Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Optimal Elderberry Plus Liquid Ingredients & Drug Interactions

by Seeking Health

Optimal Elderberry Plus Liquid label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Optimal Elderberry Plus Liquid against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Optimal Elderberry Plus Liquid is a dietary supplement by Seeking Health with 6 active ingredients. Its ingredients are commonly taken for high cholesterol, heart health, immune support.Based on those ingredients, 1,040 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Wild Cherry, Shiitake Mushroom, Beta 1,3 Glucan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Optimal Elderberry Plus Liquid by Seeking Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Optimal Elderberry Plus Liquid by Seeking Health — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Optimal Elderberry Plus Liquid by Seeking Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This liquid contains six active plant and fungal ingredients. Beta-glucan (from yeast cell walls or mushrooms) is included for heart and cholesterol support.

Astragalus is a traditional herb used to support immune function. Wild cherry, elderberry, maitake mushroom, and shiitake mushroom round out the formula—elderberry and maitake are commonly used for general immune support, while shiitake is included for its nutritional profile.

The product also contains four inactive ingredients: vegetable glycerin (sweetener and preservative), deionized water (solvent), and raspberry and berry natural flavors for taste.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: immune support and respiratory health.
  • We looked for evidence on: Common cold, Exercise-induced respiratory infections, Coronavirus disease 2019 (COVID-19), Influenza, Upper respiratory infection, Bronchitis.
  • The closest evidence on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Coronavirus disease 2019 (COVID-19) (Natural Medicines).
  • Also on file: Shiitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Common cold, Influenza, Coronavirus disease 2019 (COVID-19).
  • Also on file: Beta-glucans is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced respiratory infections.

The evidence for this product's ingredients is limited in our data. Beta-glucan is rated Likely Effective for cholesterol and heart disease, based on clinical research.

For the other five active ingredients—astragalus, wild cherry, elderberry, maitake mushroom, and shiitake mushroom—the evidence we hold shows Insufficient Reliable Evidence to Rate them for the conditions they're traditionally used for, which include immune support, respiratory health, and general wellness. That doesn't mean they don't work; it means large, well-designed human studies backing their use haven't been completed or aren't yet in our monographs.

The evidence, ingredient by ingredient Beta-glucans Astragalus Wild Cherry Elderberry Maitake Mushroom Shiitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-glucan, astragalus, elderberry, maitake, and shiitake are generally well tolerated when properly prepared. Beta-glucan from food is considered safe, but concentrated supplements lack complete safety data, so use caution.

Astragalus is generally tolerated short-term in healthy adults, though long-term safety data is limited. Elderberry extracts made from ripe, cooked berries are well tolerated; raw or unripe berries and other plant parts contain cyanide-forming compounds and can be harmful.

Wild cherry similarly contains cyanide-forming compounds and should not be used in large amounts; a case of accidental poisoning from 300 grams of wild cherries resulted in severe symptoms including confusion and respiratory distress. Maitake and shiitake mushrooms are generally well tolerated as food; the most common side effects reported in trials are mild gastrointestinal effects like diarrhea, nausea, and bloating.

Raw shiitake can cause a skin condition called shiitake dermatitis (whiplash-like marks); cooking eliminates this risk. For pregnancy, elderberry is rated Likely Safe based on limited data, so you may consider it.

Beta-glucan, astragalus, maitake, and shiitake all lack enough safety data and should be avoided during pregnancy. Wild cherry is rated Likely Unsafe in pregnancy.

For breastfeeding, astragalus and wild cherry should be avoided due to insufficient safety data. Elderberry, maitake, and shiitake also lack breastfeeding safety data, so caution is advised.

Beta-glucan has no pregnancy or breastfeeding data on file; talk with your doctor or pharmacist about what's right for you.

Side effects, ingredient by ingredient Beta-glucans Astragalus Wild Cherry Elderberry Maitake Mushroom Shiitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Elderberry, Maitake Mushroom, Shiitake Mushroom, Wild Cherry, Astragalus, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,041 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Optimal Elderberry Plus Liquid, double-check with your doctor or pharmacist if you take lithium (a Moderate concern), immunosuppressants, diabetes medications, blood pressure medications, warfarin, or drugs metabolized by the CYP3A4 or CYP2D6 liver enzymes. The most serious documented interaction is with lithium; astragalus may theoretically raise lithium levels.

The other categories carry Moderate-severity interactions as well. If you're unsure whether any of your medications fall into these groups, the search tool on this page and your pharmacist can help you check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to someone looking for broad immune support and general wellness, since most of its ingredients are traditionally used that way—though evidence for many of them is still developing. If you take lithium, immunosuppressants, diabetes or blood pressure medications, warfarin, or any drug metabolized by liver enzymes, you should check with your doctor or pharmacist before adding this product, because interactions are documented.

Pregnant or breastfeeding individuals should also discuss it with their healthcare provider, since safety data varies by ingredient.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Optimal Elderberry Plus Liquid, straight from the product label.

Brand Seeking Health
Barcode (UPC) 710465148819
Net contents 4 fl. Oz.; 118 mL
Market status On market
Date entered into DSLD Mar 23, 2018
DSLD ID 174628
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Optimal Elderberry Plus Liquid by Seeking Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
118
UPC/BARCODE
710465148819
IngredientAmount% DV
Beta 1,3 Glucan25 mg--
Astragalus100 mg--
Wild Cherry50 mg--
Elderberry200 mg--
Maitake Mushroom75 mg--
Shiitake Mushroom75 mg--

Other ingredients: Vegetable Glycerin, deionized Water, Raspberry natural flavor, Berry natural flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 mL (approx. 35 drops) per day, or as directed by your health care practitioner.

Shake well.

Storage

Storage: Store at room temperature.

Precautions

Keep out of reach of children.

General Statements

Notice: This is a natural product that may exhibit color, taste, and density variations from lot to lot. Optimal Elderberry Plus Liquid meets cGMP standards.

Physician formulated

Formulation

Does Not Contain: Gluten.

Made With Non-GMO Ingredients

FDA Statement of Identity

Dietary Supplement

General

Item IBL4OZ-PL-2

Seals/Symbols

Made With Non-GMO Ingredients

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Optimal Elderberry Plus Liquid by Seeking Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Optimal Elderberry Plus Liquid label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Optimal Elderberry Plus Liquid by Seeking Health

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container118 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Beta 1,3 Glucan

Interacts with
293 drugs
25 mg per serving

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly low...

Beta 1,3 Glucan monograph & interactions

Astragalus

Interacts with
208 drugs
100 mg per serving

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While...

Astragalus monograph & interactions

Wild Cherry

Interacts with
643 drugs
50 mg per serving

Wild cherry bark is a traditional cough remedy found in many old-fashioned cough syrups and lozenges, but there is little modern scientific evidence p...

Wild Cherry monograph & interactions

Elderberry

Interacts with
121 drugs
200 mg per serving

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...

Elderberry monograph & interactions

Maitake Mushroom

Interacts with
260 drugs
75 mg per serving

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake Mushroom monograph & interactions

Shiitake Mushroom

Interacts with
312 drugs
75 mg per serving

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have b...

Shiitake Mushroom monograph & interactions

Other (inactive) ingredients: Vegetable Glycerin, Deionized Water, Raspberry natural flavor, Berry natural flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Optimal Elderberry Plus Liquid by Seeking Health Drug Interactions

Want to check YOUR meds against Optimal Elderberry Plus Liquid?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,040Drugs
1,040 Moderate

Ingredients driving the most interactions

Wild Cherry 643
Shiitake Mushroom 312
Beta 1,3 Glucan 293
Maitake Mushroom 260
Astragalus 208

Individual Drug Interactions

The ingredients in Optimal Elderberry Plus Liquid interact with 1,040 drugs. Click any drug to see the details.

6 of the 6 ingredients in Optimal Elderberry Plus Liquid interact with drugs. Each result below shows which ingredient is responsible. Wild Cherry Shiitake Mushroom Beta 1,3 Glucan Maitake Mushroom Astragalus Elderberry

Each ingredient & the kinds of drugs it affects

For each ingredient in Optimal Elderberry Plus Liquid with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Wild Cherry1 drug type · 643 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes. Theoretically, wild cherry might increase levels of drugs metabolized by CYP3A4. However, so far, this interaction has not been reported in humans.
Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and others.

Likelihood Possible Evidence D
Wild Cherry full monograph & interactions

Shiitake Mushroom2 drug types · 312 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.

Likelihood Possible Evidence D
Shiitake Mushroom full monograph & interactions

Beta 1,3 Glucan2 drug types · 293 drugs

Antihypertensive Drugs

Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that taking beta-glucans may reduce systolic and diastolic blood pressure in some hypertensive individuals.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Some clinical research shows that beta-glucans have immunostimulant effects.

Likelihood Possible Evidence D
Beta 1,3 Glucan full monograph & interactions

Maitake Mushroom3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake Mushroom full monograph & interactions

Astragalus4 drug types · 208 drugs

Antidiabetes Drugs

Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research in humans shows that astragalus might have hypoglycemic effects. Theoretically, taking astragalus, especially in combination with other hypoglycemic agents, might increase the risk of hypoglycemia.

Likelihood Probable Evidence A
Cyclophosphamide

Theoretically, astragalus might interfere with cyclophosphamide therapy.
Evidence regarding the effect of astragalus on immunosuppression caused by cyclophosphamide is conflicting. Some animal research suggests that astragalus reverses cyclophosphamide-induced immunosuppression. However, other animal research shows no effect.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, astragalus might interfere with immunosuppressive therapy.
Astragalus seems to stimulate immune function. Theoretically, taking astragalus might decrease the effects of immunosuppressive therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, astragalus might increase levels and adverse effects of lithium.
Animal research suggests that astragalus has diuretic properties. Theoretically, due to this diuretic effect, astragalus might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Astragalus full monograph & interactions

Elderberry2 drug types · 121 drugs

Immunosuppressants

Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.

Likelihood Possible Evidence B
Pazopanib (Votrient)

Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 4 weeks for soft-tissue sarcoma developed severe nausea, loose stools, and elevated alanine transaminase and aspartate transaminase levels and was diagnosed with grade 3 liver injury. The patient reported taking elderberry supplements for 2 years, dose unspecified, and was also taking a multivitamin and a calcium supplement. The patient's symptoms and liver enzyme levels improved upon discontinuation of pazopanib and all supplements. Pazopanib treatment was re-initiated, at a lower dose, with no further evidence of liver injury. It was unclear in this case report if the elderberry supplements were derived from the berry, the flower, or the combination.

Likelihood Possible Evidence D
Elderberry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Optimal Elderberry Plus Liquid, from the product label.

Seeking Health

See all Seeking Health products
Name
Seeking Health
Street Address
3140 Mercer Ave
City
Bellingham
State
WA
ZipCode
98225
Phone Number
(800) 547-9812
Web Address
www.seekinghealth.com
Pharmacist Counseling Corner

Optimal Elderberry Plus Liquid by Seeking Health: Common Questions

Does Optimal Elderberry Plus Liquid by Seeking Health interact with any medications?
Yes. Based on its ingredients, Optimal Elderberry Plus Liquid has a known interaction with 1,040 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Optimal Elderberry Plus Liquid contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have any side effects?
The ingredients are generally well tolerated, but mild gastrointestinal effects—nausea, diarrhea, bloating, or abdominal discomfort—have been reported in some clinical trials, especially with the mushroom ingredients. Raw or inadequately cooked elderberry and shiitake can cause nausea, diarrhea, and in rare cases, skin reactions. When properly prepared (ripe elderberry, cooked shiitake), adverse effects are uncommon.
Can I take this while pregnant?
Elderberry is rated Likely Safe, so it may be an option. However, astragalus, wild cherry, beta-glucan, maitake, and shiitake all lack enough pregnancy safety data; wild cherry is actually rated Likely Unsafe. Talk with your doctor or pharmacist about which ingredients are right for you during pregnancy.
Can I take this while breastfeeding?
Elderberry, maitake, and shiitake lack enough breastfeeding safety data, so caution is advised. Astragalus and wild cherry should be avoided. Talk with your doctor or pharmacist for personalized guidance.
What does beta-glucan do?
Beta-glucan is included for its effects on cholesterol and heart health. Clinical research shows it's Likely Effective for both dyslipidemia (abnormal blood lipids) and coronary heart disease when used as part of an overall health plan.
Is this safe if I've got an autoimmune condition or I'm on an immune-suppressing drug?
This product contains four ingredients (beta-glucan, astragalus, elderberry, and shiitake mushroom) that theoretically may interfere with immunosuppressants. If you have an autoimmune condition or take any immune-suppressing medication, check with your doctor or pharmacist before using this product.
Does this product contain any fillers or artificial ingredients?
The inactive ingredients are vegetable glycerin, deionized water, and natural raspberry and berry flavors—no synthetic additives. The product is a liquid, so these are the carriers and flavorings used in the formulation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Optimal Elderberry Plus Liquid label
Go deeper

The Full Monographs Behind Optimal Elderberry Plus Liquid’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Beta-glucans

Interacts with 293 drugs

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly lowering cholesterol and blood sugar, while...

Read the full Beta-glucans monograph → Herb & supplement monograph

Astragalus

Interacts with 208 drugs

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While early studies are interesting, strong h...

Read the full Astragalus monograph → Herb & supplement monograph

Wild Cherry

Interacts with 643 drugs

Wild cherry bark is a traditional cough remedy found in many old-fashioned cough syrups and lozenges, but there is little modern scientific evidence proving it works. The bark, leaves, and s...

Read the full Wild Cherry monograph → Herb & supplement monograph

Elderberry

Interacts with 121 drugs

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu symptoms, but the evidence is limited and n...

Read the full Elderberry monograph → Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph → Herb & supplement monograph

Shiitake Mushroom

Interacts with 312 drugs

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...

Read the full Shiitake Mushroom monograph →
Sources

Sources & How We Checked

Optimal Elderberry Plus Liquid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 109 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beta-glucans 11 references
  1. Katz, D. L., Nawaz, H., Boukhalil, J., Giannamore, V., Chan, W., Ahmadi, R., and Sarrel, P. M. Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am.J.Prev.Med. 2001;20(2):124-129. PubMed
  2. Keenan, J. M., Pins, J. J., Frazel, C., Moran, A., and Turnquist, L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J.Fam.Pract. 2002;51(4):369.
  3. Maki, K. C., Galant, R., Samuel, P., Tesser, J., Witchger, M. S., Ribaya-Mercado, J. D., Blumberg, J. B., and Geohas, J. Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress i
  4. Bergendiova, K., Tibenska, E., and Majtan, J. Pleuran (beta-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur.J.Appl.Physiol 2011;111(9):2033-2040.
  5. Talbott S, Talbott J. Effect of beta 1,3/1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009;8(4):509-515.
  6. Feldman S, Schwartz HI Kalman DS Mayers A Kohrman HM Clemens R Krieger DR. Randomized phase II clinical trials of Wellmune WGP® for immune support during cold and flu season. The Journal of Applied Research 2009;9(1-2):30-42.
  7. McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 2013;10(3):171-83. PubMed
  8. Jesenak M, Urbancek S, Majtan J, Banovcin P, Hercogova J. ß-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis. J Dermatolog Treat 2016;27(4):351-4.
  9. Mah E, Kaden VN, Kelley KM, Liska DJ. Beverage containing dispersible yeast ß-glucan decreases cold/flu symptomatic days after intense exercise: a randomized controlled trial. J Diet Suppl 2020;17(2):200-10. PubMed
  10. Zhong K, Liu Z, Lu Y, Xu X. Effects of yeast ß-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis. Eur J Nutr. 2021. PubMed
  11. Cardenas FI, Mauguen A, Cheung IY, et al. Phase I trial of oral yeast-derived ß-glucan to enhance anti-GD2 immunotherapy of resistant high-risk neuroblastoma. Cancers (Basel) 2021;13(24):6265. PubMed

See these in context on the Beta-glucans monograph →

Astragalus 13 references
  1. Upton R, ed. Astragalus Root: Analytical, quality control, and therapeutic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia. 1999:1-25.
  2. Khoo KS, Ang PT. Extract of astragalus membranaceus and ligustrum lucidum does not prevent cyclophosphamide-induced myelosuppression. Singapore Med J 1995;36:387-90.
  3. Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal herbs. II. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo. J Clin Lab Immunol 1988;25:125-9.
  4. Sun Y, Hersh EM, Lee SL, et al. Preliminary observations on the effects of the Chinese medicinal herbs Astragalus membranaceus and Ligustrum lucidum on lymphocyte blastogenic responses. J Biol Response Mod 1983;2:227-37..
  5. Ma J, Peng A, Lin S. Mechanisms of the therapeutic effect of astragalus membranaceus on sodium and water retention in experimental heart failure. Chin Med J (Engl) 1998;111:17-23.
  6. Matkovic Z, Zivkovic V, Korica M, et al. Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res 2010;24:175-81.
  7. Zhang, J. G., Yang, N., He, H., Wei, G. H., Gao, D. S., Wang, X. L., Wang, X. Z., and Song, G. Y. [Effect of Astragalus injection on plasma levels of apoptosis-related factors in aged patients with chronic heart failure.]. Chin J Integr.Med 2005;11(3):18 PubMed
  8. Chen, H. W., Lin, I. H., Chen, Y. J., Chang, K. H., Wu, M. H., Su, W. H., Huang, G. C., and Lai, Y. L. A novel infusible botanically-derived drug, PG2, for cancer-related fatigue: a phase II double-blind, randomized placebo-controlled study. Clin Invest PubMed
  9. Tian H, Lu J, He H, et al.The effect of Astragalus as an adjuvant treatment in type 2 diabetes mellitus: A (preliminary) meta-analysis. J Ethnopharmacol. 2016;191:206-215. doi: 10.1016/j.jep.2016.05.062. PubMed
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