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Dietary supplement

Organic Lions Mane Ingredients & Drug Interactions

by PureCo

Organic Lions Mane label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Lions Mane against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Lions Mane is a dietary supplement by PureCo with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane Fruiting Body Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Organic Lions Mane by PureCo

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Lions Mane by PureCo — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Organic Lions Mane by PureCo

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Organic Lions Mane by PureCo contains one active ingredient: lion's mane fruiting body extract, a concentrated form of the medicinal mushroom believed to support brain and nerve function. The capsule also contains several inactive ingredients — pullulan, brown rice protein, erythritol, sunflower lecithin, and medium chain triglyceride — which serve as the capsule material, flow agent, and stabilizer.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Memory and cognitive support.
  • We looked for evidence on: Memory, Cognitive function, Cognitive impairment, Dementia, Alzheimer disease, Parkinson disease — and 3 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Cognitive impairment, Dementia, Memory, and more.

The evidence we hold for lion's mane on its marketed uses — including Alzheimer disease, anxiety, athletic performance, cancer, cognitive function, and cognitive impairment — all show insufficient reliable evidence to make a rating. That doesn't mean it doesn't work; it means the research to date hasn't been strong enough for us to confirm one way or the other.

If you're considering it for a specific reason, talk it over with your doctor or pharmacist about what the current science suggests for your situation.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane is generally well tolerated as a food, though long-term safety as a supplement hasn't been extensively studied. The most common side effects from oral use are gastrointestinal discomfort, nausea, and skin rash.

There isn't enough safety data to recommend this supplement during pregnancy or while breastfeeding. If you're pregnant, nursing, or planning to become pregnant, talk with your doctor or pharmacist before taking it.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel) — lion's mane may increase bleeding risk. Also confirm your use if you're on diabetes medications or drugs that suppress your immune system, such as those taken after organ transplant, since lion's mane may interfere with how these work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Organic Lions Mane may appeal to you if you're interested in mushroom-based supplements for cognitive support, but the evidence we have is currently insufficient to confirm how well it works for that purpose. Before you take it, check your medications — especially blood thinners, diabetes drugs, and immunosuppressants — with your own doctor or pharmacist, since lion's mane can interact with these.

If you're pregnant or breastfeeding, skip it unless you've cleared it with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Lions Mane, straight from the product label.

Brand PureCo
Net contents 60 Vegan Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 318404
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Lions Mane by PureCo, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegan Capsule(s)
Maximum serving Sizes:
2 Vegan Capsule(s)
Servings per container
30
IngredientAmount% DV
Lion's Mane Fruiting Body Extract1000 mg--

Other ingredients: Pullulan, Brown Rice Protein, Erythritol, Sunflower Lecithin, Medium Chain Triglyceride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use For adults: Take two (2) capsules once daily, preferably with a meal, or as directed by a healthcare professional.

Precautions

Discontinue use if side effects appear.

If you are pregnant, nursing, taking medications or have any medical condition please discuss use with your healthcare practitioner.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

Formulation

Satisfaction Guarantee We offer a full refund on the purchase price of your order within 90 days of purchase. Restrictions apply. For details please visit: www.mypure.co/refunds

We are committed to using organic and non-GMO ingredients whenever possible, and manufacture our products right here in the USA with global & domestic ingredients.

Certified Organic by Organic Certifiers

This product does not contain: Yeast, wheat, gluten, dairy, corn, soy, eggs, sugar, tree nuts, peanuts, fish, shellfish or hydrogenated oils.

General Statements

PureCo - A company founded on one core principle: to bring you the purest dietary supplements possible.

Natural herbals

Seals/Symbols

USDA Organic Certified Organic by Organic Certifiers USA Made in the USA with domestic & international ingredients

Formula

10:1 extract Powerful 30% polysaccharides

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Lions Mane by PureCo label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Lions Mane label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Lions Mane by PureCo

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Vegan Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Lion's Mane Fruiting Body Extract

Interacts with
327 drugs
1000 mg per serving Form: Polysaccharides

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane Fruiting Body Extract monograph & interactions

Other (inactive) ingredients: Pullulan, Brown Rice Protein, Erythritol, Sunflower Lecithin, Medium Chain Triglyceride. These complete the product’s ingredient list but are not active constituents.

Interaction report

Organic Lions Mane by PureCo Drug Interactions

Want to check YOUR meds against Organic Lions Mane?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane Fruiting Body Extract 327

Individual Drug Interactions

The ingredients in Organic Lions Mane interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Organic Lions Mane interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane Fruiting Body Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Lions Mane with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane Fruiting Body Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane Fruiting Body Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Lions Mane, from the product label.

PureCo

See all PureCo products
Name
Pure Co USA Supplements, LLC
Street Address
239 2nd Ave. S., 2nd Floor
City
St. Petersburg
State
FL
ZipCode
33701
Pharmacist Counseling Corner

Organic Lions Mane by PureCo: Common Questions

Does Organic Lions Mane by PureCo interact with any medications?
Yes. Based on its ingredients, Organic Lions Mane has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Lions Mane contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is lion's mane mushroom?
Lion's mane is a medicinal mushroom used in traditional medicine and now sold as a supplement. This product contains an extract of the fruiting body — the visible part you'd recognize as a mushroom — concentrated to provide a potent dose.
Could lion's mane cause stomach upset?
Yes. The most common side effects are gastrointestinal discomfort and nausea, along with the occasional skin rash. Most people tolerate it well, but if your stomach is sensitive, take it with food or talk with your pharmacist about whether it's right for you.
Is lion's mane safe to take while pregnant?
There isn't enough safety data, so it's best to avoid it during pregnancy. Talk with your doctor or pharmacist before taking it if you're pregnant or planning to become pregnant.
Can I take this if I'm on a blood thinner?
Not without checking first. Lion's mane may increase your bleeding risk when combined with blood thinners like warfarin or antiplatelet drugs like aspirin. Confirm with your doctor or pharmacist before starting.
Does this product actually work for brain health?
The evidence we have for lion's mane on cognitive function, Alzheimer disease, anxiety, and other brain-related concerns shows insufficient reliable evidence to confirm effectiveness. There's research ongoing, but we can't make a solid claim yet.
What are the inactive ingredients?
The capsule contains pullulan, brown rice protein, erythritol, sunflower lecithin, and medium chain triglyceride — materials that make up the capsule itself and help keep the product stable.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Lions Mane is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Lions Mane label
Go deeper

The Full Monographs Behind Organic Lions Mane’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Organic Lions Mane's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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