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Dietary supplement

OmegaPure Krill Ingredients & Drug Interactions

by Arctic Oils

OmegaPure Krill label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking OmegaPure Krill against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

OmegaPure Krill is a dietary supplement by Arctic Oils with 2 active ingredients. Its ingredients are commonly taken for heart and cholesterol support, high triglycerides, joint pain and inflammation.Based on those ingredients, 838 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, K-REAL Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against OmegaPure Krill by Arctic Oils

Ask about any prescription or over-the-counter medication and we check it for interactions with OmegaPure Krill by Arctic Oils — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of OmegaPure Krill by Arctic Oils

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (363 mg) without saying how much of each component you get.
  • “Phospholipids” is listed as a grouped ingredient — the label gives one combined amount (540 mg) without saying how much of each component you get.
  • “K-REAL Krill Oil” is listed as a grouped ingredient — the label gives one combined amount (1.65 Gram(s)) without saying how much of each component you get.

OmegaPure Krill contains 3 active ingredients: two omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid), astaxanthin, and phospholipids. Krill oil is the source—a small crustacean rich in omega-3s, which play a role in heart and brain health.

Astaxanthin is a red carotenoid (pigment) antioxidant found naturally in krill. The softgels also contain inactive ingredients including sorbitol, mixed tocopherols (a form of vitamin E), and ascorbyl palmitate (vitamin C derivative) as excipients.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Omega-3 support for heart and cognitive health.
  • We looked for evidence on: Cardiovascular disease (CVD), Hyperlipidemia, Hypertriglyceridemia, Heart failure, Hypertension, Stroke — and 4 related terms.
  • The closest evidence on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Age-related macular degeneration (AMD), Heart failure, Dry eye, Hyperlipidemia, and more.

We hold insufficient evidence to rate astaxanthin for any of the conditions listed in our data—age-related cognitive decline, age-related macular degeneration, aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome. The evidence isn't established for these uses in the data we have on file.

If you're considering this product for a specific health goal, talk it over with your doctor or pharmacist to see what the research actually supports.

The evidence, ingredient by ingredient Krill Oil Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astaxanthin is generally well tolerated in studies, though long-term safety data are limited. The most common side effects reported orally are abdominal pain, diarrhea, and red-colored stools.

At low doses (6 mg daily), a small number of trial participants reported increased bowel movements and red stools; at higher doses (40 mg daily), two patients experienced severe stomach pain. There isn't enough safety data to know whether astaxanthin is safe in pregnancy or while breastfeeding—the safety data advises against it during both.

Talk with your doctor or pharmacist for personalized advice if you're pregnant, nursing, or planning to become pregnant.

Side effects, ingredient by ingredient Krill Oil Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 672 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist whether you take any drugs metabolized by CYP3A4 or CYP2B6 enzymes. These are Moderate-severity interactions; astaxanthin may theoretically lower their blood levels and reduce how well they work.

The two omega-3 fatty acids in this product couldn't be checked against our interaction data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

OmegaPure Krill is an omega-3 supplement whose main interaction concern is astaxanthin's theoretical effect on two liver enzymes that clear many medications. If you take any prescription drugs, run them through the medication checker on this page before starting this product.

Astaxanthin is generally well tolerated but has limited long-term safety data and is not recommended during pregnancy or breastfeeding. Chat with your doctor or pharmacist about whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about OmegaPure Krill, straight from the product label.

Brand Arctic Oils
Barcode (UPC) 871149003753
Net contents 60 Fish Gelatin Softgel(s)
Market status On market
Date entered into DSLD Dec 26, 2020
DSLD ID 240414
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for OmegaPure Krill by Arctic Oils, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
UPC/BARCODE
871149003753
IngredientAmount% DV
Calories10 Calorie(s)--
Eicosapentaenoic Acid165 mg--
Docosahexaenoic Acid99 mg--
Total Fat1 Gram(s)2%
Total Omega-3 Fatty Acids363 mg--
Phospholipids540 mg--
K-REAL Krill Oil1.65 Gram(s)--
Astaxanthin2 mg--

Other ingredients: Softgel, Sorbitol, Mixed Tocopherols, Ascorbyl Palmitate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Professional use only Not for resale on third-party websites, including, but not limited to, Amazon and eBay.

Clinical testing suggests that this molecular composition absorbs into red blood cells, reduces the n-6:n-3 PUFA ratio, and increases the omega-3 index more effectively that fish oil.

IKOS

Third-Party Certificate of Analysis (COA) for this specific lot can be found by visiting http://www.ifosprogram.com/consumer-reports.aspx or by scanning the QR code.

This package is completely recyclable

Suggested/Recommended/Usage/Directions

Directions: Take two softgels in the morning, preferably after breakfast, or as recommended by your healthcare practitioner. Do not crush or chew softgels.

Precautions

Consult your healthcare practitioner prior to use.

Individuals taking medication should discuss potential interactions with their healthcare practitioner, especially if you have coagulopathy or are taking an anticoaglulant.

Do not use if tamper seal is damaged.

Storage: Keep closed in a cool, dry place out of reach of children.

Contains: Crustacean shellfish (krill) and fish (tilapia [source of fish gelatin])

Formula

OmegaPure Krill features K-REAL Antarctic krill oil, which provides the omega-3 fatty acids (EPA and DHA) attached to phospholipids as well as to triglycerides.

Krill oil is also naturally complexed with astaxanthin, which provides powerful antioxidant activity and helps stabilize the oil.

Omega-3 oil from sustainable antarctic krill

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Storage: Keep closed in a cool, dry place out of reach of children.

Formulation

Does Not Contain: Wheat, gluten, yeast, soy protein, dairy products, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Brand IP Statement(s)

2017 XYMOGEN

IKOS certification mark is a registered trademark of Nutrasource Diagnostics Inc.

K-REAL is a registered trademark of Enzymotec Ltd.

Seals/Symbols

Third-Party GMP Compliant Verified

ePV (ePedigree Verification)

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

OmegaPure Krill by Arctic Oils label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

OmegaPure Krill label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in OmegaPure Krill by Arctic Oils

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

K-REAL Krill Oil

Interacts with
208 drugs
1.65 Gram(s) per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

K-REAL Krill Oil monograph & interactions
  • › Phospholipids

Astaxanthin

Interacts with
671 drugs
2 mg per serving Form: Microalgae

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Other (inactive) ingredients: Softgel, Sorbitol, Mixed Tocopherols, Ascorbyl Palmitate. These complete the product’s ingredient list but are not active constituents.

Interaction report

OmegaPure Krill by Arctic Oils Drug Interactions

Want to check YOUR meds against OmegaPure Krill?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
838Drugs
838 Moderate

Ingredients driving the most interactions

Astaxanthin 671
K-REAL Krill Oil 208

Individual Drug Interactions

The ingredients in OmegaPure Krill interact with 838 drugs. Click any drug to see the details.

2 of the 2 ingredients in OmegaPure Krill interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin K-REAL Krill Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in OmegaPure Krill with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions

K-REAL Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
K-REAL Krill Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for OmegaPure Krill, from the product label.

Arctic Oils

See all Arctic Oils products
Name
XYMOGEN Exclusive Professional Formulas
Street Address
6900 Kingspointe Pkwy.
City
Orlando
State
FL
ZipCode
32819
Phone Number
800-647-6100
Web Address
www.xymogen.com
Pharmacist Counseling Corner

OmegaPure Krill by Arctic Oils: Common Questions

Does OmegaPure Krill by Arctic Oils interact with any medications?
Yes. Based on its ingredients, OmegaPure Krill has a known interaction with 838 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
OmegaPure Krill contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the omega-3s in krill oil doing in my body?
Eicosapentaenoic acid and docosahexaenoic acid are two omega-3 fatty acids your body needs. They play roles in heart and brain health, but we don't have effectiveness ratings for them on file for specific conditions.
What's astaxanthin, and why is it in here?
Astaxanthin is a red pigment and antioxidant that occurs naturally in krill. It's included for potential health benefits, but we hold insufficient evidence to rate it for the conditions in our data—age-related cognitive decline, macular degeneration, aging skin, and others.
Are there any side effects I should know about?
Astaxanthin is generally well tolerated. The most common side effects are abdominal pain, diarrhea, and red-colored stools. At higher doses, severe stomach pain has been reported in a small number of people.
Is this safe if I'm pregnant or breastfeeding?
There isn't enough safety data for astaxanthin in pregnancy or while breastfeeding, so the safety data advises against it during both. Talk with your doctor or pharmacist for personalized advice.
How do I know if this interacts with my medications?
Astaxanthin may theoretically lower blood levels of drugs cleared by two liver enzymes—CYP3A4 and CYP2B6. Use the medication checker on this page to see if any of your specific drugs are affected. If you're unsure, ask your pharmacist or doctor before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if OmegaPure Krill is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

OmegaPure Krill label
Go deeper

The Full Monographs Behind OmegaPure Krill’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

OmegaPure Krill's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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