Optiflora Pearl Ingredients & Drug Interactions
by Shaklee
What is this page for?
First and foremost: checking Optiflora Pearl against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Optiflora Pearl is a dietary supplement by Shaklee with 2 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus, Bifidobacterium longum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Optiflora Pearl by Shaklee
Ask about any prescription or over-the-counter medication and we check it for interactions with Optiflora Pearl by Shaklee — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Optiflora Pearl by Shaklee
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Optiflora Pearl contains 2 active probiotic ingredients: Lactobacillus acidophilus and Bifidobacterium longum. Both are live, beneficial bacteria meant to support your gut and digestive health.
The product also includes inactive ingredients — palm oil, gelatin, glycerin, soy lecithin, and pectin — which help form and preserve the capsule.
Does it work?
Moderate evidence
The evidence differs between the two ingredients. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis; however, Bifidobacterium longum's effectiveness for the conditions listed in our data — including antibiotic-associated diarrhea, hay fever, anxiety, and asthma — has not been established in reliable trials.
Neither ingredient has enough evidence to rate its effectiveness for age-related cognitive decline, athletic performance, or acute respiratory distress syndrome.
How safe is it?
Well-documented data
Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Bifidobacterium longum is generally well tolerated in healthy people, though caution is advised for those who are seriously ill or immune-compromised.
Both ingredients can occasionally cause mild gastrointestinal side effects — such as bloating, abdominal pain, flatulence, or diarrhea — though these are uncommon. There is a theoretical concern that live probiotics could cause infection in severely ill patients; most documented cases have occurred in people on multiple intensive treatments or with compromised immune systems.
For Bifidobacterium longum, the safety data indicate it is possibly safe during pregnancy and lactation, though data are limited, so talk with your doctor or pharmacist before using it while breastfeeding.
Meds to double-check
Moderate interaction found
Separate this product from antibiotic drugs by a few hours — antibiotics are Moderate-severity interactions with both ingredients because they can kill off the live bacteria in the product. Check your exact antibiotic schedule with your pharmacist so you get the timing right.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product may help if you're dealing with IBS, antibiotic-related diarrhea, or bacterial vaginosis — Lactobacillus acidophilus has some evidence for those. If you're on antibiotics, don't take this at the same time; space them out a few hours apart so the antibiotics don't kill the live organisms.
If you're seriously ill or have a weakened immune system, check with your doctor first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Optiflora Pearl, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Optiflora Pearl by Shaklee, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Lactobacillus acidophilus | 7 mg | -- |
| Bifidobacterium longum | 10 mg | -- |
Other ingredients: Palm Oil, Gelatin, Glycerin, Soy Lecithin, Pectin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Guaranteed Delivery The two-part optiflora complex system maintains a healthy balance of intestinal microorganisms to promote long-term intestinal health. Shaklee Since 1956 Safe - Proven 100% Guaranteed
No artificial flavors, sweeteners, colors, or preservatives
Manufactured in a facility that may also process peanuts, tree nuts, milk, egg, soy, sesame, wheat, shellfish, and fish.
Brand IP Statement(s)
Shaklee Since 1956 Safe - Proven 100% Guaranteed
Seals/Symbols
Shaklee Since 1956 Safe - Proven 100% Guaranteed
Precautions
Seal under cap for your protection.
Formula
Probiotic to promote intestinal health and balance
General Statements
Dr Shaklee
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Take 1 capsule daily.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Optiflora Pearl by Shaklee label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Optiflora Pearl by Shaklee
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Lactobacillus acidophilus
Interacts with182 drugs
Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...
Lactobacillus acidophilus monograph & interactionsBifidobacterium longum
Interacts with182 drugs
Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most...
Bifidobacterium longum monograph & interactionsOther (inactive) ingredients: Palm Oil, Gelatin, Glycerin, Soy Lecithin, Pectin. These complete the product’s ingredient list but are not active constituents.
Optiflora Pearl by Shaklee Drug Interactions
HelloPharmacist Interaction Report
Optiflora Pearl by Shaklee contains two live probiotic ingredients, and both interact with antibiotic drugs.
The main concern is that antibiotics might kill off the live organisms in these probiotics, reducing their effectiveness — so timing matters here.
Read the full breakdown — every affected drug type, severity by severity
Lactobacillus acidophilus and Bifidobacterium longum both have a Moderate interaction with antibiotics. Since these products contain live, active microorganisms, taking them at the same time as antibiotic drugs can significantly reduce the number of organisms that survive.
The solution is straightforward: space out your doses. Your pharmacist or doctor can tell you the best timing — usually a few hours apart works well.
Otherwise, no interactions are documented in our data for these ingredients with other medication types. That said, this is not a guarantee that none exist.
Altogether, these interactions span 182 individual medications. Check your exact medications using the search tool on this page, especially if you're on antibiotics.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Optiflora Pearl?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Optiflora Pearl interact with 182 drugs. Click any drug to see the details.
2 of the 2 ingredients in Optiflora Pearl interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus Bifidobacterium longum
CefotetanCefotan
How Cefotetan interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Cefotetan interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cefotetan interactionCefoxitinMefoxin
How Cefoxitin interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cefoxitin interactionLactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Cefoxitin interactionCefpodoxime ProxetilVantin
How Cefpodoxime Proxetil interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Cefpodoxime Proxetil interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cefpodoxime Proxetil interactionCefprozilCefzil
How Cefprozil interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Cefprozil interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cefprozil interactionCeftazidimeCeftazidime, Ceptaz, Fortaz, Tazicef, Tazidime
How Ceftazidime interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Ceftazidime interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Ceftazidime interactionCeftibutenCedax
How Ceftibuten interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Ceftibuten interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Ceftibuten interactionCeftizoximeCefizox
How Ceftizoxime interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Ceftizoxime interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Ceftizoxime interactionCeftolozane Sulfate, Tazobactam SodiumZerbaxa
How Ceftolozane Sulfate, Tazobactam Sodium interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Ceftolozane Sulfate, Tazobactam Sodium interactionLactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Ceftolozane Sulfate, Tazobactam Sodium interactionCeftriaxoneRocephin
How Ceftriaxone interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Ceftriaxone interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Ceftriaxone interactionCefuroximeCeftin, Kefurox, Zinacef
How Cefuroxime interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Cefuroxime interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cefuroxime interactionCephalexinCephalex, Keflex, Keftab, Lexin
How Cephalexin interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Cephalexin interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cephalexin interactionCephapirinCefadyl
How Cephapirin interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Cephapirin interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cephapirin interactionCephradineAnspor, Velosef
How Cephradine interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Cephradine interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cephradine interactionChloramphenicolChloromycetin, Chloromycetin Injection, Chloromycetin Ophthalmic
How Chloramphenicol interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Chloramphenicol interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Chloramphenicol interactionChlortetracyclineAureomycin
How Chlortetracycline interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Chlortetracycline interactionLactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Chlortetracycline interactionCinoxacinCinobac
How Cinoxacin interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Cinoxacin interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cinoxacin interactionCiprofloxacinCiloxan, Cipro, Cipro IV, Cipro XR, Ciprobay, Otiprio
How Ciprofloxacin interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Ciprofloxacin interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Ciprofloxacin interactionClarithromycinBiaxin, Biaxin XL
How Clarithromycin interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Clarithromycin interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Clarithromycin interactionClinafloxacinClinafloxacin
How Clinafloxacin interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Clinafloxacin interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Clinafloxacin interactionClindamycinCleocin, Cleocin T Gel, ClindaMax, Clindesse, Dalacin C
How Clindamycin interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Clindamycin interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Clindamycin interactionClofazimineLamprene
How Clofazimine interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Clofazimine interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Clofazimine interactionCloxacillin SodiumCloxapen, Cloxi, Tegopen
How Cloxacillin Sodium interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Cloxacillin Sodium interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cloxacillin Sodium interactionColistimethateColy-Mycin M
How Colistimethate interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Colistimethate interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Colistimethate interactionCyclacillinCyclapen-W, Cylcapen
How Cyclacillin interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Cyclacillin interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cyclacillin interactionCycloserineSeromycin
How Cycloserine interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Cycloserine interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cycloserine interactionDalbavancin HydrochlorideDalvance
How Dalbavancin Hydrochloride interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Dalbavancin Hydrochloride interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Dalbavancin Hydrochloride interactionDapsoneAczone, Avlosulfon, Dapsone
How Dapsone interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Dapsone interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Dapsone interactionDaptomycinCubicin, Dapzura RT
How Daptomycin interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Daptomycin interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Daptomycin interactionDemeclocyclineDeclomycin
How Demeclocycline interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Demeclocycline interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Demeclocycline interactionDicloxacillin InjectionDynapen Injection
How Dicloxacillin Injection interacts with Optiflora Pearl — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus + Dicloxacillin Injection interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Dicloxacillin Injection interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Optiflora Pearl with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Lactobacillus acidophilus
Antibiotic Drugs
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.
Bifidobacterium longum
Antibiotic Drugs
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.
Brand information
Manufacturer and brand details for Optiflora Pearl, from the product label.
Shaklee
See all Shaklee products- Name
- Shaklee Corporation
- City
- Pleasanton
- State
- CA
- ZipCode
- 94566
- Phone Number
- 1.800.742.5533
Optiflora Pearl by Shaklee: Common Questions
Does Optiflora Pearl by Shaklee interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Do I need to space this out from my antibiotic?
Can I take this while breastfeeding?
Will this help my IBS or diarrhea?
What side effects might I notice?
Is this safe for kids?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Optiflora Pearl is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Optiflora Pearl’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lactobacillus Acidophilus
Interacts with 182 drugsLactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...
Read the full Lactobacillus Acidophilus monograph → Herb & supplement monographBifidobacterium Longum
Interacts with 182 drugsBifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...
Read the full Bifidobacterium Longum monograph →Sources & How We Checked
Optiflora Pearl's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 36 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lactobacillus Acidophilus 15 references
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
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See these in context on the Bifidobacterium Longum monograph →
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