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Dietary supplement

Noni Fruit Powder 650 mg Ingredients & Drug Interactions

by Doctor's Best

Noni Fruit Powder 650 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Noni Fruit Powder 650 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Noni Fruit Powder 650 mg is a dietary supplement by Doctor's Best with 1 active ingredient. Its ingredients are commonly taken for general wellness and energy, inflammation and joint pain, immune support.Based on those ingredients, 542 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Noni fruit powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Noni Fruit Powder 650 mg by Doctor's Best

Ask about any prescription or over-the-counter medication and we check it for interactions with Noni Fruit Powder 650 mg by Doctor's Best — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Noni Fruit Powder 650 mg by Doctor's Best

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: noni fruit powder at 650 mg per capsule. Noni is a tropical fruit traditionally used in herbal practice, though the evidence for what it actually does remains limited in our data.

The capsule itself is made with hypromellose, an inactive ingredient that helps hold the powder together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Noni product and its label doesn't state a use — see Noni's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that noni fruit powder works for any condition. It's been used traditionally for asthma, atherosclerosis, athletic performance, burns, cancer, and heart disease, but the data we have rates all of these as having insufficient reliable evidence to rate.

That doesn't mean it doesn't work — it means the quality or amount of research isn't there yet to say.

The evidence, ingredient by ingredient Noni

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Noni is generally well tolerated when taken by mouth, though good-quality safety studies haven't been done. The most common side effects are abdominal discomfort and nausea.

Rare but serious concern: noni has been linked to liver damage, including liver failure, in a small number of case reports — though it's not always clear whether noni itself or contaminants in the product were responsible. There's also concern about noni's high potassium content if you have kidney issues or take certain medications.

Because noni was traditionally used to cause abortion, the safety data advises against use during pregnancy. There isn't enough safety information for lactation, so talk with your doctor or pharmacist before taking it if you're breastfeeding.

Side effects, ingredient by ingredient Noni

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Noni.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 543 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your own doctor or pharmacist if you take blood pressure medications (especially ACE inhibitors or ARBs), blood thinners like warfarin, potassium-sparing diuretics, phenytoin (anti-seizure drug), ranitidine (acid reflux medication), or any drugs that can stress the liver. Moderate interactions exist with all of these; your healthcare provider may need to adjust dosing or monitor you closely.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Noni fruit powder has multiple interactions with blood pressure drugs, heart and kidney medications, blood thinners, and seizure drugs — most at Moderate severity. If you take any prescription medication, check it against this product before starting.

The evidence for what noni actually does is limited, and there's a rare but real concern about liver damage. Talk with your doctor or pharmacist about whether it makes sense for you and how to use it safely with your other drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Noni Fruit Powder 650 mg, straight from the product label.

Brand Doctor's Best
Barcode (UPC) 753950000964
Net contents 120 Veggie Cap(s)
Market status On market
Date entered into DSLD Nov 21, 2019
DSLD ID 209389
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Noni Fruit Powder 650 mg by Doctor's Best, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veggie Capsule(s)
Maximum serving Sizes:
2 Veggie Capsule(s)
Servings per container
60
UPC/BARCODE
753950000964
IngredientAmount% DV
Noni fruit powder1300 mg--

Other ingredients: Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Doctor's Best Noni Fruit Powder contains pure non-GMO Organic Noni fruit powder (Morinda citrifolia). Noni fruit has a long history of traditional use in Southeast Asia and South Pacific for their health maintaining nutritional content, including Vitamin C, enzymes and other beneficial antioxidative potential that supports immune system, healthy cellular life cycle, and overall well-being.

Formulation

Beneficial multifaceted antioxidative potential Helps support immune system Helps support healthy cellular lifecycles Helps support overall well-being

Vegan

Vegan

Non-GMO / Gluten free / Soy free

This product contains natural ingredients that may vary in color.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Science-Based Nutrition

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Adult Use: Take 2 capsules daily with or without food, or as recommended by a nutritionally-informed physician.

Precautions

Warning: If you are pregnant, nursing, taking blood thinners, or have a known medical condition such as kidney problems, consult your physician before taking Noni.

Storage

Store in a cool dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Noni Fruit Powder 650 mg by Doctor's Best label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Noni Fruit Powder 650 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Noni Fruit Powder 650 mg by Doctor's Best

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Veggie Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Noni fruit powder

Interacts with
542 drugs
1300 mg per serving

Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claimed benefits...

Noni fruit powder monograph & interactions

Other (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Noni Fruit Powder 650 mg by Doctor's Best Drug Interactions

Want to check YOUR meds against Noni Fruit Powder 650 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
542Drugs
541 Moderate 1 Minor

Ingredients driving the most interactions

Noni fruit powder 542

Individual Drug Interactions

The ingredients in Noni Fruit Powder 650 mg interact with 542 drugs. Click any drug to see the details.

1 of the 1 ingredient in Noni Fruit Powder 650 mg interact with drugs. Each result below shows which ingredient is responsible. Noni fruit powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Noni Fruit Powder 650 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Noni fruit powder8 drug types · 542 drugs

Ace Inhibitors (Aceis)

Theoretically, combining noni and ACE inhibitors might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ACE inhibitors, which can also increase potassium levels.

Likelihood Possible Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, combining noni and ARBs might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ARBs, which can also increase potassium levels.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Preliminary clinical research suggests that drinking noni juice can reduce blood pressure in individuals with hypertension.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
There is concern that noni might cause hepatotoxicity in some patients. Advise patients against combining noni with potentially hepatotoxic drugs.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, taking noni fruit juice concomitantly with phenytoin may lower phenytoin levels and increase the risk of seizures.
In one case report, an adult taking phenytoin for partial seizures experienced low serum phenytoin levels while taking noni juice 90-200 mL daily. Serum phenytoin levels increased after decreasing noni juice consumption; similarly, serum phenytoin levels decreased after increasing noni juice consumption. Some researchers believe noni juice may induce cytochrome P450 2C9 enzymes, which would decrease phenytoin levels, but this has not been well studied. Patients may need additional monitoring when starting or stopping noni juice supplementation.

Likelihood Possible Evidence D
Potassium-Sparing Diuretics

Theoretically, combing noni and a potassium-sparing diuretic might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with potassium-sparing diuretics, which can also increase potassium levels.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking noni juice concomitantly with warfarin might decrease the effectiveness of warfarin.
In one case, a 41-year-old patient stabilized on warfarin had a decreased international normalized ratio (INR) following consumption of a specific commercial noni juice product (Noni juice 4 Everything). While the patient was still taking noni juice, an increase in warfarin dose did not produce an increase in INR. However, it should be noted that this particular product contained extracts and derivatives from more than 115 components, many of which contained vitamin K. Furthermore, vitamin K was listed as a separate ingredient of the product, suggesting that the product was possibly fortified with vitamin K. It has not been verified that noni fruit alone contains a significant amount of vitamin K or interacts with warfarin.

Likelihood Possible Evidence D
Ranitidine (Zantac)

Taking noni fruit with ranitidine might increase the levels and clinical effects of ranitidine.
Clinical evidence shows that taking an aqueous extract of noni fruit 30 minutes prior to taking a single oral dose of ranitidine can increase the rate of absorption and plasma concentration of ranitidine.

Likelihood Possible Evidence B
Noni fruit powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Noni Fruit Powder 650 mg, from the product label.

Doctor's Best

See all Doctor's Best products
Name
Doctor's Best, Inc.
State
California
ZipCode
92612
Phone Number
(800) 777-2474
Web Address
www.drbvitamins.com
Pharmacist Counseling Corner

Noni Fruit Powder 650 mg by Doctor's Best: Common Questions

Does Noni Fruit Powder 650 mg by Doctor's Best interact with any medications?
Yes. Based on its ingredients, Noni Fruit Powder 650 mg has a known interaction with 542 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Noni Fruit Powder 650 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take noni if I'm pregnant or breastfeeding?
Noni was traditionally used to cause abortion, so the safety data advises against it during pregnancy. For breastfeeding, there isn't enough safety information to know either way — talk with your doctor or pharmacist for personalized advice.
What are the side effects?
The most common side effects from noni are abdominal discomfort and nausea. Rarely, noni has been linked to liver damage, though it's unclear whether noni itself or contaminants in some products caused it. High-quality safety studies haven't been done, so uncommon side effects may not be fully known.
Does noni actually work for anything?
The evidence we hold doesn't establish that noni works for any condition. It's been used for asthma, heart disease, cancer, and burns, but the research quality or amount isn't there yet to say it's effective for any of them.
Why does noni interact with so many blood pressure and heart drugs?
Noni contains significant amounts of potassium, which can build up in your body and raise your blood pressure or potassium levels too high — a problem if you're already on drugs that affect potassium or blood pressure. Noni also seems to lower blood pressure on its own, which adds to the risk.
I take warfarin. Can I use noni?
No — there's a Moderate interaction. In one case report, a patient on warfarin had decreased blood thinner effect while taking noni juice. Check with your doctor or pharmacist before adding any new supplement to your warfarin regimen.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Noni Fruit Powder 650 mg label
Go deeper

The Full Monographs Behind Noni Fruit Powder 650 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Noni

Interacts with 542 drugs

Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claimed benefits is limited. While moderate juice intake...

Read the full Noni monograph →
Sources

Sources & How We Checked

Noni Fruit Powder 650 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Noni 16 references
  1. Mueller BA, Scott MK, Sowinski KM, Prag KA. Noni juice (Morinda citrifolia): hidden potential for hyperkalemia? Am J Kidney Dis 2000;35:310-2. PubMed
  2. Millonig G, Stadlmann S, Vogel W. Herbal hepatotoxicity: acute hepatitis caused by a Noni preparation (Morinda citrifolia). Eur J Gastroenterol Hepatol 2005;17:445-7. PubMed
  3. Stadlbauer V, Fickert P, Lackner C, et al. Hepatotoxicity of NONI juice: report of two cases. World J Gastroenterol 2005;11:4758-60. PubMed
  4. Carr ME, Klotz J, Bergeron M. Coumadin resistance and the vitamin supplement "Noni". Am J Hematol 2004;77:103. PubMed
  5. Jensen CJ, Westendorf J, Wang MY, Wadsworth DP. Noni juice protects the liver. Eur J Gastroenterol Hepatol 2006;18:575-7. PubMed
  6. Yuce B, Gulberg V, Diebold J, Gerbes AL. Hepatitis induced by noni juice from morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg? Digestion 2006;73:167-70.
  7. Koch E, Biber A. Treatment of rats with the Pelargonium sidoides extract EPs 7630 has no effect on blood coagulation parameters or on the pharmacokinetics of warfarin. Phytomedicine 2007;14 Suppl 6:40-5. PubMed
  8. Yu EL, Sivagnanam M, Ellis L, Huang JS. Acute hepatotoxicity after ingestion of Morinda citrifolia (noni berry) juice in a 14-year-old boy. J Pediatr Gastroenterol Nutr 2011;52:222-4.
  9. Stadlbauer V, Weiss S, Payer F, Stauber RE. Herbal does not at all mean innocuous: the sixth case of hepatotoxicity associated with morinda citrifolia (noni). Am J Gastroenterol 2008;103:2406-7. PubMed
  10. López-Cepero Andrada JM, Lerma Castilla S, Fernández Olvera MD, Amaya Vidal A. [Hepatotoxicity caused by a noni (Morinda citrifolia) preparation]. [Article in Spanish] Rev Esp Enferm Dig 2007;99:179-81.
  11. Nima S, Kasiwong S, Ridtitid W, et al. Gastrokinetic activity of Morinda citrifolia aqueous fruit extract and its possible mechanism of action in human and rat models. J Ethnopharmacol. 2012;142(2):354-61. PubMed
  12. Issell, B. F., Gotay, C. C., Pagano, I., and Franke, A. A. Using quality of life measures in a Phase I clinical trial of noni in patients with advanced cancer to select a Phase II dose. J.Diet.Suppl 2009;6(4):347-359. PubMed
  13. Palu AK, Santiago RA West B Kaluhiokalani N Jensen J. The Effects of Morillda citrifolia L. Noni on High Blood Pressure: A Mechanistic Investigation and Case Study. ACS SYMPOSIUM SERIES 993 2008;
  14. Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
  15. Bussmann RW, Hennig L, Giannis A, Ortwein J, Kutchan TM, Feng X. Anthraquinone Content in Noni (Morinda citrifolia L.). Evid Based Complement Alternat Med. 2013;2013:208378.
  16. Yu-Chan Kang, Ming-Hong Chen, Shung-Lon Lai. Potentially Unsafe Herb-drug Interactions Between a Commercial Product of Noni Juice and Phenytoin- A Case Report. Acta Neurol Taiwan. 2015 Jun;24(2):43-6.

See these in context on the Noni monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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