrated goji tea daily for 2 weeks. Theoretically, goji may have inhibited the cytochrome P450 2D6 (CYP2D6) metabolism of flecainide.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of goji fruit polysaccharides or goji root bark with antidiabetes drugs might have additive effects.
Animal and in vitro research show that goji root bark and fruit polysaccharides might have hypoglycemic effects. However, clinical research has only shown that taking goji fruit polysaccharides with or without antidiabetes drugs modestly reduces postprandial glucose when compared with control, with no reports of hypoglycemia.

Likelihood Possible Evidence B
Goji full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Goji 1000 mg Extended Release, from the product label.

Nature's Plus Herbal Actives

Name
Natural Organics Laboratories, Inc. makers of Nature's Plus
Street Address
9500 New Horizons Blvd.
City
Amityville
State
New York
ZipCode
11701
Web Address
www.naturesplus.com
Pharmacist Counseling Corner

Goji 1000 mg Extended Release by Nature's Plus Herbal Actives: Common Questions

Does Goji 1000 mg Extended Release by Nature's Plus Herbal Actives interact with any medications?
Yes. Based on its ingredients, Goji 1000 mg Extended Release has a known interaction with 1,000 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Goji 1000 mg Extended Release contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
The safety data advises against medicinal amounts of goji during pregnancy due to limited safety information and traditional reports of effects on the uterus. Talk with your doctor or pharmacist about your situation before starting.
Can I take this while breastfeeding?
There isn't enough reliable data on goji supplement use while breastfeeding, so caution is advised. Your pharmacist or doctor can help you decide if it's right for you.
Has goji caused any side effects in real people?
Yes. A small number of cases report liver inflammation (autoimmune hepatitis and acute hepatitis) and allergic reactions — ranging from mouth and throat itching to serious anaphylaxis. These are rare, but worth knowing about.
Does this product actually work for anything?
The evidence we have for goji isn't strong enough to rate it yet for sunburn, heart disease, high blood pressure, weight loss, or quality of life. That means research so far hasn't proven it works for these uses — or ruled it out.
Why does goji interact with so many medications?
Goji appears to slow several liver enzymes that break down many different drugs. When these enzymes work slower, your medications can build up to higher levels in your blood, which may cause side effects or toxicity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Goji 1000 mg Extended Release is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Goji 1000 mg Extended Release label
Go deeper

The Full Monographs Behind Goji 1000 mg Extended Release’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Goji

Interacts with 1,000 drugs

Goji berries are a nutritious fruit rich in antioxidants, vitamins, and plant polysaccharides, and they are safe for most people as a food. While they are popular for eye health, immune supp...

Read the full Goji monograph →
Sources

Sources & How We Checked

Goji 1000 mg Extended Release's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Goji 14 references
  1. Huang KC. The Pharmacology of Chinese Herbs. 2nd ed. Boca Raton, FL: CRC Press, LLC 1999.
  2. Lam AY, Elmer GW, Mohutsky MA. Possible interaction between warfarin and Lycium Barbarum. Ann Pharmacother 2001;35:1199-201.
  3. Leung H, Hung A, Hui AC, Chan TY. Warfarin overdose due to the possible effects of Lycium barbarum L. Food Chem Toxicol 2008;46:1860-2. PubMed
  4. Amagase H, Nance DM. A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (goji) juice, GoChi. J Altern Complement Med 2008;14:403-12.
  5. Rivera, C. A., Ferro, C. L., Bursua, A. J., and Gerber, B. S. Probable interaction between Lycium barbarum (goji) and warfarin. Pharmacotherapy 2012;32(3):e50-e53.
  6. Monzon, Ballarin S., Lopez-Matas, M. A., Saenz, Abad D., Perez-Cinto, N., and Carnes, J. Anaphylaxis associated with the ingestion of Goji berries (Lycium barbarum). J.Investig.Allergol.Clin.Immunol. 2011;21(7):567-570.
  7. Franco, M., Monmany, J., Domingo, P., and Turbau, M. [Autoimmune hepatitis triggered by consumption of Goji berries]. Med.Clin.(Barc.) 9-22-2012;139(7):320-321.
  8. Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
  9. Larramendi CH, García-Abujeta JL, Vicario S, García-Endrino A, López-Matas MA, García-Sedeño MD, et al. Goji berries (Lycium barbarum): Risk of allergic reactions in individuals with food allergy. J Investig Allergol Clin Immunol. 2012;22(5):345-50.
  10. Cai H, Liu F, Zuo P, Huang G, Song Z, Wang T, et al. Practical application of antidiabetic efficacy of Lycium barbarum polysaccharide in patients with type 2 diabetes. Med Chem. 2015;11(4):383-90.
  11. Potterat O. Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med 2010;76(1):7-19.
  12. Guzmán CE, Guzmán-Moreno CG, Assad-Morell JL, Edgar Francisco Carrizales-Sepúlveda EF. Flecainide toxicity associated with the use of goji berries: a case report. Eur Heart J Case Rep. 2021;5(6):ytab204. PubMed
  13. Liu R, Tam TW, Mao J, et al. In vitro activity of Lycium barbarum (Goji) against major human phase I metabolism enzymes. Complement Integr Med. 2016;13(3):257-265.
  14. Zhang J, Tian L, Xie B. Bleeding due to a probable interaction between warfarin and Gouqizi (Lycium Barbarum L.). Toxicol Rep. 2015;2:1209-1212. PubMed

See these in context on the Goji monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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