Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Omega-3s with SPMs Ingredients & Drug Interactions

by Carlson

Omega-3s with SPMs label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Omega-3s with SPMs against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Omega-3s with SPMs is a dietary supplement by Carlson with 5 active ingredients. Its ingredients are commonly taken for liver health, memory and brain support, ulcerative colitis.Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Choline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Omega-3s with SPMs by Carlson

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HelloPharmacist Scorecard of Omega-3s with SPMs by Carlson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (215 mg) without saying how much of each component you get.

This softgel contains 5 active ingredients. Phosphatidyl choline and choline are compounds that support cell membranes and brain function.

Eicosapentaenoic acid and docosahexaenoic acid are omega-3 fatty acids—the key players in fish oil supplements that support heart and brain health. The product also includes total phospholipids, a group of fat-like substances that make up cell membranes.

The capsule itself is made from beef gelatin and contains a small amount of natural mixed tocopherols (vitamin E) as a preservative, plus glycerin, water, and natural vanilla flavor.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: inflammation balance, healthy brain aging, skin health.
  • We looked for evidence on: Age-related cognitive decline, Aging, Cognitive function, Memory, Atopic dermatitis (eczema), Acne — and 2 related terms.
  • The closest evidence on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Cognitive function.
  • Also on file: Phosphatidylcholine is rated "Insufficient Reliable Evidence To Rate" for Acne, Atopic dermatitis (eczema), Memory, Aging.

Evidence for these ingredients is mixed. Phosphatidyl choline shows possibly effective evidence for ulcerative colitis (a type of inflammatory bowel disease), though the data is limited.

For other uses—nonalcoholic fatty liver disease, alcohol-related liver disease, Alzheimer disease, and anxiety—the evidence isn't established. Choline is rated possibly ineffective for athletic performance, and we don't have enough data to rate it for bronchitis, age-related cognitive decline, fatty liver from total parenteral nutrition, hay fever, or Alzheimer disease.

The omega-3 fatty acids themselves weren't evaluated in the facts we hold.

The evidence, ingredient by ingredient Phosphatidylcholine Choline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both phosphatidyl choline and choline are generally well tolerated at normal doses. At high doses—choline above 3.5 grams daily, or phosphatidyl choline at 30 grams daily—they can cause digestive upset like bloating, diarrhea, nausea, and vomiting.

Choline may also cause a fishy body odor. Phosphatidyl choline may increase sweating and itching when taken by mouth.

For pregnancy, choline is important and rated likely safe, but the safety of high-dose supplements beyond what food provides isn't well studied; talk with your doctor about what's right for you. Breastfeeding requirements for choline are higher, and supplement use should be guided by your healthcare provider.

Side effects, ingredient by ingredient Phosphatidylcholine Choline

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Choline.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications before starting this product, especially if you take atropine, an anticholinergic drug sometimes used for various conditions—choline may reduce its effects. We could not check three other active components (eicosapentaenoic acid, docosahexaenoic acid, and total phospholipids) because we hold no interaction data for them, so use the search tool on this page to verify your full medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

This product may be worth considering if you're looking for omega-3 support combined with choline and phospholipid compounds, though the evidence for most claimed benefits is limited or not yet established. If you take atropine or any other prescription medication, check with your doctor or pharmacist first—the interaction checker on this page can help you see your exact medications.

Pregnant or breastfeeding people should discuss this supplement with their healthcare provider before starting. It's generally well tolerated, but high doses can cause digestive upset.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Omega-3s with SPMs, straight from the product label.

Brand Carlson
Barcode (UPC) 088395214103
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 309820
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Omega-3s with SPMs by Carlson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Soft Gel(s)
Maximum serving Sizes:
1 Soft Gel(s)
Servings per container
120
UPC/BARCODE
088395214103
IngredientAmount% DV
Cholesterol20 mg7%
Total Fat0.5 Gram(s)1%
Phosphatidyl Choline110 mg--
Calories5 Calorie(s)--
Choline13 mg2%
Eicosapentaenoic Acid40 mg--
Docosahexaenoic Acid150 mg--
Total Omega-3 Fatty Acids215 mg--
Total Phospholipids140 mg--

Other ingredients: Romega, natural Mixed Tocopherol, Beef Gelatin, Glycerin, Water, Vanilla Flavor, Natural

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Wild Norwegian Inflammation balance Healthy brain aging Skin health

Purity guaranteed This product is regularly tested by independent FDA registered laboratories. It has been determined to be fresh and fully potent (per AOCS international protocols) and is free of detrimental levels of mercury, cadmium, lead, PCBs and 28 other contaminants.

An FDA Regulated Facility

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Contains fish (anchovy and herring).

Suggested/Recommended/Usage/Directions

Directions: Adults: take one soft gel once or twice daily at mealtime. Do not chew.

Formula

Omega-3s with SPMs blends sustainably sourced arctic herring caviar extract with fish oil concentrate, which provides naturally-occurring phospholipids, specialized pro-resolving mediators (SPMs), and omega-3s, including EPA and DHA. Phospholipids enhance the absorption of fat-soluble nutrients, like omega-3s, and have the ability to cross the blood-brain barrier.

Brand IP Statement(s)

ROMEGA is a trademark of Arctic Bioscience A.S.

Seals/Symbols

Freshness & Potency Purity Guaranteed

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Omega-3s with SPMs by Carlson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Omega-3s with SPMs label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Omega-3s with SPMs by Carlson

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Soft Gel(s) Dosage formSoftgel Capsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Phosphatidyl Choline

No known
interactions
110 mg per serving

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, bu...

Phosphatidyl Choline monograph & interactions

Choline

Interacts with
16 drugs
13 mg per serving

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Total Omega-3 Fatty Acids

215 mg per serving Form: Triglycerides
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid

Total Phospholipids

140 mg per serving

Other (inactive) ingredients: Romega, Natural Mixed Tocopherol, Beef Gelatin, Glycerin, Water, Vanilla Flavor, Natural. These complete the product’s ingredient list but are not active constituents.

Interaction report

Omega-3s with SPMs by Carlson Drug Interactions

Want to check YOUR meds against Omega-3s with SPMs?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Choline 16

Individual Drug Interactions

The ingredients in Omega-3s with SPMs interact with 16 drugs. Click any drug to see the details.

1 of the 5 ingredients in Omega-3s with SPMs interact with drugs. Each result below shows which ingredient is responsible. Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Omega-3s with SPMs with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Omega-3s with SPMs, from the product label.

Carlson

See all Carlson products
Name
Carlson Division of J.R. Carlson Laboratories, Inc.
City
Arlington Heights
State
IL
ZipCode
60004
Phone Number
888-234-5656
Web Address
www.carlsonlabs.com
Pharmacist Counseling Corner

Omega-3s with SPMs by Carlson: Common Questions

Does Omega-3s with SPMs by Carlson interact with any medications?
Yes. Based on its ingredients, Omega-3s with SPMs has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Omega-3s with SPMs contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm pregnant or breastfeeding?
Choline is important during pregnancy and is rated likely safe, but high-dose supplements beyond what you get from food haven't been well studied. If you're breastfeeding, your choline needs are higher, but supplements should be guided by your healthcare provider. Talk with your doctor or pharmacist about what's right for your situation.
What side effects might I notice?
At normal doses, most people tolerate this well. At high doses (choline above 3.5 grams daily), some people report a fishy body odor, bloating, diarrhea, nausea, vomiting, or sweating. Phosphatidyl choline may also cause altered taste or itching. If you notice any of these, cut back and talk with your pharmacist.
Does this actually work for Alzheimer disease or brain health?
The evidence isn't established yet. Phosphatidyl choline shows possibly effective evidence for ulcerative colitis, but for Alzheimer disease and other brain conditions, we don't have enough reliable data to say whether it works. The omega-3 fatty acids in fish oil are well-studied for heart health, but that data wasn't rated in the facts we hold.
Can I take this with atropine?
There is a documented minor interaction—choline may theoretically reduce how well atropine works in the brain. Check with your doctor or pharmacist before combining them, or use the interaction checker on this page with your specific medications.
Why couldn't you check some of the ingredients?
We hold no monograph data for eicosapentaenoic acid, docosahexaenoic acid, and total phospholipids, so we couldn't check them for interactions. That doesn't mean they're safe or unsafe—it means the data isn't on file with us. Use the search tool on this page to verify all your medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Omega-3s with SPMs is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Omega-3s with SPMs label
Go deeper

The Full Monographs Behind Omega-3s with SPMs’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylcholine

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for mo...

Read the full Phosphatidylcholine monograph → Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph →
Sources

Sources & How We Checked

Omega-3s with SPMs's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 29 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylcholine 15 references
  1. Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
  2. Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
  3. Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. PubMed
  4. Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. PubMed
  5. Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
  6. Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
  7. Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8.
  8. Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
  9. Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
  10. Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
  11. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
  12. Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
  13. Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
  14. Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
  15. Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed

See these in context on the Phosphatidylcholine monograph →

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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