Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

NOx Boost Ingredients & Drug Interactions

by AOR Advanced Orthomolecular Research Advanced

NOx Boost label
See full label image
Lozenge Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking NOx Boost against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

NOx Boost is a dietary supplement by AOR Advanced Orthomolecular Research Advanced with 5 active ingredients. Its ingredients are commonly taken for tooth decay prevention, dry mouth, sugar substitute.Based on those ingredients, 945 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Red Beet (Beta vulgaris) powder, Vitamin C, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against NOx Boost by AOR Advanced Orthomolecular Research Advanced

Ask about any prescription or over-the-counter medication and we check it for interactions with NOx Boost by AOR Advanced Orthomolecular Research Advanced — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of NOx Boost by AOR Advanced Orthomolecular Research Advanced

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

NOx Boost contains five active ingredients. Xylitol is a sweetener that's been studied for dental health.

Vitamin C is an antioxidant vitamin. D-mannose is a simple sugar.

Potassium is a mineral that your body needs for heart rhythm and muscle function. Red beet powder provides the plant compounds found in beets, including the pigment betanin.

The product also contains several inactive ingredients used as binders, thickeners, and flavoring agents: sodium carboxy methylcellulose, potassium nitrate, xanthan gum, sodium stearyl fumarate, red raspberry and blueberry natural flavors, maltodextrin, and citric acid.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support blood flow and nitric oxide production.
  • We looked for evidence on: Hypertension, Coronary heart disease (CHD), Atherosclerosis, Cardiovascular disease (CVD), Dyslipidemia, Athletic performance — and 4 related terms.
  • The strongest evidence on file: Beet is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Vitamin C is rated "Possibly Effective" for Hypertension, Nitrate tolerance.
  • Also on file: Vitamin C is rated "Possibly Ineffective" for Atherosclerosis, Cardiovascular disease (CVD).

Xylitol is likely effective for preventing dental cavities and possibly effective for ear infections. Vitamin C is effective for vitamin C deficiency and possibly effective for anemia related to chronic disease, atrial fibrillation, cataracts, and preventing exercise-triggered respiratory infections.

D-mannose is likely effective for a rare inherited disorder called carbohydrate-deficient glycoprotein syndrome type 1b, but is possibly ineffective for urinary tract infections. Red beet powder is possibly effective for athletic performance and exercise-induced muscle soreness.

The effectiveness of this product for any specific condition beyond these uses is not established in our data.

The evidence, ingredient by ingredient Xylitol Vitamin C D-mannose Potassium Beet

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Xylitol is generally well tolerated in typical food amounts but can cause digestive upset—diarrhea, flatulence, and bowel sounds—at high doses (30–40 grams). Rare allergic reactions have been reported, including anaphylaxis.

Vitamin C is well tolerated at normal dietary and supplement doses; adverse effects like cramping, heartburn, nausea, and diarrhea are more likely above 2 grams daily. Very high-dose intravenous vitamin C has rarely caused kidney damage.

D-mannose is generally well tolerated short-term but may cause bloating, diarrhea, and nausea; long-term safety data are limited. Potassium is generally well tolerated from food, but supplements can raise blood levels dangerously, especially in people with kidney disease; serious adverse effects from high blood potassium include heart rhythm problems and collapse.

Red beet powder is well tolerated; the most common effect is red or black stools, which are harmless. For pregnancy and lactation: vitamin C at normal amounts is likely safe but avoid high-dose supplements; D-mannose safety in pregnancy and lactation is not well studied; potassium from diet is likely safe in pregnancy; beet safety data during lactation are limited.

Side effects, ingredient by ingredient Xylitol Vitamin C D-mannose Potassium Beet

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 5 matched ingredients can interact with medications — Beet, Potassium, Vitamin C.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments.
  • For scale: 946 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take estrogens (oral contraceptives or hormone replacement therapy), blood thinners like warfarin, chemotherapy drugs, thyroid medication (levothyroxine), blood pressure medications (particularly ACE inhibitors, ARBs, or potassium-sparing diuretics), antipsychotics (like fluphenazine), HIV medications (like indinavir), or any drugs processed by the liver enzyme CYP3A4. Also mention it if you take aluminum-containing products or have kidney disease.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're on birth control pills, hormone replacement, blood thinners like warfarin, thyroid medication, blood pressure drugs (especially ACE inhibitors, ARBs, or potassium-sparing diuretics), chemotherapy, or antipsychotics, this product warrants a conversation with your doctor or pharmacist before you start. The same goes if you have kidney disease or are prone to kidney stones.

For others without these concerns, the active ingredients are generally well tolerated at the amounts typically found in lozenges, though high doses can cause digestive upset.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NOx Boost, straight from the product label.

Brand AOR Advanced Orthomolecular Research Advanced
Barcode (UPC) 624917180114
Net contents 60 Lozenge(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 214771
Product type Other Combinations
Supplement form Lozenge
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Women (not pregnant or lactating), Adult Male (18-50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NOx Boost by AOR Advanced Orthomolecular Research Advanced, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Lozenge(s)
Maximum serving Sizes:
2 Lozenge(s)
Servings per container
30
UPC/BARCODE
624917180114
IngredientAmount% DV
Xylitol400 mg--
Vitamin C100 mg111%
D-Mannose300 mg--
Potassium40 mg1%
Red Beet (Beta vulgaris) powder500 mg--

Other ingredients: Sodium Carboxy Methylcellulose, Potassium Nitrate, Xanthan Gum, Sodium Stearyl Fumarate, Red Raspberry natural flavor, Blueberry natural flavor, Maltodextrin, Citric Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

GMP Manufacturing Quality Assured Independent Testing

Discussion: Nitric oxide is a simple molecule produced in the body that carries out numerous functions, such as vasodilation, supporting blood flow, oxygenation and nutrient delivery to the tissues.

Supports nitric oxide levels

Vegetarian

Gluten free

Made without wheat, gluten, nuts, peanuts, sesame seeds, sulfites, mustard, dairy, eggs, fish or shellfish.

Precautions

Do not use if safety seal is broken

Warning: Do not use if you’re pregnant or lactating. Consult your physician if you have a medical condition, or if you’re taking any medication (eg. erectile dysfunction type products).

Keep out of reach of children.

To report a serious adverse event or obtain product information, call 1-866-215-0450

Storage

Store tightly sealed in a cool, dry place

Suggested/Recommended/Usage/Directions

Directions: Dissolve two lozenges in the mouth daily with/without food, or as directed by a qualified health care practitioner.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Absorbable

AOR guarantees that all ingredients have been declared on the label.

Product of Canada

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

NOx Boost by AOR Advanced Orthomolecular Research Advanced label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

NOx Boost label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in NOx Boost by AOR Advanced Orthomolecular Research Advanced

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Lozenge(s) Dosage formLozenge Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Xylitol

No known
interactions
400 mg per serving

Xylitol is a sugar alcohol used as a low-calorie sweetener that has the best-supported benefit for reducing cavities, especially in chewing gum or loz...

Xylitol monograph & interactions

Vitamin C

Interacts with
207 drugs
100 mg per serving Form: Ascorbic Acid

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...

Vitamin C monograph & interactions

D-Mannose

No known
interactions
300 mg per serving

D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...

D-Mannose monograph & interactions

Potassium

Interacts with
62 drugs
40 mg per serving Form: Potassium Nitrate

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Red Beet (Beta vulgaris) powder

Interacts with
861 drugs
500 mg per serving

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some peopl...

Red Beet (Beta vulgaris) powder monograph & interactions

Other (inactive) ingredients: Sodium Carboxy Methylcellulose, Potassium Nitrate, Xanthan Gum, Sodium Stearyl Fumarate, Red Raspberry natural flavor, Blueberry natural flavor, Maltodextrin, Citric Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

NOx Boost by AOR Advanced Orthomolecular Research Advanced Drug Interactions

Want to check YOUR meds against NOx Boost?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
945Drugs
745 Moderate 200 Minor

Ingredients driving the most interactions

Red Beet (Beta vulgaris) powder 861
Vitamin C 207
Potassium 62

Individual Drug Interactions

The ingredients in NOx Boost interact with 945 drugs. Click any drug to see the details.

3 of the 5 ingredients in NOx Boost interact with drugs. Each result below shows which ingredient is responsible. Red Beet (Beta vulgaris) powder Vitamin C Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in NOx Boost with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Red Beet (Beta vulgaris) powder3 drug types · 861 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.

Likelihood Possible Evidence D
Antihypertensive Drugs

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Red Beet (Beta vulgaris) powder full monograph & interactions

Vitamin C13 drug types · 207 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Aluminum

Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.

Likelihood Probable Evidence B
Antitumor Antibiotics

Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Estrogens

Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.

Likelihood Probable Evidence B
Fluphenazine (Prolixin)

Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.

Likelihood Possible Evidence D
Indinavir (Crixivan)

Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.

Likelihood Probable Evidence B
Warfarin (Coumadin)

High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.

Likelihood Probable Evidence B
Aspirin

Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.

Likelihood Possible Evidence B
Choline Magnesium Trisalicylate (Trilisate)

Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Niacin

Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Salsalate (Disalcid)

Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Vitamin C full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for NOx Boost, from the product label.

AOR Advanced Orthomolecular Research Advanced

See all AOR Advanced Orthomolecular Research Advanced products
Name
AOR Inc.
Street Address
30 Industrial West
City
Clifton
State
NJ
ZipCode
07012
Phone Number
1-866-215-0450
Pharmacist Counseling Corner

NOx Boost by AOR Advanced Orthomolecular Research Advanced: Common Questions

Does NOx Boost by AOR Advanced Orthomolecular Research Advanced interact with any medications?
Yes. Based on its ingredients, NOx Boost has a known interaction with 945 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NOx Boost contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is this product supposed to do?
NOx Boost contains ingredients studied for different purposes—xylitol for dental health, vitamin C as an antioxidant, potassium for heart and muscle function, and red beet powder for exercise performance and recovery. The product's specific intended use is not stated in the label information we have.
Can I take this if I'm on birth control?
The vitamin C in this product has a documented Moderate-severity interaction with estrogens, including oral contraceptives—it may raise estrogen blood levels by up to 55% in some cases. Talk to your doctor or pharmacist before taking this product; they can assess the amount of vitamin C in a lozenge and whether it matters for your specific situation.
Will this upset my stomach?
Both xylitol and D-mannose can cause bloating, diarrhea, nausea, and flatulence, especially at higher doses. Vitamin C can cause similar digestive upset above 2 grams daily. Most people tolerate a lozenge well, but if you have a sensitive stomach, start cautiously and mention it to your pharmacist.
Is xylitol safe?
Xylitol is generally well tolerated in food amounts, though high doses can cause digestive problems. The most important thing: xylitol is highly toxic to dogs, so keep this product away from pets.
Can I take this while pregnant?
Vitamin C at normal dietary amounts is likely safe in pregnancy, but high-dose supplements should be avoided unless your doctor advises otherwise. Safety data for D-mannose and the other ingredients during pregnancy are limited or not available. Talk with your doctor or pharmacist before taking this product during pregnancy.
Is this safe for people with kidney disease?
Potassium supplements can raise blood levels dangerously in people with kidney disease, and very high-dose vitamin C has rarely caused kidney damage. If you have kidney disease or are prone to kidney stones, check with your doctor or pharmacist before taking this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NOx Boost label
Go deeper

The Full Monographs Behind NOx Boost’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Xylitol

Xylitol is a sugar alcohol used as a low-calorie sweetener that has the best-supported benefit for reducing cavities, especially in chewing gum or lozenges. It is generally safe for people i...

Read the full Xylitol monograph → Herb & supplement monograph

Vitamin C

Interacts with 207 drugs

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...

Read the full Vitamin C monograph → Herb & supplement monograph

D-mannose

D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising for prevention, but the evidence is sti...

Read the full D-mannose monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Beet

Interacts with 861 drugs

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but s...

Read the full Beet monograph →
Sources

Sources & How We Checked

NOx Boost's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 90 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Xylitol 7 references
  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. Weissman JD, Fernandez F, Hwang PH. Xylitol nasal irrigation in the management of chronic rhinosinusitis: a pilot study. Laryngoscope 2011;121:2468-72. PubMed
  3. Okamoto K, Kagami M, Kawai M, et al. Anaphylaxis to xylitol diagnosed by skin prick test and basophil activation test. Allergol Int. 2019;68(1):130-131. PubMed
  4. Rabago D, Kille T, Mundt M, Obasi C. Results of a RCT assessing saline and xylitol nasal irrigation for CRS and fatigue in Gulf War illness. Laryngoscope Investig Otolaryngol 2020;5(4):613-620.
  5. Wołyniec W, Szwarc A, Kasprowicz K, et al. Impact of hydration with beverages containing free sugars or xylitol on metabolic and acute kidney injury markers after physical exercise. Front Physiol 2022;13:841056. PubMed
  6. Bordier V, Teysseire F, Drewe J, et al. Effects of a 5-week intake of erythritol and xylitol on vascular function, abdominal fat and glucose tolerance in humans with obesity: a pilot trial. BMJ Nutr Prev Health 2023;6(2):264-272. PubMed
  7. Margulis I, Cohen-Kerem R, Stein N, et al. Xylitol nasal spray for prevention of recurrent acute otitis media in children: A prospective two-center cohort study. Int J Pediatr Otorhinolaryngol 2024;176:111818. PubMed

See these in context on the Xylitol monograph →

Vitamin C 51 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516.
  3. Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
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Beet 14 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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