Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Organic Apple Cider Vinegar Ingredients & Drug Interactions

by PureCo

Organic Apple Cider Vinegar label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Apple Cider Vinegar against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Apple Cider Vinegar is a dietary supplement by PureCo with 3 active ingredients. Its ingredients are commonly taken for blood sugar support, weight management, digestive upset.Based on those ingredients, 1,097 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Black Pepper extract, organic Cayenne powder, organic Apple Cider Vinegar powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Organic Apple Cider Vinegar by PureCo

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Apple Cider Vinegar by PureCo — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Organic Apple Cider Vinegar by PureCo

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

PureCo Organic Apple Cider Vinegar is a 3-ingredient powder. The three active ingredients are organic apple cider vinegar powder, organic black pepper extract, and organic cayenne powder.

There are no other inactive ingredients listed.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Diabetic neuropathy — rated "Likely Effective" (Capsicum) (Natural Medicines).
  • On file: Postherpetic neuralgia — rated "Likely Effective" (Capsicum) (Natural Medicines).
  • On file: Back pain — rated "Possibly Effective" (Capsicum) (Natural Medicines).
  • On file: Cluster headache — rated "Possibly Effective" (Capsicum) (Natural Medicines).
  • On file: Postoperative nausea and vomiting (PONV) — rated "Possibly Effective" (Capsicum) (Natural Medicines).

The evidence for apple cider vinegar is not established in the data we hold — it rates insufficient evidence for acne, athletic performance, cognitive function, dental plaque, depression, and atopic dermatitis (eczema). Black pepper extract also rates insufficient evidence for allergic rhinitis (hay fever), asthma, athletic performance, headache, depression, and diarrhea.

Cayenne powder, however, has stronger support: it's rated Likely Effective for postherpetic neuralgia (a nerve pain that follows shingles) and diabetic neuropathy (nerve damage from diabetes), and Possibly Effective for cluster headaches, back pain, and postoperative nausea and vomiting.

The evidence, ingredient by ingredient Apple Cider Vinegar Black Pepper Capsicum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

In food amounts, apple cider vinegar is well tolerated. However, in larger doses or long-term use — especially undiluted — it can cause serious side effects including low potassium levels, elevated renin (a kidney hormone), and bone loss.

Topically, it may cause chemical burns and skin irritation. Black pepper in food amounts is generally safe and well tolerated; the main side effects are burning aftertaste, indigestion, and reduced taste perception.

Allergic reactions are rare. Cayenne is generally well tolerated in food amounts and approved topical products, but commonly causes burning and irritation.

In larger oral doses, it can cause belching, bloating, diarrhea, indigestion, gas, headache, nausea, and skin flushing. Serious effects are rare.

Black pepper is rated Likely Safe in pregnancy and Likely Safe during lactation, but the pregnancy and lactation data for apple cider vinegar and cayenne were not specified in the safety notes we hold.

Side effects, ingredient by ingredient Apple Cider Vinegar Black Pepper Capsicum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Black Pepper, Apple Cider Vinegar, Capsicum.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,098 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any heart medications (digoxin, propranolol), blood thinners or blood-thinner-like drugs (warfarin, aspirin, antiplatelet agents), blood sugar medications (insulin, antidiabetes drugs), anti-seizure drugs (phenytoin), breathing medications (theophylline), antibiotics (rifampin, ciprofloxacin), HIV medications (nevirapine), organ-transplant medications (cyclosporine), cholesterol drugs (atorvastatin), sedatives (pentobarbital), blood pressure drugs (ACE inhibitors), or water pills (diuretics). These interactions span 1,098 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product pairs three ingredients with different strengths: cayenne has good evidence for specific nerve pain conditions, while apple cider vinegar and black pepper have insufficient evidence for the claims often made about them. The bigger concern is the number of medication interactions — especially with heart drugs, blood thinners, blood sugar medications, and seizure medications — and the risk of dangerously low potassium with long-term use of apple cider vinegar in larger doses.

If you take any prescription medication or have heart, kidney, or bone health concerns, talk with your doctor or pharmacist before starting this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Apple Cider Vinegar, straight from the product label.

Brand PureCo
Barcode (UPC) X001U47U63
Net contents 50 Serving(s); 53 Gram(s); 1.87 Ounce(s)
Market status On market
Date entered into DSLD Jan 22, 2021
DSLD ID 242868
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Qualified Health
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Apple Cider Vinegar by PureCo, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Rounded Scoop(s)
Maximum serving Sizes:
1 Rounded Scoop(s)
Servings per container
50
UPC/BARCODE
X001U47U63
IngredientAmount% DV
organic Apple Cider Vinegar powder1000 mg--
organic Black Pepper extract20 mg--
organic Cayenne powder40 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Natural Herbals

Scoop included

Satisfaction Guarantee We offer a full refund on the purchase price of your order within 90 days of purchase. Restrictions apply. For details please visit www.mypure.co/refunds Visit online at www.mypure.co

We're here to help! For any questions, concerns, refunds [email protected] Connect with us to catch our latest deals and product news. Facebook mypureco Instagram mypure.co

Have a Pure Day!

Formula

Pure organic herbal powder 1000mg apple cider vinegar boosted with black pepper & cayenne.

Organic Cayenne We've added Cayenne fr its active ingredient, Capsaicin, and its interaction with ACV. Together, they naturally boost your metabolism and provide a range of benefits for your digestive system. Organic Black Pepper We've also added black pepper to dramatically increase your body's absorption of the nutrients found in ACV and Cayenne. Less wasted nutrients giving you better results.

Seals/Symbols

USDA Organic

"Certified Organic By: Organic Certifiers" GMP Certified Manufactured in USA

Formulation

USDA Organic

Non GMO Product No fillers

Organic and raw apple cider vinegar powder For thousands of years, Apple Cider Vinegar (ACV) has been used for its health-promoting probiotics and enzymes. With Pure Co powder, you can experience all the benefits without any of the harsh tastes, odors or irritations typically associated with ACV.

Organic Apple Cider Vinegar ACV has long been used to support a healthy digestive system while maintaining normal blood sugar and cholesterol levels. In addition, it's used to curb hunger and help weight loss, we only use organic unfiltered apple Cider Vinegar.

This product does not contain: Yeast, wheat, gluten, dairy, corn, soy, eggs, sugar, tree nuts, peanuts, fish, shellfish or hydrogenated oils.

Pure Co A company founded on one core principle to bring you the purest dietary supplement possible, We are committed to using organic and non-GMO ingredients whenever possible and manufacture all of our products right here in the USA.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: 1 rounded scoop daily with breakfast in a smoothie, sprinkled on top of food or in water. Or as directed by a healthcare professional.

Precautions

Discontinue use if side effects occur. For adults only.

If you are pregnant, nursing, taking medications or have any medical condition please discuss use with your healthcare practitioner.

Keep out of reach of children.

Do not use if safety seal is broken.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Apple Cider Vinegar by PureCo label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Apple Cider Vinegar label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Apple Cider Vinegar by PureCo

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Rounded Scoop(s) Dosage formPowder Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Organic Apple Cider Vinegar powder

Interacts with
162 drugs
1000 mg per serving

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of...

Organic Apple Cider Vinegar powder monograph & interactions

Organic Black Pepper extract

Interacts with
1,019 drugs
20 mg per serving

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to he...

Organic Black Pepper extract monograph & interactions

Organic Cayenne powder

Interacts with
239 drugs
40 mg per serving

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin p...

Organic Cayenne powder monograph & interactions
Interaction report

Organic Apple Cider Vinegar by PureCo Drug Interactions

Want to check YOUR meds against Organic Apple Cider Vinegar?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,097Drugs
1,043 Moderate 54 Minor

Ingredients driving the most interactions

organic Black Pepper extract 1,019
organic Cayenne powder 239
organic Apple Cider Vinegar powder 162

Individual Drug Interactions

The ingredients in Organic Apple Cider Vinegar interact with 1,097 drugs. Click any drug to see the details.

3 of the 3 ingredients in Organic Apple Cider Vinegar interact with drugs. Each result below shows which ingredient is responsible. organic Black Pepper extract organic Cayenne powder organic Apple Cider Vinegar powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Apple Cider Vinegar with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Black Pepper extract17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
organic Black Pepper extract full monograph & interactions

organic Cayenne powder6 drug types · 239 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro research shows that capsicum might increase the effects of antiplatelet drugs. Also, population research shows that capsicum is associated with an increased risk of self-reported bleeding in patients taking warfarin. However, clinical research shows that taking a single dose of capsaicin (Asian Herbex Ltd.), the active ingredient in capsicum, 400-800 mcg orally in combination with aspirin 500 mg does not decrease platelet aggregation when compared with taking aspirin 500 mg alone. Also, there was no notable effect on measures of platelet aggregation with capsaicin. It is unclear whether capsaicin must be used in more than a single dose to affect platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.
Preliminary clinical research shows that consuming capsicum 5 grams along with a glucose drink attenuates the rise in plasma glucose after 30 minutes by 21%, decreases the 2-hour postprandial area under the curve of plasma glucose by 11%, and increases the 2-hour postprandial area under the curve of plasma insulin by 58% in healthy individuals when compared with placebo. Other clinical research shows that taking capsicum 5 mg daily for 28 days significantly reduces postprandial blood glucose and insulin levels, but not fasting blood glucose and insulin levels, in patients with gestational diabetes.

Likelihood Possible Evidence B
Aspirin

Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Animal research shows that acute or chronic intake of capsicum pepper reduces oral aspirin bioavailability. This has not been shown in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, taking capsicum with theophylline might increase the levels and adverse effects of theophylline.
In animal research, oral administration of capsicum reduced excretion of theophylline. However, capsicum does not seem to affect the pharmacokinetics of theophylline when administered intravenously.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.
There is one case report of a topically applied capsaicin cream contributing to the cough reflex in a patient using an ACEI. However, it is unclear if this interaction is clinically significant.

Likelihood Unlikely Evidence D
Ciprofloxacin (Cipro)

Theoretically, taking capsicum with ciprofloxacin might increase levels and adverse effects of ciprofloxacin.
Animal research shows that concomitant use of capsaicin, the active constituent of capsicum, and ciprofloxacin increases the bioavailability of ciprofloxacin by up to 70%.

Likelihood Possible Evidence D
organic Cayenne powder full monograph & interactions

organic Apple Cider Vinegar powder4 drug types · 162 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of apple cider vinegar with digoxin might increase the risk of cardiac toxicity.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar could decrease potassium levels, increasing the risk of toxicity with digoxin.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. There is some concern that people taking apple cider vinegar along with potassium depleting diuretics might have an increased risk for hypokalemia.

Likelihood Possible Evidence D
Insulin

Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar concomitantly with insulin might increase the risk of hypokalemia.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Apple cider vinegar might reduce fasting and postprandial blood glucose levels and decrease gastric emptying in people with diabetes. However, not all research agrees. Theoretically, it might have additive effects on glucose levels when used with antidiabetes drugs.

Likelihood Possible Evidence B
organic Apple Cider Vinegar powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Apple Cider Vinegar, from the product label.

PureCo

See all PureCo products
Name
Pure Co, USA Supplements LLC
Street Address
31 N. Gould St. Ste. 6594
City
Sheridan
State
WY
ZipCode
82801
Web Address
www.mypure.co
Pharmacist Counseling Corner

Organic Apple Cider Vinegar by PureCo: Common Questions

Does Organic Apple Cider Vinegar by PureCo interact with any medications?
Yes. Based on its ingredients, Organic Apple Cider Vinegar has a known interaction with 1,097 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Apple Cider Vinegar contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually help with blood sugar or weight loss?
The evidence for apple cider vinegar is insufficient for us to say it works. Cayenne has good evidence for certain nerve pain conditions, but not for general health or weight. If you're managing diabetes or trying to lose weight, talk with your doctor or pharmacist about whether this product fits into your plan.
Is it safe to take long-term?
In food amounts, apple cider vinegar is fine long-term. However, in larger medicinal doses, long-term use has caused serious side effects including low potassium levels, bone loss, and kidney issues in reported cases. Stick to amounts your doctor approves, and don't take it undiluted.
Can I use the black pepper or cayenne topically?
The safety data we hold covers oral use. Topically, apple cider vinegar can cause chemical burns, and cayenne is approved in topical products but commonly causes burning and irritation. If you're thinking about topical use, check with your doctor or pharmacist first.
Is this safe during pregnancy or while breastfeeding?
Black pepper is rated Likely Safe in pregnancy and during lactation. The safety data for apple cider vinegar and cayenne in pregnancy and lactation is not specified in our records. If you're pregnant or breastfeeding, talk with your doctor before taking this product.
What are the most common side effects?
Apple cider vinegar in larger doses can cause gastrointestinal upset. Black pepper commonly causes a burning aftertaste and indigestion. Cayenne causes belching, bloating, diarrhea, indigestion, gas, and skin flushing. Most of these are mild in food amounts.
Will this powder make a noticeable difference if I just add it to drinks?
We don't have evidence that apple cider vinegar powder works for the conditions it's commonly marketed for. Cayenne has solid evidence for specific types of nerve pain, but you'd need to talk with your doctor about whether this product in powder form would give you a meaningful dose for that purpose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Apple Cider Vinegar is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Apple Cider Vinegar label
Go deeper

The Full Monographs Behind Organic Apple Cider Vinegar’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Apple Cider Vinegar

Interacts with 162 drugs

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of these uses is limited and mixed, and the...

Read the full Apple Cider Vinegar monograph → Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph → Herb & supplement monograph

Capsicum

Interacts with 239 drugs

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin products are supported by reasonable evid...

Read the full Capsicum monograph →
Sources

Sources & How We Checked

Organic Apple Cider Vinegar's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 129 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Apple Cider Vinegar 11 references
  1. Lhotta K, Hofle G, Gasser R, Finkenstedt G. Hypokalemia, hyperreninemia, and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80:242-3. PubMed
  2. Hill LL, Woodruff LH, Foote JC, Barreto-Alcoba M. Esophageal injury by apple cider vinegar tablets and subsequent evaluation of products. J Am Diet Assoc 2005;105:1141-4. PubMed
  3. Hlebowicz J, Darwiche G, Björgell O, Almér LO. Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study. BMC Gastroenterol 2007;7:46. PubMed
  4. Johnston CS, Kim CM, Buller AJ. Vinegar improves insulin sensitivity to a high-carbohydrate meal in subjects with insulin resistance or type 2 diabetes. Diabetes Care 2004;27:281-2. PubMed
  5. Lhotta, K., Hofle, G., Gasser, R., and Finkenstedt, G. Hypokalemia, hyperreninemia and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80(2):242-243. PubMed
  6. Bunick CG, Lott JP, Warren CB, et al. Chemical burn from topical apple cider vinegar. J Am Acad Dermatol 2012;67(4):e143-4. PubMed
  7. Feldstein S, Afshar M, Krakowski AC. Chemical Burn from Vinegar Following an Internet-based Protocol for Self-removal of Nevi. J Clin Aesthet Dermatol. 2015 Jun;8(6):50.
  8. Luu LA, Flowers RH, Kellams AL, et al. Apple cider vinegar soaks [0.5%] as a treatment for atopic dermatitis do not improve skin barrier integrity. Pediatr Dermatol. 2019;36(5):634-639. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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