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Dietary supplement

Nopal Cactus Ingredients & Drug Interactions

by Tadin

Nopal Cactus label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nopal Cactus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nopal Cactus is a dietary supplement by Tadin with 1 active ingredient. Its ingredients are commonly taken for blood sugar control, high cholesterol, hangover symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cactus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nopal Cactus by Tadin

Ask about any prescription or over-the-counter medication and we check it for interactions with Nopal Cactus by Tadin — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nopal Cactus by Tadin

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Tadin Nopal Cactus is a single-ingredient supplement: prickly pear cactus (also called nopal). The capsule also contains gelatin as an inactive ingredient.

Prickly pear has been used traditionally for blood sugar support, and some research backs that use — though the data we hold rates it only as possibly effective for diabetes. Its other studied uses don't yet have enough reliable evidence to confirm whether they work.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Prickly Pear Cactus's overall clinical evidence instead.

Moderate

Some clinical evidence supports Prickly Pear Cactus for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Diabetes — rated "Possibly Effective" (Natural Medicines).

The supplement's strongest evidence is for diabetes: prickly pear cactus is rated possibly effective for that use. For age-related cognitive decline, benign prostatic hyperplasia, dyspepsia, and high cholesterol — familial and otherwise — we don't hold enough reliable evidence to rate whether it works.

If you're considering it for one of those other purposes, you'd be working with unconfirmed data.

The evidence, ingredient by ingredient Prickly Pear Cactus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Prickly pear cactus is generally well tolerated when taken by mouth. The most common side effects are mild: abdominal fullness, indigestion, mild diarrhea, and nausea.

A small number of people in clinical trials have reported headache, dizziness, or insomnia. Extremely rare cases of bowel blockage from the fruit seeds have been reported, but only when very large amounts were eaten.

There isn't enough safety data to know whether supplement doses are safe during pregnancy or while breastfeeding — talk with your doctor or pharmacist for personalized advice on those situations.

Side effects, ingredient by ingredient Prickly Pear Cactus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Prickly Pear Cactus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Tadin Nopal Cactus, double-check with your doctor or pharmacist if you take any antidiabetes drugs — including insulin, sulfonylureas like glyburide and glipizide, metformin, or any other diabetes medication. The risk of dropping your blood sugar too low is moderate but worth preventing.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Tadin Nopal Cactus may help support blood sugar control if you have type 2 diabetes, but only if you're carefully monitoring your levels and working with your healthcare provider. If you take any diabetes medication, check with your doctor or pharmacist before starting — the risk of low blood sugar is real.

For other uses, the evidence isn't there yet.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nopal Cactus, straight from the product label.

Brand Tadin
Barcode (UPC) 083703301063
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 278482
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nopal Cactus by Tadin, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
20
UPC/BARCODE
083703301063
IngredientAmount% DV
Cactus1.05 Gram(s)--

Other ingredients: Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

No caffeine

Formula

Nopal Cactus 350 mg

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Directions: Take 2 to 3 capsules daily with water.

Precautions

Keep out of reach of children.

General Statements

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Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nopal Cactus by Tadin label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nopal Cactus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nopal Cactus by Tadin

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container20 Amounts shown are per serving.

Cactus

Interacts with
86 drugs
1.05 Gram(s) per serving Form: Nopal

Prickly pear cactus is a desert plant whose pads and fruit are eaten as food and taken as a supplement, mainly for blood sugar, cholesterol, and hango...

Cactus monograph & interactions

Other (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nopal Cactus by Tadin Drug Interactions

Want to check YOUR meds against Nopal Cactus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Cactus 86

Individual Drug Interactions

The ingredients in Nopal Cactus interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nopal Cactus interact with drugs. Each result below shows which ingredient is responsible. Cactus

Each ingredient & the kinds of drugs it affects

For each ingredient in Nopal Cactus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cactus1 drug type · 86 drugs

Antidiabetes Drugs

Combining prickly pear cactus with antidiabetes drugs might increase the risk of hypoglycemia.
Case reports show that combining prickly pear cactus with antidiabetes drugs such as chlorpropamide, glyburide, glipizide, and metformin can increase the risk of hypoglycemia in patients with type 2 diabetes. Advise patients to monitor glucose levels closely. Dose adjustments may be necessary.

Likelihood Probable Evidence D
Cactus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nopal Cactus, from the product label.

Tadin

See all Tadin products
Name
Tadin Herb & Tea Co.
City
Vernon
State
CA
ZipCode
90058
Phone Number
1-800-838-2346
Web Address
www.Tadin.com
Pharmacist Counseling Corner

Nopal Cactus by Tadin: Common Questions

Does Nopal Cactus by Tadin interact with any medications?
Yes. Based on its ingredients, Nopal Cactus has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nopal Cactus contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data for supplement doses during pregnancy or breastfeeding. Talk with your doctor or pharmacist — they can give you personalized advice based on your situation.
What are the most common side effects?
Most people tolerate it well. The most common side effects are mild: stomach fullness, indigestion, mild diarrhea, and nausea. A very small number of people have reported headache, dizziness, or insomnia.
Does prickly pear cactus really help with blood sugar?
The evidence suggests it may help — it's rated possibly effective for type 2 diabetes. But the research isn't conclusive, and if you take diabetes medication, combining them needs careful monitoring by your doctor.
What is prickly pear cactus used for?
Traditionally and in some research, it's used to support blood sugar control in diabetes. Other uses — like for cholesterol, digestion, or cognitive health — don't yet have enough reliable evidence behind them.
Is this supplement safe to take with other medications?
The main concern is antidiabetes drugs — combining them raises your risk of low blood sugar. For other medications, use the search tool on this page to check your exact drugs before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nopal Cactus is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nopal Cactus label
Go deeper

The Full Monographs Behind Nopal Cactus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Prickly Pear Cactus

Interacts with 86 drugs

Prickly pear cactus is a desert plant whose pads and fruit are eaten as food and taken as a supplement, mainly for blood sugar, cholesterol, and hangover symptoms. Some small studies suggest...

Read the full Prickly Pear Cactus monograph →
Sources

Sources & How We Checked

Nopal Cactus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Prickly Pear Cactus 9 references
  1. Meckes-Lozyoa M, Roman-Ramos R. Opuntia streptacantha; a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14:116-8.
  2. Rayburn K, Martinez R, Escobedo M, et al. Glycemic effects of various species of nopal (Opuntia sp.) in type 2 diabetes mellitus. Texas J Rural Health 1998;26:68-76.
  3. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  4. Sobieraj DM, Freyer CW. Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. Ann Pharmacother 2010;44:1334-7. PubMed
  5. Kleiner, O., Cohen, Z., and Mares, A. J. Low colonic obstruction due to Opuntia ficus indica seeds: the aftermath of enjoying delicious cactus fruits. Acta Paediatr. 2002;91(5):606-607.
  6. Steinberg, J. M. and Eitan, A. Prickly pear fruit bezoar presenting as rectal perforation in an elderly patient. Int J Colorectal Dis. 2003;18(4):365-367. PubMed
  7. Meckes-Lozyoa, M. and Roman-Ramos, R. Opuntia streptacantha: a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14(3-4):116-118.
  8. Onakpoya IJ, O'Sullivan J, Heneghan CJ. The effect of cactus pear (Opuntia ficus-indica) on body weight and cardiovascular risk factors: a systematic review and meta-analysis of randomized clinical trials. Nutrition. 2015;31(5):640-6. PubMed
  9. Han EH, Lim MK, Lee S, et al. Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55-85 Years of Age: A Randomized, Double-Blind, Placebo-Controlled Study. J Med Food 2020;23(11):11

See these in context on the Prickly Pear Cactus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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