Major interaction on record — check this product against your medications before combining. Based on 6 of 8 ingredients. Check your meds →
Dietary supplement

Once-Daily Health Booster Ingredients & Drug Interactions

by Life Extension

Once-Daily Health Booster label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Once-Daily Health Booster against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Once-Daily Health Booster is a dietary supplement by Life Extension with 8 active ingredients. Its ingredients are commonly taken for general antioxidant support, skin and hair care, heart health.Based on those ingredients, 1,263 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin E, Saffron Stigma Extract, Chlorophyllin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Once-Daily Health Booster by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Once-Daily Health Booster by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Once-Daily Health Booster by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 10 of its 13 active ingredients.
  • “Vitamin K” is listed as a grouped ingredient — the label gives one combined amount (2,600 mcg) without saying how much of each component you get.
  • “Mixed Carotenoids” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “MacuGuard Proprietary Blend” is a proprietary blend — the label gives one combined amount (173 mg) without saying how much of each component you get.

Once-Daily Health Booster contains 13 active ingredients. The formula pairs fat-soluble vitamins—vitamin E, vitamin K1, and vitamin K2, plus mixed tocotrienols (another form of vitamin E)—with a blend of carotenoids and botanical extracts.

The carotenoids include lutein, lycopene, trans-zeaxanthin, meso-zeaxanthin, and alpha-carotene, along with a proprietary MacuGuard blend containing meso-zeaxanthin and trans-zeaxanthin again. The botanicals are saffron stigma extract and chlorophyllin.

The product also lists phospholipids as an active ingredient. Inactive ingredients—the capsule material, oils, and binders—include gelatin, glycerin, safflower oil, corn oil, flax seed oil, beeswax, palm oil, acacia gum, carob, microcrystalline cellulose, soybean oil, maltodextrin, and purified water.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Daily supply of key nutrients and antioxidant support.
  • We looked for evidence on: Age-related macular degeneration (AMD), Cataracts, Asthenopia (eye strain), Cardiovascular disease (CVD), Atherosclerosis, Aging skin — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Vitamin E is effective for vitamin E deficiency and a rare condition called ataxia with vitamin E deficiency (AVED), and it's possibly effective for Alzheimer disease, beta-thalassemia, G6PD deficiency, and intracranial hemorrhage. Vitamin K1 and K2 are effective for clotting disorders and possibly effective for osteoporosis.

Lutein is possibly effective for age-related macular degeneration and cataracts, but possibly ineffective for retinitis pigmentosa and other eye conditions. Lycopene is possibly effective for prostate cancer.

Zeaxanthin (both forms) is possibly effective for age-related macular degeneration. Saffron is possibly effective for chemotherapy-related nerve damage and Alzheimer disease.

For chlorophyllin, the evidence is insufficient—it's possibly ineffective for urinary odor and rated insufficient for acne and other conditions. We don't hold effectiveness data for phospholipids or alpha-carotene.

The evidence, ingredient by ingredient Vitamin E Vitamin K Lycopene Calendula Saffron Chlorophyllin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin E is generally well tolerated at dietary amounts, but high-dose long-term supplements may raise the risk of bleeding and other serious effects—including rare cases of bleeding, stroke, or cardiovascular problems. There's also some concern about increased risk of hemorrhagic stroke in male smokers on synthetic vitamin E long-term, though other studies haven't confirmed this.

Vitamin K is generally well tolerated; common mild side effects are diarrhea, nausea, and stomach upset. Lutein and zeaxanthin are generally well tolerated at typical doses.

Lycopene can cause mild stomach complaints like diarrhea, gas, and nausea. Saffron is generally well tolerated short-term but can cause drowsiness, nausea, or gastrointestinal upset; rarely, allergic reactions have occurred.

Chlorophyllin is generally well tolerated short-term, though long-term safety data are limited. It may cause photosensitization (sun sensitivity) and has been linked in rare cases to pseudoporphyria (blistering on sun-exposed skin).

Side effects, ingredient by ingredient Vitamin E Vitamin K Lycopene Calendula Saffron Chlorophyllin

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Lycopene, Chlorophyllin, Saffron, Vitamin E, Vitamin K, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications.
  • For scale: 1,262 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you're on warfarin or any blood thinner, this product is a must-check—vitamin K can reverse warfarin's effect, and vitamin E can increase bleeding risk. Blood-thinning or antiplatelet drugs (like aspirin, clopidogrel, or apixaban) also interact with both vitamin E and lycopene.

Chemotherapy drugs (especially alkylating agents and antitumor antibiotics) may lose effectiveness. Diabetes medications may carry added hypoglycemia risk with saffron and zeaxanthin.

Blood-pressure drugs could have stronger effects with saffron. Sleep aids and other CNS depressants may be more sedating with saffron.

Medications that are light-sensitive (photosensitizing drugs) may have stronger effects with chlorophyllin. Cyclosporine, niacin, caffeine, and certain enzyme-metabolized drugs (CYP3A4 substrates) are also documented concerns.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is a multitarget formula for eye and general antioxidant support. If you take warfarin, or blood thinners, diabetes medications, chemotherapy, sleep aids, blood-pressure drugs, or light-sensitive medications, check with your pharmacist before starting.

Anyone on high-dose vitamin E or dealing with bleeding disorders should be cautious. For others, the individual ingredients are generally safe at supplement doses—but run your exact medications through the checker on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 11 of 13 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Once-Daily Health Booster, straight from the product label.

Brand Life Extension
Net contents 30 Packet(s); 30 Softgel(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 328403
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Once-Daily Health Booster by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
IngredientAmount% DV
Vitamin E30.2 mg201%
Vitamin K2600 mcg2167%
Vitamin K11500 mcg--
Vitamin K21000 mcg--
Lutein10 mg--
Lycopene10 mg--
Phospholipids0 NP--
Trans-Zeaxanthin0 NP--
Mixed Carotenoids0 NP--
Meso-Zeaxanthin0 NP--
MacuGuard Proprietary Blend173 mg--
Meso-Zeaxanthin & Trans-Zeaxanthin4 mg--
Alpha-Carotene1.24 mg--
Mixed Tocotrienols55 mg--
Marigold Flower Extract0 NP--
Saffron Stigma Extract20 mg--
Chlorophyllin100 mg--
Vitamin K2100 mcg--

Other ingredients: Flax seed oil, Gelatin, Glycerin, Safflower Oil, Corn Oil, Water, Purified, Beeswax, Palm Oil, Acacia Gum, Carob, Microcrystalline Cellulose, Soybean Oil, Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

LuteinPlus and MZ are registered trademarks of Nutriproducts Ltd., UK, licensed under U.S. Patent 8,623,428.

Precautions

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Warning: Reproductive Harm - www.P65Warnings.ca.gov.

If you are taking a vitamin K antagonist (e.g. warfarin), consult your healthcare practitioner before taking this product.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Formulation

Gluten free Non GMO Le certified

Seals/Symbols

Non GMO Le certified

Formula

Daily supply of key nutrients in convenient packets

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take one (1) packet daily with a meal, or as recommended by a healthcare practitioner.

Storage

To ensure product consistency, store tightly closed in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Once-Daily Health Booster by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Once-Daily Health Booster label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Once-Daily Health Booster by Life Extension

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin E

Interacts with
766 drugs
30.2 mg per serving Form: D-Alpha-Tocopherol

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Vitamin K

Interacts with
2 drugs
2600 mcg per serving

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K monograph & interactions

Lycopene

Interacts with
122 drugs
10 mg per serving Form: Tomato fruit extract

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible hear...

Lycopene monograph & interactions

MacuGuard Proprietary Blend

173 mg per serving

Mixed Tocotrienols

Interacts with
766 drugs
55 mg per serving

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Mixed Tocotrienols monograph & interactions

Saffron Stigma Extract

Interacts with
521 drugs
20 mg per serving

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research us...

Saffron Stigma Extract monograph & interactions

Chlorophyllin

Interacts with
335 drugs
100 mg per serving Form: Sodium Magnesium Chlorophyllin

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing....

Chlorophyllin monograph & interactions

Other (inactive) ingredients: Flax seed oil, Gelatin, Glycerin, Safflower Oil, Corn Oil, Water, Purified, Beeswax, Palm Oil, Acacia Gum, Carob, Microcrystalline Cellulose, Soybean Oil, Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Once-Daily Health Booster by Life Extension Drug Interactions

Want to check YOUR meds against Once-Daily Health Booster?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,263Drugs
2 Major 1,260 Moderate 1 Minor

Ingredients driving the most interactions

Vitamin E 766
Saffron Stigma Extract 521
Chlorophyllin 335
Marigold Flower Extract 248
Lycopene 122

Individual Drug Interactions

The ingredients in Once-Daily Health Booster interact with 1,263 drugs. Click any drug to see the details.

6 of the 8 ingredients in Once-Daily Health Booster interact with drugs. Each result below shows which ingredient is responsible. Vitamin E Saffron Stigma Extract Chlorophyllin Marigold Flower Extract Lycopene Vitamin K

Each ingredient & the kinds of drugs it affects

For each ingredient in Once-Daily Health Booster with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 766 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions

Saffron Stigma Extract4 drug types · 521 drugs

Antidiabetes Drugs

Theoretically, concomitant use of saffron with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that taking saffron extract reduces fasting levels of glucose when used in addition to hypoglycemic agents. However, saffron powder itself has not been shown to reduce fasting glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.
Animal and human research suggests that saffron extract can decrease blood pressure.

Likelihood Possible Evidence D
Caffeine

Theoretically, saffron might inhibit the metabolism of caffeine.
A small clinical study suggests that taking saffron powder 300 mg in 150 mL water daily for 5 days and then taking caffeine 200 mg seems to reduce caffeine metabolite levels in the saliva and urine in males, but not females. Theoretically, this may be due to the inhibition of cytochrome P450 1A2 by saffron.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.
Clinical research shows that taking saffron extract 60 mg orally daily for 26 weeks can cause drowsiness and sedation. Animal research suggests that adding saffron to hexobarbital further increases sleeping and slows motor activity.

Likelihood Possible Evidence D
Saffron Stigma Extract full monograph & interactions

Chlorophyllin1 drug type · 335 drugs

Photosensitizing Drugs

Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.
Chlorophyllin is a semi-synthetic derivative of chlorophyll. Chlorophyll has been reported to cause photosensitization. Orally, chlorophyll has also been associated with the development of pseudoporphyria in multiple case reports.

Likelihood Probable Evidence B
Chlorophyllin full monograph & interactions

Marigold Flower Extract1 drug type · 248 drugs

Cns Depressants

Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.
Although some animal research has suggested that a saponoside constituent in calendula may have sedative effects, calendula has been used for over 30 years without reports of sedation in humans.

Likelihood Unlikely Evidence D
Marigold Flower Extract full monograph & interactions

Lycopene1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lycopene has antiplatelet effects.

Likelihood Possible Evidence D
Lycopene full monograph & interactions

Vitamin K1 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Once-Daily Health Booster, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Once-Daily Health Booster by Life Extension: Common Questions

Does Once-Daily Health Booster by Life Extension interact with any medications?
Yes. Based on its ingredients, Once-Daily Health Booster has a known interaction with 1,263 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Once-Daily Health Booster contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe during pregnancy or while breastfeeding?
Vitamin K1 and K2 are likely safe in pregnancy and lactation. Lutein and zeaxanthin are also likely safe. However, saffron should be avoided in pregnancy—the data suggests it may stimulate the uterus. For saffron while breastfeeding, there isn't enough safety information, so it's best to avoid it. Vitamin E, lycopene, and chlorophyllin don't have clear pregnancy/lactation ratings in our data, so talk to your doctor or pharmacist before using them during pregnancy or while nursing.
What is saffron stigma extract in this formula supposed to do?
Saffron is included for its antioxidant and anti-inflammatory properties. The data shows it's possibly effective for chemotherapy-related nerve pain and Alzheimer disease. It may also have mild sedative and blood-pressure-lowering effects, which is why it matters if you take sleep aids or blood-pressure medications.
Can I take this if I'm on diabetes medication?
You'll want to check with your pharmacist first. Both saffron and zeaxanthin theoretically increase the risk of low blood sugar (hypoglycemia) when combined with diabetes drugs. The risk is described as moderate, so it's not automatic—but your pharmacist should review your specific medication and dose before you start.
What are the carotenoids (lutein, lycopene, zeaxanthin) for?
These are plant pigments that act as antioxidants. Lutein and zeaxanthin are possibly effective for age-related macular degeneration and cataracts—they accumulate in the eye. Lycopene is possibly effective for prostate cancer. All three are included for their potential eye and general antioxidant support.
I'm on a blood thinner. Can I use this product?
Not without checking with your pharmacist or doctor first. This product contains vitamin K (both K1 and K2), which can directly reverse the effect of warfarin—and vitamin E, which can increase bleeding risk. These are both Major or Moderate severity interactions, so you need personalized guidance on whether it's safe for you and at what dose.
What side effects are possible?
At typical supplement doses, most ingredients are generally well tolerated. Mild stomach upset—nausea, diarrhea, or abdominal discomfort—can occur with vitamin K, lycopene, or saffron. Saffron may cause drowsiness. Vitamin E at high doses carries a small rare risk of bleeding or stroke. Chlorophyllin may cause sun sensitivity. If you experience unusual bleeding, severe headache, or an allergic reaction, stop and call your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Once-Daily Health Booster label
Go deeper

The Full Monographs Behind Once-Daily Health Booster’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin E

Interacts with 766 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph → Herb & supplement monograph

Lycopene

Interacts with 122 drugs

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible heart and prostate benefits, but evidence fr...

Read the full Lycopene monograph → Herb & supplement monograph

Calendula

Interacts with 248 drugs

Calendula is a flowering plant whose petals are used mainly in skin creams, oils, and ointments to soothe minor irritation and support wound healing. Some early research is promising for ski...

Read the full Calendula monograph → Herb & supplement monograph

Saffron

Interacts with 521 drugs

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research uses small trials, so results are not defi...

Read the full Saffron monograph → Herb & supplement monograph

Chlorophyllin

Interacts with 335 drugs

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing. The best evidence is for its use as a d...

Read the full Chlorophyllin monograph →
Sources

Sources & How We Checked

Once-Daily Health Booster's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 128 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin E 64 references
  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
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Vitamin K 11 references
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Lutein 2 references
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Lycopene 10 references
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Zeaxanthin 4 references
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Calendula 9 references
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Saffron 22 references
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Chlorophyllin 6 references
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