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Dietary supplement

Pure D-Ribose Powder Ingredients & Drug Interactions

by Doctor's Best

Pure D-Ribose Powder label
See full label image
Powder Category: Fiber And Other Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pure D-Ribose Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pure D-Ribose Powder is a dietary supplement by Doctor's Best with 1 active ingredient. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bioenergy Ribose. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pure D-Ribose Powder by Doctor's Best

Ask about any prescription or over-the-counter medication and we check it for interactions with Pure D-Ribose Powder by Doctor's Best — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pure D-Ribose Powder by Doctor's Best

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Pure D-Ribose Powder is a single-ingredient product containing Bioenergy Ribose, a five-carbon sugar your body naturally makes. Ribose plays a role in energy production at the cellular level.

The product contains no inactive ingredients or fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Ribose's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: enhance ATP energy production and support muscle recovery.
  • We looked for evidence on: Athletic performance, Chronic fatigue syndrome (CFS), Fibromyalgia, Heart failure, Coronary heart disease (CHD), Muscle soreness — and 3 related terms.
  • The closest evidence on file: Ribose is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Ribose is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Chronic fatigue syndrome (CFS), Congestive heart failure (CHF), Fibromyalgia, and more.

The evidence on ribose's benefits is mixed and often limited. It's rated possibly ineffective for athletic performance and McArdle disease.

For restless legs syndrome, heart failure, muscle soreness, and recovery from coronary artery bypass surgery, there isn't enough reliable evidence to know whether it works. If you're thinking about it for one of these reasons, there's no solid proof it'll help.

The evidence, ingredient by ingredient Ribose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ribose is generally well tolerated in the short term (up to about a month in studies), but long-term safety hasn't been well studied. The most common side effects when taken by mouth are diarrhea, gastrointestinal discomfort, headache, nausea, and low blood sugar—and because ribose can lower your blood glucose, that's an important consideration if you have diabetes or take blood sugar medications.

A few people have also reported lightheadedness, increased appetite, and mild anxiety; lowering the dose resolved these symptoms in some cases. There isn't enough safety information to use ribose during pregnancy or while breastfeeding, so it's best avoided at those times.

Side effects, ingredient by ingredient Ribose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ribose.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take insulin or any antidiabetes drugs (blood sugar medications). Moderate-severity interactions are documented: ribose can lower blood glucose and may increase insulin's effect, raising the risk of low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Pure D-Ribose Powder is a single-ingredient supplement with limited evidence for most of its claimed uses. If you take insulin or any blood sugar medication, this product poses a moderate risk of low blood sugar and isn't something to add without checking with your doctor or pharmacist first.

Even if you don't take diabetes medications, talk it over with your own healthcare provider to see if it's right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure D-Ribose Powder, straight from the product label.

Brand Doctor's Best
Barcode (UPC) 753950001732
Net contents 8.8 Ounce(s); 250 Gram(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 302702
Product type Fiber And Other Nutrients
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure D-Ribose Powder by Doctor's Best, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gram(s)
Maximum serving Sizes:
5 Gram(s)
Servings per container
50
UPC/BARCODE
753950001732
IngredientAmount% DV
Calories20 Calorie(s)--
Total Carbohydrates5 Gram(s)2%
Total Sugars5 Gram(s)--
Bioenergy Ribose5 Gram(s)--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Doctor's Best D-Ribose is a unique 5-carbon carbohydrate that is fundamental building block of ATP (adenosine triphosphate), the source for all cellular energy. Ribose is the starting point and rate limiting compound in the synthesis of these fundamental cellular compounds and the availability of ribose determines the rate at which they can be made by our cells and tissues.

Pure D-Ribose Powder with Bioenergy Ribose

Formulation

Studies have shown that ribose supplementation can enhance cardiac energy levels and support cardiovascular metabolism. Further studies suggest that ribose plays a role in supporting muscle energy recovery after exercise. Exercise increases free radical production in muscle tissue. Ribose may strengthen and support the body's crucial antioxidant defenses. Helps support energy production in heart and muscle Helps promote muscle recovery following exercise Helps decrease free radical production during exercise

Helps enhance ATP energy production

Vegan

Non-GMO Gluten Free Soy Free Vegan

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Doctor's Best Science-Based Nutrition

Use of BioEnergy Ribose is licensed by BioEnergy Life Science, Inc. under U.S. and foreign patents issued and pending.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested adult use: Mix 1 scoop into 8 ounces water or beverage of your choice, twice daily or as recommended by a nutritionally informed physician.

Precautions

Warning: Diabetics, pregnant or lactating women, and those with chronic gout should consult their physician before using this product.

Warning: Diabetics, pregnant or lactating women, and those with chronic gout should consult their physician before using this product.

Storage

Storage instructions: Store tightly closed container in a cool dry place. Avoid excess heat and moisture.

Store in a cool dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pure D-Ribose Powder by Doctor's Best label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pure D-Ribose Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pure D-Ribose Powder by Doctor's Best

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 Gram(s) Dosage formPowder Servings per container50 Amounts shown are per serving.

Bioenergy Ribose

Interacts with
86 drugs
5 Gram(s) per serving Form: D-Ribose

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

Bioenergy Ribose monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pure D-Ribose Powder by Doctor's Best Drug Interactions

Want to check YOUR meds against Pure D-Ribose Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Bioenergy Ribose 86

Individual Drug Interactions

The ingredients in Pure D-Ribose Powder interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pure D-Ribose Powder interact with drugs. Each result below shows which ingredient is responsible. Bioenergy Ribose

Each ingredient & the kinds of drugs it affects

For each ingredient in Pure D-Ribose Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bioenergy Ribose2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
Bioenergy Ribose full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pure D-Ribose Powder, from the product label.

Doctor's Best

See all Doctor's Best products
Name
Doctor's Best, Inc.
City
Tustin
State
California
ZipCode
92780
Phone Number
(800) 777-2474
Web Address
drbvitamins.com
Pharmacist Counseling Corner

Pure D-Ribose Powder by Doctor's Best: Common Questions

Does Pure D-Ribose Powder by Doctor's Best interact with any medications?
Yes. Based on its ingredients, Pure D-Ribose Powder has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pure D-Ribose Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have diabetes or take blood sugar medication?
Not without talking to your doctor or pharmacist first. Ribose lowers blood glucose levels and can theoretically increase the risk of low blood sugar when combined with insulin or antidiabetes drugs. Your healthcare provider needs to know you're considering it so they can assess whether it's safe for you and whether your medication dose needs adjusting.
What side effects might I experience?
The most common are diarrhea, gastrointestinal upset, headache, nausea, and low blood sugar. Some people also report lightheadedness, increased appetite, or mild anxiety—and in studies, lowering the dose resolved nausea and anxiety in some cases. Ribose is generally well tolerated short-term, but we don't have much data on long-term use.
Is there proof it helps with athletic performance or sore muscles?
Not strong proof. Ribose is rated possibly ineffective for athletic performance. For muscle soreness and other common reasons people take it, there isn't enough reliable evidence to know whether it actually works.
Can I take this while pregnant or breastfeeding?
There isn't enough safety information, so it's best avoided at those times. If you're pregnant or breastfeeding and interested in ribose, talk with your doctor or pharmacist about whether it's appropriate for your situation.
How long can I safely take this?
Studies show ribose is generally well tolerated for up to about one month. Beyond that, long-term safety hasn't been well studied, so talk with your doctor or pharmacist about how long it's okay for you to use it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pure D-Ribose Powder is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure D-Ribose Powder label
Go deeper

The Full Monographs Behind Pure D-Ribose Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph →
Sources

Sources & How We Checked

Pure D-Ribose Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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